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Protein

Neutrophil antibiotic peptide NP-4

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microbicidal activity.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil antibiotic peptide NP-4
Alternative name(s):
Microbicidal peptide NP-4
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000681320 – 621 PublicationAdd BLAST43
PeptideiPRO_000000681463 – 95Neutrophil antibiotic peptide NP-4Add BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 93By similarity
Disulfide bondi67 ↔ 82By similarity
Disulfide bondi72 ↔ 92By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSOCUG00000025488

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000020922

Structurei

3D structure databases

SMRiP07467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2 Eukaryota
ENOG4111A2R LUCA
GeneTreeiENSGT00920000150057
HOGENOMiHOG000233351
HOVERGENiHBG011703
InParanoidiP07467
KOiK05230
OMAiRCRISER
OrthoDBiEOG091G12GE
TreeFamiTF338414

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLALLAAI LLVTLQAQAE LHSGMADDGV DQQQPRAQDL DVAVYIKQDE
60 70 80 90
TSPLEVLGAK AGVSCTCRRF SCGFGERASG SCTVNGVRHT LCCRR
Length:95
Mass (Da):10,181
Last modified:August 1, 1992 - v2
Checksum:i61C86A5807064B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64601 mRNA Translation: AAA31238.1
PIRiI46705
RefSeqiNP_001075768.1, NM_001082299.1
XP_008272397.1, XM_008274175.2
UniGeneiOcu.1866

Genome annotation databases

EnsembliENSOCUT00000024778; ENSOCUP00000020922; ENSOCUG00000025488
GeneIDi100009135
KEGGiocu:100009135

Similar proteinsi

Entry informationi

Entry nameiDEF5_RABIT
AccessioniPrimary (citable) accession number: P07467
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: August 1, 1992
Last modified: June 20, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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