UniProtKB - P07455 (IGF1_BOVIN)
Protein
Insulin-like growth factor I
Gene
IGF1
Organism
Bos taurus (Bovine)
Status
Functioni
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).By similarity
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: InterPro
- insulin-like growth factor receptor binding Source: UniProtKB
GO - Biological processi
- cell population proliferation Source: AgBase
- hyperosmotic salinity response Source: AgBase
- insulin-like growth factor receptor signaling pathway Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of release of cytochrome c from mitochondria Source: UniProtKB
- negative regulation of sodium:potassium-exchanging ATPase activity Source: AgBase
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of glucose import Source: UniProtKB
- positive regulation of glycogen biosynthetic process Source: UniProtKB
- positive regulation of sodium:potassium-exchanging ATPase activity Source: AgBase
- response to electrical stimulus Source: AgBase
- response to food Source: AgBase
- response to growth hormone Source: AgBase
- response to insulin Source: AgBase
- response to magnetism Source: AgBase
Keywordsi
Molecular function | Growth factor |
Enzyme and pathway databases
Reactomei | R-BTA-114608, Platelet degranulation R-BTA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-BTA-422085, Synthesis, secretion, and deacylation of Ghrelin |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor IShort name: IGF-I Alternative name(s): Somatomedin |
Gene namesi | Name:IGF1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:30076, IGF1 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Cytosol
- cytosol Source: AgBase
Extracellular region or secreted
- extracellular space Source: AgBase
Plasma Membrane
- alphav-beta3 integrin-IGF-1-IGF1R complex Source: UniProtKB
Other locations
- exocytic vesicle Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – ? | Sequence analysis | ||
PropeptideiPRO_0000015647 | ? – 49 | |||
ChainiPRO_0000015648 | 50 – 119 | Insulin-like growth factor IAdd BLAST | 70 | |
PropeptideiPRO_0000015649 | 120 – 154 | E peptideAdd BLAST | 35 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 55 ↔ 97 | By similarity | ||
Disulfide bondi | 67 ↔ 110 | By similarity | ||
Disulfide bondi | 96 ↔ 101 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P07455 |
PRIDEi | P07455 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000011082, Expressed in liver and 18 other tissues |
ExpressionAtlasi | P07455, baseline and differential |
Interactioni
Subunit structurei
Forms a ternary complex with IGFR1 and ITGAV:ITGB3.
Forms a ternary complex with IGFR1 and ITGA6:ITGB4.
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- hormone activity Source: InterPro
- insulin-like growth factor receptor binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000055243 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 50 – 78 | BAdd BLAST | 29 | |
Regioni | 79 – 90 | CAdd BLAST | 12 | |
Regioni | 91 – 111 | AAdd BLAST | 21 | |
Regioni | 112 – 119 | D | 8 |
Sequence similaritiesi
Belongs to the insulin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RCAB, Eukaryota |
GeneTreei | ENSGT00940000159081 |
HOGENOMi | CLU_123939_0_0_1 |
InParanoidi | P07455 |
OMAi | LVKCCFC |
Family and domain databases
InterProi | View protein in InterPro IPR022341, IGF-I IPR016179, Insulin-like IPR022350, Insulin-like_growth_factor IPR036438, Insulin-like_sf IPR022353, Insulin_CS IPR022352, Insulin_family |
Pfami | View protein in Pfam PF00049, Insulin, 1 hit |
PRINTSi | PR02002, INSLNLIKEGF PR02005, INSLNLIKEGF1 PR00276, INSULINFAMLY |
SMARTi | View protein in SMART SM00078, IlGF, 1 hit |
SUPFAMi | SSF56994, SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262, INSULIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P07455-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKISSLPTQ LFKCCFCDFL KQVKMPITSS SHLFYLALCL LAFTSSATAG
60 70 80 90 100
PETLCGAELV DALQFVCGDR GFYFNKPTGY GSSSRRAPQT GIVDECCFRS
110 120 130 140 150
CDLRRLEMYC APLKPAKSAR SVRAQRHTDM PKAQKEVHLK NTSRGSAGNK
NYRM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF2X2F1 | F2X2F1_BOVIN | Insulin-like growth factor I | IGF1 IGF-I | 188 | Annotation score: | ||
F2X2F3 | F2X2F3_BOVIN | Insulin-like growth factor I | IGF1 IGF-I | 172 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15726 mRNA Translation: CAA33746.1 S76122 mRNA Translation: AAD14209.1 |
PIRi | S12672, IGBO1 |
RefSeqi | NP_001071296.1, NM_001077828.1 |
Genome annotation databases
Ensembli | ENSBTAT00000014713; ENSBTAP00000014713; ENSBTAG00000011082 |
GeneIDi | 281239 |
KEGGi | bta:281239 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15726 mRNA Translation: CAA33746.1 S76122 mRNA Translation: AAD14209.1 |
PIRi | S12672, IGBO1 |
RefSeqi | NP_001071296.1, NM_001077828.1 |
3D structure databases
BMRBi | P07455 |
SMRi | P07455 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000055243 |
Proteomic databases
PaxDbi | P07455 |
PRIDEi | P07455 |
Genome annotation databases
Ensembli | ENSBTAT00000014713; ENSBTAP00000014713; ENSBTAG00000011082 |
GeneIDi | 281239 |
KEGGi | bta:281239 |
Organism-specific databases
CTDi | 3479 |
VGNCi | VGNC:30076, IGF1 |
Phylogenomic databases
eggNOGi | ENOG502RCAB, Eukaryota |
GeneTreei | ENSGT00940000159081 |
HOGENOMi | CLU_123939_0_0_1 |
InParanoidi | P07455 |
OMAi | LVKCCFC |
Enzyme and pathway databases
Reactomei | R-BTA-114608, Platelet degranulation R-BTA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-BTA-422085, Synthesis, secretion, and deacylation of Ghrelin |
Gene expression databases
Bgeei | ENSBTAG00000011082, Expressed in liver and 18 other tissues |
ExpressionAtlasi | P07455, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR022341, IGF-I IPR016179, Insulin-like IPR022350, Insulin-like_growth_factor IPR036438, Insulin-like_sf IPR022353, Insulin_CS IPR022352, Insulin_family |
Pfami | View protein in Pfam PF00049, Insulin, 1 hit |
PRINTSi | PR02002, INSLNLIKEGF PR02005, INSLNLIKEGF1 PR00276, INSULINFAMLY |
SMARTi | View protein in SMART SM00078, IlGF, 1 hit |
SUPFAMi | SSF56994, SSF56994, 1 hit |
PROSITEi | View protein in PROSITE PS00262, INSULIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IGF1_BOVIN | |
Accessioni | P07455Primary (citable) accession number: P07455 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | November 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families