UniProtKB - P07437 (TBB5_HUMAN)
Tubulin beta chain
TUBB
Functioni
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 140 – 146 | GTPSequence analysis | 7 |
GO - Molecular functioni
- GTPase activating protein binding Source: Ensembl
- GTPase activity Source: InterPro
- GTP binding Source: GO_Central
- MHC class I protein binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- structural constituent of cytoskeleton Source: GO_Central
- structural molecule activity Source: BHF-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- cell division Source: BHF-UCL
- cytoskeleton-dependent intracellular transport Source: BHF-UCL
- microtubule-based process Source: BHF-UCL
- microtubule cytoskeleton organization Source: GO_Central
- mitotic cell cycle Source: GO_Central
- natural killer cell mediated cytotoxicity Source: UniProtKB
- odontoblast differentiation Source: GO_Central
- regulation of synapse organization Source: Ensembl
- spindle assembly Source: Ensembl
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P07437 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-6798695, Neutrophil degranulation R-HSA-8854518, AURKA Activation by TPX2 R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | P07437 |
SIGNORi | P07437 |
Names & Taxonomyi
Protein namesi | Recommended name: Tubulin beta chainAlternative name(s): Tubulin beta-5 chain |
Gene namesi | Name:TUBB Synonyms:TUBB5 ORF Names:OK/SW-cl.56 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20778, TUBB |
MIMi | 191130, gene |
neXtProti | NX_P07437 |
VEuPathDBi | HostDB:ENSG00000196230 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Cytoskeleton
- cytoskeleton Source: UniProtKB
- microtubule Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Lysosome
- azurophil granule lumen Source: Reactome
Nucleus
- nuclear envelope lumen Source: DFLAT
- nucleus Source: UniProtKB
Other locations
- cell body Source: DFLAT
- cytoplasm Source: CAFA
- cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
- membrane raft Source: Ensembl
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Involvement in diseasei
Cortical dysplasia, complex, with other brain malformations 6 (CDCBM6)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071763 | 299 | M → V in CDCBM6; decreases the ability of the protein to assemble into tubulin heterodimers. 1 PublicationCorresponds to variant dbSNP:rs587777355EnsemblClinVar. | 1 | |
Natural variantiVAR_071764 | 353 | V → I in CDCBM6; does not affect the ability of the mutant polypeptides to assemble into heterodimers and incorporate into microtubules. 1 PublicationCorresponds to variant dbSNP:rs587777356EnsemblClinVar. | 1 | |
Natural variantiVAR_071765 | 401 | E → K in CDCBM6; arrests the assembly pathway of alpha/beta-tubulin; the mutant protein is unable to coassemble into a tubulin heterodimer but is instead distributed throughout the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs587777357EnsemblClinVar. | 1 |
Skin creases, congenital symmetric circumferential, 1 (CSCSC1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076543 | 15 | Q → K in CSCSC1; disrupts heterodimer assembly and microtubule dynamics. 1 PublicationCorresponds to variant dbSNP:rs864321676EnsemblClinVar. | 1 | |
Natural variantiVAR_076544 | 222 | Y → F in CSCSC1; disrupts heterodimer assembly and microtubule dynamics. 1 PublicationCorresponds to variant dbSNP:rs864321677EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 203068 |
GeneReviewsi | TUBB |
MalaCardsi | TUBB |
MIMi | 156610, phenotype 615771, phenotype |
OpenTargetsi | ENSG00000196230 |
Orphaneti | 2505, Multiple benign circumferential skin creases on limbs |
PharmGKBi | PA358 |
Miscellaneous databases
Pharosi | P07437, Tclin |
Chemistry databases
ChEMBLi | CHEMBL5444 |
DrugBanki | DB11638, Artenimol DB05284, CA4P DB15534, Colchiceine DB01394, Colchicine DB09130, Copper DB05147, CYT997 DB11731, Depatuxizumab mafodotin DB01873, Epothilone D DB12334, Milataxel DB03010, Patupilone DB01179, Podofilox DB06137, Tirbanibulin DB00570, Vinblastine DB00541, Vincristine DB11641, Vinflunine DB00361, Vinorelbine DB06042, ZEN-012 |
DrugCentrali | P07437 |
GuidetoPHARMACOLOGYi | 2640 |
Genetic variation databases
BioMutai | TUBB |
DMDMi | 56757569 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000048243 | 1 – 444 | Tubulin beta chainAdd BLAST | 444 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 40 | PhosphoserineBy similarity | 1 | |
Modified residuei | 55 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 58 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 58 | N6-succinyllysine; alternateBy similarity | 1 | |
Cross-linki | 58 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate | ||
Modified residuei | 172 | Phosphoserine; by CDK11 Publication | 1 | |
Modified residuei | 285 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 290 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 318 | Omega-N-methylarginine1 Publication | 1 | |
Cross-linki | 324 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||
Modified residuei | 434 | 5-glutamyl polyglutamate1 Publication | 1 | |
Modified residuei | 438 | 5-glutamyl glycine1 Publication | 1 | |
Modified residuei | 438 | 5-glutamyl polyglutamate1 Publication | 1 | |
Modified residuei | 439 | 5-glutamyl glycine1 Publication | 1 | |
Modified residuei | 439 | 5-glutamyl polyglutamate1 Publication | 1 | |
Modified residuei | 441 | 5-glutamyl glycine1 Publication | 1 | |
Modified residuei | 441 | 5-glutamyl polyglutamate1 Publication | 1 | |
Modified residuei | 442 | 5-glutamyl glycine1 Publication | 1 | |
Modified residuei | 443 | 5-glutamyl glycine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P07437 |
jPOSTi | P07437 |
MassIVEi | P07437 |
PaxDbi | P07437 |
PeptideAtlasi | P07437 |
PRIDEi | P07437 |
ProteomicsDBi | 52002 |
TopDownProteomicsi | P07437 |
2D gel databases
OGPi | P07437 |
REPRODUCTION-2DPAGEi | P07437 |
SWISS-2DPAGEi | P07437 |
UCD-2DPAGEi | P07437 |
PTM databases
GlyGeni | P07437, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P07437 |
MetOSitei | P07437 |
PhosphoSitePlusi | P07437 |
SwissPalmi | P07437 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000196230, Expressed in cerebral cortex and 247 other tissues |
ExpressionAtlasi | P07437, baseline and differential |
Genevisiblei | P07437, HS |
Organism-specific databases
HPAi | ENSG00000196230, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer of alpha and beta chains (PubMed:26637975). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Interacts with PIFO (PubMed:20643351).
Interacts with DIAPH1 (PubMed:23325789).
Interacts with MX1 (By similarity). May interact with RNABP10 (By similarity).
Interacts with CFAP157 (By similarity). Nascent tubulin polypeptide interacts (via beta-tubulin MREI motif) with TTC5/STRAP; this interaction results in tubulin mRNA-targeted degradation (PubMed:31727855).
By similarity4 PublicationsBinary interactionsi
P07437
GO - Molecular functioni
- GTPase activating protein binding Source: Ensembl
- MHC class I protein binding Source: UniProtKB
- protein domain specific binding Source: Ensembl
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 128444, 586 interactors |
CORUMi | P07437 |
DIPi | DIP-32772N |
IntActi | P07437, 206 interactors |
MINTi | P07437 |
STRINGi | 9606.ENSP00000339001 |
Chemistry databases
BindingDBi | P07437 |
Miscellaneous databases
RNActi | P07437, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 423 – 444 | DisorderedSequence analysisAdd BLAST | 22 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1 – 4 | MREI motif1 Publication | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 427 – 444 | Acidic residuesSequence analysisAdd BLAST | 18 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1375, Eukaryota |
GeneTreei | ENSGT00940000154370 |
HOGENOMi | CLU_015718_1_1_1 |
InParanoidi | P07437 |
OMAi | YNEGSAG |
OrthoDBi | 962471at2759 |
PhylomeDBi | P07437 |
TreeFami | TF300298 |
Family and domain databases
Gene3Di | 1.10.287.600, 1 hit 3.30.1330.20, 1 hit 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR013838, Beta-tubulin_BS IPR002453, Beta_tubulin IPR008280, Tub_FtsZ_C IPR000217, Tubulin IPR037103, Tubulin/FtsZ-like_C IPR018316, Tubulin/FtsZ_2-layer-sand-dom IPR036525, Tubulin/FtsZ_GTPase_sf IPR023123, Tubulin_C IPR017975, Tubulin_CS IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit PF03953, Tubulin_C, 1 hit |
PRINTSi | PR01163, BETATUBULIN PR01161, TUBULIN |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit SM00865, Tubulin_C, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit SSF55307, SSF55307, 1 hit |
PROSITEi | View protein in PROSITE PS00227, TUBULIN, 1 hit PS00228, TUBULIN_B_AUTOREG, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLDRISVY
60 70 80 90 100
YNEATGGKYV PRAILVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN
110 120 130 140 150
WAKGHYTEGA ELVDSVLDVV RKEAESCDCL QGFQLTHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRIMNTFSVV PSPKVSDTVV EPYNATLSVH QLVENTDETY
210 220 230 240 250
CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL RFPGQLNADL
260 270 280 290 300
RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQVFDAKNMM
310 320 330 340 350
AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK
360 370 380 390 400
TAVCDIPPRG LKMAVTFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG
410 420 430 440
EGMDEMEFTE AESNMNDLVS EYQQYQDATA EEEEDFGEEA EEEA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5ST81 | Q5ST81_HUMAN | Tubulin beta chain | TUBB | 372 | Annotation score: | ||
Q5JP53 | Q5JP53_HUMAN | Tubulin beta chain | TUBB | 426 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 | K → R no nucleotide entry (PubMed:6688039).Curated | 1 | |
Sequence conflicti | 216 | K → R in AAB59507 (PubMed:6865944).Curated | 1 | |
Sequence conflicti | 231 | A → G no nucleotide entry (PubMed:6688039).Curated | 1 | |
Sequence conflicti | 231 | A → G in AAB59507 (PubMed:6865944).Curated | 1 | |
Sequence conflicti | 234 – 235 | SG → EC no nucleotide entry (PubMed:6688039).Curated | 2 | |
Sequence conflicti | 234 – 235 | SG → EC in AAB59507 (PubMed:6865944).Curated | 2 | |
Sequence conflicti | 288 | E → D no nucleotide entry (PubMed:6688039).Curated | 1 | |
Sequence conflicti | 288 | E → D in AAB59507 (PubMed:6865944).Curated | 1 | |
Sequence conflicti | 298 | N → D in AAH20946 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076543 | 15 | Q → K in CSCSC1; disrupts heterodimer assembly and microtubule dynamics. 1 PublicationCorresponds to variant dbSNP:rs864321676EnsemblClinVar. | 1 | |
Natural variantiVAR_076544 | 222 | Y → F in CSCSC1; disrupts heterodimer assembly and microtubule dynamics. 1 PublicationCorresponds to variant dbSNP:rs864321677EnsemblClinVar. | 1 | |
Natural variantiVAR_071763 | 299 | M → V in CDCBM6; decreases the ability of the protein to assemble into tubulin heterodimers. 1 PublicationCorresponds to variant dbSNP:rs587777355EnsemblClinVar. | 1 | |
Natural variantiVAR_071764 | 353 | V → I in CDCBM6; does not affect the ability of the mutant polypeptides to assemble into heterodimers and incorporate into microtubules. 1 PublicationCorresponds to variant dbSNP:rs587777356EnsemblClinVar. | 1 | |
Natural variantiVAR_071765 | 401 | E → K in CDCBM6; arrests the assembly pathway of alpha/beta-tubulin; the mutant protein is unable to coassemble into a tubulin heterodimer but is instead distributed throughout the cytoplasm. 1 PublicationCorresponds to variant dbSNP:rs587777357EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00314 Genomic DNA Translation: AAB59507.1 AF141349 mRNA Translation: AAD33873.1 AF070561 mRNA Translation: AAC28642.1 AF070593 mRNA Translation: AAC28650.1 AF070600 mRNA Translation: AAC28654.1 BA000025 Genomic DNA Translation: BAB63321.1 AB088100 Genomic DNA Translation: BAC54932.1 AB062393 mRNA Translation: BAB93480.1 BC001938 mRNA Translation: AAH01938.1 BC002347 mRNA Translation: AAH02347.1 BC005838 mRNA Translation: AAH05838.1 BC007605 mRNA Translation: AAH07605.1 BC013374 mRNA Translation: AAH13374.1 BC019924 mRNA Translation: AAH19924.1 BC020946 mRNA Translation: AAH20946.1 BC021909 mRNA Translation: AAH21909.1 BC070326 mRNA Translation: AAH70326.1 |
CCDSi | CCDS4687.1 |
PIRi | A26561 |
RefSeqi | NP_001280141.1, NM_001293212.1 NP_001280142.1, NM_001293213.1 NP_001280143.1, NM_001293214.1 NP_001280144.1, NM_001293215.1 NP_001280145.1, NM_001293216.1 NP_821133.1, NM_178014.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Tubulin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00314 Genomic DNA Translation: AAB59507.1 AF141349 mRNA Translation: AAD33873.1 AF070561 mRNA Translation: AAC28642.1 AF070593 mRNA Translation: AAC28650.1 AF070600 mRNA Translation: AAC28654.1 BA000025 Genomic DNA Translation: BAB63321.1 AB088100 Genomic DNA Translation: BAC54932.1 AB062393 mRNA Translation: BAB93480.1 BC001938 mRNA Translation: AAH01938.1 BC002347 mRNA Translation: AAH02347.1 BC005838 mRNA Translation: AAH05838.1 BC007605 mRNA Translation: AAH07605.1 BC013374 mRNA Translation: AAH13374.1 BC019924 mRNA Translation: AAH19924.1 BC020946 mRNA Translation: AAH20946.1 BC021909 mRNA Translation: AAH21909.1 BC070326 mRNA Translation: AAH70326.1 |
CCDSi | CCDS4687.1 |
PIRi | A26561 |
RefSeqi | NP_001280141.1, NM_001293212.1 NP_001280142.1, NM_001293213.1 NP_001280143.1, NM_001293214.1 NP_001280144.1, NM_001293215.1 NP_001280145.1, NM_001293216.1 NP_821133.1, NM_178014.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3QNZ | X-ray | 2.20 | C | 429-438 | [»] | |
3QO0 | X-ray | 2.30 | C | 422-441 | [»] | |
5N5N | electron microscopy | 4.00 | A/B/C/D/E/F | 1-426 | [»] | |
6I2I | electron microscopy | 3.60 | B | 1-444 | [»] | |
6QUS | electron microscopy | 3.70 | S/U | 1-444 | [»] | |
6QUY | electron microscopy | 3.80 | G/H | 1-444 | [»] | |
6QVE | electron microscopy | 3.70 | G/H | 1-444 | [»] | |
6QVJ | electron microscopy | 3.80 | S/U | 1-444 | [»] | |
SMRi | P07437 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 128444, 586 interactors |
CORUMi | P07437 |
DIPi | DIP-32772N |
IntActi | P07437, 206 interactors |
MINTi | P07437 |
STRINGi | 9606.ENSP00000339001 |
Chemistry databases
BindingDBi | P07437 |
ChEMBLi | CHEMBL5444 |
DrugBanki | DB11638, Artenimol DB05284, CA4P DB15534, Colchiceine DB01394, Colchicine DB09130, Copper DB05147, CYT997 DB11731, Depatuxizumab mafodotin DB01873, Epothilone D DB12334, Milataxel DB03010, Patupilone DB01179, Podofilox DB06137, Tirbanibulin DB00570, Vinblastine DB00541, Vincristine DB11641, Vinflunine DB00361, Vinorelbine DB06042, ZEN-012 |
DrugCentrali | P07437 |
GuidetoPHARMACOLOGYi | 2640 |
PTM databases
GlyGeni | P07437, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P07437 |
MetOSitei | P07437 |
PhosphoSitePlusi | P07437 |
SwissPalmi | P07437 |
Genetic variation databases
BioMutai | TUBB |
DMDMi | 56757569 |
2D gel databases
OGPi | P07437 |
REPRODUCTION-2DPAGEi | P07437 |
SWISS-2DPAGEi | P07437 |
UCD-2DPAGEi | P07437 |
Proteomic databases
EPDi | P07437 |
jPOSTi | P07437 |
MassIVEi | P07437 |
PaxDbi | P07437 |
PeptideAtlasi | P07437 |
PRIDEi | P07437 |
ProteomicsDBi | 52002 |
TopDownProteomicsi | P07437 |
Protocols and materials databases
ABCDi | P07437, 2 sequenced antibodies |
Antibodypediai | 48344, 1048 antibodies from 43 providers |
CPTCi | P07437, 1 antibody |
DNASUi | 203068 |
Genome annotation databases
Organism-specific databases
CTDi | 203068 |
DisGeNETi | 203068 |
GeneCardsi | TUBB |
GeneReviewsi | TUBB |
HGNCi | HGNC:20778, TUBB |
HPAi | ENSG00000196230, Low tissue specificity |
MalaCardsi | TUBB |
MIMi | 156610, phenotype 191130, gene 615771, phenotype |
neXtProti | NX_P07437 |
OpenTargetsi | ENSG00000196230 |
Orphaneti | 2505, Multiple benign circumferential skin creases on limbs |
PharmGKBi | PA358 |
VEuPathDBi | HostDB:ENSG00000196230 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1375, Eukaryota |
GeneTreei | ENSGT00940000154370 |
HOGENOMi | CLU_015718_1_1_1 |
InParanoidi | P07437 |
OMAi | YNEGSAG |
OrthoDBi | 962471at2759 |
PhylomeDBi | P07437 |
TreeFami | TF300298 |
Enzyme and pathway databases
PathwayCommonsi | P07437 |
Reactomei | R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-6798695, Neutrophil degranulation R-HSA-8854518, AURKA Activation by TPX2 R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | P07437 |
SIGNORi | P07437 |
Miscellaneous databases
BioGRID-ORCSi | 203068, 757 hits in 1023 CRISPR screens |
ChiTaRSi | TUBB, human |
GeneWikii | TUBB |
GenomeRNAii | 203068 |
Pharosi | P07437, Tclin |
PROi | PR:P07437 |
RNActi | P07437, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196230, Expressed in cerebral cortex and 247 other tissues |
ExpressionAtlasi | P07437, baseline and differential |
Genevisiblei | P07437, HS |
Family and domain databases
Gene3Di | 1.10.287.600, 1 hit 3.30.1330.20, 1 hit 3.40.50.1440, 1 hit |
InterProi | View protein in InterPro IPR013838, Beta-tubulin_BS IPR002453, Beta_tubulin IPR008280, Tub_FtsZ_C IPR000217, Tubulin IPR037103, Tubulin/FtsZ-like_C IPR018316, Tubulin/FtsZ_2-layer-sand-dom IPR036525, Tubulin/FtsZ_GTPase_sf IPR023123, Tubulin_C IPR017975, Tubulin_CS IPR003008, Tubulin_FtsZ_GTPase |
PANTHERi | PTHR11588, PTHR11588, 1 hit |
Pfami | View protein in Pfam PF00091, Tubulin, 1 hit PF03953, Tubulin_C, 1 hit |
PRINTSi | PR01163, BETATUBULIN PR01161, TUBULIN |
SMARTi | View protein in SMART SM00864, Tubulin, 1 hit SM00865, Tubulin_C, 1 hit |
SUPFAMi | SSF52490, SSF52490, 1 hit SSF55307, SSF55307, 1 hit |
PROSITEi | View protein in PROSITE PS00227, TUBULIN, 1 hit PS00228, TUBULIN_B_AUTOREG, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TBB5_HUMAN | |
Accessioni | P07437Primary (citable) accession number: P07437 Secondary accession number(s): P05218, Q8WUC1, Q9CY33 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 23, 2022 | |
This is version 240 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families