UniProtKB - P07412 (HBB_FELCA)
Protein
Hemoglobin subunit beta-A/B
Gene
HBB
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Functioni
Involved in oxygen transport from the lung to the various peripheral tissues.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 63 | Iron (heme distal ligand) | 1 | |
Metal bindingi | 92 | Iron (heme proximal ligand) | 1 |
GO - Molecular functioni
- heme binding Source: GO_Central
- hemoglobin alpha binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- organic acid binding Source: GO_Central
- oxygen binding Source: GO_Central
- oxygen carrier activity Source: GO_Central
GO - Biological processi
- cellular oxidant detoxification Source: GOC
- hydrogen peroxide catabolic process Source: GO_Central
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit beta-A/BAlternative name(s): Beta-A/B-globin Hemoglobin beta-A/B chain |
Gene namesi | Name:HBB |
Organismi | Felis catus (Cat) (Felis silvestris catus) |
Taxonomic identifieri | 9685 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Proteomesi |
|
Subcellular locationi
Cytosol
- hemoglobin complex Source: GO_Central
Other locations
- haptoglobin-hemoglobin complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052958 | 1 – 146 | Hemoglobin subunit beta-A/BAdd BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylserine; in variant beta-B1 Publication | 1 | |
Modified residuei | 44 | PhosphoserineBy similarity | 1 | |
Modified residuei | 59 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 82 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 93 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 144 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Phosphoprotein, S-nitrosylationProteomic databases
PRIDEi | P07412 |
PTM databases
iPTMneti | P07412 |
Expressioni
Tissue specificityi
Red blood cells.
Interactioni
Subunit structurei
Heterotetramer of two alpha chains and two beta chains.
GO - Molecular functioni
- hemoglobin alpha binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9685.ENSFCAP00000015261 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P07412 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07412 |
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3378 Eukaryota COG1018 LUCA |
InParanoidi | P07412 |
Family and domain databases
CDDi | cd08925 Hb-beta_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00814 BETAHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P07412-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GFLTAEEKGL VNGLWGKVNV DEVGGEALGR LLVVYPWTQR FFESFGDLSS
60 70 80 90 100
ADAIMSNAKV KAHGKKVLNS FSDGLKNIDD LKGAFAKLSE LHCDKLHVDP
110 120 130 140
ENFRLLGNVL VCVLAHHFGH DFNPQVQAAF QKVVAGVANA LAHKYH
Polymorphismi
There are two alleles. The sequence shown is that of beta-A.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 1 | G → S in beta-B. 1 Publication | 1 | |
Natural varianti | 4 | T → S in beta-B. 1 Publication | 1 | |
Natural varianti | 139 | N → S in beta-B. 1 Publication | 1 | |
Natural varianti | 144 | K → R in beta-B. 1 Publication | 1 |
Sequence databases
PIRi | B25203 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
PIRi | B25203 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3D4X | X-ray | 2.20 | B/D | 2-146 | [»] | |
3GQP | X-ray | 2.00 | B/D | 2-146 | [»] | |
3GQR | X-ray | 2.40 | B/D/F/H | 2-146 | [»] | |
3GYS | X-ray | 2.90 | B/D/F/H | 2-146 | [»] | |
SMRi | P07412 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9685.ENSFCAP00000015261 |
PTM databases
iPTMneti | P07412 |
Proteomic databases
PRIDEi | P07412 |
Phylogenomic databases
eggNOGi | KOG3378 Eukaryota COG1018 LUCA |
InParanoidi | P07412 |
Miscellaneous databases
EvolutionaryTracei | P07412 |
Family and domain databases
CDDi | cd08925 Hb-beta_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00814 BETAHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HBB_FELCA | |
Accessioni | P07412Primary (citable) accession number: P07412 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | April 1, 1988 | |
Last modified: | June 5, 2019 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references