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Protein

Serine proteinase inhibitor 2

Gene

CRMA

Organism
Cowpox virus (strain Brighton Red) (CPV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a "cross-class" interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei303 – 304Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor
Biological processHost-virus interaction, Inhibition of host caspases by virus, Modulation of host cell apoptosis by virus

Enzyme and pathway databases

ReactomeiR-HSA-5218900 CASP8 activity is inhibited
R-HSA-5357905 Regulation of TNFR1 signaling

Protein family/group databases

MEROPSiI04.028

Names & Taxonomyi

Protein namesi
Recommended name:
Serine proteinase inhibitor 2
Short name:
Serp-2
Short name:
Serpin-2
Alternative name(s):
Cytokine response modifier protein A
Hemorrhage-inducing 38 kDa protein
ICE inhibitor
Gene namesi
Name:CRMA
Synonyms:SPI-2
Ordered Locus Names:CPXV207
OrganismiCowpox virus (strain Brighton Red) (CPV)
Taxonomic identifieri265872 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
Homo sapiens (Human) [TaxID: 9606]
Loxodonta africana (African elephant) [TaxID: 9785]
Microtus agrestis (Short-tailed field vole) [TaxID: 29092]
Mus musculus (Mouse) [TaxID: 10090]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941461 – 341Serine proteinase inhibitor 2Add BLAST341

Interactioni

Protein-protein interaction databases

MINTiP07385

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07385
SMRiP07385
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07385

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Poxviruses subfamily.Curated

Phylogenomic databases

KOiK21537

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

P07385-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIFREIASS MKGENVFISP PSISSVLTIL YYGANGSTAE QLSKYVEKEA
60 70 80 90 100
DKNKDDISFK SMNKVYGRYS AVFKDSFLRK IGDNFQTVDF TDCRTVDAIN
110 120 130 140 150
KCVDIFTEGK INPLLDEPLS PDTCLLAISA VYFKAKWLMP FEKEFTSDYP
160 170 180 190 200
FYVSPTEMVD VSMMSMYGEA FNHASVKESF GNFSIIELPY VGDTSMVVIL
210 220 230 240 250
PDNIDGLESI EQNLTDTNFK KWCDSMDAMF IDVHIPKFKV TGSYNLVDAL
260 270 280 290 300
VKLGLTEVFG STGDYSNMCN SDVSVDAMIH KTYIDVNEEY TEAAAATCAL
310 320 330 340
VADCASTVTN EFCADHPFIY VIRHVDGKIL FVGRYCSPTT N
Length:341
Mass (Da):38,077
Last modified:April 1, 1988 - v1
Checksum:i25AE4E0CB123E172
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14217 Genomic DNA Translation: AAA42922.1
AF482758 Genomic DNA Translation: AAM13646.1
PIRiA26477 WMVZHI
RefSeqiNP_619988.1, NC_003663.2

Genome annotation databases

GeneIDi1486086
KEGGivg:1486086

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14217 Genomic DNA Translation: AAA42922.1
AF482758 Genomic DNA Translation: AAM13646.1
PIRiA26477 WMVZHI
RefSeqiNP_619988.1, NC_003663.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C8OX-ray2.90A1-300[»]
B301-341[»]
1F0CX-ray2.26A1-305[»]
B306-341[»]
1M93X-ray1.65A1-55[»]
B56-300[»]
C301-341[»]
ProteinModelPortaliP07385
SMRiP07385
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiP07385

Protein family/group databases

MEROPSiI04.028

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1486086
KEGGivg:1486086

Phylogenomic databases

KOiK21537

Enzyme and pathway databases

ReactomeiR-HSA-5218900 CASP8 activity is inhibited
R-HSA-5357905 Regulation of TNFR1 signaling

Miscellaneous databases

EvolutionaryTraceiP07385

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPI2_CWPXB
AccessioniPrimary (citable) accession number: P07385
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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