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UniProtKB - P07360 (CO8G_HUMAN)
Protein
Complement component C8 gamma chain
Gene
C8G
Organism
Homo sapiens (Human)
Status
Functioni
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
GO - Molecular functioni
- complement binding Source: GO_Central
- retinol binding Source: UniProtKB-KW
GO - Biological processi
- complement activation, alternative pathway Source: UniProtKB-KW
- complement activation, classical pathway Source: UniProtKB-KW
- cytolysis Source: UniProtKB-KW
Keywordsi
Biological process | Complement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity |
Ligand | Retinol-binding |
Enzyme and pathway databases
PathwayCommonsi | P07360 |
Reactomei | R-HSA-166665, Terminal pathway of complement R-HSA-977606, Regulation of Complement cascade |
SignaLinki | P07360 |
SIGNORi | P07360 |
Names & Taxonomyi
Protein namesi | Recommended name: Complement component C8 gamma chain |
Gene namesi | Name:C8G |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1354, C8G |
MIMi | 120930, gene |
neXtProti | NX_P07360 |
VEuPathDBi | HostDB:ENSG00000176919 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Plasma Membrane
- membrane attack complex Source: ComplexPortal
Keywords - Cellular componenti
Membrane attack complex, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 733 |
MalaCardsi | C8G |
OpenTargetsi | ENSG00000176919 |
Orphaneti | 169150, Immunodeficiency due to a late component of complement deficiency |
PharmGKBi | PA25953 |
Miscellaneous databases
Pharosi | P07360, Tbio |
Chemistry databases
DrugBanki | DB04272, Citric acid DB03017, Lauric acid DB01593, Zinc DB14487, Zinc acetate |
Genetic variation databases
BioMutai | C8G |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Add BLAST | 20 | |
ChainiPRO_0000017881 | 21 – 202 | Complement component C8 gamma chainAdd BLAST | 182 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Disulfide bondi | 60 | Interchain (with C-194 in C8-alpha chain) | ||
Disulfide bondi | 96 ↔ 188 |
Keywords - PTMi
Disulfide bond, Pyrrolidone carboxylic acidProteomic databases
jPOSTi | P07360 |
MassIVEi | P07360 |
PaxDbi | P07360 |
PeptideAtlasi | P07360 |
PRIDEi | P07360 |
ProteomicsDBi | 52000 |
PTM databases
iPTMneti | P07360 |
PhosphoSitePlusi | P07360 |
Expressioni
Gene expression databases
Bgeei | ENSG00000176919, Expressed in right lobe of liver and 115 other tissues |
ExpressionAtlasi | P07360, baseline and differential |
Genevisiblei | P07360, HS |
Organism-specific databases
HPAi | ENSG00000176919, Tissue enriched (liver) |
Interactioni
Subunit structurei
C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.
Binary interactionsi
P07360
With | #Exp. | IntAct |
---|---|---|
UBQLN2 [Q9UHD9] | 3 | EBI-9021652,EBI-947187 |
GO - Molecular functioni
- complement binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 107194, 9 interactors |
ComplexPortali | CPX-6159, Membrane attack complex |
IntActi | P07360, 7 interactors |
STRINGi | 9606.ENSP00000224181 |
Miscellaneous databases
RNActi | P07360, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P07360 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07360 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S0KX, Eukaryota |
GeneTreei | ENSGT00440000034309 |
HOGENOMi | CLU_094061_0_0_1 |
InParanoidi | P07360 |
OMAi | YLINHGT |
OrthoDBi | 1227818at2759 |
PhylomeDBi | P07360 |
TreeFami | TF336103 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR002968, A1-microglobln IPR043245, C8G IPR012674, Calycin IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR47304, PTHR47304, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR01215, A1MCGLOBULIN |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P07360-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPPGTATLL TLLLAAGSLG QKPQRPRRPA SPISTIQPKA NFDAQQFAGT
60 70 80 90 100
WLLVAVGSAC RFLQEQGHRA EATTLHVAPQ GTAMAVSTFR KLDGICWQVR
110 120 130 140 150
QLYGDTGVLG RFLLQARDAR GAVHVVVAET DYQSFAVLYL ERAGQLSVKL
160 170 180 190 200
YARSLPVSDS VLSGFEQRVQ EAHLTEDQIF YFPKYGFCEA ADQFHVLDEV
RR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITK5 | A0A3B3ITK5_HUMAN | Complement component C8 gamma chain | C8G | 65 | Annotation score: | ||
A0A3B3ITY0 | A0A3B3ITY0_HUMAN | Complement component C8 gamma chain | C8G | 41 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014668 | 69 | R → Q. Corresponds to variant dbSNP:rs17614EnsemblClinVar. | 1 | |
Natural variantiVAR_044319 | 118 | D → G5 PublicationsCorresponds to variant dbSNP:rs7850844Ensembl. | 1 | |
Natural variantiVAR_014669 | 124 | H → N1 PublicationCorresponds to variant dbSNP:rs17613Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17263 mRNA Translation: AAA51888.1 M17999 mRNA Translation: AAA51863.1 X06465 mRNA Translation: CAA29773.1 U08198 Genomic DNA Translation: AAA18482.1 AL807752 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88316.1 BC113624 mRNA Translation: AAI13625.1 BC113626 mRNA Translation: AAI13627.1 |
CCDSi | CCDS7017.1 |
PIRi | A27487, C8HUG |
RefSeqi | NP_000597.2, NM_000606.2 |
Genome annotation databases
Ensembli | ENST00000371634; ENSP00000360697; ENSG00000176919 |
GeneIDi | 733 |
KEGGi | hsa:733 |
MANE-Selecti | ENST00000371634.7; ENSP00000360697.3; NM_000606.3; NP_000597.2 |
UCSCi | uc004cka.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17263 mRNA Translation: AAA51888.1 M17999 mRNA Translation: AAA51863.1 X06465 mRNA Translation: CAA29773.1 U08198 Genomic DNA Translation: AAA18482.1 AL807752 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW88316.1 BC113624 mRNA Translation: AAI13625.1 BC113626 mRNA Translation: AAI13627.1 |
CCDSi | CCDS7017.1 |
PIRi | A27487, C8HUG |
RefSeqi | NP_000597.2, NM_000606.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IW2 | X-ray | 1.90 | A | 21-202 | [»] | |
1LF7 | X-ray | 1.20 | A | 21-202 | [»] | |
2OVA | X-ray | 1.50 | A | 21-202 | [»] | |
2OVD | X-ray | 1.80 | A | 21-202 | [»] | |
2OVE | X-ray | 2.00 | A | 21-202 | [»] | |
2QOS | X-ray | 1.81 | C | 30-202 | [»] | |
2RD7 | X-ray | 2.15 | C | 21-202 | [»] | |
3OJY | X-ray | 2.51 | C | 21-202 | [»] | |
6H03 | electron microscopy | 5.60 | E | 21-202 | [»] | |
6H04 | electron microscopy | 5.60 | E | 21-202 | [»] | |
7NYC | electron microscopy | 3.50 | F | 21-202 | [»] | |
7NYD | electron microscopy | 3.30 | F | 21-202 | [»] | |
SMRi | P07360 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107194, 9 interactors |
ComplexPortali | CPX-6159, Membrane attack complex |
IntActi | P07360, 7 interactors |
STRINGi | 9606.ENSP00000224181 |
Chemistry databases
DrugBanki | DB04272, Citric acid DB03017, Lauric acid DB01593, Zinc DB14487, Zinc acetate |
PTM databases
iPTMneti | P07360 |
PhosphoSitePlusi | P07360 |
Genetic variation databases
BioMutai | C8G |
Proteomic databases
jPOSTi | P07360 |
MassIVEi | P07360 |
PaxDbi | P07360 |
PeptideAtlasi | P07360 |
PRIDEi | P07360 |
ProteomicsDBi | 52000 |
Protocols and materials databases
Antibodypediai | 18835, 82 antibodies from 20 providers |
DNASUi | 733 |
Genome annotation databases
Ensembli | ENST00000371634; ENSP00000360697; ENSG00000176919 |
GeneIDi | 733 |
KEGGi | hsa:733 |
MANE-Selecti | ENST00000371634.7; ENSP00000360697.3; NM_000606.3; NP_000597.2 |
UCSCi | uc004cka.3, human |
Organism-specific databases
CTDi | 733 |
DisGeNETi | 733 |
GeneCardsi | C8G |
HGNCi | HGNC:1354, C8G |
HPAi | ENSG00000176919, Tissue enriched (liver) |
MalaCardsi | C8G |
MIMi | 120930, gene |
neXtProti | NX_P07360 |
OpenTargetsi | ENSG00000176919 |
Orphaneti | 169150, Immunodeficiency due to a late component of complement deficiency |
PharmGKBi | PA25953 |
VEuPathDBi | HostDB:ENSG00000176919 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0KX, Eukaryota |
GeneTreei | ENSGT00440000034309 |
HOGENOMi | CLU_094061_0_0_1 |
InParanoidi | P07360 |
OMAi | YLINHGT |
OrthoDBi | 1227818at2759 |
PhylomeDBi | P07360 |
TreeFami | TF336103 |
Enzyme and pathway databases
PathwayCommonsi | P07360 |
Reactomei | R-HSA-166665, Terminal pathway of complement R-HSA-977606, Regulation of Complement cascade |
SignaLinki | P07360 |
SIGNORi | P07360 |
Miscellaneous databases
BioGRID-ORCSi | 733, 6 hits in 1033 CRISPR screens |
EvolutionaryTracei | P07360 |
GenomeRNAii | 733 |
Pharosi | P07360, Tbio |
PROi | PR:P07360 |
RNActi | P07360, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000176919, Expressed in right lobe of liver and 115 other tissues |
ExpressionAtlasi | P07360, baseline and differential |
Genevisiblei | P07360, HS |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR002968, A1-microglobln IPR043245, C8G IPR012674, Calycin IPR022272, Lipocalin_CS IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR47304, PTHR47304, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR01215, A1MCGLOBULIN |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00213, LIPOCALIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CO8G_HUMAN | |
Accessioni | P07360Primary (citable) accession number: P07360 Secondary accession number(s): Q14CT8, Q14CU0, Q5SQ07 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | October 3, 2006 | |
Last modified: | February 23, 2022 | |
This is version 208 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families