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Protein

Complement component C8 gamma chain

Gene

C8G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity
LigandRetinol-binding

Enzyme and pathway databases

ReactomeiR-HSA-166665 Terminal pathway of complement
R-HSA-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C8 gamma chain
Gene namesi
Name:C8G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000176919.11
HGNCiHGNC:1354 C8G
MIMi120930 gene
neXtProtiNX_P07360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane attack complex, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi733
MalaCardsiC8G
OpenTargetsiENSG00000176919
Orphaneti169150 Immunodeficiency due to a late component of complement deficiency
PharmGKBiPA25953

Chemistry databases

DrugBankiDB04272 Citric Acid
DB03017 Lauric Acid

Polymorphism and mutation databases

BioMutaiC8G

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001788121 – 202Complement component C8 gamma chainAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi60Interchain (with C-194 in C8-alpha chain)
Disulfide bondi96 ↔ 188

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP07360
PeptideAtlasiP07360
PRIDEiP07360
ProteomicsDBi52000

PTM databases

iPTMnetiP07360
PhosphoSitePlusiP07360

Expressioni

Gene expression databases

BgeeiENSG00000176919 Expressed in 91 organ(s), highest expression level in right lobe of liver
CleanExiHS_C8G
ExpressionAtlasiP07360 baseline and differential
GenevisibleiP07360 HS

Organism-specific databases

HPAiHPA046269

Interactioni

Subunit structurei

C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.

Protein-protein interaction databases

BioGridi107194, 6 interactors
IntActiP07360, 1 interactor
STRINGi9606.ENSP00000224181

Structurei

Secondary structure

1202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07360
SMRiP07360
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07360

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IX6K Eukaryota
ENOG4111Y9C LUCA
GeneTreeiENSGT00440000034309
HOGENOMiHOG000111143
HOVERGENiHBG005369
InParanoidiP07360
KOiK03999
OMAiLNTASKC
OrthoDBiEOG091G0QPN
PhylomeDBiP07360
TreeFamiTF336103

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR002968 A1-microglobln
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01215 A1MCGLOBULIN
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P07360-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPPGTATLL TLLLAAGSLG QKPQRPRRPA SPISTIQPKA NFDAQQFAGT
60 70 80 90 100
WLLVAVGSAC RFLQEQGHRA EATTLHVAPQ GTAMAVSTFR KLDGICWQVR
110 120 130 140 150
QLYGDTGVLG RFLLQARDAR GAVHVVVAET DYQSFAVLYL ERAGQLSVKL
160 170 180 190 200
YARSLPVSDS VLSGFEQRVQ EAHLTEDQIF YFPKYGFCEA ADQFHVLDEV

RR
Length:202
Mass (Da):22,277
Last modified:October 3, 2006 - v3
Checksum:i4E4F73140E607FFE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SQ08Q5SQ08_HUMAN
Complement component C8 gamma chain
C8G
164Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01466869R → Q. Corresponds to variant dbSNP:rs17614Ensembl.1
Natural variantiVAR_044319118D → G5 PublicationsCorresponds to variant dbSNP:rs7850844Ensembl.1
Natural variantiVAR_014669124H → N1 PublicationCorresponds to variant dbSNP:rs17613Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17263 mRNA Translation: AAA51888.1
M17999 mRNA Translation: AAA51863.1
X06465 mRNA Translation: CAA29773.1
U08198 Genomic DNA Translation: AAA18482.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88316.1
BC113624 mRNA Translation: AAI13625.1
BC113626 mRNA Translation: AAI13627.1
CCDSiCCDS7017.1
PIRiA27487 C8HUG
RefSeqiNP_000597.2, NM_000606.2
UniGeneiHs.1285

Genome annotation databases

EnsembliENST00000224181; ENSP00000224181; ENSG00000176919
GeneIDi733
KEGGihsa:733
UCSCiuc004cka.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17263 mRNA Translation: AAA51888.1
M17999 mRNA Translation: AAA51863.1
X06465 mRNA Translation: CAA29773.1
U08198 Genomic DNA Translation: AAA18482.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88316.1
BC113624 mRNA Translation: AAI13625.1
BC113626 mRNA Translation: AAI13627.1
CCDSiCCDS7017.1
PIRiA27487 C8HUG
RefSeqiNP_000597.2, NM_000606.2
UniGeneiHs.1285

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IW2X-ray1.90A21-202[»]
1LF7X-ray1.20A21-202[»]
2OVAX-ray1.50A21-202[»]
2OVDX-ray1.80A21-202[»]
2OVEX-ray2.00A21-202[»]
2QOSX-ray1.81C30-202[»]
2RD7X-ray2.15C21-202[»]
3OJYX-ray2.51C21-202[»]
ProteinModelPortaliP07360
SMRiP07360
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107194, 6 interactors
IntActiP07360, 1 interactor
STRINGi9606.ENSP00000224181

Chemistry databases

DrugBankiDB04272 Citric Acid
DB03017 Lauric Acid

PTM databases

iPTMnetiP07360
PhosphoSitePlusiP07360

Polymorphism and mutation databases

BioMutaiC8G

Proteomic databases

PaxDbiP07360
PeptideAtlasiP07360
PRIDEiP07360
ProteomicsDBi52000

Protocols and materials databases

DNASUi733
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000224181; ENSP00000224181; ENSG00000176919
GeneIDi733
KEGGihsa:733
UCSCiuc004cka.3 human

Organism-specific databases

CTDi733
DisGeNETi733
EuPathDBiHostDB:ENSG00000176919.11
GeneCardsiC8G
H-InvDBiHIX0201411
HGNCiHGNC:1354 C8G
HPAiHPA046269
MalaCardsiC8G
MIMi120930 gene
neXtProtiNX_P07360
OpenTargetsiENSG00000176919
Orphaneti169150 Immunodeficiency due to a late component of complement deficiency
PharmGKBiPA25953
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX6K Eukaryota
ENOG4111Y9C LUCA
GeneTreeiENSGT00440000034309
HOGENOMiHOG000111143
HOVERGENiHBG005369
InParanoidiP07360
KOiK03999
OMAiLNTASKC
OrthoDBiEOG091G0QPN
PhylomeDBiP07360
TreeFamiTF336103

Enzyme and pathway databases

ReactomeiR-HSA-166665 Terminal pathway of complement
R-HSA-977606 Regulation of Complement cascade

Miscellaneous databases

EvolutionaryTraceiP07360
GenomeRNAii733
PROiPR:P07360
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176919 Expressed in 91 organ(s), highest expression level in right lobe of liver
CleanExiHS_C8G
ExpressionAtlasiP07360 baseline and differential
GenevisibleiP07360 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR002968 A1-microglobln
IPR012674 Calycin
IPR002345 Lipocalin
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01215 A1MCGLOBULIN
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCO8G_HUMAN
AccessioniPrimary (citable) accession number: P07360
Secondary accession number(s): Q14CT8, Q14CU0, Q5SQ07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 3, 2006
Last modified: November 7, 2018
This is version 189 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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