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UniProtKB - P07360 (CO8G_HUMAN)

Entry version 208 (23 Feb 2022)
Sequence version 3 (03 Oct 2006)
Previous versions | rss
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Protein

Complement component C8 gamma chain

Gene

C8G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity
LigandRetinol-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P07360

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166665, Terminal pathway of complement
R-HSA-977606, Regulation of Complement cascade

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P07360

SIGNOR Signaling Network Open Resource

More...SIGNORi		P07360

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement component C8 gamma chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C8G
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1354, C8G

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		120930, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07360

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000176919

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane attack complex, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		733

MalaCards human disease database

More...MalaCardsi		C8G

Open Targets

More...OpenTargetsi		ENSG00000176919

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		169150, Immunodeficiency due to a late component of complement deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25953

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P07360, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB04272, Citric acid
DB03017, Lauric acid
DB01593, Zinc
DB14487, Zinc acetate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C8G

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Add BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001788121 – 202Complement component C8 gamma chainAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi60Interchain (with C-194 in C8-alpha chain)
Disulfide bondi96 ↔ 188

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P07360

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P07360

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07360

PeptideAtlas

More...PeptideAtlasi		P07360

PRoteomics IDEntifications database

More...PRIDEi		P07360

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52000

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07360

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P07360

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000176919, Expressed in right lobe of liver and 115 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P07360, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07360, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000176919, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107194, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6159, Membrane attack complex

Protein interaction database and analysis system

More...IntActi		P07360, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000224181

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P07360, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07360

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P07360

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S0KX, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00440000034309

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_094061_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07360

Identification of Orthologs from Complete Genome Data

More...OMAi		YLINHGT

Database of Orthologous Groups

More...OrthoDBi		1227818at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07360

TreeFam database of animal gene trees

More...TreeFami		TF336103

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.128.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002968, A1-microglobln
IPR043245, C8G
IPR012674, Calycin
IPR022272, Lipocalin_CS
IPR000566, Lipocln_cytosolic_FA-bd_dom

The PANTHER Classification System

More...PANTHERi		PTHR47304, PTHR47304, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00061, Lipocalin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01215, A1MCGLOBULIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50814, SSF50814, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00213, LIPOCALIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P07360-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPPGTATLL TLLLAAGSLG QKPQRPRRPA SPISTIQPKA NFDAQQFAGT 
        60         70         80         90        100
WLLVAVGSAC RFLQEQGHRA EATTLHVAPQ GTAMAVSTFR KLDGICWQVR 
       110        120        130        140        150
QLYGDTGVLG RFLLQARDAR GAVHVVVAET DYQSFAVLYL ERAGQLSVKL 
       160        170        180        190        200
YARSLPVSDS VLSGFEQRVQ EAHLTEDQIF YFPKYGFCEA ADQFHVLDEV 

RR
Length:202
Mass (Da):22,277
Last modified:October 3, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E4F73140E607FFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ITK5A0A3B3ITK5_HUMAN
Complement component C8 gamma chain
C8G
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITY0A0A3B3ITY0_HUMAN
Complement component C8 gamma chain
C8G
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01466869R → Q. Corresponds to variant dbSNP:rs17614EnsemblClinVar.1
Natural variantiVAR_044319118D → G5 PublicationsCorresponds to variant dbSNP:rs7850844Ensembl.1
Natural variantiVAR_014669124H → N1 PublicationCorresponds to variant dbSNP:rs17613Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M17263 mRNA Translation: AAA51888.1
M17999 mRNA Translation: AAA51863.1
X06465 mRNA Translation: CAA29773.1
U08198 Genomic DNA Translation: AAA18482.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88316.1
BC113624 mRNA Translation: AAI13625.1
BC113626 mRNA Translation: AAI13627.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7017.1

Protein sequence database of the Protein Information Resource

More...PIRi		A27487, C8HUG

NCBI Reference Sequences

More...RefSeqi		NP_000597.2, NM_000606.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371634; ENSP00000360697; ENSG00000176919

Database of genes from NCBI RefSeq genomes

More...GeneIDi		733

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:733

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000371634.7; ENSP00000360697.3; NM_000606.3; NP_000597.2

UCSC genome browser

More...UCSCi		uc004cka.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17263 mRNA Translation: AAA51888.1
M17999 mRNA Translation: AAA51863.1
X06465 mRNA Translation: CAA29773.1
U08198 Genomic DNA Translation: AAA18482.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88316.1
BC113624 mRNA Translation: AAI13625.1
BC113626 mRNA Translation: AAI13627.1
CCDSiCCDS7017.1
PIRiA27487, C8HUG
RefSeqiNP_000597.2, NM_000606.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IW2X-ray1.90A21-202[»]
1LF7X-ray1.20A21-202[»]
2OVAX-ray1.50A21-202[»]
2OVDX-ray1.80A21-202[»]
2OVEX-ray2.00A21-202[»]
2QOSX-ray1.81C30-202[»]
2RD7X-ray2.15C21-202[»]
3OJYX-ray2.51C21-202[»]
6H03electron microscopy5.60E21-202[»]
6H04electron microscopy5.60E21-202[»]
7NYCelectron microscopy3.50F21-202[»]
7NYDelectron microscopy3.30F21-202[»]
SMRiP07360
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107194, 9 interactors
ComplexPortaliCPX-6159, Membrane attack complex
IntActiP07360, 7 interactors
STRINGi9606.ENSP00000224181

Chemistry databases

DrugBankiDB04272, Citric acid
DB03017, Lauric acid
DB01593, Zinc
DB14487, Zinc acetate

PTM databases

iPTMnetiP07360
PhosphoSitePlusiP07360

Genetic variation databases

BioMutaiC8G

Proteomic databases

jPOSTiP07360
MassIVEiP07360
PaxDbiP07360
PeptideAtlasiP07360
PRIDEiP07360
ProteomicsDBi52000

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18835, 82 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		733

Genome annotation databases

EnsembliENST00000371634; ENSP00000360697; ENSG00000176919
GeneIDi733
KEGGihsa:733
MANE-SelectiENST00000371634.7; ENSP00000360697.3; NM_000606.3; NP_000597.2
UCSCiuc004cka.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		733
DisGeNETi733

GeneCards: human genes, protein and diseases

More...GeneCardsi		C8G
HGNCiHGNC:1354, C8G
HPAiENSG00000176919, Tissue enriched (liver)
MalaCardsiC8G
MIMi120930, gene
neXtProtiNX_P07360
OpenTargetsiENSG00000176919
Orphaneti169150, Immunodeficiency due to a late component of complement deficiency
PharmGKBiPA25953
VEuPathDBiHostDB:ENSG00000176919

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S0KX, Eukaryota
GeneTreeiENSGT00440000034309
HOGENOMiCLU_094061_0_0_1
InParanoidiP07360
OMAiYLINHGT
OrthoDBi1227818at2759
PhylomeDBiP07360
TreeFamiTF336103

Enzyme and pathway databases

PathwayCommonsiP07360
ReactomeiR-HSA-166665, Terminal pathway of complement
R-HSA-977606, Regulation of Complement cascade
SignaLinkiP07360
SIGNORiP07360

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		733, 6 hits in 1033 CRISPR screens
EvolutionaryTraceiP07360

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		733
PharosiP07360, Tbio

Protein Ontology

More...PROi		PR:P07360
RNActiP07360, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000176919, Expressed in right lobe of liver and 115 other tissues
ExpressionAtlasiP07360, baseline and differential
GenevisibleiP07360, HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR002968, A1-microglobln
IPR043245, C8G
IPR012674, Calycin
IPR022272, Lipocalin_CS
IPR000566, Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR47304, PTHR47304, 1 hit
PfamiView protein in Pfam
PF00061, Lipocalin, 1 hit
PRINTSiPR01215, A1MCGLOBULIN
SUPFAMiSSF50814, SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213, LIPOCALIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO8G_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07360
Secondary accession number(s): Q14CT8, Q14CU0, Q5SQ07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 3, 2006
Last modified: February 23, 2022
This is version 208 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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