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Entry version 238 (16 Oct 2019)
Sequence version 2 (16 Apr 2014)
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Protein

Platelet glycoprotein Ib alpha chain

Gene

GP1BA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

Miscellaneous

Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Cell adhesion, Hemostasis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-430116 GP1b-IX-V activation signalling
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P07359

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P07359

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P07359 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet glycoprotein Ib alpha chain
Short name:
GP-Ib alpha
Short name:
GPIb-alpha
Short name:
GPIbA
Short name:
Glycoprotein Ibalpha
Alternative name(s):
Antigen CD42b-alpha
CD_antigen: CD42b
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GP1BA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4439 GP1BA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606672 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07359

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini17 – 531ExtracellularSequence analysisAdd BLAST515
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 652CytoplasmicSequence analysisAdd BLAST100

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Non-arteritic anterior ischemic optic neuropathy (NAION)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAn ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage.
Related information in OMIM
Bernard-Soulier syndrome (BSS)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, thrombocytopenia, and impaired prothrombin consumption.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01420673L → F in BSS. 1 PublicationCorresponds to variant dbSNP:rs121908063EnsemblClinVar.1
Natural variantiVAR_00525681C → R in BSS. 1 PublicationCorresponds to variant dbSNP:rs781541857Ensembl.1
Natural variantiVAR_014207145L → P in BSS. 1 PublicationCorresponds to variant dbSNP:rs771048666Ensembl.1
Natural variantiVAR_005258172A → V in BSS and BSSA2. 2 PublicationsCorresponds to variant dbSNP:rs121908065EnsemblClinVar.1
Natural variantiVAR_005259195Missing in BSS. 1 Publication1
Natural variantiVAR_005260225C → S in BSS. 1 PublicationCorresponds to variant dbSNP:rs1394634674EnsemblClinVar.1
Bernard-Soulier syndrome A2, autosomal dominant (BSSA2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA coagulation disorder characterized by mild to moderate bleeding tendency, thrombocytopenia, and an increased mean platelet volume. Some individuals have no symptoms. Mild bleeding tendencies manifest as epistaxis, gingival bleeding, menorrhagia, easy bruising, or prolonged bleeding after dental surgery.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_005258172A → V in BSS and BSSA2. 2 PublicationsCorresponds to variant dbSNP:rs121908065EnsemblClinVar.1
Pseudo-von Willebrand disease (VWDP)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA bleeding disorder characterized by abnormally enhanced binding of von Willebrand factor by the platelet glycoprotein Ib (GP Ib) receptor complex. Hemostatic function is impaired due to the removal of VWF multimers from the circulation.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019657249G → S in VWDP. 1 Publication1
Natural variantiVAR_005261249G → V in VWDP. 2 PublicationsCorresponds to variant dbSNP:rs121908062EnsemblClinVar.1
Natural variantiVAR_005262255M → V in VWDP; increased binding to vWF. 2 PublicationsCorresponds to variant dbSNP:rs121908064EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi249G → A: No change. 1 Publication1
Mutagenesisi249G → K or D: Decreased binding to vWF. 1 Publication1
Mutagenesisi249G → S or V: Increased binding to vWF. 1 Publication1

Keywords - Diseasei

Bernard Soulier syndrome, Disease mutation, von Willebrand disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
2811

MalaCards human disease database

More...
MalaCardsi
GP1BA
MIMi153670 phenotype
177820 phenotype
231200 phenotype
258660 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000185245

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
274 Bernard-Soulier syndrome
853 Fetal and neonatal alloimmune thrombocytopenia
52530 Pseudo-von Willebrand disease

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P07359

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB09213 Dexibuprofen
DB05202 Egaptivon pegol
DB01050 Ibuprofen
DB05391 liposomal prostaglandin E1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GP1BA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121531

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 161 PublicationAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002134317 – 652Platelet glycoprotein Ib alpha chainAdd BLAST636
ChainiPRO_000002134417 – 506Glycocalicin1 PublicationAdd BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi20 ↔ 331 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi175N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi225 ↔ 2641 Publication
Disulfide bondi227 ↔ 2801 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei292Sulfotyrosine1 Publication1
Modified residuei294Sulfotyrosine1 Publication1
Modified residuei295Sulfotyrosine1 Publication1
Glycosylationi308O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi526Interchain (with C-147 in GP1BB)1 Publication
Disulfide bondi527Interchain (with C-147 in GP1BB)1 Publication
Modified residuei629PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei506 – 507Cleavage; by ADAM171 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P07359

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P07359

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07359

PeptideAtlas

More...
PeptideAtlasi
P07359

PRoteomics IDEntifications database

More...
PRIDEi
P07359

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17927
51999

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
176

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P07359

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P07359

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P07359

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P07359

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185245 Expressed in 147 organ(s), highest expression level in adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P07359 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P07359 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002496
HPA013316

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage (PubMed:17008541, PubMed:2070794).

Interacts with FLNB (PubMed:9651345).

Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450).

4 Publications

(Microbial infection) Interacts with Staphylococcus aureus protein SSL5.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109073, 15 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-114 Glycoprotein Ib-IX-V complex
CPX-117 Glycoprotein Ib-IX-V-Filamin-A complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P07359

Protein interaction database and analysis system

More...
IntActi
P07359, 13 interactors

Molecular INTeraction database

More...
MINTi
P07359

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000329380

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1652
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P07359

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P07359

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 47LRRNTAdd BLAST31
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati48 – 68LRR 1Add BLAST21
Repeati72 – 93LRR 2Add BLAST22
Repeati94 – 115LRR 3Add BLAST22
Repeati117 – 137LRR 4Add BLAST21
Repeati141 – 162LRR 5Add BLAST22
Repeati165 – 186LRR 6Add BLAST22
Repeati189 – 210LRR 7Add BLAST22
Domaini221 – 282LRRCTAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi345 – 482Pro/Thr-richAdd BLAST138

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163073

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07359

KEGG Orthology (KO)

More...
KOi
K06261

Identification of Orthologs from Complete Genome Data

More...
OMAi
FLWVRAN

Database of Orthologous Groups

More...
OrthoDBi
156064at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P07359

TreeFam database of animal gene trees

More...
TreeFami
TF351114

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P07359-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLLLLLLL PSPLHPHPIC EVSKVASHLE VNCDKRNLTA LPPDLPKDTT
60 70 80 90 100
ILHLSENLLY TFSLATLMPY TRLTQLNLDR CELTKLQVDG TLPVLGTLDL
110 120 130 140 150
SHNQLQSLPL LGQTLPALTV LDVSFNRLTS LPLGALRGLG ELQELYLKGN
160 170 180 190 200
ELKTLPPGLL TPTPKLEKLS LANNNLTELP AGLLNGLENL DTLLLQENSL
210 220 230 240 250
YTIPKGFFGS HLLPFAFLHG NPWLCNCEIL YFRRWLQDNA ENVYVWKQGV
260 270 280 290 300
DVKAMTSNVA SVQCDNSDKF PVYKYPGKGC PTLGDEGDTD LYDYYPEEDT
310 320 330 340 350
EGDKVRATRT VVKFPTKAHT TPWGLFYSWS TASLDSQMPS SLHPTQESTK
360 370 380 390 400
EQTTFPPRWT PNFTLHMESI TFSKTPKSTT EPTPSPTTSE PVPEPAPNMT
410 420 430 440 450
TLEPTPSPTT PEPTSEPAPS PTTPEPTSEP APSPTTPEPT SEPAPSPTTP
460 470 480 490 500
EPTPIPTIAT SPTILVSATS LITPKSTFLT TTKPVSLLES TKKTIPELDQ
510 520 530 540 550
PPKLRGVLQG HLESSRNDPF LHPDFCCLLP LGFYVLGLFW LLFASVVLIL
560 570 580 590 600
LLSWVGHVKP QALDSGQGAA LTTATQTTHL ELQRGRQVTV PRAWLLFLRG
610 620 630 640 650
SLPTFRSSLF LWVRPNGRVG PLVAGRRPSA LSQGRGQDLL STVSIRYSGH

SL
Length:652
Mass (Da):71,540
Last modified:April 16, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i053346683AEB927E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGZ8A0A0C4DGZ8_HUMAN
Glycoprotein Ib (Platelet), alpha p...
GP1BA hCG_32689
626Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti619V → L in AAH27955 (PubMed:15489334).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Position 161 is associated with platelet-specific alloantigen Siba (PubMed:1586750). Siba- has Thr-161 and Siba+ has Met-161 (PubMed:1586750). Siba is involved in neonatal alloimmune thrombocytopenia (NATP) (PubMed:1586750, PubMed:7632942).2 Publications
Polymorphisms arise from a variable number of tandem 13-amino acid repeats of S-E-P-A-P-S-P-T-T-P-E-P-T in the mucin-like macroglycopeptide (Pro/Thr-rich) domain (PubMed:1577776, PubMed:7632942). Allele D contains one repeat starting at position 415, allele C contains two repeats, allele B (shown here) contains three repeats and allele A contains four repeats (PubMed:1577776). Allele B is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy (PubMed:1577776).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01190972R → H1 PublicationCorresponds to variant dbSNP:rs6068Ensembl.1
Natural variantiVAR_01420673L → F in BSS. 1 PublicationCorresponds to variant dbSNP:rs121908063EnsemblClinVar.1
Natural variantiVAR_00525681C → R in BSS. 1 PublicationCorresponds to variant dbSNP:rs781541857Ensembl.1
Natural variantiVAR_01351186L → F1 PublicationCorresponds to variant dbSNP:rs13306411EnsemblClinVar.1
Natural variantiVAR_014207145L → P in BSS. 1 PublicationCorresponds to variant dbSNP:rs771048666Ensembl.1
Natural variantiVAR_005257161T → M in Siba(+). 4 PublicationsCorresponds to variant dbSNP:rs6065EnsemblClinVar.1
Natural variantiVAR_005258172A → V in BSS and BSSA2. 2 PublicationsCorresponds to variant dbSNP:rs121908065EnsemblClinVar.1
Natural variantiVAR_005259195Missing in BSS. 1 Publication1
Natural variantiVAR_005260225C → S in BSS. 1 PublicationCorresponds to variant dbSNP:rs1394634674EnsemblClinVar.1
Natural variantiVAR_019657249G → S in VWDP. 1 Publication1
Natural variantiVAR_005261249G → V in VWDP. 2 PublicationsCorresponds to variant dbSNP:rs121908062EnsemblClinVar.1
Natural variantiVAR_011910254A → S. Corresponds to variant dbSNP:rs382524Ensembl.1
Natural variantiVAR_005262255M → V in VWDP; increased binding to vWF. 2 PublicationsCorresponds to variant dbSNP:rs121908064EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J02940 mRNA Translation: AAA52595.1
M22403 Genomic DNA Translation: AAA52596.1
AB038516 Genomic DNA Translation: BAB12038.1
AB086948 Genomic DNA Translation: BAC10305.1
AF395009 Genomic DNA Translation: AAK71325.1
AC233723 Genomic DNA No translation available.
BC027955 mRNA Translation: AAH27955.1
D85894 Genomic DNA Translation: BAA12911.1
S34436 Genomic DNA Translation: AAB22152.1
S34439 Genomic DNA Translation: AAB22153.1
L39103 Genomic DNA Translation: AAA69491.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54068.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A94174 NBHUIA
I70082

NCBI Reference Sequences

More...
RefSeqi
NP_000164.5, NM_000173.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329125; ENSP00000329380; ENSG00000185245

Database of genes from NCBI RefSeq genomes

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GeneIDi
2811

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2811

UCSC genome browser

More...
UCSCi
uc021tnz.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02940 mRNA Translation: AAA52595.1
M22403 Genomic DNA Translation: AAA52596.1
AB038516 Genomic DNA Translation: BAB12038.1
AB086948 Genomic DNA Translation: BAC10305.1
AF395009 Genomic DNA Translation: AAK71325.1
AC233723 Genomic DNA No translation available.
BC027955 mRNA Translation: AAH27955.1
D85894 Genomic DNA Translation: BAA12911.1
S34436 Genomic DNA Translation: AAB22152.1
S34439 Genomic DNA Translation: AAB22153.1
L39103 Genomic DNA Translation: AAA69491.1
CCDSiCCDS54068.1
PIRiA94174 NBHUIA
I70082
RefSeqiNP_000164.5, NM_000173.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GWBX-ray2.80A/B16-296[»]
1K13model-A52-216[»]
1M0ZX-ray1.85A/B17-306[»]
1M10X-ray3.10B17-306[»]
1OOKX-ray2.30G17-306[»]
1P8VX-ray2.60A17-294[»]
1P9AX-ray1.70G17-306[»]
1QYYX-ray2.80A/G17-306[»]
1SQ0X-ray2.60B17-304[»]
1U0NX-ray2.95D17-281[»]
2BP3X-ray2.32S/T598-619[»]
3P72X-ray1.90A17-281[»]
3PMHX-ray3.20G17-306[»]
4C2AX-ray2.08B17-306[»]
4C2BX-ray2.80B/D/F/H17-306[»]
4CH2X-ray1.60P/Q287-300[»]
4CH8X-ray1.75P/Q/R/S287-300[»]
4MGXX-ray3.16B603-611[»]
4YR6X-ray2.38C/F503-512[»]
SMRiP07359
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109073, 15 interactors
ComplexPortaliCPX-114 Glycoprotein Ib-IX-V complex
CPX-117 Glycoprotein Ib-IX-V-Filamin-A complex
CORUMiP07359
IntActiP07359, 13 interactors
MINTiP07359
STRINGi9606.ENSP00000329380

Chemistry databases

DrugBankiDB09213 Dexibuprofen
DB05202 Egaptivon pegol
DB01050 Ibuprofen
DB05391 liposomal prostaglandin E1

Protein family/group databases

MoonDBiP07359 Predicted

PTM databases

GlyConnecti176
iPTMnetiP07359
PhosphoSitePlusiP07359
UniCarbKBiP07359

Polymorphism and mutation databases

BioMutaiGP1BA
DMDMi121531

Proteomic databases

jPOSTiP07359
MassIVEiP07359
PaxDbiP07359
PeptideAtlasiP07359
PRIDEiP07359
ProteomicsDBi17927
51999

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P07359

The DNASU plasmid repository

More...
DNASUi
2811

Genome annotation databases

EnsembliENST00000329125; ENSP00000329380; ENSG00000185245
GeneIDi2811
KEGGihsa:2811
UCSCiuc021tnz.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2811
DisGeNETi2811

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GP1BA
HGNCiHGNC:4439 GP1BA
HPAiCAB002496
HPA013316
MalaCardsiGP1BA
MIMi153670 phenotype
177820 phenotype
231200 phenotype
258660 phenotype
606672 gene
neXtProtiNX_P07359
OpenTargetsiENSG00000185245
Orphaneti274 Bernard-Soulier syndrome
853 Fetal and neonatal alloimmune thrombocytopenia
52530 Pseudo-von Willebrand disease

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000163073
InParanoidiP07359
KOiK06261
OMAiFLWVRAN
OrthoDBi156064at2759
PhylomeDBiP07359
TreeFamiTF351114

Enzyme and pathway databases

ReactomeiR-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-430116 GP1b-IX-V activation signalling
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
SignaLinkiP07359
SIGNORiP07359

Miscellaneous databases

EvolutionaryTraceiP07359

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2811
PharosiP07359
PMAP-CutDBiP07359

Protein Ontology

More...
PROi
PR:P07359

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185245 Expressed in 147 organ(s), highest expression level in adrenal gland
ExpressionAtlasiP07359 baseline and differential
GenevisibleiP07359 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP1BA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07359
Secondary accession number(s): E7ES66
, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 16, 2014
Last modified: October 16, 2019
This is version 238 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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