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UniProtKB - P07358 (CO8B_HUMAN)

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Protein

Complement component C8 beta chain

Gene

C8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • complement activation Source: ProtInc
  • complement activation, alternative pathway Source: UniProtKB-KW
  • complement activation, classical pathway Source: UniProtKB-KW
  • cytolysis Source: UniProtKB-KW
  • immune response Source: ProtInc
  • regulation of complement activation Source: Reactome
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-166665 Terminal pathway of complement
R-HSA-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C8 beta chain
Alternative name(s):
Complement component 8 subunit beta
Gene namesi
Name:C8B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000021852.12
HGNCiHGNC:1353 C8B
MIMi120960 gene
neXtProtiNX_P07358

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane attack complex, Secreted

Pathology & Biotechi

Involvement in diseasei

Complement component 8 deficiency, 2 (C8D2)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
See also OMIM:613789

Organism-specific databases

DisGeNETi732
MalaCardsiC8B
MIMi613789 phenotype
Orphaneti169150 Immunodeficiency due to a late component of complements deficiency
PharmGKBiPA25952

Polymorphism and mutation databases

DMDMi20141201

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
PropeptideiPRO_000002359133 – 541 PublicationAdd BLAST22
ChainiPRO_000002359255 – 591Complement component C8 beta chainAdd BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 1001 Publication
Glycosylationi70C-linked (Man) tryptophan1 Publication1
Glycosylationi73C-linked (Man) tryptophan1 Publication1
Disulfide bondi76 ↔ 1101 Publication
Disulfide bondi79 ↔ 1161 Publication
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi122 ↔ 1331 Publication
Disulfide bondi127 ↔ 1461 Publication
Disulfide bondi140 ↔ 1551 Publication
Glycosylationi243N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi378 ↔ 4031 Publication
Modified residuei418Phosphothreonine1 Publication1
Disulfide bondi503 ↔ 5501 Publication
Disulfide bondi505 ↔ 5211 Publication
Disulfide bondi508 ↔ 5231 Publication
Disulfide bondi525 ↔ 5341 Publication
Glycosylationi551C-linked (Man) tryptophan1 Publication1
Glycosylationi554C-linked (Man) tryptophan1 Publication1
Disulfide bondi557 ↔ 5901 Publication

Post-translational modificationi

N-glycosylated; contains one or two bound glycans. Not O-glycosylated.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP07358
PeptideAtlasiP07358
PRIDEiP07358
ProteomicsDBi51998

PTM databases

iPTMnetiP07358
PhosphoSitePlusiP07358

Expressioni

Gene expression databases

BgeeiENSG00000021852
CleanExiHS_C8B
ExpressionAtlasiP07358 baseline and differential
GenevisibleiP07358 HS

Organism-specific databases

HPAiHPA023694

Interactioni

Subunit structurei

Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.2 Publications

Protein-protein interaction databases

BioGridi107193, 6 interactors
STRINGi9606.ENSP00000360281

Structurei

Secondary structure

1591
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni78 – 81Combined sources4
Beta strandi82 – 86Combined sources5
Beta strandi89 – 91Combined sources3
Beta strandi104 – 109Combined sources6
Beta strandi123 – 126Combined sources4
Turni128 – 130Combined sources3
Helixi136 – 138Combined sources3
Beta strandi141 – 143Combined sources3
Beta strandi146 – 149Combined sources4
Helixi172 – 176Combined sources5
Beta strandi177 – 179Combined sources3
Turni181 – 183Combined sources3
Beta strandi186 – 189Combined sources4
Beta strandi201 – 205Combined sources5
Beta strandi208 – 212Combined sources5
Beta strandi216 – 221Combined sources6
Beta strandi229 – 236Combined sources8
Helixi237 – 240Combined sources4
Turni256 – 258Combined sources3
Turni269 – 271Combined sources3
Beta strandi272 – 275Combined sources4
Helixi276 – 283Combined sources8
Beta strandi290 – 297Combined sources8
Beta strandi299 – 306Combined sources8
Beta strandi308 – 310Combined sources3
Helixi315 – 321Combined sources7
Helixi330 – 340Combined sources11
Beta strandi342 – 352Combined sources11
Beta strandi355 – 361Combined sources7
Helixi362 – 365Combined sources4
Turni366 – 369Combined sources4
Helixi372 – 378Combined sources7
Turni379 – 381Combined sources3
Turni404 – 408Combined sources5
Helixi409 – 412Combined sources4
Turni413 – 415Combined sources3
Beta strandi419 – 426Combined sources8
Helixi435 – 439Combined sources5
Beta strandi441 – 443Combined sources3
Helixi449 – 457Combined sources9
Beta strandi461 – 469Combined sources9
Helixi470 – 473Combined sources4
Turni476 – 478Combined sources3
Helixi482 – 499Combined sources18
Helixi502 – 504Combined sources3
Beta strandi513 – 517Combined sources5
Beta strandi520 – 524Combined sources5
Helixi532 – 534Combined sources3
Beta strandi536 – 541Combined sources6
Beta strandi557 – 563Combined sources7
Beta strandi584 – 588Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OJYX-ray2.51B55-591[»]
ProteinModelPortaliP07358
SMRiP07358
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07358

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 117TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini120 – 157LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Domaini158 – 504MACPFPROSITE-ProRule annotationAdd BLAST347
Domaini505 – 535EGF-likeAdd BLAST31
Domaini545 – 591TSP type-1 2PROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IE7H Eukaryota
ENOG410Y2J1 LUCA
HOGENOMiHOG000231146
HOVERGENiHBG106489
InParanoidiP07358
KOiK03998
OrthoDBiEOG091G07LK
PhylomeDBiP07358
TreeFamiTF330498

Family and domain databases

CDDicd00112 LDLa, 1 hit
Gene3Di2.20.100.10, 2 hits
InterProiView protein in InterPro
IPR037566 Complement_C8_beta
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001862 MAC_perforin
IPR020864 MACPF
IPR020863 MACPF_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR19325:SF401 PTHR19325:SF401, 1 hit
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF01823 MACPF, 1 hit
PF00090 TSP_1, 2 hits
PRINTSiPR00764 COMPLEMENTC9
SMARTiView protein in SMART
SM00192 LDLa, 1 hit
SM00457 MACPF, 1 hit
SM00209 TSP1, 2 hits
SUPFAMiSSF57424 SSF57424, 1 hit
SSF82895 SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS00279 MACPF_1, 1 hit
PS51412 MACPF_2, 1 hit
PS50092 TSP1, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNSRTWAWR APVELFLLCA ALGCLSLPGS RGERPHSFGS NAVNKSFAKS 
        60         70         80         90        100
RQMRSVDVTL MPIDCELSSW SSWTTCDPCQ KKRYRYAYLL QPSQFHGEPC 
       110        120        130        140        150
NFSDKEVEDC VTNRPCRSQV RCEGFVCAQT GRCVNRRLLC NGDNDCGDQS 
       160        170        180        190        200
DEANCRRIYK KCQHEMDQYW GIGSLASGIN LFTNSFEGPV LDHRYYAGGC 
       210        220        230        240        250
SPHYILNTRF RKPYNVESYT PQTQGKYEFI LKEYESYSDF ERNVTEKMAS 
       260        270        280        290        300
KSGFSFGFKI PGIFELGISS QSDRGKHYIR RTKRFSHTKS VFLHARSDLE 
       310        320        330        340        350
VAHYKLKPRS LMLHYEFLQR VKRLPLEYSY GEYRDLFRDF GTHYITEAVL 
       360        370        380        390        400
GGIYEYTLVM NKEAMERGDY TLNNVHACAK NDFKIGGAIE EVYVSLGVSV 
       410        420        430        440        450
GKCRGILNEI KDRNKRDTMV EDLVVLVRGG ASEHITTLAY QELPTADLMQ 
       460        470        480        490        500
EWGDAVQYNP AIIKVKVEPL YELVTATDFA YSSTVRQNMK QALEEFQKEV 
       510        520        530        540        550
SSCHCAPCQG NGVPVLKGSR CDCICPVGSQ GLACEVSYRK NTPIDGKWNC 
       560        570        580        590 
WSNWSSCSGR RKTRQRQCNN PPPQNGGSPC SGPASETLDC S
Length:591
Mass (Da):67,047
Last modified:January 23, 2002 - v3
Checksum:iB01722A6F2E9AFCE
GO

Polymorphismi

The sequence shown is that of allotype C8B B.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027649108E → K. Corresponds to variant dbSNP:rs12067507Ensembl.1
Natural variantiVAR_012642117R → G in allotype C8B A. 2 PublicationsCorresponds to variant dbSNP:rs1013579Ensembl.1
Natural variantiVAR_027650261P → L. Corresponds to variant dbSNP:rs12085435Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16973 mRNA Translation: AAA51862.1
AK313382 mRNA Translation: BAG36180.1
AL121998 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06641.1
BC130575 mRNA Translation: AAI30576.1
X04393 mRNA Translation: CAA27981.1
CCDSiCCDS30730.1
PIRiA43071 C8HUB
RefSeqiNP_000057.2, NM_000066.3
XP_016857724.1, XM_017002235.1
UniGeneiHs.391835

Genome annotation databases

EnsembliENST00000371237; ENSP00000360281; ENSG00000021852
GeneIDi732
KEGGihsa:732
UCSCiuc001cyp.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCO8B_HUMAN
AccessioniPrimary (citable) accession number: P07358
Secondary accession number(s): A1L4K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2002
Last modified: June 20, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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