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UniProtKB - P07358 (CO8B_HUMAN)

Entry version 201 (23 Feb 2022)
Sequence version 3 (23 Jan 2002)
Previous versions | rss
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Protein

Complement component C8 beta chain

Gene

C8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P07358

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166665, Terminal pathway of complement
R-HSA-977606, Regulation of Complement cascade

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P07358

SIGNOR Signaling Network Open Resource

More...SIGNORi		P07358

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement component C8 beta chain
Alternative name(s):
Complement component 8 subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C8B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1353, C8B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		120960, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07358

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000021852

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane attack complex, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Complement component 8 deficiency, 2 (C8D2)
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		732

MalaCards human disease database

More...MalaCardsi		C8B
MIMi613789, phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		169150, Immunodeficiency due to a late component of complement deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25952

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P07358, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB09130, Copper
DB01593, Zinc
DB14487, Zinc acetate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C8B

Domain mapping of disease mutations (DMDM)

More...DMDMi		20141201

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002359133 – 541 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002359255 – 591Complement component C8 beta chainAdd BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi65 ↔ 1001 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi70C-linked (Man) tryptophan1 Publication1
Glycosylationi73C-linked (Man) tryptophan1 Publication1
Disulfide bondi76 ↔ 1101 Publication
Disulfide bondi79 ↔ 1161 Publication
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi122 ↔ 1331 Publication
Disulfide bondi127 ↔ 1461 Publication
Disulfide bondi140 ↔ 1551 Publication
Glycosylationi243N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi378 ↔ 4031 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei418Phosphothreonine1 Publication1
Disulfide bondi503 ↔ 5501 Publication
Disulfide bondi505 ↔ 5211 Publication
Disulfide bondi508 ↔ 5231 Publication
Disulfide bondi525 ↔ 5341 Publication
Glycosylationi551C-linked (Man) tryptophan1 Publication1
Glycosylationi554C-linked (Man) tryptophan1 Publication1
Disulfide bondi557 ↔ 5901 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated; contains one or two bound glycans. Not O-glycosylated.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P07358

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P07358

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07358

PeptideAtlas

More...PeptideAtlasi		P07358

PRoteomics IDEntifications database

More...PRIDEi		P07358

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51998

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1149, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P07358, 6 sites, 4 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07358

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P07358

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000021852, Expressed in liver and 74 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P07358, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07358, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000021852, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.

Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107193, 6 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6159, Membrane attack complex

Protein interaction database and analysis system

More...IntActi		P07358, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360281

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P07358, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1591
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07358

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P07358

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 117TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini120 – 157LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Domaini158 – 504MACPFPROSITE-ProRule annotationAdd BLAST347
Domaini505 – 535EGF-likeAdd BLAST31
Domaini545 – 591TSP type-1 2PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni568 – 591DisorderedSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3535, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07358

Database of Orthologous Groups

More...OrthoDBi		787014at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07358

TreeFam database of animal gene trees

More...TreeFami		TF330498

Family and domain databases

Conserved Domains Database

More...CDDi		cd00112, LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 2 hits
4.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037566, Complement_C8_beta
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR001862, MAC_perforin
IPR020864, MACPF
IPR020863, MACPF_CS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

The PANTHER Classification System

More...PANTHERi		PTHR45742:SF5, PTHR45742:SF5, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00057, Ldl_recept_a, 1 hit
PF01823, MACPF, 1 hit
PF00090, TSP_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00764, COMPLEMENTC9

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00192, LDLa, 1 hit
SM00457, MACPF, 1 hit
SM00209, TSP1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57424, SSF57424, 1 hit
SSF82895, SSF82895, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS00279, MACPF_1, 1 hit
PS51412, MACPF_2, 1 hit
PS50092, TSP1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P07358-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNSRTWAWR APVELFLLCA ALGCLSLPGS RGERPHSFGS NAVNKSFAKS 
        60         70         80         90        100
RQMRSVDVTL MPIDCELSSW SSWTTCDPCQ KKRYRYAYLL QPSQFHGEPC 
       110        120        130        140        150
NFSDKEVEDC VTNRPCRSQV RCEGFVCAQT GRCVNRRLLC NGDNDCGDQS 
       160        170        180        190        200
DEANCRRIYK KCQHEMDQYW GIGSLASGIN LFTNSFEGPV LDHRYYAGGC 
       210        220        230        240        250
SPHYILNTRF RKPYNVESYT PQTQGKYEFI LKEYESYSDF ERNVTEKMAS 
       260        270        280        290        300
KSGFSFGFKI PGIFELGISS QSDRGKHYIR RTKRFSHTKS VFLHARSDLE 
       310        320        330        340        350
VAHYKLKPRS LMLHYEFLQR VKRLPLEYSY GEYRDLFRDF GTHYITEAVL 
       360        370        380        390        400
GGIYEYTLVM NKEAMERGDY TLNNVHACAK NDFKIGGAIE EVYVSLGVSV 
       410        420        430        440        450
GKCRGILNEI KDRNKRDTMV EDLVVLVRGG ASEHITTLAY QELPTADLMQ 
       460        470        480        490        500
EWGDAVQYNP AIIKVKVEPL YELVTATDFA YSSTVRQNMK QALEEFQKEV 
       510        520        530        540        550
SSCHCAPCQG NGVPVLKGSR CDCICPVGSQ GLACEVSYRK NTPIDGKWNC 
       560        570        580        590 
WSNWSSCSGR RKTRQRQCNN PPPQNGGSPC SGPASETLDC S
Length:591
Mass (Da):67,047
Last modified:January 23, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB01722A6F2E9AFCE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H7G1F5H7G1_HUMAN
Complement component 8 subunit beta
C8B
539Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GY80F5GY80_HUMAN
Complement component 8 subunit beta
C8B
529Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The sequence shown is that of allotype C8B B.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027649108E → K. Corresponds to variant dbSNP:rs12067507Ensembl.1
Natural variantiVAR_012642117R → G in allotype C8B A. 2 PublicationsCorresponds to variant dbSNP:rs1013579Ensembl.1
Natural variantiVAR_027650261P → L. Corresponds to variant dbSNP:rs12085435Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M16973 mRNA Translation: AAA51862.1
AK313382 mRNA Translation: BAG36180.1
AL121998 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06641.1
BC130575 mRNA Translation: AAI30576.1
X04393 mRNA Translation: CAA27981.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30730.1

Protein sequence database of the Protein Information Resource

More...PIRi		A43071, C8HUB

NCBI Reference Sequences

More...RefSeqi		NP_000057.2, NM_000066.3
XP_016857724.1, XM_017002235.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371237; ENSP00000360281; ENSG00000021852

Database of genes from NCBI RefSeq genomes

More...GeneIDi		732

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:732

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000371237.9; ENSP00000360281.4; NM_000066.4; NP_000057.3

UCSC genome browser

More...UCSCi		uc001cyp.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

C8Bbase

C8B mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16973 mRNA Translation: AAA51862.1
AK313382 mRNA Translation: BAG36180.1
AL121998 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06641.1
BC130575 mRNA Translation: AAI30576.1
X04393 mRNA Translation: CAA27981.1
CCDSiCCDS30730.1
PIRiA43071, C8HUB
RefSeqiNP_000057.2, NM_000066.3
XP_016857724.1, XM_017002235.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OJYX-ray2.51B55-591[»]
6H03electron microscopy5.60C55-591[»]
6H04electron microscopy5.60C55-591[»]
7NYCelectron microscopy3.50D55-591[»]
7NYDelectron microscopy3.30D55-591[»]
SMRiP07358
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107193, 6 interactors
ComplexPortaliCPX-6159, Membrane attack complex
IntActiP07358, 1 interactor
STRINGi9606.ENSP00000360281

Chemistry databases

DrugBankiDB09130, Copper
DB01593, Zinc
DB14487, Zinc acetate

PTM databases

GlyConnecti1149, 3 N-Linked glycans (1 site)
GlyGeniP07358, 6 sites, 4 N-linked glycans (1 site)
iPTMnetiP07358
PhosphoSitePlusiP07358

Genetic variation databases

BioMutaiC8B
DMDMi20141201

Proteomic databases

jPOSTiP07358
MassIVEiP07358
PaxDbiP07358
PeptideAtlasiP07358
PRIDEiP07358
ProteomicsDBi51998

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19370, 208 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		732

Genome annotation databases

EnsembliENST00000371237; ENSP00000360281; ENSG00000021852
GeneIDi732
KEGGihsa:732
MANE-SelectiENST00000371237.9; ENSP00000360281.4; NM_000066.4; NP_000057.3
UCSCiuc001cyp.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		732
DisGeNETi732

GeneCards: human genes, protein and diseases

More...GeneCardsi		C8B
HGNCiHGNC:1353, C8B
HPAiENSG00000021852, Tissue enriched (liver)
MalaCardsiC8B
MIMi120960, gene
613789, phenotype
neXtProtiNX_P07358
Orphaneti169150, Immunodeficiency due to a late component of complement deficiency
PharmGKBiPA25952
VEuPathDBiHostDB:ENSG00000021852

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3535, Eukaryota
InParanoidiP07358
OrthoDBi787014at2759
PhylomeDBiP07358
TreeFamiTF330498

Enzyme and pathway databases

PathwayCommonsiP07358
ReactomeiR-HSA-166665, Terminal pathway of complement
R-HSA-977606, Regulation of Complement cascade
SignaLinkiP07358
SIGNORiP07358

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		732, 9 hits in 1035 CRISPR screens
EvolutionaryTraceiP07358

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		732
PharosiP07358, Tbio

Protein Ontology

More...PROi		PR:P07358
RNActiP07358, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000021852, Expressed in liver and 74 other tissues
ExpressionAtlasiP07358, baseline and differential
GenevisibleiP07358, HS

Family and domain databases

CDDicd00112, LDLa, 1 hit
Gene3Di2.20.100.10, 2 hits
4.10.400.10, 1 hit
InterProiView protein in InterPro
IPR037566, Complement_C8_beta
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR001862, MAC_perforin
IPR020864, MACPF
IPR020863, MACPF_CS
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PANTHERiPTHR45742:SF5, PTHR45742:SF5, 1 hit
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 1 hit
PF01823, MACPF, 1 hit
PF00090, TSP_1, 2 hits
PRINTSiPR00764, COMPLEMENTC9
SMARTiView protein in SMART
SM00192, LDLa, 1 hit
SM00457, MACPF, 1 hit
SM00209, TSP1, 2 hits
SUPFAMiSSF57424, SSF57424, 1 hit
SSF82895, SSF82895, 2 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS00279, MACPF_1, 1 hit
PS51412, MACPF_2, 1 hit
PS50092, TSP1, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO8B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07358
Secondary accession number(s): A1L4K7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2002
Last modified: February 23, 2022
This is version 201 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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