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Entry version 235 (16 Oct 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Annexin A2

Gene

ANXA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).3 Publications

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-445355 Smooth Muscle Contraction
R-HSA-6798695 Neutrophil degranulation
R-HSA-75205 Dissolution of Fibrin Clot
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P07355

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.31.1.4 the annexin (annexin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Annexin A2
Alternative name(s):
Annexin II
Annexin-2
Calpactin I heavy chain
Calpactin-1 heavy chain
Chromobindin-8
Lipocortin II
Placental anticoagulant protein IV
Short name:
PAP-IV
Protein I
p36
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANXA2
Synonyms:ANX2, ANX2L4, CAL1H, LPC2D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:537 ANXA2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
151740 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07355

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi24Y → A: Abolishes heat stress-induced cell surface localization. 1 Publication1
Mutagenesisi28 – 36KAYTNFDAE → SAYTNFNAS: No effect on interaction with PCSK9. 1 Publication9
Mutagenesisi37 – 47RDALNIETAIK → SDALNIHTAIM: Slightly decreases interaction with PCSK9. 1 PublicationAdd BLAST11
Mutagenesisi77 – 81RRTKK → AATAA: Strongly decreases interaction with PCSK9. 2 Publications5
Mutagenesisi77 – 80RRTK → AATA: Decreases interaction with PCSK9. Strongly decreases interaction with PCSK9; when associated with K-88. 1 Publication4
Mutagenesisi80 – 84KKELA → GKPLD: No effect on interaction with PCSK9. 1 Publication5
Mutagenesisi88K → A: Strongly decreases interaction with PCSK9; when associated with 77-A--A-80. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
302

Open Targets

More...
OpenTargetsi
ENSG00000182718

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24827

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P07355

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1764938

Drug and drug target database

More...
DrugBanki
DB11638 Artenimol
DB00591 Fluocinolone acetonide
DB06245 Lanoteplase
DB00031 Tenecteplase

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANXA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113950

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000674702 – 339Annexin A2Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
Modified residuei24Phosphotyrosine; by SRC1 Publication1
Modified residuei26Phosphoserine; by PKC1 Publication1
Modified residuei49N6-acetyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki49Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki49Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei152N6-acetyllysineBy similarity1
Modified residuei184PhosphoserineCombined sources1
Modified residuei199PhosphotyrosineBy similarity1
Modified residuei227N6-acetyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.2 Publications
ISGylated.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-462

Encyclopedia of Proteome Dynamics

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EPDi
P07355

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P07355

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P07355

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P07355

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07355

PeptideAtlas

More...
PeptideAtlasi
P07355

PRoteomics IDEntifications database

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PRIDEi
P07355

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51995 [P07355-1]
51996 [P07355-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P07355-1 [P07355-1]

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P07355

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00455315
P07355

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P07355

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P07355

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P07355

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P07355

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000182718 Expressed in 227 organ(s), highest expression level in epithelium of bronchus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P07355 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P07355 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004311
HPA046964
HPA061798

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (By similarity).

Interacts with ATP1B1 (By similarity).

Interacts with DYSF (By similarity).

Interacts with COCH (PubMed:21886777).

Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR (PubMed:18799458).

Interacts with CEACAM1 (via the cytoplasmic domain); this interaction is regulated by phosphorylation of CEACAM1 (PubMed:14522961).

Interacts with APPL2 and APPL1; targets APPL2 to endosomes and acting in parallel to RAB5A (By similarity).

By similarity3 Publications

(Microbial infection) Interacts with human cytomegalovirus (HCMV).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106799, 154 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-130 ANXA2-PCSK9 complex
CPX-850 AHNAK - Annexin A2 - S100-A10 complex
CPX-853 Annexin A2 - S100-A10 complex
CPX-856 SMARCA3 - Annexin A2 - S100-A10 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P07355

Protein interaction database and analysis system

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IntActi
P07355, 85 interactors

Molecular INTeraction database

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MINTi
P07355

STRING: functional protein association networks

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STRINGi
9606.ENSP00000346032

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07355

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P07355

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati33 – 104Annexin 1PROSITE-ProRule annotationAdd BLAST72
Repeati105 – 176Annexin 2PROSITE-ProRule annotationAdd BLAST72
Repeati189 – 261Annexin 3PROSITE-ProRule annotationAdd BLAST73
Repeati265 – 336Annexin 4PROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 24S100A10-binding siteSequence analysisAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the annexin family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0819 Eukaryota
ENOG410XPUN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154257

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000158803

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07355

KEGG Orthology (KO)

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KOi
K17092

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTEFKRQ

Database of Orthologous Groups

More...
OrthoDBi
856254at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105452

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.220.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002389 ANX2

The PANTHER Classification System

More...
PANTHERi
PTHR10502:SF18 PTHR10502:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00191 Annexin, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00196 ANNEXIN
PR00198 ANNEXINII

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00335 ANX, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00223 ANNEXIN_1, 4 hits
PS51897 ANNEXIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P07355-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG
60 70 80 90 100
VDEVTIVNIL TNRSNAQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL
110 120 130 140 150
GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM
160 170 180 190 200
YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD
210 220 230 240 250
AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM LESIRKEVKG
260 270 280 290 300
DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM
310 320 330
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
Length:339
Mass (Da):38,604
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5126E1337A0CBEA1
GO
Isoform 2 (identifier: P07355-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGRQLAGCGDAGKKASFKM

Show »
Length:357
Mass (Da):40,411
Checksum:i2AA081CB4E7AC75C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YKZ7H0YKZ7_HUMAN
Annexin
ANXA2
119Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL33H0YL33_HUMAN
Annexin
ANXA2
142Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLV6H0YLV6_HUMAN
Annexin
ANXA2
132Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMD0H0YMD0_HUMAN
Annexin
ANXA2
227Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMU9H0YMU9_HUMAN
Annexin
ANXA2
230Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN42H0YN42_HUMAN
Annexin
ANXA2
256Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKL9H0YKL9_HUMAN
Annexin
ANXA2
110Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKS4H0YKS4_HUMAN
Annexin
ANXA2
176Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKX9H0YKX9_HUMAN
Annexin
ANXA2
134Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM50H0YM50_HUMAN
Annexin
ANXA2
248Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH66955 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29A → P AA sequence (PubMed:8110754).Curated1
Sequence conflicti166D → G in CAE45704 (PubMed:17974005).Curated1
Sequence conflicti293V → A in AAH23990 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01298298V → L Polymorphism; does not affect interaction with PCSK9. 2 PublicationsCorresponds to variant dbSNP:rs17845226Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0380911M → MGRQLAGCGDAGKKASFKM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D00017 mRNA Translation: BAA00013.1
BT007432 mRNA Translation: AAP36100.1
BX640598 mRNA Translation: CAE45704.1
AC087385 Genomic DNA No translation available.
BC001388 mRNA Translation: AAH01388.1
BC009564 mRNA Translation: AAH09564.1
BC015834 mRNA Translation: AAH15834.1
BC016774 mRNA Translation: AAH16774.1
BC021114 mRNA Translation: AAH21114.1
BC023990 mRNA Translation: AAH23990.1
BC052558 mRNA Translation: AAH52558.1
BC052567 mRNA Translation: AAH52567.1
BC066955 mRNA Translation: AAH66955.2 Different initiation.
BC068065 mRNA Translation: AAH68065.1
BC093056 mRNA Translation: AAH93056.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10175.1 [P07355-1]
CCDS32256.1 [P07355-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A23942 LUHU36

NCBI Reference Sequences

More...
RefSeqi
NP_001002857.1, NM_001002857.1 [P07355-1]
NP_001002858.1, NM_001002858.2 [P07355-2]
NP_001129487.1, NM_001136015.2 [P07355-1]
NP_004030.1, NM_004039.2 [P07355-1]
XP_016877579.1, XM_017022090.1 [P07355-1]
XP_016877580.1, XM_017022091.1 [P07355-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332680; ENSP00000346032; ENSG00000182718 [P07355-2]
ENST00000396024; ENSP00000379342; ENSG00000182718 [P07355-1]
ENST00000421017; ENSP00000411352; ENSG00000182718 [P07355-1]
ENST00000451270; ENSP00000387545; ENSG00000182718 [P07355-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:302

UCSC genome browser

More...
UCSCi
uc002agk.4 human [P07355-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Red velvet - Issue 86 of September 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00017 mRNA Translation: BAA00013.1
BT007432 mRNA Translation: AAP36100.1
BX640598 mRNA Translation: CAE45704.1
AC087385 Genomic DNA No translation available.
BC001388 mRNA Translation: AAH01388.1
BC009564 mRNA Translation: AAH09564.1
BC015834 mRNA Translation: AAH15834.1
BC016774 mRNA Translation: AAH16774.1
BC021114 mRNA Translation: AAH21114.1
BC023990 mRNA Translation: AAH23990.1
BC052558 mRNA Translation: AAH52558.1
BC052567 mRNA Translation: AAH52567.1
BC066955 mRNA Translation: AAH66955.2 Different initiation.
BC068065 mRNA Translation: AAH68065.1
BC093056 mRNA Translation: AAH93056.1
CCDSiCCDS10175.1 [P07355-1]
CCDS32256.1 [P07355-2]
PIRiA23942 LUHU36
RefSeqiNP_001002857.1, NM_001002857.1 [P07355-1]
NP_001002858.1, NM_001002858.2 [P07355-2]
NP_001129487.1, NM_001136015.2 [P07355-1]
NP_004030.1, NM_004039.2 [P07355-1]
XP_016877579.1, XM_017022090.1 [P07355-1]
XP_016877580.1, XM_017022091.1 [P07355-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W7BX-ray1.52A1-339[»]
1XJLX-ray2.59A/B21-339[»]
2HYUX-ray1.86A32-339[»]
2HYVX-ray1.42A32-339[»]
2HYWX-ray2.10A/B32-339[»]
4DRWX-ray3.50A/B/C/D2-16[»]
4FTGX-ray2.51C/D2-16[»]
4HRHX-ray3.00A/B2-16[»]
5LPUX-ray2.10A/B2-339[»]
5LPXX-ray1.90A2-339[»]
5LQ0X-ray2.90A/B2-339[»]
5LQ2X-ray3.40A/B2-339[»]
5N7DX-ray2.30A/B22-339[»]
5N7FX-ray2.30A/B22-339[»]
5N7GX-ray2.95A/B22-339[»]
SMRiP07355
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106799, 154 interactors
ComplexPortaliCPX-130 ANXA2-PCSK9 complex
CPX-850 AHNAK - Annexin A2 - S100-A10 complex
CPX-853 Annexin A2 - S100-A10 complex
CPX-856 SMARCA3 - Annexin A2 - S100-A10 complex
CORUMiP07355
IntActiP07355, 85 interactors
MINTiP07355
STRINGi9606.ENSP00000346032

Chemistry databases

ChEMBLiCHEMBL1764938
DrugBankiDB11638 Artenimol
DB00591 Fluocinolone acetonide
DB06245 Lanoteplase
DB00031 Tenecteplase

Protein family/group databases

TCDBi1.A.31.1.4 the annexin (annexin) family

PTM databases

iPTMnetiP07355
PhosphoSitePlusiP07355
SwissPalmiP07355

Polymorphism and mutation databases

BioMutaiANXA2
DMDMi113950

2D gel databases

DOSAC-COBS-2DPAGEiP07355
REPRODUCTION-2DPAGEiIPI00455315
P07355
UCD-2DPAGEiP07355

Proteomic databases

CPTACiCPTAC-462
EPDiP07355
jPOSTiP07355
MassIVEiP07355
MaxQBiP07355
PaxDbiP07355
PeptideAtlasiP07355
PRIDEiP07355
ProteomicsDBi51995 [P07355-1]
51996 [P07355-2]
TopDownProteomicsiP07355-1 [P07355-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
302

Genome annotation databases

EnsembliENST00000332680; ENSP00000346032; ENSG00000182718 [P07355-2]
ENST00000396024; ENSP00000379342; ENSG00000182718 [P07355-1]
ENST00000421017; ENSP00000411352; ENSG00000182718 [P07355-1]
ENST00000451270; ENSP00000387545; ENSG00000182718 [P07355-1]
GeneIDi302
KEGGihsa:302
UCSCiuc002agk.4 human [P07355-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
302
DisGeNETi302

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANXA2
HGNCiHGNC:537 ANXA2
HPAiCAB004311
HPA046964
HPA061798
MIMi151740 gene
neXtProtiNX_P07355
OpenTargetsiENSG00000182718
PharmGKBiPA24827

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00940000154257
HOGENOMiHOG000158803
InParanoidiP07355
KOiK17092
OMAiRTEFKRQ
OrthoDBi856254at2759
TreeFamiTF105452

Enzyme and pathway databases

ReactomeiR-HSA-445355 Smooth Muscle Contraction
R-HSA-6798695 Neutrophil degranulation
R-HSA-75205 Dissolution of Fibrin Clot
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiP07355

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANXA2 human
EvolutionaryTraceiP07355

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Annexin_A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
302
PharosiP07355

Protein Ontology

More...
PROi
PR:P07355

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182718 Expressed in 227 organ(s), highest expression level in epithelium of bronchus
ExpressionAtlasiP07355 baseline and differential
GenevisibleiP07355 HS

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002389 ANX2
PANTHERiPTHR10502:SF18 PTHR10502:SF18, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00198 ANNEXINII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN_1, 4 hits
PS51897 ANNEXIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANXA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07355
Secondary accession number(s): Q567R4
, Q6N0B3, Q8TBV2, Q96DD5, Q9UDH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 235 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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