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Protein

Fructose-bisphosphate aldolase B

Gene

ALDOB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (GPI), Glucose-6-phosphate isomerase (RCJMB04_1c14), Glucose-6-phosphate isomerase (GPI)
  3. ATP-dependent 6-phosphofructokinase (PFKL), ATP-dependent 6-phosphofructokinase (pfk), ATP-dependent 6-phosphofructokinase (PFKP), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase (PFKM), ATP-dependent 6-phosphofructokinase (PFKL), ATP-dependent 6-phosphofructokinase (PFKP), ATP-dependent 6-phosphofructokinase (pfk)
  4. Fructose-bisphosphate aldolase C (ALDOC), Fructose-bisphosphate aldolase B (ALDOB), Fructose-bisphosphate aldolase (ALDOB), Fructose-bisphosphate aldolase (ALDOC)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-GGA-352875 Gluconeogenesis
R-GGA-352882 Glycolysis
R-GGA-70171 Glycolysis
R-GGA-70263 Gluconeogenesis
R-GGA-70350 Fructose catabolism
UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Liver-type aldolase
Gene namesi
Name:ALDOB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002169452 – 364Fructose-bisphosphate aldolase BAdd BLAST363

Proteomic databases

PaxDbiP07341
PRIDEiP07341

Expressioni

Gene expression databases

BgeeiENSGALG00000015544 Expressed in 7 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi686645, 1 interactor
IntActiP07341, 1 interactor
STRINGi9031.ENSGALP00000025010

Structurei

3D structure databases

ProteinModelPortaliP07341
SMRiP07341
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOGENOMiHOG000220876
HOVERGENiHBG002386
InParanoidiP07341
KOiK01623
OMAiPLCKPWA
OrthoDBiEOG091G0A9T
PhylomeDBiP07341
TreeFamiTF314203

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07341-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHQFPALSP EQKKALSDIA QRIVASGKGI LAADESVGTM GNRLQRINVE
60 70 80 90 100
NTEENRRAFR EILFSSDASI SKSIGGVILF HETLYQKDSS GKPFPAIIKE
110 120 130 140 150
KGMVVGIKLD AGTAPLAGTN GETTIQGLDK LAERCAQYKK DGADFGKWRA
160 170 180 190 200
VLKISSTTPS QLAIQENANT LARYASICQQ NGLVPIVEPE VLPDGDHDLQ
210 220 230 240 250
RCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHSC PKKYTPQDVA
260 270 280 290 300
VATVTTLLRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQS PLPKPWKLTF
310 320 330 340 350
SYGRALQASA LAAWLGKSEN KKAAQEAFCK RAQINSLACR GQYVTSGKTD
360
TAATQSLFTA SYTY
Length:364
Mass (Da):39,296
Last modified:January 23, 2007 - v3
Checksum:i40E0C300FB574CEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10946 Genomic DNA Translation: AAA48587.1
PIRiA22568 ADCHB
RefSeqiNP_001007978.1, NM_001007977.2
UniGeneiGga.4760

Genome annotation databases

EnsembliENSGALT00000037630; ENSGALP00000036836; ENSGALG00000015544
ENSGALT00000086136; ENSGALP00000062100; ENSGALG00000015544
GeneIDi427308
KEGGigga:427308

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10946 Genomic DNA Translation: AAA48587.1
PIRiA22568 ADCHB
RefSeqiNP_001007978.1, NM_001007977.2
UniGeneiGga.4760

3D structure databases

ProteinModelPortaliP07341
SMRiP07341
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi686645, 1 interactor
IntActiP07341, 1 interactor
STRINGi9031.ENSGALP00000025010

Proteomic databases

PaxDbiP07341
PRIDEiP07341

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000037630; ENSGALP00000036836; ENSGALG00000015544
ENSGALT00000086136; ENSGALP00000062100; ENSGALG00000015544
GeneIDi427308
KEGGigga:427308

Organism-specific databases

CTDi229

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOGENOMiHOG000220876
HOVERGENiHBG002386
InParanoidiP07341
KOiK01623
OMAiPLCKPWA
OrthoDBiEOG091G0A9T
PhylomeDBiP07341
TreeFamiTF314203

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

ReactomeiR-GGA-352875 Gluconeogenesis
R-GGA-352882 Glycolysis
R-GGA-70171 Glycolysis
R-GGA-70263 Gluconeogenesis
R-GGA-70350 Fructose catabolism

Miscellaneous databases

PROiPR:P07341

Gene expression databases

BgeeiENSGALG00000015544 Expressed in 7 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALDOB_CHICK
AccessioniPrimary (citable) accession number: P07341
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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