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Protein

Cathepsin D

Gene

CTSD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. EC:3.4.23.5

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei97PROSITE-ProRule annotation1 Publication1
Active sitei295PROSITE-ProRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS04183-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.4.23.5 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1442490 Collagen degradation
R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6798695 Neutrophil degranulation
R-HSA-9018519 Estrogen-dependent gene expression

SIGNOR Signaling Network Open Resource

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SIGNORi
P07339

Protein family/group databases

MEROPS protease database

More...
MEROPSi
A01.009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cathepsin D (EC:3.4.23.5)
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTSD
Synonyms:CPSD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000117984.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2529 CTSD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
116840 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07339

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ceroid lipofuscinosis, neuronal, 10 (CLN10)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
See also OMIM:610127
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029362229F → I in CLN10. 2 PublicationsCorresponds to variant dbSNP:rs121912789EnsemblClinVar.1
Natural variantiVAR_029363383W → C in CLN10. 1 PublicationCorresponds to variant dbSNP:rs121912790EnsemblClinVar.1

Keywords - Diseasei

Alzheimer disease, Disease mutation, Neurodegeneration, Neuronal ceroid lipofuscinosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
1509

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
CTSD

MalaCards human disease database

More...
MalaCardsi
CTSD
MIMi610127 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000117984

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
228337 CLN10 disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27029

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2581

Drug and drug target database

More...
DrugBanki
DB03028 1h-Benoximidazole-2-Carboxylic Acid
DB07542 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID
DB00030 Insulin Human
DB00071 Insulin Pork
DB03096 N-Aminoethylmorpholine
DB02216 S-Methylcysteine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2345

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTSD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
115717

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002594921 – 64Activation peptideAdd BLAST44
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002595065 – 412Cathepsin DAdd BLAST348
ChainiPRO_000002595165 – 162Cathepsin D light chain1 PublicationAdd BLAST98
ChainiPRO_0000025952169 – 412Cathepsin D heavy chain1 PublicationAdd BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63O-linked (GalNAc...) threonine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi91 ↔ 1601 Publication
Disulfide bondi110 ↔ 1171 Publication
Glycosylationi134N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi263N-linked (GlcNAc...) asparagine5 Publications1
Disulfide bondi286 ↔ 2901 Publication
Disulfide bondi329 ↔ 366

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated.5 Publications
Undergoes proteolytic cleavage and activation by ADAM30.1 Publication
As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified (PubMed:1426530). An additional form starting at Ala-168 has also been identified (PubMed:27333034).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P07339

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P07339

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P07339

PeptideAtlas

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PeptideAtlasi
P07339

PRoteomics IDEntifications database

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PRIDEi
P07339

ProteomicsDB human proteome resource

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ProteomicsDBi
12622
51994

Consortium for Top Down Proteomics

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TopDownProteomicsi
P07339

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P07339

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00011229

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P07339

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P07339

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1079

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P07339

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P07339

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P07339

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P07339

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000117984 Expressed in 229 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_CTSD

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P07339 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P07339 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000109
HPA003001

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of a light chain and a heavy chain (PubMed:8393577, PubMed:1426530). Interacts with ADAM30; this leads to activation of CTSD (PubMed:27333034).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
APPP050672EBI-2115097,EBI-77613

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107889, 50 interactors

Database of interacting proteins

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DIPi
DIP-43906N

Protein interaction database and analysis system

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IntActi
P07339, 25 interactors

Molecular INTeraction database

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MINTi
P07339

STRING: functional protein association networks

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STRINGi
9606.ENSP00000236671

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P07339

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1412
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LYAX-ray2.50A/C65-161[»]
B/D170-410[»]
1LYBX-ray2.50A/C65-161[»]
B/D170-410[»]
1LYWX-ray2.50A/C/E/G65-161[»]
B/D/F/H170-410[»]
4OBZX-ray2.90A/C60-162[»]
B/D170-412[»]
4OC6X-ray2.64A60-162[»]
B170-412[»]
4OD9X-ray1.90A/C60-162[»]
B/D170-412[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P07339

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07339

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P07339

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini79 – 407Peptidase A1PROSITE-ProRule annotationAdd BLAST329

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1339 Eukaryota
ENOG410XNV7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155733

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000197681

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000482

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P07339

KEGG Orthology (KO)

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KOi
K01379

Identification of Orthologs from Complete Genome Data

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OMAi
WNGQYTV

Database of Orthologous Groups

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OrthoDBi
247531at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P07339

TreeFam database of animal gene trees

More...
TreeFami
TF314990

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05490 Cathepsin_D2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.70.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033144 Cathepsin_D
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13683 PTHR13683, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00792 PEPSIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50630 SSF50630, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

P07339-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPSSLLPLA LCLLAAPASA LVRIPLHKFT SIRRTMSEVG GSVEDLIAKG
60 70 80 90 100
PVSKYSQAVP AVTEGPIPEV LKNYMDAQYY GEIGIGTPPQ CFTVVFDTGS
110 120 130 140 150
SNLWVPSIHC KLLDIACWIH HKYNSDKSST YVKNGTSFDI HYGSGSLSGY
160 170 180 190 200
LSQDTVSVPC QSASSASALG GVKVERQVFG EATKQPGITF IAAKFDGILG
210 220 230 240 250
MAYPRISVNN VLPVFDNLMQ QKLVDQNIFS FYLSRDPDAQ PGGELMLGGT
260 270 280 290 300
DSKYYKGSLS YLNVTRKAYW QVHLDQVEVA SGLTLCKEGC EAIVDTGTSL
310 320 330 340 350
MVGPVDEVRE LQKAIGAVPL IQGEYMIPCE KVSTLPAITL KLGGKGYKLS
360 370 380 390 400
PEDYTLKVSQ AGKTLCLSGF MGMDIPPPSG PLWILGDVFI GRYYTVFDRD
410
NNRVGFAEAA RL
Length:412
Mass (Da):44,552
Last modified:April 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i903FB8412E0CF0B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GVD5A0A1B0GVD5_HUMAN
Cathepsin D
CTSD
409Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV23A0A1B0GV23_HUMAN
Cathepsin D
CTSD
406Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GVP3A0A1B0GVP3_HUMAN
Cathepsin D
CTSD
405Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GWE8A0A1B0GWE8_HUMAN
Cathepsin D
CTSD
410Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GW44A0A1B0GW44_HUMAN
Cathepsin D
CTSD
405Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD96F8WD96_HUMAN
Cathepsin D
CTSD
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JH19C9JH19_HUMAN
Cathepsin D
CTSD
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W787F8W787_HUMAN
Cathepsin D
CTSD
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1V0H7C1V0_HUMAN
Cathepsin D
CTSD
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV01A0A1B0GV01_HUMAN
Cathepsin D
CTSD
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01162158A → V Associated with increased risk for AD; possibly influences secretion and intracellular maturation. 1 PublicationCorresponds to variant dbSNP:rs17571EnsemblClinVar.1
Natural variantiVAR_029362229F → I in CLN10. 2 PublicationsCorresponds to variant dbSNP:rs121912789EnsemblClinVar.1
Natural variantiVAR_058490282G → R1 PublicationCorresponds to variant dbSNP:rs147278302EnsemblClinVar.1
Natural variantiVAR_029363383W → C in CLN10. 1 PublicationCorresponds to variant dbSNP:rs121912790EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M11233 mRNA Translation: AAB59529.1
X05344 mRNA Translation: CAA28955.1
M63138
, M63134, M63135, M63136, M63137 Genomic DNA Translation: AAA51922.1
CR456947 mRNA Translation: CAG33228.1
BT006910 mRNA Translation: AAP35556.1
BT020155 mRNA Translation: AAV38957.1
BC016320 mRNA Translation: AAH16320.1
L12980 Genomic DNA Translation: AAA16314.1
S74689 Genomic DNA Translation: AAD14156.1
S52557 Genomic DNA Translation: AAD13868.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7725.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A25771 KHHUD

NCBI Reference Sequences

More...
RefSeqi
NP_001900.1, NM_001909.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654447

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000236671; ENSP00000236671; ENSG00000117984

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1509

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1509

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NCL CTSD

Neural Ceroid Lipofuscinoses mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11233 mRNA Translation: AAB59529.1
X05344 mRNA Translation: CAA28955.1
M63138
, M63134, M63135, M63136, M63137 Genomic DNA Translation: AAA51922.1
CR456947 mRNA Translation: CAG33228.1
BT006910 mRNA Translation: AAP35556.1
BT020155 mRNA Translation: AAV38957.1
BC016320 mRNA Translation: AAH16320.1
L12980 Genomic DNA Translation: AAA16314.1
S74689 Genomic DNA Translation: AAD14156.1
S52557 Genomic DNA Translation: AAD13868.1
CCDSiCCDS7725.1
PIRiA25771 KHHUD
RefSeqiNP_001900.1, NM_001909.4
UniGeneiHs.654447

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LYAX-ray2.50A/C65-161[»]
B/D170-410[»]
1LYBX-ray2.50A/C65-161[»]
B/D170-410[»]
1LYWX-ray2.50A/C/E/G65-161[»]
B/D/F/H170-410[»]
4OBZX-ray2.90A/C60-162[»]
B/D170-412[»]
4OC6X-ray2.64A60-162[»]
B170-412[»]
4OD9X-ray1.90A/C60-162[»]
B/D170-412[»]
ProteinModelPortaliP07339
SMRiP07339
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107889, 50 interactors
DIPiDIP-43906N
IntActiP07339, 25 interactors
MINTiP07339
STRINGi9606.ENSP00000236671

Chemistry databases

BindingDBiP07339
ChEMBLiCHEMBL2581
DrugBankiDB03028 1h-Benoximidazole-2-Carboxylic Acid
DB07542 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID
DB00030 Insulin Human
DB00071 Insulin Pork
DB03096 N-Aminoethylmorpholine
DB02216 S-Methylcysteine
GuidetoPHARMACOLOGYi2345

Protein family/group databases

MEROPSiA01.009

PTM databases

GlyConnecti1079
iPTMnetiP07339
PhosphoSitePlusiP07339
SwissPalmiP07339

Polymorphism and mutation databases

BioMutaiCTSD
DMDMi115717

2D gel databases

DOSAC-COBS-2DPAGEiP07339
REPRODUCTION-2DPAGEiIPI00011229
SWISS-2DPAGEiP07339
UCD-2DPAGEiP07339

Proteomic databases

EPDiP07339
jPOSTiP07339
PaxDbiP07339
PeptideAtlasiP07339
PRIDEiP07339
ProteomicsDBi12622
51994
TopDownProteomicsiP07339

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1509
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236671; ENSP00000236671; ENSG00000117984
GeneIDi1509
KEGGihsa:1509

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1509
DisGeNETi1509
EuPathDBiHostDB:ENSG00000117984.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CTSD
GeneReviewsiCTSD

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0009359
HGNCiHGNC:2529 CTSD
HPAiCAB000109
HPA003001
MalaCardsiCTSD
MIMi116840 gene
610127 phenotype
neXtProtiNX_P07339
OpenTargetsiENSG00000117984
Orphaneti228337 CLN10 disease
PharmGKBiPA27029

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00940000155733
HOGENOMiHOG000197681
HOVERGENiHBG000482
InParanoidiP07339
KOiK01379
OMAiWNGQYTV
OrthoDBi247531at2759
PhylomeDBiP07339
TreeFamiTF314990

Enzyme and pathway databases

BioCyciMetaCyc:HS04183-MONOMER
BRENDAi3.4.23.5 2681
ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6798695 Neutrophil degranulation
R-HSA-9018519 Estrogen-dependent gene expression
SIGNORiP07339

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CTSD human
EvolutionaryTraceiP07339

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Cathepsin_D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1509
PMAP-CutDBiP07339

Protein Ontology

More...
PROi
PR:P07339

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117984 Expressed in 229 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_CTSD
ExpressionAtlasiP07339 baseline and differential
GenevisibleiP07339 HS

Family and domain databases

CDDicd05490 Cathepsin_D2, 1 hit
Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033144 Cathepsin_D
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07339
Secondary accession number(s): Q6IB57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: January 16, 2019
This is version 218 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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