UniProtKB - P07332 (FES_HUMAN)
Tyrosine-protein kinase Fes/Fps
FES
Functioni
Miscellaneous
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]PROSITE-ProRule annotation6 PublicationsEC:2.7.10.2PROSITE-ProRule annotation6 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 590 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 683 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 567 – 575 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- immunoglobulin receptor binding Source: UniProtKB
- microtubule binding Source: Ensembl
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB
- phosphatidylinositol binding Source: UniProtKB
- protein tyrosine kinase activity Source: UniProtKB
- signaling receptor binding Source: GO_Central
GO - Biological processi
- cell adhesion Source: GO_Central
- cell differentiation Source: GO_Central
- cellular response to vitamin D Source: ARUK-UCL
- centrosome cycle Source: Ensembl
- chemotaxis Source: GO_Central
- innate immune response Source: GO_Central
- microtubule bundle formation Source: Ensembl
- peptidyl-tyrosine autophosphorylation Source: GO_Central
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of actin cytoskeleton reorganization Source: UniProtKB
- positive regulation of microtubule polymerization Source: UniProtKB
- positive regulation of monocyte differentiation Source: ARUK-UCL
- positive regulation of myeloid cell differentiation Source: UniProtKB
- positive regulation of neuron projection development Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- regulation of cell adhesion Source: UniProtKB
- regulation of cell differentiation Source: UniProtKB
- regulation of cell motility Source: UniProtKB
- regulation of cell population proliferation Source: UniProtKB
- regulation of cell shape Source: UniProtKB
- regulation of mast cell degranulation Source: UniProtKB
- regulation of vesicle-mediated transport Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Lipid-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P07332 |
Reactomei | R-HSA-1433557, Signaling by SCF-KIT R-HSA-399954, Sema3A PAK dependent Axon repulsion R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399956, CRMPs in Sema3A signaling |
SignaLinki | P07332 |
SIGNORi | P07332 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase Fes/Fps (EC:2.7.10.2)Alternative name(s): Feline sarcoma/Fujinami avian sarcoma oncogene homolog Proto-oncogene c-Fes Proto-oncogene c-Fps p93c-fes |
Gene namesi | Name:FES Synonyms:FPS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3657, FES |
MIMi | 190030, gene |
neXtProti | NX_P07332 |
VEuPathDBi | HostDB:ENSG00000182511.11 |
Subcellular locationi
Plasma membrane
Cytosol
Golgi apparatus
Cytoskeleton
Other locations
Note: Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
Cytoskeleton
- microtubule cytoskeleton Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle Source: UniProtKB-KW
- focal adhesion Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 113 – 114 | RK → EE: Reduced binding to membranes containing phosphoinositides. 1 Publication | 2 | |
Mutagenesisi | 113 – 114 | RK → QQ: Reduced binding to membranes containing phosphoinositides. 1 Publication | 2 | |
Mutagenesisi | 145 | L → P: Constitutively activated kinase that can act as oncogene. Promotes myeloid cell survival and proliferation. 2 Publications | 1 | |
Mutagenesisi | 334 | L → P: Abolishes autophosphorylation. 1 Publication | 1 | |
Mutagenesisi | 463 | G → V: Abolishes kinase activity. 1 Publication | 1 | |
Mutagenesisi | 483 | R → M: Abolishes pTyr binding. Abolishes association with microtubules. Abolishes autophosphorylation. Reduced kinase activity. 2 Publications | 1 | |
Mutagenesisi | 590 | K → E: Abolishes kinase activity. Fails to inhibit proliferation of melanoma cells. 2 Publications | 1 | |
Mutagenesisi | 704 | M → V: Reduced autophosphorylation and strongly reduced kinase activity. 2 Publications | 1 | |
Mutagenesisi | 706 | R → Q: Negligible effect on autophosphorylation and kinase activity. 2 Publications | 1 | |
Mutagenesisi | 713 | Y → F: Reduces kinase activity by over 90%. 1 Publication | 1 | |
Mutagenesisi | 743 | V → M: Strongly reduced autophosphorylation and kinase activity. 2 Publications | 1 | |
Mutagenesisi | 759 | S → F: Reduced autophosphorylation and strongly reduced kinase activity. 2 Publications | 1 |
Keywords - Diseasei
Proto-oncogene, Tumor suppressorOrganism-specific databases
DisGeNETi | 2242 |
OpenTargetsi | ENSG00000182511 |
PharmGKBi | PA28098 |
Miscellaneous databases
Pharosi | P07332, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5455 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P07332 |
GuidetoPHARMACOLOGYi | 2023 |
Genetic variation databases
BioMutai | FES |
DMDMi | 115502390 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088088 | 1 – 822 | Tyrosine-protein kinase Fes/FpsAdd BLAST | 822 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 64 | PhosphoserineCombined sources | 1 | |
Modified residuei | 67 | PhosphoserineCombined sources | 1 | |
Modified residuei | 261 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 408 | PhosphoserineCombined sources | 1 | |
Modified residuei | 411 | PhosphoserineCombined sources | 1 | |
Modified residuei | 421 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 713 | Phosphotyrosine; by autocatalysisCombined sources5 Publications | 1 | |
Modified residuei | 716 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-1778 |
EPDi | P07332 |
jPOSTi | P07332 |
MassIVEi | P07332 |
MaxQBi | P07332 |
PaxDbi | P07332 |
PeptideAtlasi | P07332 |
PRIDEi | P07332 |
ProteomicsDBi | 51989 [P07332-1] 51990 [P07332-2] 51991 [P07332-3] 51992 [P07332-4] |
PTM databases
iPTMneti | P07332 |
PhosphoSitePlusi | P07332 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000182511, Expressed in spleen and 134 other tissues |
ExpressionAtlasi | P07332, baseline and differential |
Genevisiblei | P07332, HS |
Organism-specific databases
HPAi | ENSG00000182511, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Homooligomer.
Interacts with BCR.
Interacts (when activated, via coiled coil domain) with TRIM28.
Interacts (via SH2 domain) with phosphorylated EZR, MS4A2/FCER1B and HCLS1/HS1.
Interacts with phosphorylated KIT.
Interacts with FLT3.
Interacts (via F-BAR domain) with soluble tubulin.
Interacts (via SH2 domain) with microtubules.
9 PublicationsBinary interactionsi
Hide detailsP07332
With | #Exp. | IntAct |
---|---|---|
AR [P10275] | 3 | EBI-1055635,EBI-608057 |
EZR [P15311] | 8 | EBI-1055635,EBI-1056902 |
GAB1 [Q13480] | 2 | EBI-1055635,EBI-517684 |
KIT [P10721] | 2 | EBI-1055635,EBI-1379503 |
TERF1 [P54274] | 2 | EBI-1055635,EBI-710997 |
GO - Molecular functioni
- immunoglobulin receptor binding Source: UniProtKB
- microtubule binding Source: Ensembl
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 108533, 25 interactors |
IntActi | P07332, 32 interactors |
MINTi | P07332 |
STRINGi | 9606.ENSP00000331504 |
Chemistry databases
BindingDBi | P07332 |
Miscellaneous databases
RNActi | P07332, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P07332 |
SMRi | P07332 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07332 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 260 | F-BARPROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 460 – 549 | SH2PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 561 – 822 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 262 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 300 | Important for interaction with membranes containing phosphoinositidesAdd BLAST | 300 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 125 – 169 | Sequence analysisAdd BLAST | 45 | |
Coiled coili | 324 – 368 | Sequence analysisAdd BLAST | 45 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH2 domainPhylogenomic databases
eggNOGi | KOG0194, Eukaryota |
GeneTreei | ENSGT00940000158881 |
HOGENOMi | CLU_005265_0_1_1 |
InParanoidi | P07332 |
OMAi | HFIIQSA |
PhylomeDBi | P07332 |
TreeFami | TF315363 |
Family and domain databases
CDDi | cd10361, SH2_Fps_family, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR035849, Fes/Fps/Fer_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR016250, Tyr-prot_kinase_Fes/Fps IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit |
PIRSFi | PIRSF000632, TyrPK_fps, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGFSSELCSP QGHGVLQQMQ EAELRLLEGM RKWMAQRVKS DREYAGLLHH
60 70 80 90 100
MSLQDSGGQS RAISPDSPIS QSWAEITSQT EGLSRLLRQH AEDLNSGPLS
110 120 130 140 150
KLSLLIRERQ QLRKTYSEQW QQLQQELTKT HSQDIEKLKS QYRALARDSA
160 170 180 190 200
QAKRKYQEAS KDKDRDKAKD KYVRSLWKLF AHHNRYVLGV RAAQLHHQHH
210 220 230 240 250
HQLLLPGLLR SLQDLHEEMA CILKEILQEY LEISSLVQDE VVAIHREMAA
260 270 280 290 300
AAARIQPEAE YQGFLRQYGS APDVPPCVTF DESLLEEGEP LEPGELQLNE
310 320 330 340 350
LTVESVQHTL TSVTDELAVA TEMVFRRQEM VTQLQQELRN EEENTHPRER
360 370 380 390 400
VQLLGKRQVL QEALQGLQVA LCSQAKLQAQ QELLQTKLEH LGPGEPPPVL
410 420 430 440 450
LLQDDRHSTS SSEQEREGGR TPTLEILKSH ISGIFRPKFS LPPPLQLIPE
460 470 480 490 500
VQKPLHEQLW YHGAIPRAEV AELLVHSGDF LVRESQGKQE YVLSVLWDGL
510 520 530 540 550
PRHFIIQSLD NLYRLEGEGF PSIPLLIDHL LSTQQPLTKK SGVVLHRAVP
560 570 580 590 600
KDKWVLNHED LVLGEQIGRG NFGEVFSGRL RADNTLVAVK SCRETLPPDL
610 620 630 640 650
KAKFLQEARI LKQYSHPNIV RLIGVCTQKQ PIYIVMELVQ GGDFLTFLRT
660 670 680 690 700
EGARLRVKTL LQMVGDAAAG MEYLESKCCI HRDLAARNCL VTEKNVLKIS
710 720 730 740 750
DFGMSREEAD GVYAASGGLR QVPVKWTAPE ALNYGRYSSE SDVWSFGILL
760 770 780 790 800
WETFSLGASP YPNLSNQQTR EFVEKGGRLP CPELCPDAVF RLMEQCWAYE
810 820
PGQRPSFSTI YQELQSIRKR HR
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ENM8 | E7ENM8_HUMAN | Tyrosine-protein kinase | FES | 681 | Annotation score: | ||
E9PIJ7 | E9PIJ7_HUMAN | Tyrosine-protein kinase Fes/Fps | FES | 545 | Annotation score: | ||
H0YNT6 | H0YNT6_HUMAN | Tyrosine-protein kinase Fes/Fps | FES | 121 | Annotation score: | ||
H0YNN8 | H0YNN8_HUMAN | Tyrosine-protein kinase Fes/Fps | FES | 169 | Annotation score: | ||
E7EMJ7 | E7EMJ7_HUMAN | Tyrosine-protein kinase Fes/Fps | FES | 147 | Annotation score: | ||
E9PGC7 | E9PGC7_HUMAN | Tyrosine-protein kinase Fes/Fps | FES | 114 | Annotation score: | ||
C9J3W6 | C9J3W6_HUMAN | Tyrosine-protein kinase Fes/Fps | FES | 42 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 719 | L → S in CAA36438 (PubMed:2179816).Curated | 1 | |
Sequence conflicti | 719 | L → S in AAS82866 (Ref. 3) Curated | 1 | |
Sequence conflicti | 719 | L → S in AAS82869 (Ref. 3) Curated | 1 | |
Sequence conflicti | 719 | L → S in AAS82868 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041697 | 85 | R → C1 PublicationCorresponds to variant dbSNP:rs56041861Ensembl. | 1 | |
Natural variantiVAR_041698 | 246 | R → Q1 PublicationCorresponds to variant dbSNP:rs34573430Ensembl. | 1 | |
Natural variantiVAR_041699 | 323 | M → V1 PublicationCorresponds to variant dbSNP:rs56296062EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041748 | 72 – 129 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 58 | |
Alternative sequenceiVSP_041749 | 441 – 510 | Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 70 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000328850; ENSP00000331504; ENSG00000182511 [P07332-1] ENST00000394300; ENSP00000377837; ENSG00000182511 [P07332-3] ENST00000414248; ENSP00000414629; ENSG00000182511 [P07332-2] ENST00000444422; ENSP00000400868; ENSG00000182511 [P07332-4] |
GeneIDi | 2242 |
KEGGi | hsa:2242 |
UCSCi | uc002bpv.4, human [P07332-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WQU | NMR | - | A | 450-550 | [»] | |
2DCR | NMR | - | A | 450-550 | [»] | |
3BKB | X-ray | 1.78 | A | 448-822 | [»] | |
3CBL | X-ray | 1.75 | A | 448-822 | [»] | |
3CD3 | X-ray | 1.98 | A | 448-822 | [»] | |
4DYL | X-ray | 2.18 | A | 1-405 | [»] | |
4E93 | X-ray | 1.84 | A | 448-822 | [»] | |
6JMF | X-ray | 2.00 | A | 449-822 | [»] | |
BMRBi | P07332 | |||||
SMRi | P07332 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108533, 25 interactors |
IntActi | P07332, 32 interactors |
MINTi | P07332 |
STRINGi | 9606.ENSP00000331504 |
Chemistry databases
BindingDBi | P07332 |
ChEMBLi | CHEMBL5455 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P07332 |
GuidetoPHARMACOLOGYi | 2023 |
PTM databases
iPTMneti | P07332 |
PhosphoSitePlusi | P07332 |
Genetic variation databases
BioMutai | FES |
DMDMi | 115502390 |
Proteomic databases
CPTACi | CPTAC-1778 |
EPDi | P07332 |
jPOSTi | P07332 |
MassIVEi | P07332 |
MaxQBi | P07332 |
PaxDbi | P07332 |
PeptideAtlasi | P07332 |
PRIDEi | P07332 |
ProteomicsDBi | 51989 [P07332-1] 51990 [P07332-2] 51991 [P07332-3] 51992 [P07332-4] |
Protocols and materials databases
Antibodypediai | 734, 441 antibodies |
DNASUi | 2242 |
Genome annotation databases
Ensembli | ENST00000328850; ENSP00000331504; ENSG00000182511 [P07332-1] ENST00000394300; ENSP00000377837; ENSG00000182511 [P07332-3] ENST00000414248; ENSP00000414629; ENSG00000182511 [P07332-2] ENST00000444422; ENSP00000400868; ENSG00000182511 [P07332-4] |
GeneIDi | 2242 |
KEGGi | hsa:2242 |
UCSCi | uc002bpv.4, human [P07332-1] |
Organism-specific databases
CTDi | 2242 |
DisGeNETi | 2242 |
GeneCardsi | FES |
HGNCi | HGNC:3657, FES |
HPAi | ENSG00000182511, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 190030, gene |
neXtProti | NX_P07332 |
OpenTargetsi | ENSG00000182511 |
PharmGKBi | PA28098 |
VEuPathDBi | HostDB:ENSG00000182511.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0194, Eukaryota |
GeneTreei | ENSGT00940000158881 |
HOGENOMi | CLU_005265_0_1_1 |
InParanoidi | P07332 |
OMAi | HFIIQSA |
PhylomeDBi | P07332 |
TreeFami | TF315363 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P07332 |
Reactomei | R-HSA-1433557, Signaling by SCF-KIT R-HSA-399954, Sema3A PAK dependent Axon repulsion R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399956, CRMPs in Sema3A signaling |
SignaLinki | P07332 |
SIGNORi | P07332 |
Miscellaneous databases
BioGRID-ORCSi | 2242, 9 hits in 900 CRISPR screens |
ChiTaRSi | FES, human |
EvolutionaryTracei | P07332 |
GeneWikii | Feline_sarcoma_oncogene |
GenomeRNAii | 2242 |
Pharosi | P07332, Tchem |
PROi | PR:P07332 |
RNActi | P07332, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182511, Expressed in spleen and 134 other tissues |
ExpressionAtlasi | P07332, baseline and differential |
Genevisiblei | P07332, HS |
Family and domain databases
CDDi | cd10361, SH2_Fps_family, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR035849, Fes/Fps/Fer_SH2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR016250, Tyr-prot_kinase_Fes/Fps IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit |
PIRSFi | PIRSF000632, TyrPK_fps, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00252, SH2, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FES_HUMAN | |
Accessioni | P07332Primary (citable) accession number: P07332 Secondary accession number(s): B2R6E6 Q6GTU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | October 3, 2006 | |
Last modified: | February 10, 2021 | |
This is version 223 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index