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Protein

Alcohol dehydrogenase 1A

Gene

ADH1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Metal bindingi175Zinc 1; catalytic1
Binding sitei224NAD2 Publications1
Binding sitei229NAD2 Publications1
Binding sitei370NAD2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205NAD2 Publications6
Nucleotide bindingi293 – 295NAD2 Publications3

GO - Molecular functioni

GO - Biological processi

  • alcohol metabolic process Source: UniProtKB
  • drug metabolic process Source: Reactome
  • ethanol oxidation Source: Reactome

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2161541 Abacavir metabolism
R-HSA-5365859 RA biosynthesis pathway
R-HSA-71384 Ethanol oxidation
SABIO-RKiP07327

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1A (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase subunit alpha
Gene namesi
Name:ADH1A
Synonyms:ADH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000187758.7
HGNCiHGNC:249 ADH1A
MIMi103700 gene
neXtProtiNX_P07327

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi124
OpenTargetsiENSG00000187758
PharmGKBiPA24570

Chemistry databases

ChEMBLiCHEMBL1970
DrugBankiDB02721 4-Iodopyrazole
DB00898 Ethanol
DB01213 Fomepizole
DB04065 N-Cyclopentyl-N-Cyclobutylformamide
DB00157 NADH

Polymorphism and mutation databases

BioMutaiADH1A
DMDMi113390

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001606582 – 375Alcohol dehydrogenase 1AAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei23PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP07327
PaxDbiP07327
PeptideAtlasiP07327
PRIDEiP07327
ProteomicsDBi51988

PTM databases

iPTMnetiP07327
PhosphoSitePlusiP07327

Expressioni

Gene expression databases

BgeeiENSG00000187758 Expressed in 114 organ(s), highest expression level in liver
CleanExiHS_ADH1A
GenevisibleiP07327 HS

Organism-specific databases

HPAiCAB009562
HPA047814
HPA060902

Interactioni

Subunit structurei

Dimer of identical or non-identical chains of three types; alpha, beta and gamma.2 Publications

Protein-protein interaction databases

BioGridi106636, 2 interactors
IntActiP07327, 2 interactors
STRINGi9606.ENSP00000209668

Chemistry databases

BindingDBiP07327

Structurei

Secondary structure

1375
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07327
SMRiP07327
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07327

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiP07327
KOiK13951
OMAiNPQGTLQ
OrthoDBiEOG091G08N3
PhylomeDBiP07327
TreeFamiTF300429

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07327-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAVGICGTD
60 70 80 90 100
DHVVSGTMVT PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLAIPQCGK
110 120 130 140 150
CRICKNPESN YCLKNDVSNP QGTLQDGTSR FTCRRKPIHH FLGISTFSQY
160 170 180 190 200
TVVDENAVAK IDAASPLEKV CLIGCGFSTG YGSAVNVAKV TPGSTCAVFG
210 220 230 240 250
LGGVGLSAIM GCKAAGAARI IAVDINKDKF AKAKELGATE CINPQDYKKP
260 270 280 290 300
IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ
310 320 330 340 350
NLSMNPMLLL TGRTWKGAIL GGFKSKECVP KLVADFMAKK FSLDALITHV
360 370
LPFEKINEGF DLLHSGKSIR TILMF
Length:375
Mass (Da):39,859
Last modified:January 23, 2007 - v2
Checksum:iB6DF4D57080D9BC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12963 mRNA Translation: AAA51590.1
M12271 mRNA Translation: AAA68131.1
BT019812 mRNA Translation: AAV38615.1
AY948115 Genomic DNA Translation: AAX20115.1
AK290558 mRNA Translation: BAF83247.1
CH471057 Genomic DNA Translation: EAX06094.1
BC074738 mRNA Translation: AAH74738.1
BC117442 mRNA Translation: AAI17443.1
BC126306 mRNA Translation: AAI26307.1
M37066 Genomic DNA Translation: AAA51591.1
CCDSiCCDS3648.1
PIRiS02265 DEHUAA
RefSeqiNP_000658.1, NM_000667.3
UniGeneiHs.654433

Genome annotation databases

EnsembliENST00000209668; ENSP00000209668; ENSG00000187758
GeneIDi124
KEGGihsa:124
UCSCiuc003hur.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12963 mRNA Translation: AAA51590.1
M12271 mRNA Translation: AAA68131.1
BT019812 mRNA Translation: AAV38615.1
AY948115 Genomic DNA Translation: AAX20115.1
AK290558 mRNA Translation: BAF83247.1
CH471057 Genomic DNA Translation: EAX06094.1
BC074738 mRNA Translation: AAH74738.1
BC117442 mRNA Translation: AAI17443.1
BC126306 mRNA Translation: AAI26307.1
M37066 Genomic DNA Translation: AAA51591.1
CCDSiCCDS3648.1
PIRiS02265 DEHUAA
RefSeqiNP_000658.1, NM_000667.3
UniGeneiHs.654433

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSOX-ray2.50A/B2-375[»]
1U3TX-ray2.49A/B2-375[»]
ProteinModelPortaliP07327
SMRiP07327
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106636, 2 interactors
IntActiP07327, 2 interactors
STRINGi9606.ENSP00000209668

Chemistry databases

BindingDBiP07327
ChEMBLiCHEMBL1970
DrugBankiDB02721 4-Iodopyrazole
DB00898 Ethanol
DB01213 Fomepizole
DB04065 N-Cyclopentyl-N-Cyclobutylformamide
DB00157 NADH

PTM databases

iPTMnetiP07327
PhosphoSitePlusiP07327

Polymorphism and mutation databases

BioMutaiADH1A
DMDMi113390

Proteomic databases

MaxQBiP07327
PaxDbiP07327
PeptideAtlasiP07327
PRIDEiP07327
ProteomicsDBi51988

Protocols and materials databases

DNASUi124
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000209668; ENSP00000209668; ENSG00000187758
GeneIDi124
KEGGihsa:124
UCSCiuc003hur.3 human

Organism-specific databases

CTDi124
DisGeNETi124
EuPathDBiHostDB:ENSG00000187758.7
GeneCardsiADH1A
HGNCiHGNC:249 ADH1A
HPAiCAB009562
HPA047814
HPA060902
MIMi103700 gene
neXtProtiNX_P07327
OpenTargetsiENSG00000187758
PharmGKBiPA24570
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
GeneTreeiENSGT00430000030800
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiP07327
KOiK13951
OMAiNPQGTLQ
OrthoDBiEOG091G08N3
PhylomeDBiP07327
TreeFamiTF300429

Enzyme and pathway databases

ReactomeiR-HSA-2161541 Abacavir metabolism
R-HSA-5365859 RA biosynthesis pathway
R-HSA-71384 Ethanol oxidation
SABIO-RKiP07327

Miscellaneous databases

EvolutionaryTraceiP07327
GeneWikiiADH1A
GenomeRNAii124
PROiPR:P07327
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187758 Expressed in 114 organ(s), highest expression level in liver
CleanExiHS_ADH1A
GenevisibleiP07327 HS

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1A_HUMAN
AccessioniPrimary (citable) accession number: P07327
Secondary accession number(s): A8K3E3, Q17R68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 192 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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