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Protein

Gamma-crystallin D

Gene

CRYGD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural constituent of eye lens Source: UniProtKB

GO - Biological processi

  • cellular response to reactive oxygen species Source: UniProtKB
  • lens development in camera-type eye Source: UniProtKB
  • lens fiber cell differentiation Source: UniProtKB
  • visual perception Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEye lens protein
Biological processSensory transduction, Vision

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P07320

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-crystallin D
Alternative name(s):
Gamma-D-crystallin
Gamma-crystallin 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRYGD
Synonyms:CRYG4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000118231.4

Human Gene Nomenclature Database

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HGNCi
HGNC:2411 CRYGD

Online Mendelian Inheritance in Man (OMIM)

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MIMi
123690 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07320

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cataract 4, multiple types (CTRCT4)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT4 includes crystalline aculeiform, congenital cerulean and non-nuclear polymorphic cataracts, among others. Crystalline aculeiform cataract is characterized by fiberglass-like or needle-like crystals projecting in different directions, through or close to the axial region of the lens. Non-nuclear polymorphic cataract is a partial opacity with variable location between the fetal nucleus of the lens and the equator. The fetal nucleus is normal. The opacities are irregular and look similar to a bunch of grapes and may be present simultaneously in different lens layers. Congenital cerulean cataract is characterized by peripheral bluish and white opacifications organized in concentric layers with occasional central lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as well as the adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in childhood. In adulthood, the opacifications may progress, making lens extraction necessary. Histologically the lesions are described as fusiform cavities between lens fibers which contain a deeply staining granular material. Although the lesions may take on various colors, a dull blue is the most common appearance and is responsible for the designation cerulean cataract.
See also OMIM:115700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01073315R → C in CTRCT4; progressive punctate cataract with early onset; causes disulfide-linked oligomers formation with consequent protein aggregation and precipitation. 2 PublicationsCorresponds to variant dbSNP:rs121909595EnsemblClinVar.1
Natural variantiVAR_03495524P → S in CTRCT4; lowered solubility. 2 PublicationsCorresponds to variant dbSNP:rs28931605EnsemblClinVar.1
Natural variantiVAR_02114524P → T in CTRCT4; lowered solubility. 3 PublicationsCorresponds to variant dbSNP:rs28931605EnsemblClinVar.1
Natural variantiVAR_01073437R → S in CTRCT4; very low solubility; crystallizes spontaneously. 2 PublicationsCorresponds to variant dbSNP:rs121909597EnsemblClinVar.1
Natural variantiVAR_06482943W → R in CTRCT4; much less stable than the wild-type protein; more prone to aggregate when subjected to environmental stresses such as heat and UV irradiation. 1 Publication1
Natural variantiVAR_01073559R → H in CTRCT4; lowered solubility; crystallizes easily. 3 PublicationsCorresponds to variant dbSNP:rs121909596EnsemblClinVar.1
Natural variantiVAR_034956107E → A in CTRCT4. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi24 – 25PN → TK: Wild-type solubility. 2
Mutagenesisi24P → TP: Wild-type solubility. 1 Publication1
Mutagenesisi24P → V: Slightly lowered solubility. 1 Publication1

Keywords - Diseasei

Cataract, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1421

MalaCards human disease database

More...
MalaCardsi
CRYGD
MIMi115700 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000118231

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1377 Cataract-microcornea syndrome
98989 Cerulean cataract
98990 Coralliform cataract
441452 Early-onset lamellar cataract
98991 Early-onset nuclear cataract
98984 Pulverulent cataract

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26918

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CRYGD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2506321

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000575882 – 174Gamma-crystallin DAdd BLAST173

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P07320

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P07320

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07320

PeptideAtlas

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PeptideAtlasi
P07320

PRoteomics IDEntifications database

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PRIDEi
P07320

ProteomicsDB human proteome resource

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ProteomicsDBi
51987

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P07320

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P07320

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118231 Expressed in 88 organ(s), highest expression level in left ovary

CleanEx database of gene expression profiles

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CleanExi
HS_CRYGD

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P07320 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P07320 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA041269

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107811, 5 interactors

Database of interacting proteins

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DIPi
DIP-46208N

Protein interaction database and analysis system

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IntActi
P07320, 2 interactors

Molecular INTeraction database

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MINTi
P07320

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264376

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H4AX-ray1.15X2-174[»]
1HK0X-ray1.25X2-174[»]
1LD0model-A1-174[»]
2G98X-ray2.20A/B2-174[»]
2KFBNMR-A2-174[»]
2KLJOther-A2-174[»]
4GR7X-ray1.70A/X2-174[»]
4JGFX-ray2.50A/B2-172[»]
6ETAX-ray2.20A/B1-174[»]
6ETCX-ray1.20X1-174[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P07320

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07320

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P07320

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini88 – 128Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 171Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 87Connecting peptide4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IWCR Eukaryota
ENOG411298R LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158720

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234389

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG003364

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P07320

Identification of Orthologs from Complete Genome Data

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OMAi
QMIEITE

Database of Orthologous Groups

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OrthoDBi
1220704at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P07320

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like

Pfam protein domain database

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Pfami
View protein in Pfam
PF00030 Crystall, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01367 BGCRYSTALLIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00247 XTALbg, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49695 SSF49695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P07320-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKITLYEDR GFQGRHYECS SDHPNLQPYL SRCNSARVDS GCWMLYEQPN
60 70 80 90 100
YSGLQYFLRR GDYADHQQWM GLSDSVRSCR LIPHSGSHRI RLYEREDYRG
110 120 130 140 150
QMIEFTEDCS CLQDRFRFNE IHSLNVLEGS WVLYELSNYR GRQYLLMPGD
160 170
YRRYQDWGAT NARVGSLRRV IDFS
Length:174
Mass (Da):20,738
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i437EC83FD79F12E4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01073315R → C in CTRCT4; progressive punctate cataract with early onset; causes disulfide-linked oligomers formation with consequent protein aggregation and precipitation. 2 PublicationsCorresponds to variant dbSNP:rs121909595EnsemblClinVar.1
Natural variantiVAR_03495524P → S in CTRCT4; lowered solubility. 2 PublicationsCorresponds to variant dbSNP:rs28931605EnsemblClinVar.1
Natural variantiVAR_02114524P → T in CTRCT4; lowered solubility. 3 PublicationsCorresponds to variant dbSNP:rs28931605EnsemblClinVar.1
Natural variantiVAR_01073437R → S in CTRCT4; very low solubility; crystallizes spontaneously. 2 PublicationsCorresponds to variant dbSNP:rs121909597EnsemblClinVar.1
Natural variantiVAR_06482943W → R in CTRCT4; much less stable than the wild-type protein; more prone to aggregate when subjected to environmental stresses such as heat and UV irradiation. 1 Publication1
Natural variantiVAR_01073559R → H in CTRCT4; lowered solubility; crystallizes easily. 3 PublicationsCorresponds to variant dbSNP:rs121909596EnsemblClinVar.1
Natural variantiVAR_021146102M → V2 Publications1
Natural variantiVAR_034956107E → A in CTRCT4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
K03006, K03005 Genomic DNA Translation: AAA52112.1
U66583 mRNA Translation: AAB38686.1
AC093698 Genomic DNA Translation: AAY24041.1
BC117338 mRNA Translation: AAI17339.1
BC117340 mRNA Translation: AAI17341.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2378.1

Protein sequence database of the Protein Information Resource

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PIRi
I77413

NCBI Reference Sequences

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RefSeqi
NP_008822.2, NM_006891.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.546247

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264376; ENSP00000264376; ENSG00000118231
ENST00000644920; ENSP00000496652; ENSG00000285434

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1421

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1421

UCSC genome browser

More...
UCSCi
uc002vcn.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Eye disease Crystallin, gamma-D (CRYGD)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03006, K03005 Genomic DNA Translation: AAA52112.1
U66583 mRNA Translation: AAB38686.1
AC093698 Genomic DNA Translation: AAY24041.1
BC117338 mRNA Translation: AAI17339.1
BC117340 mRNA Translation: AAI17341.1
CCDSiCCDS2378.1
PIRiI77413
RefSeqiNP_008822.2, NM_006891.3
UniGeneiHs.546247

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H4AX-ray1.15X2-174[»]
1HK0X-ray1.25X2-174[»]
1LD0model-A1-174[»]
2G98X-ray2.20A/B2-174[»]
2KFBNMR-A2-174[»]
2KLJOther-A2-174[»]
4GR7X-ray1.70A/X2-174[»]
4JGFX-ray2.50A/B2-172[»]
6ETAX-ray2.20A/B1-174[»]
6ETCX-ray1.20X1-174[»]
ProteinModelPortaliP07320
SMRiP07320
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107811, 5 interactors
DIPiDIP-46208N
IntActiP07320, 2 interactors
MINTiP07320
STRINGi9606.ENSP00000264376

PTM databases

iPTMnetiP07320
PhosphoSitePlusiP07320

Polymorphism and mutation databases

BioMutaiCRYGD
DMDMi2506321

Proteomic databases

EPDiP07320
MaxQBiP07320
PaxDbiP07320
PeptideAtlasiP07320
PRIDEiP07320
ProteomicsDBi51987

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1421
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264376; ENSP00000264376; ENSG00000118231
ENST00000644920; ENSP00000496652; ENSG00000285434
GeneIDi1421
KEGGihsa:1421
UCSCiuc002vcn.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1421
DisGeNETi1421
EuPathDBiHostDB:ENSG00000118231.4

GeneCards: human genes, protein and diseases

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GeneCardsi
CRYGD
HGNCiHGNC:2411 CRYGD
HPAiHPA041269
MalaCardsiCRYGD
MIMi115700 phenotype
123690 gene
neXtProtiNX_P07320
OpenTargetsiENSG00000118231
Orphaneti1377 Cataract-microcornea syndrome
98989 Cerulean cataract
98990 Coralliform cataract
441452 Early-onset lamellar cataract
98991 Early-onset nuclear cataract
98984 Pulverulent cataract
PharmGKBiPA26918

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IWCR Eukaryota
ENOG411298R LUCA
GeneTreeiENSGT00940000158720
HOGENOMiHOG000234389
HOVERGENiHBG003364
InParanoidiP07320
OMAiQMIEITE
OrthoDBi1220704at2759
PhylomeDBiP07320

Enzyme and pathway databases

SIGNORiP07320

Miscellaneous databases

EvolutionaryTraceiP07320

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Crystallin,_gamma_D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1421

Protein Ontology

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PROi
PR:P07320

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000118231 Expressed in 88 organ(s), highest expression level in left ovary
CleanExiHS_CRYGD
ExpressionAtlasiP07320 baseline and differential
GenevisibleiP07320 HS

Family and domain databases

InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
PfamiView protein in Pfam
PF00030 Crystall, 2 hits
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00247 XTALbg, 2 hits
SUPFAMiSSF49695 SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRGD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07320
Secondary accession number(s): Q17RF7, Q53R51, Q99681
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 193 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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