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UniProtKB - P07315 (CRGC_HUMAN)

Entry version 196 (23 Feb 2022)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Gamma-crystallin C

Gene

CRYGC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEye lens protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P07315

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P07315

SIGNOR Signaling Network Open Resource

More...SIGNORi		P07315

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-crystallin C
Alternative name(s):
Gamma-C-crystallin
Gamma-crystallin 2-1
Gamma-crystallin 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRYGC
Synonyms:CRYG3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2410, CRYGC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		123680, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07315

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000163254

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cataract 2, multiple types (CTRCT2)10 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT2 includes Coppock-like cataract, among others. Coppock-like cataract is a congenital pulverulent disk-like opacity involving the embryonic nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited. In some cases, CTRCT2 is associated with microcornea without any other systemic anomaly or dysmorphism. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0211425T → P in CTRCT2; reduces protein-protein interactions in vivo. 3 PublicationsCorresponds to variant dbSNP:rs104893618EnsemblClinVar.1
Natural variantiVAR_08479878S → F in CTRCT2; unknown pathological significance. 1 Publication1
Natural variantiVAR_067212129G → C in CTRCT2. 1 PublicationCorresponds to variant dbSNP:rs137853924EnsemblClinVar.1
Natural variantiVAR_084799144 – 174Missing in CTRCT2; unknown pathological significance. 1 PublicationAdd BLAST31
Natural variantiVAR_021144168R → W in CTRCT2; congenital lamellar cataract; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs28931604EnsemblClinVar.1

Keywords - Diseasei

Cataract, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		1420

MalaCards human disease database

More...MalaCardsi		CRYGC
MIMi604307, phenotype

Open Targets

More...OpenTargetsi		ENSG00000163254

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1377, Cataract-microcornea syndrome
441452, Early-onset lamellar cataract
98991, Early-onset nuclear cataract
98984, Pulverulent cataract

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26917

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P07315, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4296285

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CRYGC

Domain mapping of disease mutations (DMDM)

More...DMDMi		117464

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000575872 – 174Gamma-crystallin CAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23S-methylcysteine1 Publication1

Keywords - PTMi

Methylation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P07315

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07315

PeptideAtlas

More...PeptideAtlasi		P07315

PRoteomics IDEntifications database

More...PRIDEi		P07315

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51985

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07315

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P07315

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163254, Expressed in tendon and 33 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P07315, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07315, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000163254, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107810, 13 interactors

Protein interaction database and analysis system

More...IntActi		P07315, 6 interactors

Molecular INTeraction database

More...MINTi		P07315

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000282141

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P07315, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07315

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini88 – 128Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini129 – 171Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 87Connecting peptide4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RXJY, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159232

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_081883_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07315

Identification of Orthologs from Complete Genome Data

More...OMAi		YEMPNYL

Database of Orthologous Groups

More...OrthoDBi		1220704at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07315

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001064, Beta/gamma_crystallin
IPR011024, G_crystallin-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00030, Crystall, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01367, BGCRYSTALLIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00247, XTALbg, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49695, SSF49695, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50915, CRYSTALLIN_BETA_GAMMA, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P07315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKITFYEDR AFQGRSYETT TDCPNLQPYF SRCNSIRVES GCWMLYERPN 
        60         70         80         90        100
YQGQQYLLRR GEYPDYQQWM GLSDSIRSCC LIPQTVSHRL RLYEREDHKG 
       110        120        130        140        150
LMMELSEDCP SIQDRFHLSE IRSLHVLEGC WVLYELPNYR GRQYLLRPQE 
       160        170 
YRRCQDWGAM DAKAGSLRRV VDLY
Length:174
Mass (Da):20,879
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB01DC167171A7668
GO

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 20747±0.2 Da. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0211425T → P in CTRCT2; reduces protein-protein interactions in vivo. 3 PublicationsCorresponds to variant dbSNP:rs104893618EnsemblClinVar.1
Natural variantiVAR_0384326F → L. Corresponds to variant dbSNP:rs2242072Ensembl.1
Natural variantiVAR_02114348R → H3 PublicationsCorresponds to variant dbSNP:rs61751949EnsemblClinVar.1
Natural variantiVAR_08479878S → F in CTRCT2; unknown pathological significance. 1 Publication1
Natural variantiVAR_067212129G → C in CTRCT2. 1 PublicationCorresponds to variant dbSNP:rs137853924EnsemblClinVar.1
Natural variantiVAR_084799144 – 174Missing in CTRCT2; unknown pathological significance. 1 PublicationAdd BLAST31
Natural variantiVAR_021144168R → W in CTRCT2; congenital lamellar cataract; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs28931604EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M11973, M11972 Genomic DNA Translation: AAA52114.1
K03004, K03003 Genomic DNA Translation: AAA52111.1
M19364 Genomic DNA Translation: AAA52110.1
U66582 mRNA Translation: AAC50899.1
AC093698 Genomic DNA Translation: AAY24042.1
CH471063 Genomic DNA Translation: EAW70433.1
BC074954 mRNA Translation: AAH74954.1
BC074955 mRNA Translation: AAH74955.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2379.1

Protein sequence database of the Protein Information Resource

More...PIRi		B24520, CYHUG2

NCBI Reference Sequences

More...RefSeqi		NP_066269.1, NM_020989.3
XP_011508964.1, XM_011510662.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000282141; ENSP00000282141; ENSG00000163254
ENST00000646204; ENSP00000496418; ENSG00000285011

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1420

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1420

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000282141.4; ENSP00000282141.3; NM_020989.4; NP_066269.1

UCSC genome browser

More...UCSCi		uc002vco.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Eye disease Crystallin, gamma-C (CRYGC)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11973, M11972 Genomic DNA Translation: AAA52114.1
K03004, K03003 Genomic DNA Translation: AAA52111.1
M19364 Genomic DNA Translation: AAA52110.1
U66582 mRNA Translation: AAC50899.1
AC093698 Genomic DNA Translation: AAY24042.1
CH471063 Genomic DNA Translation: EAW70433.1
BC074954 mRNA Translation: AAH74954.1
BC074955 mRNA Translation: AAH74955.1
CCDSiCCDS2379.1
PIRiB24520, CYHUG2
RefSeqiNP_066269.1, NM_020989.3
XP_011508964.1, XM_011510662.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NBRNMR-A2-174[»]
SMRiP07315
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107810, 13 interactors
IntActiP07315, 6 interactors
MINTiP07315
STRINGi9606.ENSP00000282141

Chemistry databases

ChEMBLiCHEMBL4296285

PTM databases

iPTMnetiP07315
PhosphoSitePlusiP07315

Genetic variation databases

BioMutaiCRYGC
DMDMi117464

Proteomic databases

MassIVEiP07315
PaxDbiP07315
PeptideAtlasiP07315
PRIDEiP07315
ProteomicsDBi51985

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34194, 167 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		1420

Genome annotation databases

EnsembliENST00000282141; ENSP00000282141; ENSG00000163254
ENST00000646204; ENSP00000496418; ENSG00000285011
GeneIDi1420
KEGGihsa:1420
MANE-SelectiENST00000282141.4; ENSP00000282141.3; NM_020989.4; NP_066269.1
UCSCiuc002vco.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1420
DisGeNETi1420

GeneCards: human genes, protein and diseases

More...GeneCardsi		CRYGC
HGNCiHGNC:2410, CRYGC
HPAiENSG00000163254, Tissue enriched (testis)
MalaCardsiCRYGC
MIMi123680, gene
604307, phenotype
neXtProtiNX_P07315
OpenTargetsiENSG00000163254
Orphaneti1377, Cataract-microcornea syndrome
441452, Early-onset lamellar cataract
98991, Early-onset nuclear cataract
98984, Pulverulent cataract
PharmGKBiPA26917
VEuPathDBiHostDB:ENSG00000163254

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RXJY, Eukaryota
GeneTreeiENSGT00940000159232
HOGENOMiCLU_081883_1_1_1
InParanoidiP07315
OMAiYEMPNYL
OrthoDBi1220704at2759
PhylomeDBiP07315

Enzyme and pathway databases

PathwayCommonsiP07315
SignaLinkiP07315
SIGNORiP07315

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1420, 8 hits in 1039 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CRYGC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1420
PharosiP07315, Tbio

Protein Ontology

More...PROi		PR:P07315
RNActiP07315, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000163254, Expressed in tendon and 33 other tissues
ExpressionAtlasiP07315, baseline and differential
GenevisibleiP07315, HS

Family and domain databases

InterProiView protein in InterPro
IPR001064, Beta/gamma_crystallin
IPR011024, G_crystallin-like
PfamiView protein in Pfam
PF00030, Crystall, 2 hits
PRINTSiPR01367, BGCRYSTALLIN
SMARTiView protein in SMART
SM00247, XTALbg, 2 hits
SUPFAMiSSF49695, SSF49695, 1 hit
PROSITEiView protein in PROSITE
PS50915, CRYSTALLIN_BETA_GAMMA, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRGC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07315
Secondary accession number(s): Q53R50
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: February 23, 2022
This is version 196 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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