CRYGC

Protein namesⁱ	Recommended name: Gamma-crystallin C Alternative name(s): Gamma-C-crystallin Gamma-crystallin 2-1 Gamma-crystallin 3
Gene namesⁱ	Name:CRYGC Synonyms:CRYG3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163254.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2410 CRYGC
MIMⁱ	123680 gene
neXtProtⁱ	NX_P07315

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cataract 2, multiple types (CTRCT2)7 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT2 includes Coppock-like cataract, among others. Coppock-like cataract is a congenital pulverulent disk-like opacity involving the embryonic nucleus with many tiny white dots in the lamellar portion of the lens. It is usually bilateral and dominantly inherited. In some cases, CTRCT2 is associated with microcornea without any other systemic anomaly or dysmorphism. Microcornea is defined by a corneal diameter inferior to 10 mm in both meridians in an otherwise normal eye.

Keywords - Diseaseⁱ

Cataract, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1420
MalaCards human disease database More...MalaCardsⁱ	CRYGC
MIMⁱ	604307 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000163254
Orphanetⁱ	1377 Cataract-microcornea syndrome 441452 Early-onset lamellar cataract 98991 Early-onset nuclear cataract 98984 Pulverulent cataract
PharmGKBⁱ	PA26917

Polymorphism and mutation databases

BioMutaⁱ	CRYGC
DMDMⁱ	117464

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000057587	2 – 174	Gamma-crystallin CAdd BLAST		173

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	23	S-methylcysteine1 Publication		1

Keywords - PTMⁱ

Methylation

Proteomic databases

PaxDbⁱ	P07315
PeptideAtlas More...PeptideAtlasⁱ	P07315
PRIDEⁱ	P07315
ProteomicsDBⁱ	51985

PTM databases

iPTMnetⁱ	P07315
PhosphoSitePlusⁱ	P07315

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163254 Expressed in 20 organ(s), highest expression level in tendon
CleanExⁱ	HS_CRYGC
ExpressionAtlasⁱ	P07315 baseline and differential
Genevisibleⁱ	P07315 HS

Interactionⁱ

Subunit structureⁱ

Monomer.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CRYAA	P02489	3	EBI-6875941,EBI-6875961
CRYAB	P02511	3	EBI-6875941,EBI-739060

Protein-protein interaction databases

BioGridⁱ	107810, 9 interactors
IntActⁱ	P07315, 4 interactors
Molecular INTeraction database More...MINTⁱ	P07315
STRINGⁱ	9606.ENSP00000282141

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	4 – 9	Combined sources	6
Turnⁱ	10 – 12	Combined sources	3
Beta strandⁱ	13 – 21	Combined sources	9
Turnⁱ	27 – 29	Combined sources	3
Beta strandⁱ	34 – 38	Combined sources	5
Beta strandⁱ	40 – 48	Combined sources	9
Turnⁱ	49 – 51	Combined sources	3
Beta strandⁱ	52 – 58	Combined sources	7
Beta strandⁱ	60 – 65	Combined sources	6
Helixⁱ	66 – 69	Combined sources	4
Beta strandⁱ	78 – 82	Combined sources	5
Beta strandⁱ	89 – 95	Combined sources	7
Turnⁱ	96 – 98	Combined sources	3
Beta strandⁱ	99 – 105	Combined sources	7
Helixⁱ	112 – 115	Combined sources	4
Beta strandⁱ	122 – 129	Combined sources	8
Beta strandⁱ	131 – 136	Combined sources	6
Turnⁱ	137 – 139	Combined sources	3
Beta strandⁱ	140 – 146	Combined sources	7
Beta strandⁱ	148 – 151	Combined sources	4
Turnⁱ	154 – 158	Combined sources	5
Beta strandⁱ	165 – 169	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P07315
SMRⁱ	P07315
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	2 – 40	Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST	39
Domainⁱ	41 – 83	Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST	43
Domainⁱ	88 – 128	Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST	41
Domainⁱ	129 – 171	Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST	43

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	84 – 87	Connecting peptide		4

Domainⁱ

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesⁱ

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IWCR Eukaryota ENOG411298R LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118812
HOGENOMⁱ	HOG000234389
HOVERGENⁱ	HBG003364
InParanoidⁱ	P07315
OMAⁱ	YEDKAFQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L2P
PhylomeDBⁱ	P07315

Family and domain databases

InterProⁱ	View protein in InterPro IPR001064 Beta/gamma_crystallin IPR033483 CRYGC IPR011024 G_crystallin-like
PANTHERⁱ	PTHR11818:SF32 PTHR11818:SF32, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00030 Crystall, 2 hits
PRINTSⁱ	PR01367 BGCRYSTALLIN
SMARTⁱ	View protein in SMART SM00247 XTALbg, 2 hits
SUPFAMⁱ	SSF49695 SSF49695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P07315-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGKITFYEDR AFQGRSYETT TDCPNLQPYF SRCNSIRVES GCWMLYERPN 
        60         70         80         90        100
YQGQQYLLRR GEYPDYQQWM GLSDSIRSCC LIPQTVSHRL RLYEREDHKG 
       110        120        130        140        150
LMMELSEDCP SIQDRFHLSE IRSLHVLEGC WVLYELPNYR GRQYLLRPQE 
       160        170 
YRRCQDWGAM DAKAGSLRRV VDLY

Length:174

Mass (Da):20,879

Last modified:January 23, 2007 - v2

Checksum:ⁱB01DC167171A7668

GO

Mass spectrometryⁱ

Molecular mass is 20747±0.2 Da from positions 2 - 174. Determined by ESI. 1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021142	5	T → P in CTRCT2; affects protein-protein interactions. 2 PublicationsCorresponds to variant dbSNP:rs104893618EnsemblClinVar.	1
Natural variantⁱVAR_038432	6	F → L. Corresponds to variant dbSNP:rs2242072Ensembl.	1
Natural variantⁱVAR_021143	48	R → H2 PublicationsCorresponds to variant dbSNP:rs61751949EnsemblClinVar.	1
Natural variantⁱVAR_067212	129	G → C in CTRCT2. 1 PublicationCorresponds to variant dbSNP:rs137853924EnsemblClinVar.	1
Natural variantⁱVAR_021144	168	R → W in CTRCT2; congenital lamellar cataract; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs28931604EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11973, M11972 Genomic DNA Translation: AAA52114.1 K03004, K03003 Genomic DNA Translation: AAA52111.1 M19364 Genomic DNA Translation: AAA52110.1 U66582 mRNA Translation: AAC50899.1 AC093698 Genomic DNA Translation: AAY24042.1 CH471063 Genomic DNA Translation: EAW70433.1 BC074954 mRNA Translation: AAH74954.1 BC074955 mRNA Translation: AAH74955.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2379.1
PIRⁱ	B24520 CYHUG2
NCBI Reference Sequences More...RefSeqⁱ	NP_066269.1, NM_020989.3 XP_011508964.1, XM_011510662.1
UniGeneⁱ	Hs.72910

Genome annotation databases

Ensemblⁱ	ENST00000282141; ENSP00000282141; ENSG00000163254 ENST00000646204; ENSP00000496418; ENSG00000285011
GeneIDⁱ	1420
KEGGⁱ	hsa:1420
UCSC genome browser More...UCSCⁱ	uc002vco.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P07315	Gamma-crystallin C		HUMAN		174	UniRef100_P07315
UPI000012844C		HUMAN		173

Protein	Similar proteins		Species	Score	Length	Source
P07315	Gamma-crystallin C		MACMU		174	UniRef90_P07315
Gamma-crystallin C		HUMAN		174
Crystallin gamma C		MACFA		174
CRYGC isoform 1		PANTR		174
Crystallin gamma C		GORGO		174
+20

Protein	Similar proteins		Species	Score	Length	Source
P07315	Gamma-crystallin C		MACMU		174	UniRef50_P07315
Gamma-crystallin C		CANLF		174
Gamma-crystallin C		RAT		174
Gamma-crystallin C		BOVIN		174
Gamma-crystallin C		HUMAN		174
+153

Cross-referencesⁱ

Web resourcesⁱ

Eye disease Crystallin, gamma-C (CRYGC)

Leiden Open Variation Database (LOVD)

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11973, M11972 Genomic DNA Translation: AAA52114.1 K03004, K03003 Genomic DNA Translation: AAA52111.1 M19364 Genomic DNA Translation: AAA52110.1 U66582 mRNA Translation: AAC50899.1 AC093698 Genomic DNA Translation: AAY24042.1 CH471063 Genomic DNA Translation: EAW70433.1 BC074954 mRNA Translation: AAH74954.1 BC074955 mRNA Translation: AAH74955.1
CCDSⁱ	CCDS2379.1
PIRⁱ	B24520 CYHUG2
RefSeqⁱ	NP_066269.1, NM_020989.3 XP_011508964.1, XM_011510662.1
UniGeneⁱ	Hs.72910

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LFE	model	-	A	1-174	[»]
	2NBR	NMR	-	A	2-174	[»]
ProteinModelPortalⁱ	P07315
SMRⁱ	P07315
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107810, 9 interactors
IntActⁱ	P07315, 4 interactors
MINTⁱ	P07315
STRINGⁱ	9606.ENSP00000282141

PTM databases

iPTMnetⁱ	P07315
PhosphoSitePlusⁱ	P07315

Polymorphism and mutation databases

BioMutaⁱ	CRYGC
DMDMⁱ	117464

Proteomic databases

PaxDbⁱ	P07315
PeptideAtlasⁱ	P07315
PRIDEⁱ	P07315
ProteomicsDBⁱ	51985

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000282141; ENSP00000282141; ENSG00000163254 ENST00000646204; ENSP00000496418; ENSG00000285011
GeneIDⁱ	1420
KEGGⁱ	hsa:1420
UCSCⁱ	uc002vco.4 human

Organism-specific databases

CTDⁱ	1420
DisGeNETⁱ	1420
EuPathDBⁱ	HostDB:ENSG00000163254.4
GeneCardsⁱ	CRYGC
HGNCⁱ	HGNC:2410 CRYGC
MalaCardsⁱ	CRYGC
MIMⁱ	123680 gene 604307 phenotype
neXtProtⁱ	NX_P07315
OpenTargetsⁱ	ENSG00000163254
Orphanetⁱ	1377 Cataract-microcornea syndrome 441452 Early-onset lamellar cataract 98991 Early-onset nuclear cataract 98984 Pulverulent cataract
PharmGKBⁱ	PA26917
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWCR Eukaryota ENOG411298R LUCA
GeneTreeⁱ	ENSGT00760000118812
HOGENOMⁱ	HOG000234389
HOVERGENⁱ	HBG003364
InParanoidⁱ	P07315
OMAⁱ	YEDKAFQ
OrthoDBⁱ	EOG091G0L2P
PhylomeDBⁱ	P07315

Enzyme and pathway databases

SIGNORⁱ	P07315

SIGNORⁱ

P07315

Miscellaneous databases

GeneWikiⁱ	CRYGC
GenomeRNAiⁱ	1420
Protein Ontology More...PROⁱ	PR:P07315
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163254 Expressed in 20 organ(s), highest expression level in tendon
CleanExⁱ	HS_CRYGC
ExpressionAtlasⁱ	P07315 baseline and differential
Genevisibleⁱ	P07315 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001064 Beta/gamma_crystallin IPR033483 CRYGC IPR011024 G_crystallin-like
PANTHERⁱ	PTHR11818:SF32 PTHR11818:SF32, 1 hit
Pfamⁱ	View protein in Pfam PF00030 Crystall, 2 hits
PRINTSⁱ	PR01367 BGCRYSTALLIN
SMARTⁱ	View protein in SMART SM00247 XTALbg, 2 hits
SUPFAMⁱ	SSF49695 SSF49695, 1 hit
PROSITEⁱ	View protein in PROSITE PS50915 CRYSTALLIN_BETA_GAMMA, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CRGC_HUMAN
Accessionⁱ	P07315Primary (citable) accession number: P07315 Secondary accession number(s): Q53R50
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniRef

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Supporting data

UniProtKB - P07315 (CRGC_HUMAN)

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Gamma-crystallin C

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Mass spectrometryⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ