UniProtKB - P07311 (ACYP1_HUMAN)
Protein
Acylphosphatase-1
Gene
ACYP1
Organism
Homo sapiens (Human)
Status
Functioni
Its physiological role is not yet clear.
Catalytic activityi
- EC:3.6.1.7
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 24 | PROSITE-ProRule annotation | 1 | |
Active sitei | 42 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- acylphosphatase activity Source: GO_Central
GO - Biological processi
- phosphate-containing compound metabolic process Source: ProtInc
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
PathwayCommonsi | P07311 |
SABIO-RKi | P07311 |
Names & Taxonomyi
Protein namesi | Recommended name: Acylphosphatase-1 (EC:3.6.1.7)Alternative name(s): Acylphosphatase, erythrocyte isozyme Acylphosphatase, organ-common type isozyme Acylphosphate phosphohydrolase 1 |
Gene namesi | Name:ACYP1 Synonyms:ACYPE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:179, ACYP1 |
MIMi | 600875, gene |
neXtProti | NX_P07311 |
VEuPathDBi | HostDB:ENSG00000119640.8 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 97 |
OpenTargetsi | ENSG00000119640 |
PharmGKBi | PA24499 |
Miscellaneous databases
Pharosi | P07311, Tbio |
Genetic variation databases
BioMutai | ACYP1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000158535 | 2 – 99 | Acylphosphatase-1Add BLAST | 98 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P07311 |
jPOSTi | P07311 |
MassIVEi | P07311 |
MaxQBi | P07311 |
PaxDbi | P07311 |
PeptideAtlasi | P07311 |
PRIDEi | P07311 |
ProteomicsDBi | 51984 [P07311-1] 934 |
TopDownProteomicsi | P07311-1 [P07311-1] |
PTM databases
iPTMneti | P07311 |
PhosphoSitePlusi | P07311 |
Expressioni
Tissue specificityi
Organ-common type isozyme is found in many different tissues.
Gene expression databases
Bgeei | ENSG00000119640, Expressed in tendon and 230 other tissues |
ExpressionAtlasi | P07311, baseline and differential |
Genevisiblei | P07311, HS |
Organism-specific databases
HPAi | ENSG00000119640, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 106612, 2 interactors |
IntActi | P07311, 1 interactor |
STRINGi | 9606.ENSP00000238618 |
Miscellaneous databases
RNActi | P07311, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P07311 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07311 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 99 | Acylphosphatase-likePROSITE-ProRule annotationAdd BLAST | 91 |
Sequence similaritiesi
Belongs to the acylphosphatase family.Curated
Phylogenomic databases
eggNOGi | KOG3360, Eukaryota |
GeneTreei | ENSGT00390000011103 |
HOGENOMi | CLU_141932_0_1_1 |
InParanoidi | P07311 |
PhylomeDBi | P07311 |
TreeFami | TF300288 |
Family and domain databases
InterProi | View protein in InterPro IPR020456, Acylphosphatase IPR001792, Acylphosphatase-like_dom IPR036046, Acylphosphatase-like_dom_sf IPR017968, Acylphosphatase_CS |
PANTHERi | PTHR10029, PTHR10029, 1 hit |
Pfami | View protein in Pfam PF00708, Acylphosphatase, 1 hit |
PRINTSi | PR00112, ACYLPHPHTASE |
SUPFAMi | SSF54975, SSF54975, 1 hit |
PROSITEi | View protein in PROSITE PS00150, ACYLPHOSPHATASE_1, 1 hit PS00151, ACYLPHOSPHATASE_2, 1 hit PS51160, ACYLPHOSPHATASE_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P07311-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEGNTLISV DYEIFGKVQG VFFRKHTQAE GKKLGLVGWV QNTDRGTVQG
60 70 80 90
QLQGPISKVR HMQEWLETRG SPKSHIDKAN FNNEKVILKL DYSDFQIVK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V2U7 | G3V2U7_HUMAN | Acylphosphatase | ACYP1 | 129 | Annotation score: | ||
G3V3F8 | G3V3F8_HUMAN | Acylphosphatase-1 | ACYP1 | 37 | Annotation score: | ||
G3V597 | G3V597_HUMAN | Acylphosphatase-1 | ACYP1 | 62 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045688 | 29 – 99 | AEGKK…FQIVK → EMTVENRIAETHSKSCVPVS FATSYAG in isoform 2. 1 PublicationAdd BLAST | 71 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84194 mRNA Translation: CAA58987.1 AK312101 mRNA Translation: BAG35037.1 AC007055 Genomic DNA Translation: AAD31937.1 AL049780 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81216.1 BC035568 mRNA Translation: AAH35568.1 BG614847 mRNA No translation available. |
CCDSi | CCDS9838.1 [P07311-1] |
PIRi | S66187, QPHUE |
RefSeqi | NP_001098.1, NM_001107.4 [P07311-1] NP_001289545.1, NM_001302616.1 [P07311-1] |
Genome annotation databases
Ensembli | ENST00000238618; ENSP00000238618; ENSG00000119640 [P07311-1] ENST00000357971; ENSP00000350655; ENSG00000119640 [P07311-2] ENST00000555694; ENSP00000451581; ENSG00000119640 [P07311-1] |
GeneIDi | 97 |
KEGGi | hsa:97 |
UCSCi | uc001xrf.4, human [P07311-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84194 mRNA Translation: CAA58987.1 AK312101 mRNA Translation: BAG35037.1 AC007055 Genomic DNA Translation: AAD31937.1 AL049780 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81216.1 BC035568 mRNA Translation: AAH35568.1 BG614847 mRNA No translation available. |
CCDSi | CCDS9838.1 [P07311-1] |
PIRi | S66187, QPHUE |
RefSeqi | NP_001098.1, NM_001107.4 [P07311-1] NP_001289545.1, NM_001302616.1 [P07311-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K7J | NMR | - | A | 2-99 | [»] | |
2K7K | NMR | - | A | 2-99 | [»] | |
2VH7 | X-ray | 1.45 | A | 1-99 | [»] | |
2W4C | X-ray | 1.52 | A | 1-99 | [»] | |
2W4P | X-ray | 1.70 | A | 1-99 | [»] | |
3TOQ | X-ray | 2.00 | A | 1-99 | [»] | |
6CBU | X-ray | 1.20 | A | 1-98 | [»] | |
SMRi | P07311 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106612, 2 interactors |
IntActi | P07311, 1 interactor |
STRINGi | 9606.ENSP00000238618 |
PTM databases
iPTMneti | P07311 |
PhosphoSitePlusi | P07311 |
Genetic variation databases
BioMutai | ACYP1 |
Proteomic databases
EPDi | P07311 |
jPOSTi | P07311 |
MassIVEi | P07311 |
MaxQBi | P07311 |
PaxDbi | P07311 |
PeptideAtlasi | P07311 |
PRIDEi | P07311 |
ProteomicsDBi | 51984 [P07311-1] 934 |
TopDownProteomicsi | P07311-1 [P07311-1] |
Protocols and materials databases
Antibodypediai | 25782, 191 antibodies |
Genome annotation databases
Ensembli | ENST00000238618; ENSP00000238618; ENSG00000119640 [P07311-1] ENST00000357971; ENSP00000350655; ENSG00000119640 [P07311-2] ENST00000555694; ENSP00000451581; ENSG00000119640 [P07311-1] |
GeneIDi | 97 |
KEGGi | hsa:97 |
UCSCi | uc001xrf.4, human [P07311-1] |
Organism-specific databases
CTDi | 97 |
DisGeNETi | 97 |
GeneCardsi | ACYP1 |
HGNCi | HGNC:179, ACYP1 |
HPAi | ENSG00000119640, Low tissue specificity |
MIMi | 600875, gene |
neXtProti | NX_P07311 |
OpenTargetsi | ENSG00000119640 |
PharmGKBi | PA24499 |
VEuPathDBi | HostDB:ENSG00000119640.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3360, Eukaryota |
GeneTreei | ENSGT00390000011103 |
HOGENOMi | CLU_141932_0_1_1 |
InParanoidi | P07311 |
PhylomeDBi | P07311 |
TreeFami | TF300288 |
Enzyme and pathway databases
PathwayCommonsi | P07311 |
SABIO-RKi | P07311 |
Miscellaneous databases
BioGRID-ORCSi | 97, 2 hits in 873 CRISPR screens |
ChiTaRSi | ACYP1, human |
EvolutionaryTracei | P07311 |
GeneWikii | ACYP1 |
GenomeRNAii | 97 |
Pharosi | P07311, Tbio |
PROi | PR:P07311 |
RNActi | P07311, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119640, Expressed in tendon and 230 other tissues |
ExpressionAtlasi | P07311, baseline and differential |
Genevisiblei | P07311, HS |
Family and domain databases
InterProi | View protein in InterPro IPR020456, Acylphosphatase IPR001792, Acylphosphatase-like_dom IPR036046, Acylphosphatase-like_dom_sf IPR017968, Acylphosphatase_CS |
PANTHERi | PTHR10029, PTHR10029, 1 hit |
Pfami | View protein in Pfam PF00708, Acylphosphatase, 1 hit |
PRINTSi | PR00112, ACYLPHPHTASE |
SUPFAMi | SSF54975, SSF54975, 1 hit |
PROSITEi | View protein in PROSITE PS00150, ACYLPHOSPHATASE_1, 1 hit PS00151, ACYLPHOSPHATASE_2, 1 hit PS51160, ACYLPHOSPHATASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACYP1_HUMAN | |
Accessioni | P07311Primary (citable) accession number: P07311 Secondary accession number(s): A6NDV8, B2R590 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families