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Protein

Transthyretin

Gene

Ttr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Miscellaneous

The mouse protein shows increased stability and much reduced propensity to form amyloid fibrils, compared to the human protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35Thyroid hormoneBy similarity1
Binding sitei74Thyroid hormoneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-6798695 Neutrophil degranulation
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transthyretin
Alternative name(s):
Prealbumin
Gene namesi
Name:Ttr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:98865 Ttr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000003576021 – 147TransthyretinAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei624-carboxyglutamateBy similarity1
Modified residuei72PhosphoserineBy similarity1
Glycosylationi118N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP07309
PeptideAtlasiP07309
PRIDEiP07309

2D gel databases

UCD-2DPAGEiP07309

PTM databases

iPTMnetiP07309
PhosphoSitePlusiP07309

Expressioni

Tissue specificityi

Detected in plasma (at protein level). Detected in liver.

Gene expression databases

BgeeiENSMUSG00000061808 Expressed in 255 organ(s), highest expression level in brain
CleanExiMM_TTR
ExpressionAtlasiP07309 baseline and differential
GenevisibleiP07309 MM

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204369, 1 interactor
DIPiDIP-29726N
IntActiP07309, 2 interactors
MINTiP07309
STRINGi10090.ENSMUSP00000074783

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07309
SMRiP07309
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07309

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 139Thyroid hormone bindingBy similarity5

Sequence similaritiesi

Belongs to the transthyretin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3006 Eukaryota
COG2351 LUCA
GeneTreeiENSGT00390000005321
HOGENOMiHOG000251776
HOVERGENiHBG000285
InParanoidiP07309
KOiK20731
OMAiHRHYTIA
OrthoDBiEOG091G0VSV
PhylomeDBiP07309
TreeFamiTF300210

Family and domain databases

Gene3Di2.60.40.180, 1 hit
InterProiView protein in InterPro
IPR023418 Thyroxine_BS
IPR030178 Transthyretin
IPR000895 Transthyretin/HIU_hydrolase
IPR023416 Transthyretin/HIU_hydrolase_d
IPR036817 Transthyretin/HIU_hydrolase_sf
IPR023419 Transthyretin_CS
PANTHERiPTHR10395 PTHR10395, 1 hit
PTHR10395:SF12 PTHR10395:SF12, 1 hit
PfamiView protein in Pfam
PF00576 Transthyretin, 1 hit
PRINTSiPR00189 TRNSTHYRETIN
SMARTiView protein in SMART
SM00095 TR_THY, 1 hit
SUPFAMiSSF49472 SSF49472, 1 hit
PROSITEiView protein in PROSITE
PS00768 TRANSTHYRETIN_1, 1 hit
PS00769 TRANSTHYRETIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07309-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLRLFLLC LAGLVFVSEA GPAGAGESKC PLMVKVLDAV RGSPAVDVAV
60 70 80 90 100
KVFKKTSEGS WEPFASGKTA ESGELHGLTT DEKFVEGVYR VELDTKSYWK
110 120 130 140
TLGISPFHEF ADVVFTANDS GHRHYTIAAL LSPYSYSTTA VVSNPQN
Length:147
Mass (Da):15,776
Last modified:April 1, 1988 - v1
Checksum:i9803CCC3024BA911
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03351 mRNA Translation: CAA27057.1
D00073 Genomic DNA Translation: BAA00050.1
D89076 mRNA Translation: BAA13757.1
AK018701 mRNA Translation: BAB31352.1
BC024702 mRNA Translation: AAH24702.1
CCDSiCCDS29085.1
PIRiA24132 VBMS
RefSeqiNP_038725.1, NM_013697.5
UniGeneiMm.2108

Genome annotation databases

EnsembliENSMUST00000075312; ENSMUSP00000074783; ENSMUSG00000061808
GeneIDi22139
KEGGimmu:22139
UCSCiuc008eet.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03351 mRNA Translation: CAA27057.1
D00073 Genomic DNA Translation: BAA00050.1
D89076 mRNA Translation: BAA13757.1
AK018701 mRNA Translation: BAB31352.1
BC024702 mRNA Translation: AAH24702.1
CCDSiCCDS29085.1
PIRiA24132 VBMS
RefSeqiNP_038725.1, NM_013697.5
UniGeneiMm.2108

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QPFX-ray2.05A/B/C/D/E/F/G/H21-147[»]
ProteinModelPortaliP07309
SMRiP07309
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204369, 1 interactor
DIPiDIP-29726N
IntActiP07309, 2 interactors
MINTiP07309
STRINGi10090.ENSMUSP00000074783

PTM databases

iPTMnetiP07309
PhosphoSitePlusiP07309

2D gel databases

UCD-2DPAGEiP07309

Proteomic databases

PaxDbiP07309
PeptideAtlasiP07309
PRIDEiP07309

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075312; ENSMUSP00000074783; ENSMUSG00000061808
GeneIDi22139
KEGGimmu:22139
UCSCiuc008eet.2 mouse

Organism-specific databases

CTDi7276
MGIiMGI:98865 Ttr

Phylogenomic databases

eggNOGiKOG3006 Eukaryota
COG2351 LUCA
GeneTreeiENSGT00390000005321
HOGENOMiHOG000251776
HOVERGENiHBG000285
InParanoidiP07309
KOiK20731
OMAiHRHYTIA
OrthoDBiEOG091G0VSV
PhylomeDBiP07309
TreeFamiTF300210

Enzyme and pathway databases

ReactomeiR-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-6798695 Neutrophil degranulation
R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSiTtr mouse
EvolutionaryTraceiP07309
PROiPR:P07309
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061808 Expressed in 255 organ(s), highest expression level in brain
CleanExiMM_TTR
ExpressionAtlasiP07309 baseline and differential
GenevisibleiP07309 MM

Family and domain databases

Gene3Di2.60.40.180, 1 hit
InterProiView protein in InterPro
IPR023418 Thyroxine_BS
IPR030178 Transthyretin
IPR000895 Transthyretin/HIU_hydrolase
IPR023416 Transthyretin/HIU_hydrolase_d
IPR036817 Transthyretin/HIU_hydrolase_sf
IPR023419 Transthyretin_CS
PANTHERiPTHR10395 PTHR10395, 1 hit
PTHR10395:SF12 PTHR10395:SF12, 1 hit
PfamiView protein in Pfam
PF00576 Transthyretin, 1 hit
PRINTSiPR00189 TRNSTHYRETIN
SMARTiView protein in SMART
SM00095 TR_THY, 1 hit
SUPFAMiSSF49472 SSF49472, 1 hit
PROSITEiView protein in PROSITE
PS00768 TRANSTHYRETIN_1, 1 hit
PS00769 TRANSTHYRETIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTHY_MOUSE
AccessioniPrimary (citable) accession number: P07309
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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