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Protein

Asialoglycoprotein receptor 2

Gene

ASGR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Miscellaneous

Calcium is required for ligand binding.

GO - Molecular functioni

  • asialoglycoprotein receptor activity Source: UniProtKB
  • carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis, Host-virus interaction
LigandCalcium, Lectin

Enzyme and pathway databases

ReactomeiR-HSA-446203 Asparagine N-linked glycosylation

Names & Taxonomyi

Protein namesi
Recommended name:
Asialoglycoprotein receptor 2
Short name:
ASGP-R 2
Short name:
ASGPR 2
Alternative name(s):
C-type lectin domain family 4 member H2
Hepatic lectin H2
Short name:
HL-2
Gene namesi
Name:ASGR2
Synonyms:CLEC4H2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161944.16
HGNCiHGNC:743 ASGR2
MIMi108361 gene
neXtProtiNX_P07307

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
Transmembranei59 – 79Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini80 – 311ExtracellularSequence analysisAdd BLAST232

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161944
PharmGKBiPA25043

Chemistry databases

DrugBankiDB00025 Antihemophilic Factor (Recombinant)

Polymorphism and mutation databases

BioMutaiASGR2
DMDMi218511923

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466541 – 311Asialoglycoprotein receptor 2Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineBy similarity1
Lipidationi54S-palmitoyl cysteineBy similarity1
Glycosylationi102N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi170N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi177 ↔ 188PROSITE-ProRule annotation
Disulfide bondi205 ↔ 300PROSITE-ProRule annotation
Disulfide bondi278 ↔ 292PROSITE-ProRule annotation
Glycosylationi305N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP07307
PaxDbiP07307
PeptideAtlasiP07307
PRIDEiP07307
ProteomicsDBi51981
51982 [P07307-2]
51983 [P07307-3]

PTM databases

iPTMnetiP07307
PhosphoSitePlusiP07307
SwissPalmiP07307

Expressioni

Tissue specificityi

Expressed exclusively in hepatic parenchymal cells.

Gene expression databases

BgeeiENSG00000161944 Expressed in 105 organ(s), highest expression level in right lobe of liver
CleanExiHS_ASGR2
ExpressionAtlasiP07307 baseline and differential
GenevisibleiP07307 HS

Organism-specific databases

HPAiHPA014899
HPA015998

Interactioni

Subunit structurei

The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2.1 Publication
(Microbial infection) Interacts with hepatitis E virus capsid protein ORF2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CERS2Q96G233EBI-1172636,EBI-1057080

Protein-protein interaction databases

BioGridi106925, 43 interactors
IntActiP07307, 45 interactors
STRINGi9606.ENSP00000347140

Structurei

3D structure databases

ProteinModelPortaliP07307
SMRiP07307
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 302C-type lectinPROSITE-ProRule annotationAdd BLAST127

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 8Endocytosis signalSequence analysis4

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS0J Eukaryota
ENOG410ZPU8 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000034093
HOVERGENiHBG000270
InParanoidiP07307
KOiK10064
OMAiQDLKADH
OrthoDBiEOG091G062T
PhylomeDBiP07307
TreeFamiTF352155

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P07307-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA
60 70 80 90 100
QRLCSMVCFS LLALSFNILL LVVICVTGSQ SEGHGGAQLQ AELRSLKEAF
110 120 130 140 150
SNFSSSTLTE VQAISTHGGS VGDKITSLGA KLEKQQQDLK ADHDALLFHL
160 170 180 190 200
KHFPVDLRFV ACQMELLHSN GSQRTCCPVN WVEHQGSCYW FSHSGKAWAE
210 220 230 240 250
AEKYCQLENA HLVVINSWEE QKFIVQHTNP FNTWIGLTDS DGSWKWVDGT
260 270 280 290 300
DYRHNYKNWA VTQPDNWHGH ELGGSEDCVE VQPDGRWNDD FCLQVYRWVC
310
EKRRNATGEV A
Length:311
Mass (Da):35,092
Last modified:December 16, 2008 - v2
Checksum:iC86D2247FFF604DC
GO
Isoform 2 (identifier: P07307-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-42: Missing.

Show »
Length:292
Mass (Da):32,988
Checksum:iC762F780E74A6D50
GO
Isoform 3 (identifier: P07307-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-42: Missing.
     82-86: Missing.

Show »
Length:287
Mass (Da):32,550
Checksum:iE9528ACF7CBB1435
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1H2I3L1H2_HUMAN
Asialoglycoprotein receptor 2
ASGR2
135Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06874785G → R3 PublicationsCorresponds to variant dbSNP:rs2304978Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00306024 – 42Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_00306182 – 86Missing in isoform 3. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11025 mRNA Translation: AAB59519.1
U97197 mRNA Translation: AAB58308.1
X55283 mRNA Translation: CAA38997.1
AC120057 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90259.1
CH471108 Genomic DNA Translation: EAW90260.1
CH471108 Genomic DNA Translation: EAW90261.1
CH471108 Genomic DNA Translation: EAW90263.1
BC017251 mRNA Translation: AAH17251.1
CCDSiCCDS11088.1 [P07307-3]
CCDS32544.1 [P07307-1]
CCDS45598.1 [P07307-2]
PIRiA25179 LNHU2A
RefSeqiNP_001172.1, NM_001181.4
NP_001188281.1, NM_001201352.1
NP_550434.1, NM_080912.3
NP_550435.1, NM_080913.3 [P07307-3]
NP_550436.1, NM_080914.2
XP_005256705.1, XM_005256648.2 [P07307-3]
XP_006721589.1, XM_006721526.1 [P07307-3]
XP_016880140.1, XM_017024651.1 [P07307-2]
XP_016880141.1, XM_017024652.1 [P07307-1]
XP_016880142.1, XM_017024653.1 [P07307-1]
UniGeneiHs.654440

Genome annotation databases

EnsembliENST00000254850; ENSP00000254850; ENSG00000161944 [P07307-3]
ENST00000355035; ENSP00000347140; ENSG00000161944 [P07307-1]
ENST00000446679; ENSP00000405844; ENSG00000161944 [P07307-2]
GeneIDi433
KEGGihsa:433
UCSCiuc002gen.2 human [P07307-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Hepatic asialoglycoprotein receptor subunit 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11025 mRNA Translation: AAB59519.1
U97197 mRNA Translation: AAB58308.1
X55283 mRNA Translation: CAA38997.1
AC120057 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90259.1
CH471108 Genomic DNA Translation: EAW90260.1
CH471108 Genomic DNA Translation: EAW90261.1
CH471108 Genomic DNA Translation: EAW90263.1
BC017251 mRNA Translation: AAH17251.1
CCDSiCCDS11088.1 [P07307-3]
CCDS32544.1 [P07307-1]
CCDS45598.1 [P07307-2]
PIRiA25179 LNHU2A
RefSeqiNP_001172.1, NM_001181.4
NP_001188281.1, NM_001201352.1
NP_550434.1, NM_080912.3
NP_550435.1, NM_080913.3 [P07307-3]
NP_550436.1, NM_080914.2
XP_005256705.1, XM_005256648.2 [P07307-3]
XP_006721589.1, XM_006721526.1 [P07307-3]
XP_016880140.1, XM_017024651.1 [P07307-2]
XP_016880141.1, XM_017024652.1 [P07307-1]
XP_016880142.1, XM_017024653.1 [P07307-1]
UniGeneiHs.654440

3D structure databases

ProteinModelPortaliP07307
SMRiP07307
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106925, 43 interactors
IntActiP07307, 45 interactors
STRINGi9606.ENSP00000347140

Chemistry databases

DrugBankiDB00025 Antihemophilic Factor (Recombinant)

PTM databases

iPTMnetiP07307
PhosphoSitePlusiP07307
SwissPalmiP07307

Polymorphism and mutation databases

BioMutaiASGR2
DMDMi218511923

Proteomic databases

MaxQBiP07307
PaxDbiP07307
PeptideAtlasiP07307
PRIDEiP07307
ProteomicsDBi51981
51982 [P07307-2]
51983 [P07307-3]

Protocols and materials databases

DNASUi433
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254850; ENSP00000254850; ENSG00000161944 [P07307-3]
ENST00000355035; ENSP00000347140; ENSG00000161944 [P07307-1]
ENST00000446679; ENSP00000405844; ENSG00000161944 [P07307-2]
GeneIDi433
KEGGihsa:433
UCSCiuc002gen.2 human [P07307-1]

Organism-specific databases

CTDi433
EuPathDBiHostDB:ENSG00000161944.16
GeneCardsiASGR2
HGNCiHGNC:743 ASGR2
HPAiHPA014899
HPA015998
MIMi108361 gene
neXtProtiNX_P07307
OpenTargetsiENSG00000161944
PharmGKBiPA25043
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS0J Eukaryota
ENOG410ZPU8 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000034093
HOVERGENiHBG000270
InParanoidiP07307
KOiK10064
OMAiQDLKADH
OrthoDBiEOG091G062T
PhylomeDBiP07307
TreeFamiTF352155

Enzyme and pathway databases

ReactomeiR-HSA-446203 Asparagine N-linked glycosylation

Miscellaneous databases

ChiTaRSiASGR2 human
GenomeRNAii433
PROiPR:P07307
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161944 Expressed in 105 organ(s), highest expression level in right lobe of liver
CleanExiHS_ASGR2
ExpressionAtlasiP07307 baseline and differential
GenevisibleiP07307 HS

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASGR2_HUMAN
AccessioniPrimary (citable) accession number: P07307
Secondary accession number(s): A6NLV8
, A8MT12, D3DTM9, D3DTN0, O00448, Q03969
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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