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Entry version 196 (07 Oct 2020)
Sequence version 2 (16 Dec 2008)
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Protein

Asialoglycoprotein receptor 2

Gene

ASGR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Miscellaneous

Calcium is required for ligand binding.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • asialoglycoprotein receptor activity Source: UniProtKB
  • carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis, Host-virus interaction
LigandCalcium, Lectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P07307

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-446203, Asparagine N-linked glycosylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Asialoglycoprotein receptor 2
Short name:
ASGP-R 2
Short name:
ASGPR 2
Alternative name(s):
C-type lectin domain family 4 member H2
Hepatic lectin H2
Short name:
HL-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASGR2
Synonyms:CLEC4H2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000161944.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:743, ASGR2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
108361, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07307

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei59 – 79Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini80 – 311ExtracellularSequence analysisAdd BLAST232

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
433

Open Targets

More...
OpenTargetsi
ENSG00000161944

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25043

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P07307, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00025, Antihemophilic factor, human recombinant
DB13998, Lonoctocog alfa
DB13999, Moroctocog alfa

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ASGR2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
218511923

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000466541 – 311Asialoglycoprotein receptor 2Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi54S-palmitoyl cysteineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi102N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi170N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi177 ↔ 188PROSITE-ProRule annotation
Disulfide bondi205 ↔ 300PROSITE-ProRule annotation
Disulfide bondi278 ↔ 292PROSITE-ProRule annotation
Glycosylationi305N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1176

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P07307

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P07307

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P07307

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07307

PeptideAtlas

More...
PeptideAtlasi
P07307

PRoteomics IDEntifications database

More...
PRIDEi
P07307

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51981 [P07307-1]
51982 [P07307-2]
51983 [P07307-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1920, 9 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P07307, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P07307

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P07307

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P07307

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed exclusively in hepatic parenchymal cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000161944, Expressed in right lobe of liver and 127 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P07307, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P07307, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000161944, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The functioning ligand-binding unit of this receptor is thought to be at least a dimer.

Interacts with LASS2.

1 Publication

(Microbial infection) Interacts with hepatitis E virus capsid protein ORF2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P07307
With#Exp.IntAct
CERS2 [Q96G23]3EBI-1172636,EBI-1057080
Isoform 3 [P07307-3]
With#Exp.IntAct
ADAM33 [Q08AM2]3EBI-12808270,EBI-10225815
ADIPOQ [Q15848]3EBI-12808270,EBI-10827839
AIG1 - isoform 1 [Q9NVV5-2]3EBI-12808270,EBI-11957045
ATP6V0C [P27449]3EBI-12808270,EBI-721179
BET1 [O15155]3EBI-12808270,EBI-749204
CD53 [P19397]3EBI-12808270,EBI-6657396
CLEC17A [Q6ZS10]3EBI-12808270,EBI-11977093
CLEC7A - isoform 6 [Q9BXN2-6]3EBI-12808270,EBI-11989440
EMP1 [P54849]3EBI-12808270,EBI-4319440
FA2H [Q7L5A8]3EBI-12808270,EBI-11337888
FATE1 [Q969F0]3EBI-12808270,EBI-743099
HMOX2 [P30519]3EBI-12808270,EBI-712096
IL1RL1 - isoform B [Q01638-2]3EBI-12808270,EBI-12838366
LAT - isoform 2 [O43561-2]3EBI-12808270,EBI-8070286
LNPEP - isoform 2 [Q9UIQ6-2]3EBI-12808270,EBI-12133176
MCEMP1 [Q8IX19]3EBI-12808270,EBI-2816356
MMD2 - isoform 2 [Q8IY49-2]3EBI-12808270,EBI-13349813
MS4A13 [Q5J8X5]3EBI-12808270,EBI-12070086
NRG1 - isoform 10 [Q02297-10]3EBI-12808270,EBI-12842334
ORMDL1 [Q9P0S3]3EBI-12808270,EBI-1054848
PLN [P26678]3EBI-12808270,EBI-692836
PLP2 [Q04941]3EBI-12808270,EBI-608347
PMP22 [Q01453]3EBI-12808270,EBI-2845982
RPRM [Q9NS64]3EBI-12808270,EBI-1052363
SEC22A [Q96IW7]3EBI-12808270,EBI-8652744
SLC35A1 [P78382]3EBI-12808270,EBI-12870360
SLC35B2 [Q8TB61]3EBI-12808270,EBI-1054782
SMIM3 [Q9BZL3]3EBI-12808270,EBI-741850
STX8 [Q9UNK0]3EBI-12808270,EBI-727240
TFRC [P02786]3EBI-12808270,EBI-355727
TMEM140 [Q9NV12]3EBI-12808270,EBI-2844246
TMEM60 [Q9H2L4]3EBI-12808270,EBI-2852148
TMEM86B [Q8N661]3EBI-12808270,EBI-2548832
TMPPE [Q6ZT21]3EBI-12808270,EBI-11724433
TRAM1L1 [Q8N609]3EBI-12808270,EBI-11996766
TSPO2 [Q5TGU0]3EBI-12808270,EBI-12195249
UBIAD1 [Q9Y5Z9]3EBI-12808270,EBI-2819725
UPK2 [O00526]3EBI-12808270,EBI-10179682
VAMP5 [O95183]3EBI-12808270,EBI-10191195
VTI1B [Q9UEU0]3EBI-12808270,EBI-723716
YIPF1 [Q9Y548]3EBI-12808270,EBI-7850136

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
106925, 84 interactors

Protein interaction database and analysis system

More...
IntActi
P07307, 63 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000347140

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P07307, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P07307

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini176 – 302C-type lectinPROSITE-ProRule annotationAdd BLAST127

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi5 – 8Endocytosis signalSequence analysis4

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162310

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_049894_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07307

KEGG Orthology (KO)

More...
KOi
K10064

Identification of Orthologs from Complete Genome Data

More...
OMAi
NDHQLGR

Database of Orthologous Groups

More...
OrthoDBi
1247924at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P07307

TreeFam database of animal gene trees

More...
TreeFami
TF352155

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03590, CLECT_DC-SIGN_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033989, CD209-like_CTLD
IPR016187, CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00059, Lectin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034, CLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P07307-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA
60 70 80 90 100
QRLCSMVCFS LLALSFNILL LVVICVTGSQ SEGHGGAQLQ AELRSLKEAF
110 120 130 140 150
SNFSSSTLTE VQAISTHGGS VGDKITSLGA KLEKQQQDLK ADHDALLFHL
160 170 180 190 200
KHFPVDLRFV ACQMELLHSN GSQRTCCPVN WVEHQGSCYW FSHSGKAWAE
210 220 230 240 250
AEKYCQLENA HLVVINSWEE QKFIVQHTNP FNTWIGLTDS DGSWKWVDGT
260 270 280 290 300
DYRHNYKNWA VTQPDNWHGH ELGGSEDCVE VQPDGRWNDD FCLQVYRWVC
310
EKRRNATGEV A
Length:311
Mass (Da):35,092
Last modified:December 16, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC86D2247FFF604DC
GO
Isoform 2 (identifier: P07307-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-42: Missing.

Show »
Length:292
Mass (Da):32,988
Checksum:iC762F780E74A6D50
GO
Isoform 3 (identifier: P07307-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-42: Missing.
     82-86: Missing.

Show »
Length:287
Mass (Da):32,550
Checksum:iE9528ACF7CBB1435
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1H2I3L1H2_HUMAN
Asialoglycoprotein receptor 2
ASGR2
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06874785G → R3 PublicationsCorresponds to variant dbSNP:rs2304978Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00306024 – 42Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_00306182 – 86Missing in isoform 3. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M11025 mRNA Translation: AAB59519.1
U97197 mRNA Translation: AAB58308.1
X55283 mRNA Translation: CAA38997.1
AC120057 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90259.1
CH471108 Genomic DNA Translation: EAW90260.1
CH471108 Genomic DNA Translation: EAW90261.1
CH471108 Genomic DNA Translation: EAW90263.1
BC017251 mRNA Translation: AAH17251.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11088.1 [P07307-3]
CCDS32544.1 [P07307-1]
CCDS45598.1 [P07307-2]

Protein sequence database of the Protein Information Resource

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PIRi
A25179, LNHU2A

NCBI Reference Sequences

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RefSeqi
NP_001172.1, NM_001181.4
NP_001188281.1, NM_001201352.1
NP_550434.1, NM_080912.3
NP_550435.1, NM_080913.3 [P07307-3]
NP_550436.1, NM_080914.2
XP_005256705.1, XM_005256648.2 [P07307-3]
XP_006721589.1, XM_006721526.1 [P07307-3]
XP_016880140.1, XM_017024651.1 [P07307-2]
XP_016880141.1, XM_017024652.1 [P07307-1]
XP_016880142.1, XM_017024653.1 [P07307-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000254850; ENSP00000254850; ENSG00000161944 [P07307-3]
ENST00000355035; ENSP00000347140; ENSG00000161944 [P07307-1]
ENST00000446679; ENSP00000405844; ENSG00000161944 [P07307-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
433

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:433

UCSC genome browser

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UCSCi
uc002gen.2, human [P07307-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Hepatic asialoglycoprotein receptor subunit 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11025 mRNA Translation: AAB59519.1
U97197 mRNA Translation: AAB58308.1
X55283 mRNA Translation: CAA38997.1
AC120057 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90259.1
CH471108 Genomic DNA Translation: EAW90260.1
CH471108 Genomic DNA Translation: EAW90261.1
CH471108 Genomic DNA Translation: EAW90263.1
BC017251 mRNA Translation: AAH17251.1
CCDSiCCDS11088.1 [P07307-3]
CCDS32544.1 [P07307-1]
CCDS45598.1 [P07307-2]
PIRiA25179, LNHU2A
RefSeqiNP_001172.1, NM_001181.4
NP_001188281.1, NM_001201352.1
NP_550434.1, NM_080912.3
NP_550435.1, NM_080913.3 [P07307-3]
NP_550436.1, NM_080914.2
XP_005256705.1, XM_005256648.2 [P07307-3]
XP_006721589.1, XM_006721526.1 [P07307-3]
XP_016880140.1, XM_017024651.1 [P07307-2]
XP_016880141.1, XM_017024652.1 [P07307-1]
XP_016880142.1, XM_017024653.1 [P07307-1]

3D structure databases

SMRiP07307
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106925, 84 interactors
IntActiP07307, 63 interactors
STRINGi9606.ENSP00000347140

Chemistry databases

DrugBankiDB00025, Antihemophilic factor, human recombinant
DB13998, Lonoctocog alfa
DB13999, Moroctocog alfa

PTM databases

GlyConnecti1920, 9 N-Linked glycans (1 site)
GlyGeniP07307, 3 sites
iPTMnetiP07307
PhosphoSitePlusiP07307
SwissPalmiP07307

Polymorphism and mutation databases

BioMutaiASGR2
DMDMi218511923

Proteomic databases

CPTACiCPTAC-1176
jPOSTiP07307
MassIVEiP07307
MaxQBiP07307
PaxDbiP07307
PeptideAtlasiP07307
PRIDEiP07307
ProteomicsDBi51981 [P07307-1]
51982 [P07307-2]
51983 [P07307-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2656, 284 antibodies

The DNASU plasmid repository

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DNASUi
433

Genome annotation databases

EnsembliENST00000254850; ENSP00000254850; ENSG00000161944 [P07307-3]
ENST00000355035; ENSP00000347140; ENSG00000161944 [P07307-1]
ENST00000446679; ENSP00000405844; ENSG00000161944 [P07307-2]
GeneIDi433
KEGGihsa:433
UCSCiuc002gen.2, human [P07307-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
433
DisGeNETi433
EuPathDBiHostDB:ENSG00000161944.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ASGR2
HGNCiHGNC:743, ASGR2
HPAiENSG00000161944, Tissue enriched (liver)
MIMi108361, gene
neXtProtiNX_P07307
OpenTargetsiENSG00000161944
PharmGKBiPA25043

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT00940000162310
HOGENOMiCLU_049894_2_0_1
InParanoidiP07307
KOiK10064
OMAiNDHQLGR
OrthoDBi1247924at2759
PhylomeDBiP07307
TreeFamiTF352155

Enzyme and pathway databases

PathwayCommonsiP07307
ReactomeiR-HSA-446203, Asparagine N-linked glycosylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
433, 0 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ASGR2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
433
PharosiP07307, Tbio

Protein Ontology

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PROi
PR:P07307
RNActiP07307, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000161944, Expressed in right lobe of liver and 127 other tissues
ExpressionAtlasiP07307, baseline and differential
GenevisibleiP07307, HS

Family and domain databases

CDDicd03590, CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR033989, CD209-like_CTLD
IPR016187, CTDL_fold
PfamiView protein in Pfam
PF00059, Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SUPFAMiSSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 1 hit
PS50041, C_TYPE_LECTIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASGR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07307
Secondary accession number(s): A6NLV8
, A8MT12, D3DTM9, D3DTN0, O00448, Q03969
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: December 16, 2008
Last modified: October 7, 2020
This is version 196 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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