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Protein

Asialoglycoprotein receptor 1

Gene

ASGR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Miscellaneous

Calcium is required for ligand binding.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi191Calcium 1; via carbonyl oxygen1
Metal bindingi197Calcium 11
Metal bindingi216Calcium 21
Metal bindingi240Calcium 31
Binding sitei240Carbohydrate1
Metal bindingi242Calcium 31
Metal bindingi243Calcium 21
Binding sitei244Carbohydrate1
Metal bindingi253Calcium 2; via carbonyl oxygen1
Metal bindingi253Calcium 31
Binding sitei253Carbohydrate1
Metal bindingi254Calcium 21
Metal bindingi265Calcium 31
Metal bindingi266Calcium 31
Metal bindingi278Calcium 11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis, Host-virus interaction
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-446203 Asparagine N-linked glycosylation

Protein family/group databases

UniLectiniP07306

Names & Taxonomyi

Protein namesi
Recommended name:
Asialoglycoprotein receptor 1
Short name:
ASGP-R 1
Short name:
ASGPR 1
Alternative name(s):
C-type lectin domain family 4 member H1
Hepatic lectin H1
Short name:
HL-1
Gene namesi
Name:ASGR1
Synonyms:CLEC4H1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141505.11
HGNCiHGNC:742 ASGR1
MIMi108360 gene
neXtProtiNX_P07306

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicCuratedAdd BLAST40
Transmembranei41 – 61Helical; Signal-anchor for type II membrane proteinCuratedAdd BLAST21
Topological domaini62 – 291ExtracellularCuratedAdd BLAST230

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi432
OpenTargetsiENSG00000141505
PharmGKBiPA25042

Chemistry databases

ChEMBLiCHEMBL2084

Polymorphism and mutation databases

BioMutaiASGR1
DMDMi126132

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466501 – 291Asialoglycoprotein receptor 1Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Lipidationi36S-palmitoyl cysteine1 Publication1
Glycosylationi79N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi147N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi154 ↔ 165
Disulfide bondi182 ↔ 277
Disulfide bondi255 ↔ 269
Modified residuei285PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on a cytoplasmic Ser residue.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP07306
PaxDbiP07306
PeptideAtlasiP07306
PRIDEiP07306
ProteomicsDBi51980

PTM databases

iPTMnetiP07306
PhosphoSitePlusiP07306
SwissPalmiP07306

Expressioni

Tissue specificityi

Expressed exclusively in hepatic parenchymal cells.

Gene expression databases

BgeeiENSG00000141505 Expressed in 103 organ(s), highest expression level in right lobe of liver
CleanExiHS_ASGR1
ExpressionAtlasiP07306 baseline and differential
GenevisibleiP07306 HS

Organism-specific databases

HPAiHPA011954
HPA012852

Interactioni

Subunit structurei

Interacts with LASS2.1 Publication
(Microbial infection) Interacts with hepatitis E virus capsid protein ORF2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CERS2Q96G233EBI-1172335,EBI-1057080

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106924, 17 interactors
ELMiP07306
IntActiP07306, 33 interactors
STRINGi9606.ENSP00000269299

Chemistry databases

BindingDBiP07306

Structurei

Secondary structure

1291
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07306
SMRiP07306
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07306

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 278C-type lectinPROSITE-ProRule annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 123Sequence analysisAdd BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 8Endocytosis signalSequence analysis4

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000034093
HOVERGENiHBG000270
InParanoidiP07306
KOiK10063
OMAiQHHMGPV
OrthoDBiEOG091G062T
PhylomeDBiP07306
TreeFamiTF352155

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform H1a (identifier: P07306-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKEYQDLQH LDNEESDHHQ LRKGPPPPQP LLQRLCSGPR LLLLSLGLSL
60 70 80 90 100
LLLVVVCVIG SQNSQLQEEL RGLRETFSNF TASTEAQVKG LSTQGGNVGR
110 120 130 140 150
KMKSLESQLE KQQKDLSEDH SSLLLHVKQF VSDLRSLSCQ MAALQGNGSE
160 170 180 190 200
RTCCPVNWVE HERSCYWFSR SGKAWADADN YCRLEDAHLV VVTSWEEQKF
210 220 230 240 250
VQHHIGPVNT WMGLHDQNGP WKWVDGTDYE TGFKNWRPEQ PDDWYGHGLG
260 270 280 290
GGEDCAHFTD DGRWNDDVCQ RPYRWVCETE LDKASQEPPL L
Length:291
Mass (Da):33,186
Last modified:January 23, 2007 - v2
Checksum:i9B825527B2FC1FD0
GO
Isoform H1b (identifier: P07306-2) [UniParc]FASTAAdd to basket
Also known as: sASGPR

The sequence of this isoform differs from the canonical sequence as follows:
     24-63: GPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQN → D

Show »
Length:252
Mass (Da):29,144
Checksum:iB0F8C6FA80E1CCF2
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L2S9I3L2S9_HUMAN
Asialoglycoprotein receptor 1
ASGR1
117Annotation score:
J3QSZ2J3QSZ2_HUMAN
Asialoglycoprotein receptor 1
ASGR1
190Annotation score:
K7EPS5K7EPS5_HUMAN
Asialoglycoprotein receptor 1
ASGR1
162Annotation score:
I3L129I3L129_HUMAN
Asialoglycoprotein receptor 1
ASGR1
94Annotation score:
I3L1F8I3L1F8_HUMAN
Asialoglycoprotein receptor 1
ASGR1
29Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04448024 – 63GPPPP…IGSQN → D in isoform H1b. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10058 mRNA Translation: AAA51785.1
AB070933 mRNA Translation: BAB83508.1
FJ410292 mRNA Translation: ACQ90237.1
AC120057 Genomic DNA No translation available.
BC032130 mRNA Translation: AAH32130.1
CCDSiCCDS11089.1 [P07306-1]
CCDS56017.1 [P07306-2]
PIRiA22509 LNHU1
RefSeqiNP_001184145.1, NM_001197216.2 [P07306-2]
NP_001662.1, NM_001671.4 [P07306-1]
XP_011522163.1, XM_011523861.2 [P07306-1]
UniGeneiHs.12056
Hs.731669

Genome annotation databases

EnsembliENST00000269299; ENSP00000269299; ENSG00000141505 [P07306-1]
ENST00000574388; ENSP00000459169; ENSG00000141505 [P07306-2]
ENST00000619926; ENSP00000481182; ENSG00000141505 [P07306-2]
GeneIDi432
KEGGihsa:432
UCSCiuc021toy.3 human [P07306-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Hepatic asialoglycoprotein receptor subunit 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10058 mRNA Translation: AAA51785.1
AB070933 mRNA Translation: BAB83508.1
FJ410292 mRNA Translation: ACQ90237.1
AC120057 Genomic DNA No translation available.
BC032130 mRNA Translation: AAH32130.1
CCDSiCCDS11089.1 [P07306-1]
CCDS56017.1 [P07306-2]
PIRiA22509 LNHU1
RefSeqiNP_001184145.1, NM_001197216.2 [P07306-2]
NP_001662.1, NM_001671.4 [P07306-1]
XP_011522163.1, XM_011523861.2 [P07306-1]
UniGeneiHs.12056
Hs.731669

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DV8X-ray2.30A154-281[»]
5JPVX-ray1.90A/B148-291[»]
5JQ1X-ray1.83A/B148-291[»]
ProteinModelPortaliP07306
SMRiP07306
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106924, 17 interactors
ELMiP07306
IntActiP07306, 33 interactors
STRINGi9606.ENSP00000269299

Chemistry databases

BindingDBiP07306
ChEMBLiCHEMBL2084

Protein family/group databases

UniLectiniP07306

PTM databases

iPTMnetiP07306
PhosphoSitePlusiP07306
SwissPalmiP07306

Polymorphism and mutation databases

BioMutaiASGR1
DMDMi126132

Proteomic databases

EPDiP07306
PaxDbiP07306
PeptideAtlasiP07306
PRIDEiP07306
ProteomicsDBi51980

Protocols and materials databases

DNASUi432
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269299; ENSP00000269299; ENSG00000141505 [P07306-1]
ENST00000574388; ENSP00000459169; ENSG00000141505 [P07306-2]
ENST00000619926; ENSP00000481182; ENSG00000141505 [P07306-2]
GeneIDi432
KEGGihsa:432
UCSCiuc021toy.3 human [P07306-1]

Organism-specific databases

CTDi432
DisGeNETi432
EuPathDBiHostDB:ENSG00000141505.11
GeneCardsiASGR1
HGNCiHGNC:742 ASGR1
HPAiHPA011954
HPA012852
MIMi108360 gene
neXtProtiNX_P07306
OpenTargetsiENSG00000141505
PharmGKBiPA25042
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00760000118924
HOGENOMiHOG000034093
HOVERGENiHBG000270
InParanoidiP07306
KOiK10063
OMAiQHHMGPV
OrthoDBiEOG091G062T
PhylomeDBiP07306
TreeFamiTF352155

Enzyme and pathway databases

ReactomeiR-HSA-446203 Asparagine N-linked glycosylation

Miscellaneous databases

ChiTaRSiASGR1 human
EvolutionaryTraceiP07306
GenomeRNAii432
PROiPR:P07306
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141505 Expressed in 103 organ(s), highest expression level in right lobe of liver
CleanExiHS_ASGR1
ExpressionAtlasiP07306 baseline and differential
GenevisibleiP07306 HS

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASGR1_HUMAN
AccessioniPrimary (citable) accession number: P07306
Secondary accession number(s): I3L1X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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