UniProtKB - P07305 (H10_HUMAN)
Protein
Histone H1.0
Gene
H1-0
Organism
Homo sapiens (Human)
Status
Functioni
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
GO - Molecular functioni
- chromatin DNA binding Source: UniProtKB
- double-stranded DNA binding Source: GO_Central
- minor groove of adenine-thymine-rich DNA binding Source: Ensembl
- nucleosomal DNA binding Source: GO_Central
- RNA binding Source: UniProtKB
GO - Biological processi
- apoptotic DNA fragmentation Source: Reactome
- chromatin silencing Source: UniProtKB
- chromosome condensation Source: GO_Central
- negative regulation of chromatin silencing Source: GO_Central
- negative regulation of DNA recombination Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- nucleosome assembly Source: InterPro
- nucleosome positioning Source: GO_Central
- positive regulation of transcription regulatory region DNA binding Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | P07305 |
Reactomei | R-HSA-140342, Apoptosis induced DNA fragmentation R-HSA-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H1.0Alternative name(s): Histone H1' Histone H1(0) Cleaved into the following chain: |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000189060.5 |
HGNCi | HGNC:4714, H1-0 |
MIMi | 142708, gene |
neXtProti | NX_P07305 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Other locations
- Chromosome PROSITE-ProRule annotation1 Publication
Note: The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
Cytoskeleton
- actin cytoskeleton Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nuclear body Source: HPA
- nuclear chromatin Source: UniProtKB
- nuclear euchromatin Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- nucleosome Source: InterPro
- transcription repressor complex Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3005 |
OpenTargetsi | ENSG00000189060 |
PharmGKBi | PA29092 |
Miscellaneous databases
Pharosi | P07305, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3707465 |
Polymorphism and mutation databases
BioMutai | H1F0 |
DMDMi | 121897 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000423207 | 1 – 194 | Histone H1.0Add BLAST | 194 | |
Initiator methioninei | Removed; alternateCombined sources1 Publication | |||
ChainiPRO_0000195904 | 2 – 194 | Histone H1.0, N-terminally processedAdd BLAST | 193 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 2 | N-acetylthreonine; partial; in Histone H1.0, N-terminally processedCombined sources1 Publication | 1 | |
Modified residuei | 4 | Deamidated asparagine; partial1 Publication | 1 | |
Modified residuei | 42 | CitrullineBy similarity | 1 | |
Modified residuei | 104 | ADP-ribosylserine1 Publication | 1 |
Post-translational modificationi
Phosphorylated on Ser-17 in RNA edited version.1 Publication
ADP-ribosylated on Ser-104 in response to DNA damage.1 Publication
Keywords - PTMi
Acetylation, ADP-ribosylation, Citrullination, PhosphoproteinProteomic databases
EPDi | P07305 |
jPOSTi | P07305 |
MassIVEi | P07305 |
MaxQBi | P07305 |
PaxDbi | P07305 |
PeptideAtlasi | P07305 |
PRIDEi | P07305 |
ProteomicsDBi | 51978 [P07305-1] 51979 [P07305-2] |
TopDownProteomicsi | P07305-1 [P07305-1] |
PTM databases
iPTMneti | P07305 |
PhosphoSitePlusi | P07305 |
Expressioni
Inductioni
Both the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA edited version is induced by DTT, vinblastine or TNF (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000189060, Expressed in ventricular zone and 246 other tissues |
Genevisiblei | P07305, HS |
Organism-specific databases
HPAi | ENSG00000189060, Tissue enhanced (bone) |
Interactioni
Binary interactionsi
Hide detailsP07305
With | #Exp. | IntAct |
---|---|---|
RNF168 [Q8IYW5] | 2 | EBI-725224,EBI-914207 |
E1 [P04014] from Human papillomavirus type 11. | 2 | EBI-725224,EBI-7014446 |
Protein-protein interaction databases
BioGRIDi | 109260, 72 interactors |
DIPi | DIP-41775N |
ELMi | P07305 |
IntActi | P07305, 68 interactors |
MINTi | P07305 |
STRINGi | 9606.ENSP00000344504 |
Chemistry databases
BindingDBi | P07305 |
Miscellaneous databases
RNActi | P07305, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P07305 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 97 | H15PROSITE-ProRule annotationAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG4012, Eukaryota |
GeneTreei | ENSGT00810000125570 |
HOGENOMi | CLU_052897_1_1_1 |
InParanoidi | P07305 |
OMAi | HASYQDM |
OrthoDBi | 1565299at2759 |
PhylomeDBi | P07305 |
TreeFami | TF313664 |
Family and domain databases
CDDi | cd00073, H15, 1 hit |
DisProti | DP01156 |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005819, H1/H5 IPR005818, Histone_H1/H5_H15 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00538, Linker_histone, 1 hit |
PRINTSi | PR00624, HISTONEH5 |
SMARTi | View protein in SMART SM00526, H15, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51504, H15, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P07305-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI
60 70 80 90 100
QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE
110 120 130 140 150
PKKSVAFKKT KKEIKKVATP KKASKPKKAA SKAPTKKPKA TPVKKAKKKL
160 170 180 190
AATPKKAKKP KTVKAKPVKA SKPKKAKPVK PKAKSSAKRA GKKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | D → H in AAH29046 (PubMed:15489334).Curated | 1 |
RNA editingi
Modified position: not applicable.
Partially edited. In approximately 3.6% of the mRNA molecules, a new initiator methionine is created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 99 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 12-21; 22-33; 37-47; 48-67; 68-83; 84-94 and 97-113. The RNA edited version is called ET-H1.0.1 Publication
Partially edited. In approximately 3.6% of the mRNA molecules, a new initiator methionine is created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 99 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 12-21; 22-33; 37-47; 48-67; 68-83; 84-94 and 97-113. The RNA edited version is called ET-H1.0.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054789 | 1 | M → MLGKGRQRRRRQRQRQSPVP RPSDRPAGLGLAKPARRALP TPEPGRKSSDSSLASPGAAL QTGPVVRGSGADPEAGFAQP PTRAGPLEGAFNSRTRQATM in RNA edited version. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042163 | 3 – 19 | Missing in isoform 2. 1 PublicationAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03473 Genomic DNA Translation: CAA27190.1 CR456502 mRNA Translation: CAG30388.1 CR542220 mRNA Translation: CAG47016.1 AK299209 mRNA Translation: BAG61248.1 AK312583 mRNA Translation: BAG35477.1 Z97630 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60188.1 BC000145 mRNA Translation: AAH00145.1 BC029046 mRNA Translation: AAH29046.1 |
CCDSi | CCDS13956.1 [P07305-1] |
PIRi | A24850, HSHU10 |
RefSeqi | NP_005309.1, NM_005318.3 [P07305-1] |
Genome annotation databases
Ensembli | ENST00000340857; ENSP00000344504; ENSG00000189060 [P07305-1] |
GeneIDi | 3005 |
KEGGi | hsa:3005 |
UCSCi | uc003aty.4, human [P07305-1] |
Keywords - Coding sequence diversityi
Alternative splicing, RNA editingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Histone H1 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03473 Genomic DNA Translation: CAA27190.1 CR456502 mRNA Translation: CAG30388.1 CR542220 mRNA Translation: CAG47016.1 AK299209 mRNA Translation: BAG61248.1 AK312583 mRNA Translation: BAG35477.1 Z97630 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60188.1 BC000145 mRNA Translation: AAH00145.1 BC029046 mRNA Translation: AAH29046.1 |
CCDSi | CCDS13956.1 [P07305-1] |
PIRi | A24850, HSHU10 |
RefSeqi | NP_005309.1, NM_005318.3 [P07305-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6HQ1 | NMR | - | A | 24-97 | [»] | |
6N88 | electron microscopy | 6.20 | C | 1-194 | [»] | |
6N89 | electron microscopy | 7.50 | B | 1-194 | [»] | |
SMRi | P07305 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109260, 72 interactors |
DIPi | DIP-41775N |
ELMi | P07305 |
IntActi | P07305, 68 interactors |
MINTi | P07305 |
STRINGi | 9606.ENSP00000344504 |
Chemistry databases
BindingDBi | P07305 |
ChEMBLi | CHEMBL3707465 |
PTM databases
iPTMneti | P07305 |
PhosphoSitePlusi | P07305 |
Polymorphism and mutation databases
BioMutai | H1F0 |
DMDMi | 121897 |
Proteomic databases
EPDi | P07305 |
jPOSTi | P07305 |
MassIVEi | P07305 |
MaxQBi | P07305 |
PaxDbi | P07305 |
PeptideAtlasi | P07305 |
PRIDEi | P07305 |
ProteomicsDBi | 51978 [P07305-1] 51979 [P07305-2] |
TopDownProteomicsi | P07305-1 [P07305-1] |
Protocols and materials databases
ABCDi | P07305, 2 sequenced antibodies |
Antibodypediai | 211, 692 antibodies |
DNASUi | 3005 |
Genome annotation databases
Ensembli | ENST00000340857; ENSP00000344504; ENSG00000189060 [P07305-1] |
GeneIDi | 3005 |
KEGGi | hsa:3005 |
UCSCi | uc003aty.4, human [P07305-1] |
Organism-specific databases
CTDi | 3005 |
DisGeNETi | 3005 |
EuPathDBi | HostDB:ENSG00000189060.5 |
GeneCardsi | H1-0 |
HGNCi | HGNC:4714, H1-0 |
HPAi | ENSG00000189060, Tissue enhanced (bone) |
MIMi | 142708, gene |
neXtProti | NX_P07305 |
OpenTargetsi | ENSG00000189060 |
PharmGKBi | PA29092 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4012, Eukaryota |
GeneTreei | ENSGT00810000125570 |
HOGENOMi | CLU_052897_1_1_1 |
InParanoidi | P07305 |
OMAi | HASYQDM |
OrthoDBi | 1565299at2759 |
PhylomeDBi | P07305 |
TreeFami | TF313664 |
Enzyme and pathway databases
PathwayCommonsi | P07305 |
Reactomei | R-HSA-140342, Apoptosis induced DNA fragmentation R-HSA-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
Miscellaneous databases
BioGRID-ORCSi | 3005, 1 hit in 847 CRISPR screens |
ChiTaRSi | H1F0, human |
GenomeRNAii | 3005 |
Pharosi | P07305, Tchem |
PROi | PR:P07305 |
RNActi | P07305, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000189060, Expressed in ventricular zone and 246 other tissues |
Genevisiblei | P07305, HS |
Family and domain databases
CDDi | cd00073, H15, 1 hit |
DisProti | DP01156 |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005819, H1/H5 IPR005818, Histone_H1/H5_H15 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00538, Linker_histone, 1 hit |
PRINTSi | PR00624, HISTONEH5 |
SMARTi | View protein in SMART SM00526, H15, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51504, H15, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | H10_HUMAN | |
Accessioni | P07305Primary (citable) accession number: P07305 Secondary accession number(s): B2R6I0 Q8N6R3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 199 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations