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UniProtKB - P07305 (H10_HUMAN)

Entry version 205 (25 May 2022)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Histone H1.0

Gene

H1-0

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P07305

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-140342, Apoptosis induced DNA fragmentation
R-HSA-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P07305

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone H1.0
Alternative name(s):
Histone H1'
Histone H1(0)
Cleaved into the following chain:
Histone H1.0, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:H1-0Imported
Synonyms:H1F0Imported, H1FV
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4714, H1-0

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142708, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07305

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000189060

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3005

Open Targets

More...OpenTargetsi		ENSG00000189060

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29092

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P07305, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3707465

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		H1F0

Domain mapping of disease mutations (DMDM)

More...DMDMi		121897

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004232071 – 194Histone H1.0Add BLAST194
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00001959042 – 194Histone H1.0, N-terminally processedAdd BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; partial; in Histone H1.0, N-terminally processedCombined sources1 Publication1
Modified residuei4Deamidated asparagine; partial1 Publication1
Modified residuei42CitrullineBy similarity1
Modified residuei104ADP-ribosylserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser-17 in RNA edited version.1 Publication
ADP-ribosylated on Ser-104 in response to DNA damage.1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Citrullination, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P07305

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P07305

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P07305

MaxQB - The MaxQuant DataBase

More...MaxQBi		P07305

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07305

PeptideAtlas

More...PeptideAtlasi		P07305

PRoteomics IDEntifications database

More...PRIDEi		P07305

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51978 [P07305-1]
51979 [P07305-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P07305-1 [P07305-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P07305, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07305

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P07305

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Both the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA edited version is induced by DTT, vinblastine or TNF (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000189060, Expressed in ventricular zone and 247 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07305, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000189060, Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109260, 143 interactors

Database of interacting proteins

More...DIPi		DIP-41775N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P07305

Protein interaction database and analysis system

More...IntActi		P07305, 80 interactors

Molecular INTeraction database

More...MINTi		P07305

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000344504

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P07305

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P07305, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P07305

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07305

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 97H15PROSITE-ProRule annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni84 – 194DisorderedSequence analysisAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 120Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi121 – 194Basic residuesSequence analysisAdd BLAST74

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4012, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00810000125570

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_052897_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07305

Identification of Orthologs from Complete Genome Data

More...OMAi		HPAYSDM

Database of Orthologous Groups

More...OrthoDBi		1565299at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07305

TreeFam database of animal gene trees

More...TreeFami		TF313664

Family and domain databases

Conserved Domains Database

More...CDDi		cd00073, H15, 1 hit

Database of protein disorder

More...DisProti		DP01156

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005819, H1/H5
IPR005818, Histone_H1/H5_H15
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00538, Linker_histone, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00624, HISTONEH5

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00526, H15, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51504, H15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P07305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI 
        60         70         80         90        100
QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE 
       110        120        130        140        150
PKKSVAFKKT KKEIKKVATP KKASKPKKAA SKAPTKKPKA TPVKKAKKKL 
       160        170        180        190 
AATPKKAKKP KTVKAKPVKA SKPKKAKPVK PKAKSSAKRA GKKK
Length:194
Mass (Da):20,863
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03ED6F01919F8BE1
GO
Isoform 2 (identifier: P07305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-19: Missing.

Show »
Length:177
Mass (Da):19,167
Checksum:i8CD558F288DB593A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65D → H in AAH29046 (PubMed:15489334).Curated1

<p>This subsection of the 'Sequence' section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Modified position: not applicable.
Partially edited. In approximately 3.6% of the mRNA molecules, a new initiator methionine is created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 99 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 12-21; 22-33; 37-47; 48-67; 68-83; 84-94 and 97-113. The RNA edited version is called ET-H1.0.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0547891M → MLGKGRQRRRRQRQRQSPVP RPSDRPAGLGLAKPARRALP TPEPGRKSSDSSLASPGAAL QTGPVVRGSGADPEAGFAQP PTRAGPLEGAFNSRTRQATM in RNA edited version. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0421633 – 19Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X03473 Genomic DNA Translation: CAA27190.1
CR456502 mRNA Translation: CAG30388.1
CR542220 mRNA Translation: CAG47016.1
AK299209 mRNA Translation: BAG61248.1
AK312583 mRNA Translation: BAG35477.1
Z97630 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60188.1
BC000145 mRNA Translation: AAH00145.1
BC029046 mRNA Translation: AAH29046.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13956.1 [P07305-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A24850, HSHU10

NCBI Reference Sequences

More...RefSeqi		NP_005309.1, NM_005318.3 [P07305-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340857.4; ENSP00000344504.2; ENSG00000189060.6

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3005

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3005

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000340857.4; ENSP00000344504.2; NM_005318.4; NP_005309.1

UCSC genome browser

More...UCSCi		uc003aty.4, human [P07305-1]

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Histone H1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03473 Genomic DNA Translation: CAA27190.1
CR456502 mRNA Translation: CAG30388.1
CR542220 mRNA Translation: CAG47016.1
AK299209 mRNA Translation: BAG61248.1
AK312583 mRNA Translation: BAG35477.1
Z97630 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60188.1
BC000145 mRNA Translation: AAH00145.1
BC029046 mRNA Translation: AAH29046.1
CCDSiCCDS13956.1 [P07305-1]
PIRiA24850, HSHU10
RefSeqiNP_005309.1, NM_005318.3 [P07305-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6HQ1NMR-A24-97[»]
6LA2X-ray3.89S/T1-194[»]
6LA8X-ray3.40S1-194[»]
6LA9X-ray3.70S/T1-194[»]
6LABX-ray3.20U/V1-194[»]
6N88electron microscopy6.20C1-194[»]
6N89electron microscopy7.50B1-194[»]
7COWX-ray2.86S/T2-194[»]
7DBPelectron microscopy4.50K2-194[»]
7K5Xelectron microscopy2.93U1-194[»]
AlphaFoldDBiP07305
SMRiP07305
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109260, 143 interactors
DIPiDIP-41775N
ELMiP07305
IntActiP07305, 80 interactors
MINTiP07305
STRINGi9606.ENSP00000344504

Chemistry databases

BindingDBiP07305
ChEMBLiCHEMBL3707465

PTM databases

GlyGeniP07305, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP07305
PhosphoSitePlusiP07305

Genetic variation databases

BioMutaiH1F0
DMDMi121897

Proteomic databases

EPDiP07305
jPOSTiP07305
MassIVEiP07305
MaxQBiP07305
PaxDbiP07305
PeptideAtlasiP07305
PRIDEiP07305
ProteomicsDBi51978 [P07305-1]
51979 [P07305-2]
TopDownProteomicsiP07305-1 [P07305-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P07305, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		211, 736 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		3005

Genome annotation databases

EnsembliENST00000340857.4; ENSP00000344504.2; ENSG00000189060.6
GeneIDi3005
KEGGihsa:3005
MANE-SelectiENST00000340857.4; ENSP00000344504.2; NM_005318.4; NP_005309.1
UCSCiuc003aty.4, human [P07305-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3005
DisGeNETi3005

GeneCards: human genes, protein and diseases

More...GeneCardsi		H1-0
HGNCiHGNC:4714, H1-0
HPAiENSG00000189060, Tissue enhanced (bone)
MIMi142708, gene
neXtProtiNX_P07305
OpenTargetsiENSG00000189060
PharmGKBiPA29092
VEuPathDBiHostDB:ENSG00000189060

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4012, Eukaryota
GeneTreeiENSGT00810000125570
HOGENOMiCLU_052897_1_1_1
InParanoidiP07305
OMAiHPAYSDM
OrthoDBi1565299at2759
PhylomeDBiP07305
TreeFamiTF313664

Enzyme and pathway databases

PathwayCommonsiP07305
ReactomeiR-HSA-140342, Apoptosis induced DNA fragmentation
R-HSA-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SignaLinkiP07305

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3005, 4 hits in 1073 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		H1F0, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3005
PharosiP07305, Tchem

Protein Ontology

More...PROi		PR:P07305
RNActiP07305, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000189060, Expressed in ventricular zone and 247 other tissues
GenevisibleiP07305, HS

Family and domain databases

CDDicd00073, H15, 1 hit
DisProtiDP01156
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005819, H1/H5
IPR005818, Histone_H1/H5_H15
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538, Linker_histone, 1 hit
PRINTSiPR00624, HISTONEH5
SMARTiView protein in SMART
SM00526, H15, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504, H15, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07305
Secondary accession number(s): B2R6I0
, B4DRD6, Q6FG88, Q8N6R3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 205 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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