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Protein

Histone H1.0

Gene

H1F0

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

GO - Molecular functioni

  • AT DNA binding Source: Ensembl
  • chromatin DNA binding Source: UniProtKB
  • double-stranded DNA binding Source: GO_Central
  • nucleosomal DNA binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-211227 Activation of DNA fragmentation factor
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H1.0
Alternative name(s):
Histone H1'
Histone H1(0)
Cleaved into the following chain:
Gene namesi
Name:H1F0
Synonyms:H1FV
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000189060.5
HGNCiHGNC:4714 H1F0
MIMi142708 gene
neXtProtiNX_P07305

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3005
OpenTargetsiENSG00000189060
PharmGKBiPA29092

Chemistry databases

ChEMBLiCHEMBL3707465

Polymorphism and mutation databases

BioMutaiH1F0
DMDMi121897

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232071 – 194Histone H1.0Add BLAST194
Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00001959042 – 194Histone H1.0, N-terminally processedAdd BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; partial; in Histone H1.0, N-terminally processedCombined sources1 Publication1
Modified residuei4Deamidated asparagine; partial1 Publication1
Modified residuei42CitrullineBy similarity1
Modified residuei104ADP-ribosylserine1 Publication1

Post-translational modificationi

Phosphorylated on Ser-17 in RNA edited version.1 Publication
ADP-ribosylated on Ser-104 in response to DNA damage.1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Citrullination, Phosphoprotein

Proteomic databases

EPDiP07305
MaxQBiP07305
PaxDbiP07305
PeptideAtlasiP07305
PRIDEiP07305
ProteomicsDBi51978
51979 [P07305-2]
TopDownProteomicsiP07305-1 [P07305-1]

PTM databases

iPTMnetiP07305
PhosphoSitePlusiP07305

Expressioni

Inductioni

Both the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA edited version is induced by DTT, vinblastine or TNF (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000189060 Expressed in 234 organ(s), highest expression level in ectocervix
CleanExiHS_H1F0
GenevisibleiP07305 HS

Organism-specific databases

HPAiHPA000843

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi109260, 42 interactors
DIPiDIP-41775N
ELMiP07305
IntActiP07305, 19 interactors
MINTiP07305
STRINGi9606.ENSP00000344504

Chemistry databases

BindingDBiP07305

Structurei

3D structure databases

ProteinModelPortaliP07305
SMRiP07305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 97H15PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00810000125570
HOGENOMiHOG000251627
HOVERGENiHBG069502
InParanoidiP07305
KOiK11275
OMAiHASYQDM
OrthoDBiEOG091G0LIU
PhylomeDBiP07305
TreeFamiTF313664

Family and domain databases

CDDicd00073 H15, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P07305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI
60 70 80 90 100
QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE
110 120 130 140 150
PKKSVAFKKT KKEIKKVATP KKASKPKKAA SKAPTKKPKA TPVKKAKKKL
160 170 180 190
AATPKKAKKP KTVKAKPVKA SKPKKAKPVK PKAKSSAKRA GKKK
Length:194
Mass (Da):20,863
Last modified:January 23, 2007 - v3
Checksum:i03ED6F01919F8BE1
GO
Isoform 2 (identifier: P07305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-19: Missing.

Show »
Length:177
Mass (Da):19,167
Checksum:i8CD558F288DB593A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65D → H in AAH29046 (PubMed:15489334).Curated1

RNA editingi

Modified position: not applicable.
Partially edited. In approximately 3.6% of the mRNA molecules, a new initiator methionine is created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 99 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 12-21; 22-33; 37-47; 48-67; 68-83; 84-94 and 97-113. The RNA edited version is called ET-H1.0.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0547891M → MLGKGRQRRRRQRQRQSPVP RPSDRPAGLGLAKPARRALP TPEPGRKSSDSSLASPGAAL QTGPVVRGSGADPEAGFAQP PTRAGPLEGAFNSRTRQATM in RNA edited version. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0421633 – 19Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03473 Genomic DNA Translation: CAA27190.1
CR456502 mRNA Translation: CAG30388.1
CR542220 mRNA Translation: CAG47016.1
AK299209 mRNA Translation: BAG61248.1
AK312583 mRNA Translation: BAG35477.1
Z97630 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60188.1
BC000145 mRNA Translation: AAH00145.1
BC029046 mRNA Translation: AAH29046.1
CCDSiCCDS13956.1 [P07305-1]
PIRiA24850 HSHU10
RefSeqiNP_005309.1, NM_005318.3 [P07305-1]
UniGeneiHs.745024

Genome annotation databases

EnsembliENST00000340857; ENSP00000344504; ENSG00000189060 [P07305-1]
GeneIDi3005
KEGGihsa:3005
UCSCiuc003aty.4 human [P07305-1]

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Histone H1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03473 Genomic DNA Translation: CAA27190.1
CR456502 mRNA Translation: CAG30388.1
CR542220 mRNA Translation: CAG47016.1
AK299209 mRNA Translation: BAG61248.1
AK312583 mRNA Translation: BAG35477.1
Z97630 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60188.1
BC000145 mRNA Translation: AAH00145.1
BC029046 mRNA Translation: AAH29046.1
CCDSiCCDS13956.1 [P07305-1]
PIRiA24850 HSHU10
RefSeqiNP_005309.1, NM_005318.3 [P07305-1]
UniGeneiHs.745024

3D structure databases

ProteinModelPortaliP07305
SMRiP07305
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109260, 42 interactors
DIPiDIP-41775N
ELMiP07305
IntActiP07305, 19 interactors
MINTiP07305
STRINGi9606.ENSP00000344504

Chemistry databases

BindingDBiP07305
ChEMBLiCHEMBL3707465

PTM databases

iPTMnetiP07305
PhosphoSitePlusiP07305

Polymorphism and mutation databases

BioMutaiH1F0
DMDMi121897

Proteomic databases

EPDiP07305
MaxQBiP07305
PaxDbiP07305
PeptideAtlasiP07305
PRIDEiP07305
ProteomicsDBi51978
51979 [P07305-2]
TopDownProteomicsiP07305-1 [P07305-1]

Protocols and materials databases

DNASUi3005
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340857; ENSP00000344504; ENSG00000189060 [P07305-1]
GeneIDi3005
KEGGihsa:3005
UCSCiuc003aty.4 human [P07305-1]

Organism-specific databases

CTDi3005
DisGeNETi3005
EuPathDBiHostDB:ENSG00000189060.5
GeneCardsiH1F0
H-InvDBiHIX0016454
HGNCiHGNC:4714 H1F0
HPAiHPA000843
MIMi142708 gene
neXtProtiNX_P07305
OpenTargetsiENSG00000189060
PharmGKBiPA29092
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00810000125570
HOGENOMiHOG000251627
HOVERGENiHBG069502
InParanoidiP07305
KOiK11275
OMAiHASYQDM
OrthoDBiEOG091G0LIU
PhylomeDBiP07305
TreeFamiTF313664

Enzyme and pathway databases

ReactomeiR-HSA-211227 Activation of DNA fragmentation factor
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Miscellaneous databases

ChiTaRSiH1F0 human
GenomeRNAii3005
PROiPR:P07305
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189060 Expressed in 234 organ(s), highest expression level in ectocervix
CleanExiHS_H1F0
GenevisibleiP07305 HS

Family and domain databases

CDDicd00073 H15, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00538 Linker_histone, 1 hit
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51504 H15, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH10_HUMAN
AccessioniPrimary (citable) accession number: P07305
Secondary accession number(s): B2R6I0
, B4DRD6, Q6FG88, Q8N6R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 183 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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