H1F0

Functionⁱ

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

GO - Molecular functionⁱ

AT DNA binding Source: Ensembl
chromatin DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15911621
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic DNA fragmentation Source: Reactome
nucleosome assembly Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211227 Activation of DNA fragmentation factor R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Reactomeⁱ

R-HSA-211227 Activation of DNA fragmentation factor
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone H1.0 Alternative name(s): Histone H1' Histone H1(0) Cleaved into the following chain: Histone H1.0, N-terminally processed
Gene namesⁱ	Name:H1F0 Synonyms:H1FV
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000189060.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4714 H1F0
MIMⁱ	142708 gene
neXtProtⁱ	NX_P07305

Keywords - Cellular componentⁱ

Chromosome, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3005
Open Targets More...OpenTargetsⁱ	ENSG00000189060
PharmGKBⁱ	PA29092

Chemistry databases

ChEMBLⁱ	CHEMBL3707465

ChEMBLⁱ

CHEMBL3707465

Polymorphism and mutation databases

BioMutaⁱ	H1F0
DMDMⁱ	121897

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000423207	1 – 194	Histone H1.0Add BLAST	194
Initiator methionineⁱ		Removed; alternateCombined sources1 Publication
ChainⁱPRO_0000195904	2 – 194	Histone H1.0, N-terminally processedAdd BLAST	193

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	2	N-acetylthreonine; partial; in Histone H1.0, N-terminally processedCombined sources1 Publication	1
Modified residueⁱ	4	Deamidated asparagine; partial1 Publication	1
Modified residueⁱ	42	CitrullineBy similarity	1
Modified residueⁱ	104	ADP-ribosylserine1 Publication	1

Post-translational modificationⁱ

Phosphorylated on Ser-17 in RNA edited version.1 Publication

ADP-ribosylated on Ser-104 in response to DNA damage.1 Publication

Keywords - PTMⁱ

Acetylation, ADP-ribosylation, Citrullination, Phosphoprotein

Proteomic databases

EPDⁱ	P07305
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P07305
PaxDbⁱ	P07305
PeptideAtlas More...PeptideAtlasⁱ	P07305
PRIDEⁱ	P07305
ProteomicsDBⁱ	51978 51979 [P07305-2]
TopDownProteomicsⁱ	P07305-1 [P07305-1]

PTM databases

iPTMnetⁱ	P07305
PhosphoSitePlusⁱ	P07305

Expressionⁱ

Inductionⁱ

Both the unedited and the RNA edited versions are induced by butyrate (at protein level). Only RNA edited version is induced by DTT, vinblastine or TNF (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000189060
CleanExⁱ	HS_H1F0
Genevisibleⁱ	P07305 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000843

HPAⁱ

HPA000843

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
E1	P04014	2	EBI-725224,EBI-7014446	From Human papillomavirus type 11.
RAD51B	O15315	2	EBI-725224,EBI-2824089
RNF168	Q8IYW5	2	EBI-725224,EBI-914207

Show more details

Protein-protein interaction databases

BioGridⁱ	109260, 41 interactors
Database of interacting proteins More...DIPⁱ	DIP-41775N
ELMⁱ	P07305
IntActⁱ	P07305, 14 interactors
Molecular INTeraction database More...MINTⁱ	P07305
STRINGⁱ	9606.ENSP00000344504

Chemistry databases

BindingDBⁱ

P07305

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P07305
SMRⁱ	P07305
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 97	H15PROSITE-ProRule annotationAdd BLAST		74

Sequence similaritiesⁱ

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG4012 Eukaryota ENOG4112541 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125570
HOGENOMⁱ	HOG000251627
HOVERGENⁱ	HBG069502
InParanoidⁱ	P07305
KEGG Orthology (KO) More...KOⁱ	K11275
OMAⁱ	FEQPKGP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LIU
PhylomeDBⁱ	P07305
TreeFamⁱ	TF313664

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR005818 Histone_H1/H5_H15 IPR005819 Histone_H5 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00538 Linker_histone, 1 hit
PRINTSⁱ	PR00624 HISTONEH5
SMARTⁱ	View protein in SMART SM00526 H15, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS51504 H15, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P07305-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI 
        60         70         80         90        100
QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKSDE 
       110        120        130        140        150
PKKSVAFKKT KKEIKKVATP KKASKPKKAA SKAPTKKPKA TPVKKAKKKL 
       160        170        180        190 
AATPKKAKKP KTVKAKPVKA SKPKKAKPVK PKAKSSAKRA GKKK

Length:194

Mass (Da):20,863

Last modified:January 23, 2007 - v3

Checksum:ⁱ03ED6F01919F8BE1

GO

Isoform 2 (identifier: P07305-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
3-19: Missing.

« Hide

        10         20         30         40         50
MTKKSTDHPK YSDMIVAAIQ AEKNRAGSSR QSIQKYIKSH YKVGENADSQ 
        60         70         80         90        100
IKLSIKRLVT TGVLKQTKGV GASGSFRLAK SDEPKKSVAF KKTKKEIKKV 
       110        120        130        140        150
ATPKKASKPK KAASKAPTKK PKATPVKKAK KKLAATPKKA KKPKTVKAKP 
       160        170 
VKASKPKKAK PVKPKAKSSA KRAGKKK

Show »

Length:177

Mass (Da):19,167

Checksum:ⁱ8CD558F288DB593A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	65	D → H in AAH29046 (PubMed:15489334).Curated		1

RNA editingⁱ

Modified position: not applicable.
Partially edited. In approximately 3.6% of the mRNA molecules, a new initiator methionine is created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 99 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 12-21; 22-33; 37-47; 48-67; 68-83; 84-94 and 97-113. The RNA edited version is called ET-H1.0.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_054789	1	M → MLGKGRQRRRRQRQRQSPVP RPSDRPAGLGLAKPARRALP TPEPGRKSSDSSLASPGAAL QTGPVVRGSGADPEAGFAQP PTRAGPLEGAFNSRTRQATM in RNA edited version.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042163	3 – 19	Missing in isoform 2. 1 PublicationAdd BLAST		17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03473 Genomic DNA Translation: CAA27190.1 CR456502 mRNA Translation: CAG30388.1 CR542220 mRNA Translation: CAG47016.1 AK299209 mRNA Translation: BAG61248.1 AK312583 mRNA Translation: BAG35477.1 Z97630 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60188.1 BC000145 mRNA Translation: AAH00145.1 BC029046 mRNA Translation: AAH29046.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13956.1 [P07305-1]
PIRⁱ	A24850 HSHU10
NCBI Reference Sequences More...RefSeqⁱ	NP_005309.1, NM_005318.3 [P07305-1]
UniGeneⁱ	Hs.745024

Genome annotation databases

Ensemblⁱ	ENST00000340857; ENSP00000344504; ENSG00000189060 [P07305-1]
GeneIDⁱ	3005
KEGGⁱ	hsa:3005
UCSC genome browser More...UCSCⁱ	uc003aty.4 human [P07305-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, RNA editing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P07305	H1 histone family member 0		PANTR		194
Histone H1.0		MACMU		194
H1 histone family member 0		MACFA		194
H1 histone family member 0		COLAP		194
H1F0 isoform 1		PONAB		194
+6

Protein	Similar proteins		Species	Score	Length
P07305	H1 histone family member 0		PANTR		194
Histone H1.0		MACMU		194
H1 histone family member 0		MACFA		194
H1 histone family member 0		COLAP		194
H1F0 isoform 1		PONAB		194
+88

Protein	Similar proteins		Species	Score	Length
P07305	H1 histone family member 0		PANTR		194
Histone H1.0		MACMU		194
H1 histone family member 0		MACFA		194
H1 histone family member 0		COLAP		194
H1F0 isoform 1		PONAB		194
+200

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Histone H1 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03473 Genomic DNA Translation: CAA27190.1 CR456502 mRNA Translation: CAG30388.1 CR542220 mRNA Translation: CAG47016.1 AK299209 mRNA Translation: BAG61248.1 AK312583 mRNA Translation: BAG35477.1 Z97630 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60188.1 BC000145 mRNA Translation: AAH00145.1 BC029046 mRNA Translation: AAH29046.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13956.1 [P07305-1]
PIRⁱ	A24850 HSHU10
NCBI Reference Sequences More...RefSeqⁱ	NP_005309.1, NM_005318.3 [P07305-1]
UniGeneⁱ	Hs.745024

3D structure databases

ProteinModelPortalⁱ	P07305
SMRⁱ	P07305
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109260, 41 interactors
Database of interacting proteins More...DIPⁱ	DIP-41775N
ELMⁱ	P07305
IntActⁱ	P07305, 14 interactors
Molecular INTeraction database More...MINTⁱ	P07305
STRINGⁱ	9606.ENSP00000344504

Chemistry databases

BindingDBⁱ	P07305
ChEMBLⁱ	CHEMBL3707465

PTM databases

iPTMnetⁱ	P07305
PhosphoSitePlusⁱ	P07305

Polymorphism and mutation databases

BioMutaⁱ	H1F0
DMDMⁱ	121897

Proteomic databases

EPDⁱ	P07305
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P07305
PaxDbⁱ	P07305
PeptideAtlas More...PeptideAtlasⁱ	P07305
PRIDEⁱ	P07305
ProteomicsDBⁱ	51978 51979 [P07305-2]
TopDownProteomicsⁱ	P07305-1 [P07305-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3005
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000340857; ENSP00000344504; ENSG00000189060 [P07305-1]
GeneIDⁱ	3005
KEGGⁱ	hsa:3005
UCSC genome browser More...UCSCⁱ	uc003aty.4 human [P07305-1]

Organism-specific databases

CTDⁱ	3005
DisGeNET More...DisGeNETⁱ	3005
EuPathDBⁱ	HostDB:ENSG00000189060.5
GeneCardsⁱ	H1F0
H-InvDBⁱ	HIX0016454
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4714 H1F0
Human Protein Atlas More...HPAⁱ	HPA000843
MIMⁱ	142708 gene
neXtProtⁱ	NX_P07305
Open Targets More...OpenTargetsⁱ	ENSG00000189060
PharmGKBⁱ	PA29092
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4012 Eukaryota ENOG4112541 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125570
HOGENOMⁱ	HOG000251627
HOVERGENⁱ	HBG069502
InParanoidⁱ	P07305
KEGG Orthology (KO) More...KOⁱ	K11275
OMAⁱ	FEQPKGP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LIU
PhylomeDBⁱ	P07305
TreeFamⁱ	TF313664

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211227 Activation of DNA fragmentation factor R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Reactomeⁱ

R-HSA-211227 Activation of DNA fragmentation factor
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Miscellaneous databases

ChiTaRSⁱ	H1F0 human
GenomeRNAiⁱ	3005
Protein Ontology More...PROⁱ	PR:P07305
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000189060
CleanExⁱ	HS_H1F0
Genevisibleⁱ	P07305 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR005818 Histone_H1/H5_H15 IPR005819 Histone_H5 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00538 Linker_histone, 1 hit
PRINTSⁱ	PR00624 HISTONEH5
SMARTⁱ	View protein in SMART SM00526 H15, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS51504 H15, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	H10_HUMAN
Accessionⁱ	P07305Primary (citable) accession number: P07305 Secondary accession number(s): B2R6I0 , B4DRD6, Q6FG88, Q8N6R3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	July 18, 2018
	This is version 181 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P07305 (H10_HUMAN)

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Histone H1.0

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Golgi apparatus

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ