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Entry version 228 (22 Apr 2020)
Sequence version 5 (21 Sep 2011)
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Protein

Protein URA2

Gene

URA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is a 'fusion' protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase).

Miscellaneous

GATase (glutamine amidotransferase) and CPSase (carbamoyl phosphate synthase) form together the glutamine-dependent CPSase (GD-CPSase) (EC 6.3.5.5).
In eukaryotes EC 6.3.5.5 is synthesized by two pathway-specific (arginine and pyrimidine) genes under separate control.
Present with 11000 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Protein URA2 (URA2)
  2. Protein URA2 (URA2)
  3. Dihydroorotase (URA4)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei302For GATase activityBy similarity1
Active sitei386For GATase activityBy similarity1
Active sitei388For GATase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Multifunctional enzyme, Transferase
Biological processPyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:YJL130C-MONOMER
YEAST:YJL130C-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.3.5.5 984

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-500753 Pyrimidine biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00070;UER00115
UPA00070;UER00116

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C26.956

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein URA2
Including the following 2 domains:
Glutamine-dependent carbamoyl-phosphate synthase (EC:6.3.5.5)
Aspartate carbamoyltransferase (EC:2.1.3.2)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:URA2
Ordered Locus Names:YJL130C
ORF Names:J0686
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YJL130C

Saccharomyces Genome Database

More...
SGDi
S000003666 URA2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001995112 – 2214Protein URA2Add BLAST2213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1853Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei1857Phosphoserine; by PKACombined sources1 Publication1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P07259

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07259

PRoteomics IDEntifications database

More...
PRIDEi
P07259

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P07259

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P07259

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33626, 181 interactors

Database of interacting proteins

More...
DIPi
DIP-7215N

Protein interaction database and analysis system

More...
IntActi
P07259, 463 interactors

Molecular INTeraction database

More...
MINTi
P07259

STRING: functional protein association networks

More...
STRINGi
4932.YJL130C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P07259 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P07259

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini228 – 413Glutamine amidotransferase type-1Add BLAST186
Domaini562 – 754ATP-grasp 1Add BLAST193
Domaini1099 – 1290ATP-grasp 2Add BLAST192
Domaini1356 – 1508MGS-likePROSITE-ProRule annotationAdd BLAST153

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 400GATase (Glutamine amidotransferase)Add BLAST399
Regioni401 – 440LinkerAdd BLAST40
Regioni441 – 1482CPSase (Carbamoyl-phosphate synthase)Add BLAST1042
Regioni1483 – 1492Linker10
Regioni1493 – 1821Defective DHOase domainAdd BLAST329
Regioni1822 – 1909LinkerAdd BLAST88
Regioni1910 – 2214ATCase (Aspartate transcarbamylase)Add BLAST305

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DHOase domain is defective.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000513_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07259

KEGG Orthology (KO)

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KOi
K11541

Identification of Orthologs from Complete Genome Data

More...
OMAi
NNKYRRP

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01744 GATase1_CPSase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1030.10, 1 hit
3.30.1490.20, 1 hit
3.40.50.1370, 2 hits
3.40.50.1380, 1 hit
3.40.50.880, 1 hit
3.50.30.20, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00001 Asp_carb_tr, 1 hit
MF_01209 CPSase_S_chain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR006275 CarbamoylP_synth_lsu
IPR005480 CarbamoylP_synth_lsu_oligo
IPR036897 CarbamoylP_synth_lsu_oligo_sf
IPR006274 CarbamoylP_synth_ssu
IPR002474 CarbamoylP_synth_ssu_N
IPR036480 CarbP_synth_ssu_N_sf
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR005483 CbamoylP_synth_lsu_CPSase_dom
IPR029062 Class_I_gatase-like
IPR035686 CPSase_GATase1
IPR017926 GATASE
IPR032466 Metal_Hydrolase
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR016185 PreATP-grasp_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02786 CPSase_L_D2, 2 hits
PF02787 CPSase_L_D3, 1 hit
PF00988 CPSase_sm_chain, 1 hit
PF00117 GATase, 1 hit
PF02142 MGS, 1 hit
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00100 AOTCASE
PR00098 CPSASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01096 CPSase_L_D3, 1 hit
SM01097 CPSase_sm_chain, 1 hit
SM00851 MGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48108 SSF48108, 1 hit
SSF51556 SSF51556, 1 hit
SSF52021 SSF52021, 1 hit
SSF52317 SSF52317, 1 hit
SSF52335 SSF52335, 1 hit
SSF52440 SSF52440, 2 hits
SSF53671 SSF53671, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00670 asp_carb_tr, 1 hit
TIGR01369 CPSaseII_lrg, 1 hit
TIGR01368 CPSaseIIsmall, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50975 ATP_GRASP, 2 hits
PS00097 CARBAMOYLTRANSFERASE, 1 hit
PS00866 CPSASE_1, 2 hits
PS00867 CPSASE_2, 2 hits
PS51273 GATASE_TYPE_1, 1 hit
PS51855 MGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P07259-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATIAPTAPI TPPMESTGDR LVTLELKDGT VLQGYSFGAE KSVAGELVFQ
60 70 80 90 100
TGMVGYPESV TDPSYEGQIL VITYPLVGNY GVPDMHLRDE LVEELPRYFE
110 120 130 140 150
SNRIHIAGLV ISHYTDEYSH YLAKSSLGKW LQNEGIPAVY GVDTRSLTKH
160 170 180 190 200
LRDAGSMLGR LSLEKSGSDR TISRSSSWRS AFDVPEWVDP NVQNLVSKVS
210 220 230 240 250
INEPKLYVPP ADNKHIELQT GPDGKVLRIL AIDVGMKYNQ IRCFIKRGVE
260 270 280 290 300
LKVVPWNYDF TKEDYDGLFI SNGPGDPSVL DDLSQRLSNV LEAKKTPVFG
310 320 330 340 350
ICLGHQLIAR AAGASTLKLK FGNRGHNIPC TSTISGRCYI TSQNHGFAVD
360 370 380 390 400
VDTLTSGWKP LFVNANDDSN EGIYHSELPY FSVQFHPEST PGPRDTEFLF
410 420 430 440 450
DVFIQAVKEF KYTQVLKPIA FPGGLLEDNV KAHPRIEAKK VLVLGSGGLS
460 470 480 490 500
IGQAGEFDYS GSQAIKALKE EGIYTILINP NIATIQTSKG LADKVYFVPV
510 520 530 540 550
TAEFVRKVIL HERPDAIYVT FGGQTALSVG IAMKDEFEAL GVKVLGTPID
560 570 580 590 600
TIITTEDREL FSNAIDEINE KCAKSQAANS VDEALAAVKE IGFPVIVRAA
610 620 630 640 650
YALGGLGSGF ANNEKELVDL CNVAFSSSPQ VLVEKSMKGW KEVEYEVVRD
660 670 680 690 700
AFDNCITVCN MENFDPLGIH TGDSIVVAPS QTLSDEDYNM LRTTAVNVIR
710 720 730 740 750
HLGVVGECNI QYALNPVSKD YCIIEVNARL SRSSALASKA TGYPLAYTAA
760 770 780 790 800
KLGLNIPLNE VKNSVTKSTC ACFEPSLDYC VVKMPRWDLK KFTRVSTELS
810 820 830 840 850
SSMKSVGEVM SIGRTFEEAI QKAIRSTEYA NLGFNETDLD IDIDYELNNP
860 870 880 890 900
TDMRVFAIAN AFAKKGYSVD KVWEMTRIDK WFLNKLHDLV QFAEKISSFG
910 920 930 940 950
TKEELPSLVL RQAKQLGFDD RQIARFLDSN EVAIRRLRKE YGITPFVKQI
960 970 980 990 1000
DTVAAEFPAY TNYLYMTYNA DSHDLSFDDH GVMVLGSGVY RIGSSVEFDW
1010 1020 1030 1040 1050
CAVTAVRTLR ANNIKTIMVN YNPETVSTDY DEADRLYFET INLERVLDIY
1060 1070 1080 1090 1100
EIENSSGVVV SMGGQTSNNI AMTLHRENVK ILGTSPDMID SAENRYKFSR
1110 1120 1130 1140 1150
MLDQIGVDQP AWKELTSMDE AESFAEKVGY PVLVRPSYVL SGAAMNTVYS
1160 1170 1180 1190 1200
KNDLESYLNQ AVEVSRDYPV VITKYIENAK EIEMDAVARN GELVMHVVSE
1210 1220 1230 1240 1250
HVENAGVHSG DATLIVPPQD LAPETVDRIV VATAKIGKAL KITGPYNIQF
1260 1270 1280 1290 1300
IAKDNEIKVI ECNVRASRSF PFISKVVGVN LIELATKAIM GLPLTPYPVE
1310 1320 1330 1340 1350
KLPDDYVAVK VPQFSFPRLA GADPVLGVEM ASTGEVATFG HSKYEAYLKS
1360 1370 1380 1390 1400
LLATGFKLPK KNILLSIGSY KEKQELLSSV QKLYNMGYKL FATSGTADFL
1410 1420 1430 1440 1450
SEHGIAVQYL EVLNKDDDDQ KSEYSLTQHL ANNEIDLYIN LPSANRFRRP
1460 1470 1480 1490 1500
ASYVSKGYKT RRLAVDYSVP LVTNVKCAKL LIEAISRNIT LDVSERDAQT
1510 1520 1530 1540 1550
SHRTITLPGL INIATYVPNA SHVIKGPAEL KETTRLFLES GFTYCQLMPR
1560 1570 1580 1590 1600
SISGPVITDV ASLKAANSVS QDSSYTDFSF TIAGTAHNAH SVTQSASKVT
1610 1620 1630 1640 1650
ALFLPLRELK NKITAVAELL NQWPTEKQVI AEAKTADLAS VLLLTSLQNR
1660 1670 1680 1690 1700
SIHITGVSNK EDLALIMTVK AKDPRVTCDV NIYSLFIAQD DYPEAVFLPT
1710 1720 1730 1740 1750
KEDQEFFWNN LDSIDAFSVG ALPVALANVT GNKVDVGMGI KDSLPLLLAA
1760 1770 1780 1790 1800
VEEGKLTIDD IVLRLHDNPA KIFNIPTQDS VVEIDLDYSF RRNKRWSPFN
1810 1820 1830 1840 1850
KDMNGGIERV VYNGETLVLS GELVSPGAKG KCIVNPSPAS ITASAELQST
1860 1870 1880 1890 1900
SAKRRFSITE EAIADNLDAA EDAIPEQPLE QKLMSSRPPR ELVAPGAIQN
1910 1920 1930 1940 1950
LIRSNNPFRG RHILSIKQFK RSDFHVLFAV AQELRAAVAR EGVLDLMKGH
1960 1970 1980 1990 2000
VITTIFFEPS TRTCSSFIAA MERLGGRIVN VNPLVSSVKK GETLQDTIRT
2010 2020 2030 2040 2050
LACYSDAIVM RHSEEMSVHI AAKYSPVPII NGGNGSREHP TQAFLDLFTI
2060 2070 2080 2090 2100
REEIGTVNGI TVTFMGDLKH GRTVHSLCRL LMHYQVRINL VSPPELRLPE
2110 2120 2130 2140 2150
GLREELRKAG LLGVESIELT PHIISKTDVL YCTRVQEERF NSPEEYARLK
2160 2170 2180 2190 2200
DTYIVDNKIL AHAKENMAIM HPLPRVNEIK EEVDYDHRAA YFRQMKYGLF
2210
VRMALLAMVM GVDM
Length:2,214
Mass (Da):245,041
Last modified:September 21, 2011 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5A47F4E42A9B1A7
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABI95879 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti86H → D in CAA29068 (PubMed:3039294).Curated1
Sequence conflicti123A → R in CAA89425 (PubMed:8641269).Curated1
Sequence conflicti250 – 257ELKVVPWN → RIESCSMD in CAA29068 (PubMed:3039294).Curated8
Sequence conflicti270I → Y in CAA29068 (PubMed:3039294).Curated1
Sequence conflicti313 – 314GA → VQ in CAA29068 (PubMed:3039294).Curated2
Sequence conflicti372 – 373GI → RF in CAA29068 (PubMed:3039294).Curated2
Sequence conflicti394 – 402RDTEFLFDV → EIQNSCLT in CAA29068 (PubMed:3039294).Curated9
Sequence conflicti431 – 433KAH → QGT in CAA29068 (PubMed:3039294).Curated3
Sequence conflicti482I → T in CAA29068 (PubMed:3039294).Curated1
Sequence conflicti485I → N in CAA29068 (PubMed:3039294).Curated1
Sequence conflicti492A → G in CAA29068 (PubMed:3039294).Curated1
Sequence conflicti501 – 510TAEFVRKVIL → NAAKQRDVDR in CAA29068 (PubMed:3039294).Curated10
Sequence conflicti1411 – 1412EV → S in AAA35198 (PubMed:2498313).Curated2
Sequence conflicti1582I → M in AAA35198 (PubMed:2498313).Curated1
Sequence conflicti1588N → K in AAA35198 (PubMed:2498313).Curated1
Sequence conflicti1592V → G in AAA35198 (PubMed:2498313).Curated1
Sequence conflicti1595S → A in AAA35198 (PubMed:2498313).Curated1
Sequence conflicti1872Missing AA sequence (PubMed:1977585).Curated1
Sequence conflicti1937A → R in AAA68280 (PubMed:2570735).Curated1
Sequence conflicti1937A → R in AAA35198 (PubMed:2498313).Curated1
Sequence conflicti1997T → I in AAA35198 (PubMed:2498313).Curated1
Sequence conflicti2039H → L in AAA35198 (PubMed:2498313).Curated1
Sequence conflicti2158 – 2165KILAHAKE → VRSWHTQQK in AAA35198 (PubMed:2498313).Curated8

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M27174 Genomic DNA Translation: AAA68280.1
Z49405 Genomic DNA Translation: CAA89425.1
X05553 Genomic DNA Translation: CAA29068.1
DQ881452 mRNA Translation: ABI95879.1 Different initiation.
EF123133 mRNA Translation: ABM97477.1
X87371 Genomic DNA Translation: CAA60825.1
D28139 Genomic DNA Translation: BAA05680.1
J04711 Genomic DNA Translation: AAA35198.1
BK006943 Genomic DNA Translation: DAA08671.2

Protein sequence database of the Protein Information Resource

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PIRi
S56911 QZBYU2

NCBI Reference Sequences

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RefSeqi
NP_012405.2, NM_001181563.2

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
YJL130C_mRNA; YJL130C; YJL130C

Database of genes from NCBI RefSeq genomes

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GeneIDi
853311

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
sce:YJL130C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27174 Genomic DNA Translation: AAA68280.1
Z49405 Genomic DNA Translation: CAA89425.1
X05553 Genomic DNA Translation: CAA29068.1
DQ881452 mRNA Translation: ABI95879.1 Different initiation.
EF123133 mRNA Translation: ABM97477.1
X87371 Genomic DNA Translation: CAA60825.1
D28139 Genomic DNA Translation: BAA05680.1
J04711 Genomic DNA Translation: AAA35198.1
BK006943 Genomic DNA Translation: DAA08671.2
PIRiS56911 QZBYU2
RefSeqiNP_012405.2, NM_001181563.2

3D structure databases

SMRiP07259
ModBaseiSearch...

Protein-protein interaction databases

BioGridi33626, 181 interactors
DIPiDIP-7215N
IntActiP07259, 463 interactors
MINTiP07259
STRINGi4932.YJL130C

Protein family/group databases

MEROPSiC26.956

PTM databases

CarbonylDBiP07259
iPTMnetiP07259

Proteomic databases

MaxQBiP07259
PaxDbiP07259
PRIDEiP07259

Genome annotation databases

EnsemblFungiiYJL130C_mRNA; YJL130C; YJL130C
GeneIDi853311
KEGGisce:YJL130C

Organism-specific databases

EuPathDBiFungiDB:YJL130C
SGDiS000003666 URA2

Phylogenomic databases

HOGENOMiCLU_000513_2_0_1
InParanoidiP07259
KOiK11541
OMAiNNKYRRP

Enzyme and pathway databases

UniPathwayiUPA00070;UER00115
UPA00070;UER00116
BioCyciMetaCyc:YJL130C-MONOMER
YEAST:YJL130C-MONOMER
BRENDAi6.3.5.5 984
ReactomeiR-SCE-500753 Pyrimidine biosynthesis

Miscellaneous databases

Protein Ontology

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PROi
PR:P07259
RNActiP07259 protein

Family and domain databases

CDDicd01744 GATase1_CPSase, 1 hit
Gene3Di1.10.1030.10, 1 hit
3.30.1490.20, 1 hit
3.40.50.1370, 2 hits
3.40.50.1380, 1 hit
3.40.50.880, 1 hit
3.50.30.20, 1 hit
HAMAPiMF_00001 Asp_carb_tr, 1 hit
MF_01209 CPSase_S_chain, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR006275 CarbamoylP_synth_lsu
IPR005480 CarbamoylP_synth_lsu_oligo
IPR036897 CarbamoylP_synth_lsu_oligo_sf
IPR006274 CarbamoylP_synth_ssu
IPR002474 CarbamoylP_synth_ssu_N
IPR036480 CarbP_synth_ssu_N_sf
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR005483 CbamoylP_synth_lsu_CPSase_dom
IPR029062 Class_I_gatase-like
IPR035686 CPSase_GATase1
IPR017926 GATASE
IPR032466 Metal_Hydrolase
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF02786 CPSase_L_D2, 2 hits
PF02787 CPSase_L_D3, 1 hit
PF00988 CPSase_sm_chain, 1 hit
PF00117 GATase, 1 hit
PF02142 MGS, 1 hit
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00098 CPSASE
SMARTiView protein in SMART
SM01096 CPSase_L_D3, 1 hit
SM01097 CPSase_sm_chain, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF48108 SSF48108, 1 hit
SSF51556 SSF51556, 1 hit
SSF52021 SSF52021, 1 hit
SSF52317 SSF52317, 1 hit
SSF52335 SSF52335, 1 hit
SSF52440 SSF52440, 2 hits
SSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00670 asp_carb_tr, 1 hit
TIGR01369 CPSaseII_lrg, 1 hit
TIGR01368 CPSaseIIsmall, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 2 hits
PS00097 CARBAMOYLTRANSFERASE, 1 hit
PS00866 CPSASE_1, 2 hits
PS00867 CPSASE_2, 2 hits
PS51273 GATASE_TYPE_1, 1 hit
PS51855 MGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPYR1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07259
Secondary accession number(s): A2TBN0, D6VW55, Q06HN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: September 21, 2011
Last modified: April 22, 2020
This is version 228 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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