UniProtKB - P07257 (QCR2_YEAST)
Cytochrome b-c1 complex subunit 2, mitochondrial
QCR2
Functioni
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
1 PublicationMiscellaneous
Caution
GO - Molecular functioni
- metal ion binding Source: InterPro
- metalloendopeptidase activity Source: InterPro
GO - Biological processi
- aerobic respiration Source: SGD
- cellular respiration Source: ComplexPortal
- mitochondrial electron transport, ubiquinol to cytochrome c Source: SGD
- proton transmembrane transport Source: GOC
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 2, mitochondrialAlternative name(s): Complex III subunit 2 Core protein II Ubiquinol-cytochrome c oxidoreductase core protein 2 |
Gene namesi | Name:QCR2 Synonyms:COR2, UCR2 Ordered Locus Names:YPR191W ORF Names:P9677.6 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006395, QCR2 |
VEuPathDBi | FungiDB:YPR191W |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 4 Publications; Peripheral membrane protein 2 Publications; Matrix side 2 Publications
Mitochondrion
- mitochondrial crista Source: SGD
- mitochondrial inner membrane Source: ComplexPortal
- mitochondrial respiratory chain complex III Source: SGD
- mitochondrion Source: SGD
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 16 | Mitochondrion1 PublicationAdd BLAST | 16 | |
ChainiPRO_0000026801 | 17 – 368 | Cytochrome b-c1 complex subunit 2, mitochondrialAdd BLAST | 352 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 141 | PhosphoserineCombined sources | 1 | |
Modified residuei | 168 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P07257 |
PaxDbi | P07257 |
PRIDEi | P07257 |
PTM databases
iPTMneti | P07257 |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III2IV and III2IV2) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554).
7 PublicationsBinary interactionsi
P07257
With | #Exp. | IntAct |
---|---|---|
COR1 [P07256] | 3 | EBI-19929,EBI-19922 |
Protein-protein interaction databases
BioGRIDi | 36363, 434 interactors |
ComplexPortali | CPX-567, Mitochondrial respiratory chain complex III |
DIPi | DIP-3820N |
IntActi | P07257, 30 interactors |
MINTi | P07257 |
STRINGi | 4932.YPR191W |
Miscellaneous databases
RNActi | P07257, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P07257 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07257 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2583, Eukaryota |
GeneTreei | ENSGT00940000173495 |
HOGENOMi | CLU_009902_0_1_1 |
InParanoidi | P07257 |
OMAi | YKYQDAG |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit |
SUPFAMi | SSF63411, SSF63411, 2 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MLSAARLQFA QGSVRRLTVS ARDAPTKIST LAVKVHGGSR YATKDGVAHL
60 70 80 90 100
LNRFNFQNTN TRSALKLVRE SELLGGTFKS TLDREYITLK ATFLKDDLPY
110 120 130 140 150
YVNALADVLY KTAFKPHELT ESVLPAARYD YAVAEQCPVK SAEDQLYAIT
160 170 180 190 200
FRKGLGNPLL YDGVERVSLQ DIKDFADKVY TKENLEVSGE NVVEADLKRF
210 220 230 240 250
VDESLLSTLP AGKSLVSKSE PKFFLGEENR VRFIGDSVAA IGIPVNKASL
260 270 280 290 300
AQYEVLANYL TSALSELSGL ISSAKLDKFT DGGLFTLFVR DQDSAVVSSN
310 320 330 340 350
IKKIVADLKK GKDLSPAINY TKLKNAVQNE SVSSPIELNF DAVKDFKLGK
360
FNYVAVGDVS NLPYLDEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X05120 Genomic DNA Translation: CAA28768.1 U25841 Genomic DNA Translation: AAB64620.1 AY558068 Genomic DNA Translation: AAS56394.1 BK006949 Genomic DNA Translation: DAA11607.1 |
PIRi | A27535 |
RefSeqi | NP_015517.1, NM_001184288.1 |
Genome annotation databases
EnsemblFungii | YPR191W_mRNA; YPR191W; YPR191W |
GeneIDi | 856321 |
KEGGi | sce:YPR191W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X05120 Genomic DNA Translation: CAA28768.1 U25841 Genomic DNA Translation: AAB64620.1 AY558068 Genomic DNA Translation: AAS56394.1 BK006949 Genomic DNA Translation: DAA11607.1 |
PIRi | A27535 |
RefSeqi | NP_015517.1, NM_001184288.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EZV | X-ray | 2.30 | B | 17-368 | [»] | |
1KB9 | X-ray | 2.30 | B | 17-368 | [»] | |
1KYO | X-ray | 2.97 | B/M | 17-368 | [»] | |
1P84 | X-ray | 2.50 | B | 17-368 | [»] | |
2IBZ | X-ray | 2.30 | B | 17-368 | [»] | |
3CX5 | X-ray | 1.90 | B/M | 17-368 | [»] | |
3CXH | X-ray | 2.50 | B/M | 17-368 | [»] | |
4PD4 | X-ray | 3.04 | B | 17-368 | [»] | |
6GIQ | electron microscopy | 3.23 | B/M | 1-368 | [»] | |
6HU9 | electron microscopy | 3.35 | B/M | 17-368 | [»] | |
6T0B | electron microscopy | 2.80 | B/M | 17-368 | [»] | |
6T15 | electron microscopy | 3.29 | B/M | 17-368 | [»] | |
6YMX | electron microscopy | 3.17 | B/M | 17-368 | [»] | |
SMRi | P07257 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 36363, 434 interactors |
ComplexPortali | CPX-567, Mitochondrial respiratory chain complex III |
DIPi | DIP-3820N |
IntActi | P07257, 30 interactors |
MINTi | P07257 |
STRINGi | 4932.YPR191W |
PTM databases
iPTMneti | P07257 |
Proteomic databases
MaxQBi | P07257 |
PaxDbi | P07257 |
PRIDEi | P07257 |
Genome annotation databases
EnsemblFungii | YPR191W_mRNA; YPR191W; YPR191W |
GeneIDi | 856321 |
KEGGi | sce:YPR191W |
Organism-specific databases
SGDi | S000006395, QCR2 |
VEuPathDBi | FungiDB:YPR191W |
Phylogenomic databases
eggNOGi | KOG2583, Eukaryota |
GeneTreei | ENSGT00940000173495 |
HOGENOMi | CLU_009902_0_1_1 |
InParanoidi | P07257 |
OMAi | YKYQDAG |
Miscellaneous databases
EvolutionaryTracei | P07257 |
PROi | PR:P07257 |
RNActi | P07257, protein |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit |
SUPFAMi | SSF63411, SSF63411, 2 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR2_YEAST | |
Accessioni | P07257Primary (citable) accession number: P07257 Secondary accession number(s): D6W4J1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | April 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 214 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - Peptidase families
Classification of peptidase families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families