UniProtKB - P07256 (QCR1_YEAST)
Cytochrome b-c1 complex subunit 1, mitochondrial
COR1
Functioni
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
1 PublicationMiscellaneous
Caution
GO - Molecular functioni
- metal ion binding Source: InterPro
- metalloendopeptidase activity Source: GO_Central
GO - Biological processi
- aerobic respiration Source: SGD
- cellular respiration Source: ComplexPortal
- mitochondrial electron transport, ubiquinol to cytochrome c Source: ComplexPortal
- protein processing involved in protein targeting to mitochondrion Source: GO_Central
- proton transmembrane transport Source: GOC
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
BRENDAi | 2.3.1.9, 6758 |
Reactomei | R-SCE-611105, Respiratory electron transport |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 1, mitochondrialAlternative name(s): Complex III subunit 1 Core protein I Ubiquinol-cytochrome c oxidoreductase core protein 1 Ubiquinol-cytochrome c reductase 44 kDa protein |
Gene namesi | Name:COR1 Synonyms:QCR1 Ordered Locus Names:YBL045C ORF Names:YBL0403 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000141, COR1 |
VEuPathDBi | FungiDB:YBL045C |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 3 Publications; Peripheral membrane protein 2 Publications; Matrix side 2 Publications
Mitochondrion
- mitochondrial inner membrane Source: ComplexPortal
- mitochondrial respiratory chain complex III Source: SGD
- mitochondrion Source: SGD
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 26 | MitochondrionSequence analysis1 PublicationAdd BLAST | 26 | |
ChainiPRO_0000026788 | 27 – 457 | Cytochrome b-c1 complex subunit 1, mitochondrialAdd BLAST | 431 |
Proteomic databases
MaxQBi | P07256 |
PaxDbi | P07256 |
PRIDEi | P07256 |
PTM databases
iPTMneti | P07256 |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (COB), cytochrome c1 (CYT1) and Rieske protein (RIP1), 2 core protein subunits COR1 and QCR2, and 5 low-molecular weight protein subunits QCR6, QCR7, QCR8, QCR9 and QCR10 (PubMed:10873857, PubMed:11880631, PubMed:18390544, PubMed:30598554). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with a monomer or a dimer of cytochrome c oxidase (complex IV, CIV), resulting in 2 different assemblies (supercomplexes III2IV and III2IV2) (PubMed:10775262, PubMed:10764779, PubMed:30598556, PubMed:30598554). COR1 interacts with COX5A at the CIII-CIV interface (PubMed:30598556, PubMed:30598554).
7 PublicationsBinary interactionsi
P07256
With | #Exp. | IntAct |
---|---|---|
QCR2 [P07257] | 3 | EBI-19922,EBI-19929 |
Protein-protein interaction databases
BioGRIDi | 32652, 152 interactors |
ComplexPortali | CPX-567, Mitochondrial respiratory chain complex III |
DIPi | DIP-2635N |
IntActi | P07256, 33 interactors |
MINTi | P07256 |
STRINGi | 4932.YBL045C |
Miscellaneous databases
RNActi | P07256, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P07256 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07256 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0960, Eukaryota |
HOGENOMi | CLU_009902_4_2_1 |
InParanoidi | P07256 |
OMAi | PYNNGVS |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR007863, Peptidase_M16_C |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 1 hit |
SUPFAMi | SSF63411, SSF63411, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MLRTVTSKTV SNQFKRSLAT AVATPKAEVT QLSNGIVVAT EHNPSAHTAS
60 70 80 90 100
VGVVFGSGAA NENPYNNGVS NLWKNIFLSK ENSAVAAKEG LALSSNISRD
110 120 130 140 150
FQSYIVSSLP GSTDKSLDFL NQSFIQQKAN LLSSSNFEAT KKSVLKQVQD
160 170 180 190 200
FEENDHPNRV LEHLHSTAFQ NTPLSLPTRG TLESLENLVV ADLESFANNH
210 220 230 240 250
FLNSNAVVVG TGNIKHEDLV NSIESKNLSL QTGTKPVLKK KAAFLGSEVR
260 270 280 290 300
LRDDTLPKAW ISLAVEGEPV NSPNYFVAKL AAQIFGSYNA FEPASRLQGI
310 320 330 340 350
KLLDNIQEYQ LCDNFNHFSL SYKDSGLWGF STATRNVTMI DDLIHFTLKQ
360 370 380 390 400
WNRLTISVTD TEVERAKSLL KLQLGQLYES GNPVNDANLL GAEVLIKGSK
410 420 430 440 450
LSLGEAFKKI DAITVKDVKA WAGKRLWDQD IAIAGTGQIE GLLDYMRIRS
DMSMMRW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02636 Genomic DNA Translation: AAA34508.1 X78214 Genomic DNA Translation: CAA55050.1 Z35806 Genomic DNA Translation: CAA84865.1 AY693047 Genomic DNA Translation: AAT93066.1 BK006936 Genomic DNA Translation: DAA07073.1 |
PIRi | A25351 |
RefSeqi | NP_009508.1, NM_001178285.1 |
Genome annotation databases
EnsemblFungii | YBL045C_mRNA; YBL045C; YBL045C |
GeneIDi | 852235 |
KEGGi | sce:YBL045C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02636 Genomic DNA Translation: AAA34508.1 X78214 Genomic DNA Translation: CAA55050.1 Z35806 Genomic DNA Translation: CAA84865.1 AY693047 Genomic DNA Translation: AAT93066.1 BK006936 Genomic DNA Translation: DAA07073.1 |
PIRi | A25351 |
RefSeqi | NP_009508.1, NM_001178285.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EZV | X-ray | 2.30 | A | 27-457 | [»] | |
1KB9 | X-ray | 2.30 | A | 27-457 | [»] | |
1KYO | X-ray | 2.97 | A/L | 27-457 | [»] | |
1P84 | X-ray | 2.50 | A | 27-457 | [»] | |
2IBZ | X-ray | 2.30 | A | 27-457 | [»] | |
3CX5 | X-ray | 1.90 | A/L | 27-457 | [»] | |
3CXH | X-ray | 2.50 | A/L | 27-457 | [»] | |
4PD4 | X-ray | 3.04 | A | 27-457 | [»] | |
6GIQ | electron microscopy | 3.23 | A/L | 1-457 | [»] | |
6HU9 | electron microscopy | 3.35 | A/L | 27-457 | [»] | |
6T0B | electron microscopy | 2.80 | A/L | 27-457 | [»] | |
6T15 | electron microscopy | 3.29 | A/L | 27-457 | [»] | |
6YMX | electron microscopy | 3.17 | A/L | 27-457 | [»] | |
SMRi | P07256 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32652, 152 interactors |
ComplexPortali | CPX-567, Mitochondrial respiratory chain complex III |
DIPi | DIP-2635N |
IntActi | P07256, 33 interactors |
MINTi | P07256 |
STRINGi | 4932.YBL045C |
PTM databases
iPTMneti | P07256 |
Proteomic databases
MaxQBi | P07256 |
PaxDbi | P07256 |
PRIDEi | P07256 |
Genome annotation databases
EnsemblFungii | YBL045C_mRNA; YBL045C; YBL045C |
GeneIDi | 852235 |
KEGGi | sce:YBL045C |
Organism-specific databases
SGDi | S000000141, COR1 |
VEuPathDBi | FungiDB:YBL045C |
Phylogenomic databases
eggNOGi | KOG0960, Eukaryota |
HOGENOMi | CLU_009902_4_2_1 |
InParanoidi | P07256 |
OMAi | PYNNGVS |
Enzyme and pathway databases
BRENDAi | 2.3.1.9, 6758 |
Reactomei | R-SCE-611105, Respiratory electron transport |
Miscellaneous databases
EvolutionaryTracei | P07256 |
PROi | PR:P07256 |
RNActi | P07256, protein |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR007863, Peptidase_M16_C |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 1 hit |
SUPFAMi | SSF63411, SSF63411, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR1_YEAST | |
Accessioni | P07256Primary (citable) accession number: P07256 Secondary accession number(s): D6VPV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | April 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 209 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - Peptidase families
Classification of peptidase families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families