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Protein

Alcohol dehydrogenase 3, mitochondrial

Gene

ADH3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 11600 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Zinc 1; catalytic1
Metal bindingi94Zinc 1; catalytic1
Metal bindingi125Zinc 21
Metal bindingi128Zinc 21
Metal bindingi131Zinc 21
Metal bindingi139Zinc 21
Metal bindingi181Zinc 1; catalytic1
Binding sitei229NADBy similarity1
Binding sitei234NADBy similarity1
Binding sitei368NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 211NADBy similarity7
Nucleotide bindingi296 – 298NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • amino acid catabolic process to alcohol via Ehrlich pathway Source: SGD
  • ethanol metabolic process Source: GO_Central
  • fermentation Source: SGD
  • NADH oxidation Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:YMR083W-MONOMER
YEAST:YMR083W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 3, mitochondrial (EC:1.1.1.1)
Alternative name(s):
Alcohol dehydrogenase III
YADH-3
Gene namesi
Name:ADH3
Ordered Locus Names:YMR083W
ORF Names:YM9582.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR083W
SGDiS000004688 ADH3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionAdd BLAST27
ChainiPRO_000000087928 – 375Alcohol dehydrogenase 3, mitochondrialAdd BLAST348

Proteomic databases

MaxQBiP07246
PaxDbiP07246
PRIDEiP07246

PTM databases

CarbonylDBiP07246
iPTMnetiP07246

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi35258, 169 interactors
DIPiDIP-4445N
IntActiP07246, 25 interactors
MINTiP07246
STRINGi4932.YMR083W

Structurei

3D structure databases

ProteinModelPortaliP07246
SMRiP07246
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00550000075207
HOGENOMiHOG000294685
InParanoidiP07246
KOiK13953
OMAiQYAHNVF
OrthoDBiEOG092C2Q8E

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07246-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRTSTLFTR RVQPSLFSRN ILRLQSTAAI PKTQKGVIFY ENKGKLHYKD
60 70 80 90 100
IPVPEPKPNE ILINVKYSGV CHTDLHAWHG DWPLPVKLPL VGGHEGAGVV
110 120 130 140 150
VKLGSNVKGW KVGDLAGIKW LNGSCMTCEF CESGHESNCP DADLSGYTHD
160 170 180 190 200
GSFQQFATAD AIQAAKIQQG TDLAEVAPIL CAGVTVYKAL KEADLKAGDW
210 220 230 240 250
VAISGAAGGL GSLAVQYATA MGYRVLGIDA GEEKEKLFKK LGGEVFIDFT
260 270 280 290 300
KTKNMVSDIQ EATKGGPHGV INVSVSEAAI SLSTEYVRPC GTVVLVGLPA
310 320 330 340 350
NAYVKSEVFS HVVKSINIKG SYVGNRADTR EALDFFSRGL IKSPIKIVGL
360 370
SELPKVYDLM EKGKILGRYV VDTSK
Length:375
Mass (Da):40,370
Last modified:February 1, 1996 - v2
Checksum:iAB849BC4E9D4EB8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → K in AAA34409 (Ref. 1) Curated1
Sequence conflicti45K → N in AAA34409 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03292 Genomic DNA Translation: AAA34409.1
Z49259 Genomic DNA Translation: CAA89229.1
AY692988 Genomic DNA Translation: AAT93007.1
BK006946 Genomic DNA Translation: DAA09980.1
PIRiS54458
RefSeqiNP_013800.1, NM_001182582.1

Genome annotation databases

EnsemblFungiiYMR083W; YMR083W; YMR083W
GeneIDi855107
KEGGisce:YMR083W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03292 Genomic DNA Translation: AAA34409.1
Z49259 Genomic DNA Translation: CAA89229.1
AY692988 Genomic DNA Translation: AAT93007.1
BK006946 Genomic DNA Translation: DAA09980.1
PIRiS54458
RefSeqiNP_013800.1, NM_001182582.1

3D structure databases

ProteinModelPortaliP07246
SMRiP07246
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35258, 169 interactors
DIPiDIP-4445N
IntActiP07246, 25 interactors
MINTiP07246
STRINGi4932.YMR083W

PTM databases

CarbonylDBiP07246
iPTMnetiP07246

Proteomic databases

MaxQBiP07246
PaxDbiP07246
PRIDEiP07246

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR083W; YMR083W; YMR083W
GeneIDi855107
KEGGisce:YMR083W

Organism-specific databases

EuPathDBiFungiDB:YMR083W
SGDiS000004688 ADH3

Phylogenomic databases

GeneTreeiENSGT00550000075207
HOGENOMiHOG000294685
InParanoidiP07246
KOiK13953
OMAiQYAHNVF
OrthoDBiEOG092C2Q8E

Enzyme and pathway databases

BioCyciMetaCyc:YMR083W-MONOMER
YEAST:YMR083W-MONOMER

Miscellaneous databases

PROiPR:P07246

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH3_YEAST
AccessioniPrimary (citable) accession number: P07246
Secondary accession number(s): D6VZQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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