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Protein

Nucleophosmin

Gene

npm1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a chaperonin for the core histones H3, H2B and H4. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome. May stimulate endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA. May inhibit endonuclease activity on AP single-stranded RNA (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • RNA binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionChaperone, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleophosmin
Short name:
NPM
Alternative name(s):
Nucleolar phosphoprotein B23
Nucleolar protein NO38
Numatrin
Gene namesi
Name:npm1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194851 – 299NucleophosminAdd BLAST299

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP07222

Interactioni

Subunit structurei

Decamer formed by two pentameric rings associated in a head-to-head fashion.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57Interaction between pentamers1
Sitei82Interaction between pentamers1

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-11607504,EBI-11607504

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-48469N
IntActiP07222, 1 interactor

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07222
SMRiP07222
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07222

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati218 – 2203
Repeati221 – 2233
Repeati237 – 2393
Repeati240 – 2423

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 2424 X 3 AA repeats of K-T-PAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi153 – 158Nuclear localization signalSequence analysis6
Motifi189 – 195Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 7Met-rich7
Compositional biasi122 – 137Asp/Glu-rich (acidic)Add BLAST16
Compositional biasi160 – 187Asp/Glu-rich (highly acidic)Add BLAST28

Sequence similaritiesi

Belongs to the nucleoplasmin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG001860

Family and domain databases

Gene3Di1.10.10.2100, 1 hit
InterProiView protein in InterPro
IPR032569 NPM1_C
IPR038101 NPM1_C_sf
IPR004301 Nucleoplasmin
IPR024057 Nucleoplasmin_core_dom
IPR036824 Nucleoplasmin_core_dom_sf
PANTHERiPTHR22747 PTHR22747, 1 hit
PfamiView protein in Pfam
PF16276 NPM1-C, 1 hit
PF03066 Nucleoplasmin, 1 hit
SUPFAMiSSF69203 SSF69203, 1 hit

Sequencei

Sequence statusi: Complete.

P07222-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDSMDMDNI APLRPQNFLF GCELKADKKE YSFKVEDDEN EHQLSLRTVS
60 70 80 90 100
LGASAKDELH VVEAEGINYE GKTIKIALAS LKPSVQPTVS LGGFEITPPV
110 120 130 140 150
ILRLKSGSGP VYVSGQHLVA LEDLESSDDE DEEHEPSPKN AKRIAPDSAS
160 170 180 190 200
KVPRKKTRLE EEEEDSDEDD DDDEDDDDED DDEEEEETPV KKTDSTKSKA
210 220 230 240 250
AQKLNHNGKA SALSTTQKTP KTPEQKGKQD TKPQTPKTPK TPLSSEEIKA
260 270 280 290
KMQTYLEKGN VLPKVEVKFA NYVKNCFRTE NQKVIEDLWK WRQSLKDGK
Length:299
Mass (Da):33,532
Last modified:April 1, 1988 - v1
Checksum:iC16CDF9565090843
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05496 mRNA Translation: CAA29046.1
PIRiA29681
UniGeneiXl.4305

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05496 mRNA Translation: CAA29046.1
PIRiA29681
UniGeneiXl.4305

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XB9X-ray1.90A/B/C/D/E/F/G/H/I/J16-124[»]
1XE0X-ray1.70A/B/C/D/E/F/G/H/I/J16-124[»]
ProteinModelPortaliP07222
SMRiP07222
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48469N
IntActiP07222, 1 interactor

Proteomic databases

PRIDEiP07222

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG001860

Miscellaneous databases

EvolutionaryTraceiP07222

Family and domain databases

Gene3Di1.10.10.2100, 1 hit
InterProiView protein in InterPro
IPR032569 NPM1_C
IPR038101 NPM1_C_sf
IPR004301 Nucleoplasmin
IPR024057 Nucleoplasmin_core_dom
IPR036824 Nucleoplasmin_core_dom_sf
PANTHERiPTHR22747 PTHR22747, 1 hit
PfamiView protein in Pfam
PF16276 NPM1-C, 1 hit
PF03066 Nucleoplasmin, 1 hit
SUPFAMiSSF69203 SSF69203, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPM_XENLA
AccessioniPrimary (citable) accession number: P07222
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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