UniProtKB - P07207 (NOTCH_DROME)
Neurogenic locus Notch protein
N
Functioni
Essential signaling protein which has a major role in many developmental processes (PubMed:3935325).
Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination (PubMed:10935637, PubMed:15620650, PubMed:12909620, PubMed:18243100).
Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex (PubMed:7671825).
Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction (PubMed:11719214, PubMed:12369105, PubMed:3935325).
Regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt; might also regulate dpn expression through the activation of the transcriptional regulator Su(H) (PubMed:27151950, PubMed:28899667, PubMed:20152183, PubMed:18342578, PubMed:23056424, PubMed:21262215).
1 Publication13 PublicationsGO - Molecular functioni
- calcium ion binding Source: InterPro
- chromatin binding Source: FlyBase
- histone acetyltransferase binding Source: FlyBase
- transcription coactivator activity Source: FlyBase
- transmembrane signaling receptor activity Source: FlyBase
- WW domain binding Source: FlyBase
GO - Biological processi
- actin filament organization Source: FlyBase
- asymmetric cell division Source: FlyBase
- axon guidance Source: FlyBase
- border follicle cell migration Source: FlyBase
- cell dedifferentiation Source: UniProtKB
- cell differentiation Source: FlyBase
- cell fate commitment Source: FlyBase
- chaeta development Source: FlyBase
- chaeta morphogenesis Source: FlyBase
- compartment boundary maintenance Source: FlyBase
- compound eye development Source: FlyBase
- compound eye morphogenesis Source: FlyBase
- compound eye retinal cell programmed cell death Source: FlyBase
- crystal cell differentiation Source: FlyBase
- defense response to insect Source: FlyBase
- determination of adult lifespan Source: FlyBase
- dorsal/ventral axis specification Source: FlyBase
- dorsal appendage formation Source: FlyBase
- dorsal closure Source: FlyBase
- embryonic hemopoiesis Source: FlyBase
- epithelial cell proliferation involved in Malpighian tubule morphogenesis Source: FlyBase
- epithelial cell type specification, open tracheal system Source: FlyBase
- eye-antennal disc development Source: FlyBase
- eye-antennal disc morphogenesis Source: FlyBase
- female germ-line stem cell population maintenance Source: FlyBase
- foregut morphogenesis Source: FlyBase
- formation of a compartment boundary Source: FlyBase
- germarium-derived egg chamber formation Source: FlyBase
- germ-line stem-cell niche homeostasis Source: FlyBase
- germ-line stem cell population maintenance Source: FlyBase
- glial cell differentiation Source: FlyBase
- glial cell fate determination Source: FlyBase
- glial cell migration Source: FlyBase
- hemocyte proliferation Source: FlyBase
- imaginal disc-derived leg joint morphogenesis Source: FlyBase
- imaginal disc-derived leg morphogenesis Source: FlyBase
- imaginal disc-derived leg segmentation Source: FlyBase
- imaginal disc-derived male genitalia morphogenesis Source: FlyBase
- imaginal disc-derived wing margin morphogenesis Source: FlyBase
- imaginal disc-derived wing morphogenesis Source: FlyBase
- imaginal disc-derived wing vein specification Source: FlyBase
- intestinal stem cell homeostasis Source: FlyBase
- lamellocyte differentiation Source: FlyBase
- larval lymph gland hemopoiesis Source: FlyBase
- lateral inhibition Source: FlyBase
- leg disc morphogenesis Source: FlyBase
- long-term memory Source: FlyBase
- lymph gland development Source: FlyBase
- Malpighian tubule tip cell differentiation Source: FlyBase
- mesoderm development Source: FlyBase
- morphogenesis of an epithelial fold Source: FlyBase
- motor neuron axon guidance Source: FlyBase
- muscle cell cellular homeostasis Source: FlyBase
- muscle cell fate determination Source: FlyBase
- myoblast development Source: FlyBase
- negative regulation of cell-cell adhesion mediated by cadherin Source: FlyBase
- negative regulation of compound eye photoreceptor development Source: FlyBase
- negative regulation of gene expression Source: UniProtKB
- negative regulation of lamellocyte differentiation Source: FlyBase
- negative regulation of neurogenesis Source: FlyBase
- nervous system process Source: FlyBase
- neuroblast development Source: UniProtKB
- neuroblast fate determination Source: FlyBase
- neuroblast fate specification Source: UniProtKB
- neuroblast proliferation Source: UniProtKB
- neuronal stem cell population maintenance Source: FlyBase
- neuron fate determination Source: FlyBase
- neuron fate specification Source: FlyBase
- Notch signaling pathway Source: FlyBase
- oocyte localization involved in germarium-derived egg chamber formation Source: FlyBase
- oogenesis Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- ovarian follicle cell migration Source: FlyBase
- ovarian follicle cell stalk formation Source: FlyBase
- peripheral nervous system development Source: FlyBase
- positive regulation of cell population proliferation Source: FlyBase
- positive regulation of crystal cell differentiation Source: FlyBase
- positive regulation of G1/S transition of mitotic cell cycle Source: FlyBase
- positive regulation of gene expression Source: FlyBase
- positive regulation of neuroblast proliferation Source: UniProtKB
- positive regulation of neuron apoptotic process Source: FlyBase
- positive regulation of transcription, DNA-templated Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- R1/R6 cell differentiation Source: FlyBase
- R3/R4 cell differentiation Source: FlyBase
- R7 cell differentiation Source: FlyBase
- regulation of cardioblast cell fate specification Source: FlyBase
- regulation of cell differentiation Source: FlyBase
- regulation of filopodium assembly Source: FlyBase
- regulation of glycolytic process Source: FlyBase
- regulation of growth Source: FlyBase
- regulation of mitotic cell cycle Source: FlyBase
- regulation of neuroblast proliferation Source: UniProtKB
- regulation of neurogenesis Source: FlyBase
- regulation of stem cell division Source: FlyBase
- response to symbiont Source: FlyBase
- retinal cell programmed cell death Source: FlyBase
- second mitotic wave involved in compound eye morphogenesis Source: FlyBase
- sensory organ development Source: FlyBase
- sensory organ precursor cell fate determination Source: FlyBase
- stem cell differentiation Source: FlyBase
- wing disc dorsal/ventral pattern formation Source: FlyBase
- wing disc pattern formation Source: FlyBase
Keywordsi
Molecular function | Activator, Developmental protein, Receptor |
Biological process | Differentiation, Neurogenesis, Notch signaling pathway, Oogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-DME-1474228, Degradation of the extracellular matrix R-DME-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-DME-2022854, Keratan sulfate biosynthesis R-DME-2022857, Keratan sulfate degradation R-DME-2022870, Chondroitin sulfate biosynthesis R-DME-2022923, Dermatan sulfate biosynthesis R-DME-2024101, CS/DS degradation R-DME-3000178, ECM proteoglycans R-DME-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-8957275, Post-translational protein phosphorylation |
SignaLinki | P07207 |
Names & Taxonomyi
Protein namesi | Recommended name: Neurogenic locus Notch proteinCleaved into the following chain: |
Gene namesi | Name:N ORF Names:CG3936 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0004647, N |
VEuPathDBi | VectorBase:FBgn0004647 |
Subcellular locationi
Endosome
- Endosome 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: Transported to early endosomes by O-fut1 (PubMed:17329366).
Nucleus
Note: Upon activation and S3 cleavage, it is released from the cell membrane and enters into the nucleus in conjunction with Su(H).
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: FlyBase
- endoplasmic reticulum lumen Source: Reactome
Endosome
- early endosome Source: FlyBase
- endosome Source: FlyBase
- late endosome Source: FlyBase
Golgi apparatus
- Golgi lumen Source: Reactome
Nucleus
- CSL-Notch-Mastermind transcription factor complex Source: FlyBase
- nucleoplasm Source: Reactome
- nucleus Source: FlyBase
Plasma Membrane
- apical plasma membrane Source: FlyBase
- integral component of plasma membrane Source: FlyBase
- plasma membrane Source: FlyBase
Other locations
- adherens junction Source: FlyBase
- cell surface Source: FlyBase
- cytoplasm Source: FlyBase
- endocytic vesicle Source: FlyBase
- integral component of membrane Source: FlyBase
- protein-containing complex Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 53 – 1745 | ExtracellularSequence analysisAdd BLAST | 1693 | |
Transmembranei | 1746 – 1766 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1767 – 2703 | CytoplasmicSequence analysisAdd BLAST | 937 |
Keywords - Cellular componenti
Cell membrane, Endosome, Membrane, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 739 | C → Y in mcd5; induces loss of microchaetae sensory precursors. | 1 | |
Mutagenesisi | 2060 | A → V in su42c; deltex-like mutation that induces outstreched wings and variability-fused ocelli. | 1 | |
Mutagenesisi | 2328 | Y → F: Abolishes interaction with Nedd4 and reduces ubiquitination. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 52 | Sequence analysisAdd BLAST | 52 | |
ChainiPRO_0000007673 | 53 – 2703 | Neurogenic locus Notch proteinAdd BLAST | 2651 | |
ChainiPRO_0000296234 | ? – 2703 | Processed neurogenic locus Notch protein |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 62 ↔ 73 | PROSITE-ProRule annotation | ||
Disulfide bondi | 67 ↔ 83 | PROSITE-ProRule annotation | ||
Glycosylationi | 72 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 85 ↔ 94 | PROSITE-ProRule annotation | ||
Disulfide bondi | 100 ↔ 111 | PROSITE-ProRule annotation | ||
Disulfide bondi | 105 ↔ 124 | PROSITE-ProRule annotation | ||
Glycosylationi | 110 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 126 ↔ 135 | PROSITE-ProRule annotation | ||
Disulfide bondi | 143 ↔ 154 | PROSITE-ProRule annotation | ||
Disulfide bondi | 148 ↔ 164 | PROSITE-ProRule annotation | ||
Glycosylationi | 153 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 166 ↔ 175 | PROSITE-ProRule annotation | ||
Disulfide bondi | 181 ↔ 192 | PROSITE-ProRule annotation | ||
Glycosylationi | 183 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 186 ↔ 203 | PROSITE-ProRule annotation | ||
Glycosylationi | 191 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 205 ↔ 214 | PROSITE-ProRule annotation | ||
Glycosylationi | 210 | O-linked (GlcNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 221 ↔ 232 | PROSITE-ProRule annotation | ||
Glycosylationi | 223 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 226 ↔ 241 | PROSITE-ProRule annotation | ||
Glycosylationi | 231 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 243 ↔ 252 | PROSITE-ProRule annotation | ||
Disulfide bondi | 259 ↔ 270 | PROSITE-ProRule annotation | ||
Disulfide bondi | 264 ↔ 279 | PROSITE-ProRule annotation | ||
Disulfide bondi | 281 ↔ 290 | PROSITE-ProRule annotation | ||
Disulfide bondi | 297 ↔ 308 | PROSITE-ProRule annotation | ||
Disulfide bondi | 302 ↔ 317 | PROSITE-ProRule annotation | ||
Glycosylationi | 307 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 319 ↔ 328 | PROSITE-ProRule annotation | ||
Glycosylationi | 322 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 335 ↔ 349 | PROSITE-ProRule annotation | ||
Disulfide bondi | 343 ↔ 358 | PROSITE-ProRule annotation | ||
Glycosylationi | 348 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 360 ↔ 369 | PROSITE-ProRule annotation | ||
Glycosylationi | 371 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 376 ↔ 387 | PROSITE-ProRule annotation | ||
Disulfide bondi | 381 ↔ 396 | PROSITE-ProRule annotation | ||
Glycosylationi | 386 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 398 ↔ 407 | PROSITE-ProRule annotation | ||
Disulfide bondi | 413 ↔ 424 | PROSITE-ProRule annotation | ||
Disulfide bondi | 418 ↔ 435 | PROSITE-ProRule annotation | ||
Glycosylationi | 427 | O-linked (Glc...) serine1 Publication | 1 | |
Glycosylationi | 430 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 437 ↔ 446 | PROSITE-ProRule annotation | ||
Disulfide bondi | 453 ↔ 465 | PROSITE-ProRule annotation | ||
Disulfide bondi | 459 ↔ 474 | PROSITE-ProRule annotation | ||
Glycosylationi | 475 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 476 ↔ 485 | PROSITE-ProRule annotation | ||
Glycosylationi | 481 | O-linked (GlcNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 492 ↔ 503 | PROSITE-ProRule annotation | ||
Glycosylationi | 494 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 497 ↔ 512 | PROSITE-ProRule annotation | ||
Glycosylationi | 502 | O-linked (Fuc...) serine1 Publication | 1 | |
Disulfide bondi | 514 ↔ 523 | PROSITE-ProRule annotation | ||
Glycosylationi | 519 | O-linked (GlcNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 530 ↔ 541 | PROSITE-ProRule annotation | ||
Glycosylationi | 532 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 535 ↔ 550 | PROSITE-ProRule annotation | ||
Disulfide bondi | 552 ↔ 561 | PROSITE-ProRule annotation | ||
Disulfide bondi | 568 ↔ 579 | PROSITE-ProRule annotation | ||
Glycosylationi | 570 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 573 ↔ 588 | PROSITE-ProRule annotation | ||
Disulfide bondi | 590 ↔ 599 | PROSITE-ProRule annotation | ||
Glycosylationi | 595 | O-linked (GlcNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 606 ↔ 616 | PROSITE-ProRule annotation | ||
Glycosylationi | 608 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 611 ↔ 625 | PROSITE-ProRule annotation | ||
Disulfide bondi | 627 ↔ 636 | PROSITE-ProRule annotation | ||
Disulfide bondi | 643 ↔ 654 | PROSITE-ProRule annotation | ||
Glycosylationi | 645 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 648 ↔ 663 | PROSITE-ProRule annotation | ||
Disulfide bondi | 665 ↔ 674 | PROSITE-ProRule annotation | ||
Disulfide bondi | 681 ↔ 692 | PROSITE-ProRule annotation | ||
Glycosylationi | 683 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 686 ↔ 701 | PROSITE-ProRule annotation | ||
Glycosylationi | 691 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 703 ↔ 712 | PROSITE-ProRule annotation | ||
Disulfide bondi | 719 ↔ 730 | PROSITE-ProRule annotation | ||
Glycosylationi | 721 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 724 ↔ 739 | PROSITE-ProRule annotation | ||
Disulfide bondi | 741 ↔ 750 | PROSITE-ProRule annotation | ||
Disulfide bondi | 757 ↔ 768 | PROSITE-ProRule annotation | ||
Glycosylationi | 759 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 762 ↔ 777 | PROSITE-ProRule annotation | ||
Disulfide bondi | 779 ↔ 788 | PROSITE-ProRule annotation | ||
Disulfide bondi | 795 ↔ 806 | PROSITE-ProRule annotation | ||
Glycosylationi | 797 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 800 ↔ 815 | PROSITE-ProRule annotation | ||
Glycosylationi | 805 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 817 ↔ 826 | PROSITE-ProRule annotation | ||
Glycosylationi | 822 | O-linked (GlcNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 833 ↔ 844 | PROSITE-ProRule annotation | ||
Disulfide bondi | 838 ↔ 853 | PROSITE-ProRule annotation | ||
Glycosylationi | 843 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 855 ↔ 864 | PROSITE-ProRule annotation | ||
Disulfide bondi | 871 ↔ 882 | PROSITE-ProRule annotation | ||
Disulfide bondi | 876 ↔ 893 | PROSITE-ProRule annotation | ||
Disulfide bondi | 895 ↔ 904 | PROSITE-ProRule annotation | ||
Disulfide bondi | 911 ↔ 923 | PROSITE-ProRule annotation | ||
Disulfide bondi | 917 ↔ 932 | PROSITE-ProRule annotation | ||
Glycosylationi | 922 | O-linked (Fuc...) serine1 Publication | 1 | |
Disulfide bondi | 934 ↔ 943 | PROSITE-ProRule annotation | ||
Disulfide bondi | 950 ↔ 961 | PROSITE-ProRule annotation | ||
Glycosylationi | 952 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 955 ↔ 970 | PROSITE-ProRule annotation | ||
Glycosylationi | 960 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 972 ↔ 981 | PROSITE-ProRule annotation | ||
Disulfide bondi | 988 ↔ 999 | PROSITE-ProRule annotation | ||
Glycosylationi | 990 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 993 ↔ 1008 | PROSITE-ProRule annotation | ||
Glycosylationi | 998 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 1010 ↔ 1019 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1026 ↔ 1037 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1031 ↔ 1046 | PROSITE-ProRule annotation | ||
Glycosylationi | 1036 | O-linked (Fuc...) serine1 Publication | 1 | |
Glycosylationi | 1045 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1048 ↔ 1057 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1064 ↔ 1075 | PROSITE-ProRule annotation | ||
Glycosylationi | 1066 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 1069 ↔ 1084 | PROSITE-ProRule annotation | ||
Glycosylationi | 1074 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 1086 ↔ 1095 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1102 ↔ 1113 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1107 ↔ 1122 | PROSITE-ProRule annotation | ||
Glycosylationi | 1112 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 1124 ↔ 1133 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1155 ↔ 1160 | PROSITE-ProRule annotation | ||
Glycosylationi | 1157 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1171 ↔ 1180 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1187 ↔ 1198 | PROSITE-ProRule annotation | ||
Glycosylationi | 1189 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 1192 ↔ 1207 | PROSITE-ProRule annotation | ||
Glycosylationi | 1197 | O-linked (Fuc...) threonine1 Publication | 1 | |
Disulfide bondi | 1209 ↔ 1218 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1225 ↔ 1236 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1230 ↔ 1245 | PROSITE-ProRule annotation | ||
Glycosylationi | 1235 | O-linked (Fuc...) threonine1 Publication | 1 | |
Glycosylationi | 1242 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1247 ↔ 1256 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1263 ↔ 1274 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1268 ↔ 1283 | PROSITE-ProRule annotation | ||
Glycosylationi | 1271 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1273 | O-linked (Fuc...) serine1 Publication | 1 | |
Disulfide bondi | 1285 ↔ 1294 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1301 ↔ 1314 | PROSITE-ProRule annotation | ||
Glycosylationi | 1303 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 1306 ↔ 1323 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1325 ↔ 1334 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1341 ↔ 1352 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1346 ↔ 1361 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1363 ↔ 1372 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1379 ↔ 1389 | PROSITE-ProRule annotation | ||
Glycosylationi | 1381 | O-linked (Glc...) serine1 Publication | 1 | |
Disulfide bondi | 1384 ↔ 1400 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1402 ↔ 1411 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1419 ↔ 1430 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1424 ↔ 1439 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1441 ↔ 1450 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1482 ↔ 1505 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1487 ↔ 1500 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1496 ↔ 1512 | PROSITE-ProRule annotation | ||
Glycosylationi | 1521 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1522 ↔ 1545 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1527 ↔ 1540 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1536 ↔ 1552 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1559 ↔ 1585 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1567 ↔ 1580 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1576 ↔ 1592 | PROSITE-ProRule annotation | ||
Glycosylationi | 1594 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1627 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 2447 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | P07207 |
PTM databases
GlyGeni | P07207, 55 sites |
iPTMneti | P07207 |
Expressioni
Gene expression databases
Bgeei | FBgn0004647, Expressed in embryo and 39 other tissues |
ExpressionAtlasi | P07207, baseline and differential |
Genevisiblei | P07207, DM |
Interactioni
Subunit structurei
Homomer.
Interacts with Su(H) when activated.
Interacts with Dx via its ANK repeats.
Interacts with Dl via the EGF repeats and the Dl EGF repeats.
Interacts with Nedd4 and Su(dx).
Interacts with O-fut1; the interaction glycosylates N and transports N to early endosomes.
Interacts with Akap200; the interaction stabilizes N/Notch protein levels by preventing Cbl-mediated ubiquitination and subsequent lysosomal degradation of N/Notch (PubMed:29309414).
8 PublicationsBinary interactionsi
P07207
With | #Exp. | IntAct |
---|---|---|
cno [Q24279] | 3 | EBI-103438,EBI-868783 |
Dl [P10041] | 2 | EBI-103438,EBI-115346 |
dx [Q23985] | 4 | EBI-103438,EBI-190618 |
Su(H) [P28159] | 7 | EBI-103438,EBI-92180 |
GO - Molecular functioni
- histone acetyltransferase binding Source: FlyBase
- WW domain binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 57823, 309 interactors |
DIPi | DIP-5N |
IntActi | P07207, 229 interactors |
MINTi | P07207 |
STRINGi | 7227.FBpp0070483 |
Structurei
Secondary structure
3D structure databases
SMRi | P07207 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07207 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 95 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 96 – 136 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 139 – 176 | EGF-like 3PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 177 – 215 | EGF-like 4PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 217 – 253 | EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 255 – 291 | EGF-like 6PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 293 – 329 | EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 331 – 370 | EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 372 – 408 | EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 409 – 447 | EGF-like 10PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 449 – 486 | EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 488 – 524 | EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 526 – 562 | EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 564 – 600 | EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 602 – 637 | EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 639 – 675 | EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 677 – 713 | EGF-like 17; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 715 – 751 | EGF-like 18; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 753 – 789 | EGF-like 19; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 791 – 827 | EGF-like 20; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 829 – 865 | EGF-like 21; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 867 – 905 | EGF-like 22PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 907 – 944 | EGF-like 23; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 946 – 982 | EGF-like 24; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 984 – 1020 | EGF-like 25PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1022 – 1058 | EGF-like 26; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1060 – 1096 | EGF-like 27PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1098 – 1134 | EGF-like 28PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1136 – 1181 | EGF-like 29PROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 1183 – 1219 | EGF-like 30; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1221 – 1257 | EGF-like 31; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1259 – 1295 | EGF-like 32; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1297 – 1335 | EGF-like 33PROSITE-ProRule annotationAdd BLAST | 39 | |
Domaini | 1337 – 1373 | EGF-like 34PROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 1375 – 1412 | EGF-like 35PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 1415 – 1451 | EGF-like 36PROSITE-ProRule annotationAdd BLAST | 37 | |
Repeati | 1482 – 1521 | LNR 1PROSITE-ProRule annotationAdd BLAST | 40 | |
Repeati | 1522 – 1557 | LNR 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Repeati | 1559 – 1599 | LNR 3PROSITE-ProRule annotationAdd BLAST | 41 | |
Repeati | 1901 – 1945 | ANK 1Sequence analysisAdd BLAST | 45 | |
Repeati | 1950 – 1979 | ANK 2Sequence analysisAdd BLAST | 30 | |
Repeati | 1983 – 2013 | ANK 3Sequence analysisAdd BLAST | 31 | |
Repeati | 2017 – 2046 | ANK 4Sequence analysisAdd BLAST | 30 | |
Repeati | 2050 – 2079 | ANK 5Sequence analysisAdd BLAST | 30 | |
Repeati | 2083 – 2112 | ANK 6Sequence analysisAdd BLAST | 30 | |
Repeati | 2116 – 2139 | ANK 7Sequence analysisAdd BLAST | 24 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1810 – 1850 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 2172 – 2257 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 2325 – 2328 | Interaction with Nedd4 | 4 | |
Regioni | 2399 – 2452 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 2488 – 2524 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 2579 – 2620 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 2632 – 2703 | DisorderedSequence analysisAdd BLAST | 72 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2172 – 2199 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 2224 – 2248 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 2402 – 2433 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 2588 – 2620 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 2632 – 2692 | Polar residuesSequence analysisAdd BLAST | 61 |
Domaini
Sequence similaritiesi
Keywords - Domaini
ANK repeat, EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00980000198606 |
HOGENOMi | CLU_000576_0_1_1 |
InParanoidi | P07207 |
OMAi | IAGYSCE |
OrthoDBi | 7525at2759 |
PhylomeDBi | P07207 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
IDEALi | IID50157 |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR008297, Notch IPR035993, Notch-like_dom_sf IPR024600, Notch_C IPR000800, Notch_dom IPR010660, Notch_NOD_dom IPR011656, Notch_NODP_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 1 hit PF13857, Ank_5, 1 hit PF00008, EGF, 24 hits PF07645, EGF_CA, 3 hits PF12661, hEGF, 2 hits PF06816, NOD, 1 hit PF07684, NODP, 1 hit PF00066, Notch, 3 hits |
PIRSFi | PIRSF002279, Notch, 1 hit |
PRINTSi | PR01452, LNOTCHREPEAT |
SMARTi | View protein in SMART SM00248, ANK, 7 hits SM01334, DUF3454, 1 hit SM00181, EGF, 36 hits SM00179, EGF_CA, 33 hits SM00004, NL, 3 hits SM01338, NOD, 1 hit SM01339, NODP, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57184, SSF57184, 5 hits SSF90193, SSF90193, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS00010, ASX_HYDROXYL, 22 hits PS00022, EGF_1, 34 hits PS01186, EGF_2, 28 hits PS50026, EGF_3, 36 hits PS01187, EGF_CA, 21 hits PS50258, LNR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MQSQRSRRRS RAPNTWICFW INKMHAVASL PASLPLLLLT LAFANLPNTV
60 70 80 90 100
RGTDTALVAA SCTSVGCQNG GTCVTQLNGK TYCACDSHYV GDYCEHRNPC
110 120 130 140 150
NSMRCQNGGT CQVTFRNGRP GISCKCPLGF DESLCEIAVP NACDHVTCLN
160 170 180 190 200
GGTCQLKTLE EYTCACANGY TGERCETKNL CASSPCRNGA TCTALAGSSS
210 220 230 240 250
FTCSCPPGFT GDTCSYDIEE CQSNPCKYGG TCVNTHGSYQ CMCPTGYTGK
260 270 280 290 300
DCDTKYKPCS PSPCQNGGIC RSNGLSYECK CPKGFEGKNC EQNYDDCLGH
310 320 330 340 350
LCQNGGTCID GISDYTCRCP PNFTGRFCQD DVDECAQRDH PVCQNGATCT
360 370 380 390 400
NTHGSYSCIC VNGWAGLDCS NNTDDCKQAA CFYGATCIDG VGSFYCQCTK
410 420 430 440 450
GKTGLLCHLD DACTSNPCHA DAICDTSPIN GSYACSCATG YKGVDCSEDI
460 470 480 490 500
DECDQGSPCE HNGICVNTPG SYRCNCSQGF TGPRCETNIN ECESHPCQNE
510 520 530 540 550
GSCLDDPGTF RCVCMPGFTG TQCEIDIDEC QSNPCLNDGT CHDKINGFKC
560 570 580 590 600
SCALGFTGAR CQINIDDCQS QPCRNRGICH DSIAGYSCEC PPGYTGTSCE
610 620 630 640 650
ININDCDSNP CHRGKCIDDV NSFKCLCDPG YTGYICQKQI NECESNPCQF
660 670 680 690 700
DGHCQDRVGS YYCQCQAGTS GKNCEVNVNE CHSNPCNNGA TCIDGINSYK
710 720 730 740 750
CQCVPGFTGQ HCEKNVDECI SSPCANNGVC IDQVNGYKCE CPRGFYDAHC
760 770 780 790 800
LSDVDECASN PCVNEGRCED GINEFICHCP PGYTGKRCEL DIDECSSNPC
810 820 830 840 850
QHGGTCYDKL NAFSCQCMPG YTGQKCETNI DDCVTNPCGN GGTCIDKVNG
860 870 880 890 900
YKCVCKVPFT GRDCESKMDP CASNRCKNEA KCTPSSNFLD FSCTCKLGYT
910 920 930 940 950
GRYCDEDIDE CSLSSPCRNG ASCLNVPGSY RCLCTKGYEG RDCAINTDDC
960 970 980 990 1000
ASFPCQNGGT CLDGIGDYSC LCVDGFDGKH CETDINECLS QPCQNGATCS
1010 1020 1030 1040 1050
QYVNSYTCTC PLGFSGINCQ TNDEDCTESS CLNGGSCIDG INGYNCSCLA
1060 1070 1080 1090 1100
GYSGANCQYK LNKCDSNPCL NGATCHEQNN EYTCHCPSGF TGKQCSEYVD
1110 1120 1130 1140 1150
WCGQSPCENG ATCSQMKHQF SCKCSAGWTG KLCDVQTISC QDAADRKGLS
1160 1170 1180 1190 1200
LRQLCNNGTC KDYGNSHVCY CSQGYAGSYC QKEIDECQSQ PCQNGGTCRD
1210 1220 1230 1240 1250
LIGAYECQCR QGFQGQNCEL NIDDCAPNPC QNGGTCHDRV MNFSCSCPPG
1260 1270 1280 1290 1300
TMGIICEINK DDCKPGACHN NGSCIDRVGG FECVCQPGFV GARCEGDINE
1310 1320 1330 1340 1350
CLSNPCSNAG TLDCVQLVNN YHCNCRPGHM GRHCEHKVDF CAQSPCQNGG
1360 1370 1380 1390 1400
NCNIRQSGHH CICNNGFYGK NCELSGQDCD SNPCRVGNCV VADEGFGYRC
1410 1420 1430 1440 1450
ECPRGTLGEH CEIDTLDECS PNPCAQGAAC EDLLGDYECL CPSKWKGKRC
1460 1470 1480 1490 1500
DIYDANYPGW NGGSGSGNDR YAADLEQQRA MCDKRGCTEK QGNGICDSDC
1510 1520 1530 1540 1550
NTYACNFDGN DCSLGINPWA NCTANECWNK FKNGKCNEEC NNAACHYDGH
1560 1570 1580 1590 1600
DCERKLKSCD SLFDAYCQKH YGDGFCDYGC NNAECSWDGL DCENKTQSPV
1610 1620 1630 1640 1650
LAEGAMSVVM LMNVEAFREI QAQFLRNMSH MLRTTVRLKK DALGHDIIIN
1660 1670 1680 1690 1700
WKDNVRVPEI EDTDFARKNK ILYTQQVHQT GIQIYLEIDN RKCTECFTHA
1710 1720 1730 1740 1750
VEAAEFLAAT AAKHQLRNDF QIHSVRGIKN PGDEDNGEPP ANVKYVITGI
1760 1770 1780 1790 1800
ILVIIALAFF GMVLSTQRKR AHGVTWFPEG FRAPAAVMSR RRRDPHGQEM
1810 1820 1830 1840 1850
RNLNKQVAMQ SQGVGQPGAH WSDDESDMPL PKRQRSDPVS GVGLGNNGGY
1860 1870 1880 1890 1900
ASDHTMVSEY EEADQRVWSQ AHLDVVDVRA IMTPPAHQDG GKHDVDARGP
1910 1920 1930 1940 1950
CGLTPLMIAA VRGGGLDTGE DIENNEDSTA QVISDLLAQG AELNATMDKT
1960 1970 1980 1990 2000
GETSLHLAAR FARADAAKRL LDAGADANCQ DNTGRTPLHA AVAADAMGVF
2010 2020 2030 2040 2050
QILLRNRATN LNARMHDGTT PLILAARLAI EGMVEDLITA DADINAADNS
2060 2070 2080 2090 2100
GKTALHWAAA VNNTEAVNIL LMHHANRDAQ DDKDETPLFL AAREGSYEAC
2110 2120 2130 2140 2150
KALLDNFANR EITDHMDRLP RDVASERLHH DIVRLLDEHV PRSPQMLSMT
2160 2170 2180 2190 2200
PQAMIGSPPP GQQQPQLITQ PTVISAGNGG NNGNGNASGK QSNQTAKQKA
2210 2220 2230 2240 2250
AKKAKLIEGS PDNGLDATGS LRRKASSKKT SAASKKAANL NGLNPGQLTG
2260 2270 2280 2290 2300
GVSGVPGVPP TNSAAQAAAA AAAAVAAMSH ELEGSPVGVG MGGNLPSPYD
2310 2320 2330 2340 2350
TSSMYSNAMA APLANGNPNT GAKQPPSYED CIKNAQSMQS LQGNGLDMIK
2360 2370 2380 2390 2400
LDNYAYSMGS PFQQELLNGQ GLGMNGNGQR NGVGPGVLPG GLCGMGGLSG
2410 2420 2430 2440 2450
AGNGNSHEQG LSPPYSNQSP PHSVQSSLAL SPHAYLGSPS PAKSRPSLPT
2460 2470 2480 2490 2500
SPTHIQAMRH ATQQKQFGGS NLNSLLGGAN GGGVVGGGGG GGGGVGQGPQ
2510 2520 2530 2540 2550
NSPVSLGIIS PTGSDMGIML APPQSSKNSA IMQTISPQQQ QQQQQQQQQQ
2560 2570 2580 2590 2600
HQQQQQQQQQ QQQQQQQQLG GLEFGSAGLD LNGFCGSPDS FHSGQMNPPS
2610 2620 2630 2640 2650
IQSSMSGSSP STNMLSPSSQ HNQQAFYQYL TPSSQHSGGH TPQHLVQTLD
2660 2670 2680 2690 2700
SYPTPSPESP GHWSSSSPRS NSDWSEGVQS PAANNLYISG GHQANKGSEA
IYI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM9NE67 | M9NE67_DROME | Notch, isoform B | N 1.1, 16-178, 16-55, anon-EST:Liang-1.12, Ax | 2,703 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | R → G in CAB37610 (PubMed:10731137).Curated | 1 | |
Sequence conflicti | 84 | A → G in CAB37610 (PubMed:10731137).Curated | 1 | |
Sequence conflicti | 103 | M → I in AAB59220 (PubMed:3935325).Curated | 1 | |
Sequence conflicti | 119 | R → H in AAA28725 (PubMed:3097517).Curated | 1 | |
Sequence conflicti | 231 | T → I in AAB59220 (PubMed:3935325).Curated | 1 | |
Sequence conflicti | 240 | Q → R in CAB37610 (PubMed:10731137).Curated | 1 | |
Sequence conflicti | 267 | G → A in AAB59220 (PubMed:3935325).Curated | 1 | |
Sequence conflicti | 1561 | S → T in AAB59220 (PubMed:3935325).Curated | 1 | |
Sequence conflicti | 1561 | S → T in AAA28725 (PubMed:3097517).Curated | 1 | |
Sequence conflicti | 2257 | G → S in AAA28725 (PubMed:3097517).Curated | 1 | |
Sequence conflicti | 2577 | A → E in AAA74496 (PubMed:2981631).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 578 | I → T. | 1 | |
Natural varianti | 2044 | I → R. | 1 | |
Natural varianti | 2265 | A → V. | 1 | |
Natural varianti | 2407 | H → R. | 1 | |
Natural varianti | 2445 | R → L. | 1 | |
Natural varianti | 2568 | Q → QQQQQ. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16152 , M16153, M16149, M16150, M16151 Genomic DNA Translation: AAB59220.1 K03508, M13689, K03507 Genomic DNA Translation: AAA28725.1 AE014298 Genomic DNA Translation: AAF45848.2 AL035436, AL035395 Genomic DNA Translation: CAB37610.1 M16025 Genomic DNA Translation: AAA28726.1 M12175 Genomic DNA Translation: AAA74496.1 |
PIRi | A24420 |
RefSeqi | NP_001245510.1, NM_001258581.2 NP_476859.2, NM_057511.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0070507; FBpp0070483; FBgn0004647 FBtr0304659; FBpp0293201; FBgn0004647 |
GeneIDi | 31293 |
KEGGi | dme:Dmel_CG3936 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16152 , M16153, M16149, M16150, M16151 Genomic DNA Translation: AAB59220.1 K03508, M13689, K03507 Genomic DNA Translation: AAA28725.1 AE014298 Genomic DNA Translation: AAF45848.2 AL035436, AL035395 Genomic DNA Translation: CAB37610.1 M16025 Genomic DNA Translation: AAA28726.1 M12175 Genomic DNA Translation: AAA74496.1 |
PIRi | A24420 |
RefSeqi | NP_001245510.1, NM_001258581.2 NP_476859.2, NM_057511.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OT8 | X-ray | 2.00 | A/B/C | 1902-2139 | [»] | |
2JMF | NMR | - | B | 2318-2333 | [»] | |
7ALJ | X-ray | 1.52 | A | 449-564 | [»] | |
SMRi | P07207 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 57823, 309 interactors |
DIPi | DIP-5N |
IntActi | P07207, 229 interactors |
MINTi | P07207 |
STRINGi | 7227.FBpp0070483 |
PTM databases
GlyGeni | P07207, 55 sites |
iPTMneti | P07207 |
Proteomic databases
PaxDbi | P07207 |
Protocols and materials databases
DNASUi | 31293 |
Genome annotation databases
EnsemblMetazoai | FBtr0070507; FBpp0070483; FBgn0004647 FBtr0304659; FBpp0293201; FBgn0004647 |
GeneIDi | 31293 |
KEGGi | dme:Dmel_CG3936 |
Organism-specific databases
CTDi | 109544 |
FlyBasei | FBgn0004647, N |
VEuPathDBi | VectorBase:FBgn0004647 |
Phylogenomic databases
eggNOGi | KOG1217, Eukaryota |
GeneTreei | ENSGT00980000198606 |
HOGENOMi | CLU_000576_0_1_1 |
InParanoidi | P07207 |
OMAi | IAGYSCE |
OrthoDBi | 7525at2759 |
PhylomeDBi | P07207 |
Enzyme and pathway databases
Reactomei | R-DME-1474228, Degradation of the extracellular matrix R-DME-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-DME-2022854, Keratan sulfate biosynthesis R-DME-2022857, Keratan sulfate degradation R-DME-2022870, Chondroitin sulfate biosynthesis R-DME-2022923, Dermatan sulfate biosynthesis R-DME-2024101, CS/DS degradation R-DME-3000178, ECM proteoglycans R-DME-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-DME-8957275, Post-translational protein phosphorylation |
SignaLinki | P07207 |
Miscellaneous databases
BioGRID-ORCSi | 31293, 0 hits in 3 CRISPR screens |
ChiTaRSi | N, fly |
EvolutionaryTracei | P07207 |
GenomeRNAii | 31293 |
PROi | PR:P07207 |
Gene expression databases
Bgeei | FBgn0004647, Expressed in embryo and 39 other tissues |
ExpressionAtlasi | P07207, baseline and differential |
Genevisiblei | P07207, DM |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
IDEALi | IID50157 |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR001881, EGF-like_Ca-bd_dom IPR013032, EGF-like_CS IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR008297, Notch IPR035993, Notch-like_dom_sf IPR024600, Notch_C IPR000800, Notch_dom IPR010660, Notch_NOD_dom IPR011656, Notch_NODP_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 1 hit PF13857, Ank_5, 1 hit PF00008, EGF, 24 hits PF07645, EGF_CA, 3 hits PF12661, hEGF, 2 hits PF06816, NOD, 1 hit PF07684, NODP, 1 hit PF00066, Notch, 3 hits |
PIRSFi | PIRSF002279, Notch, 1 hit |
PRINTSi | PR01452, LNOTCHREPEAT |
SMARTi | View protein in SMART SM00248, ANK, 7 hits SM01334, DUF3454, 1 hit SM00181, EGF, 36 hits SM00179, EGF_CA, 33 hits SM00004, NL, 3 hits SM01338, NOD, 1 hit SM01339, NODP, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF57184, SSF57184, 5 hits SSF90193, SSF90193, 3 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS00010, ASX_HYDROXYL, 22 hits PS00022, EGF_1, 34 hits PS01186, EGF_2, 28 hits PS50026, EGF_3, 36 hits PS01187, EGF_CA, 21 hits PS50258, LNR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | NOTCH_DROME | |
Accessioni | P07207Primary (citable) accession number: P07207 Secondary accession number(s): O97458, P04154, Q9W4T8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1986 |
Last sequence update: | November 2, 2001 | |
Last modified: | May 25, 2022 | |
This is version 254 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families