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Protein

Glutathione peroxidase 1

Gene

GPX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protects the hemoglobin in erythrocytes from oxidative breakdown.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei491
Sitei49Subject to oxidation and hydroselenide loss to dehydroalanineBy similarity1

GO - Molecular functioni

  • glutathione peroxidase activity Source: BHF-UCL
  • SH3 domain binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciMetaCyc:HS00019-MONOMER
BRENDAi1.11.1.9 2681
ReactomeiR-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-74259 Purine catabolism
SIGNORiP07203

Protein family/group databases

PeroxiBasei3600 HsGPx01-A

Chemistry databases

SwissLipidsiSLP:000001632

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 1 (EC:1.11.1.9)
Short name:
GPx-1
Short name:
GSHPx-1
Alternative name(s):
Cellular glutathione peroxidase
Gene namesi
Name:GPX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000233276.3
HGNCiHGNC:4553 GPX1
MIMi138320 gene+phenotype
neXtProtiNX_P07203

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2876
MalaCardsiGPX1
MIMi138320 gene+phenotype
OpenTargetsiENSG00000233276
PharmGKBiPA28949

Chemistry databases

ChEMBLiCHEMBL2163186
DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGPX1
DMDMi311033481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666101 – 203Glutathione peroxidase 1Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineBy similarity1
Modified residuei88N6-acetyllysine; alternateBy similarity1
Modified residuei88N6-succinyllysine; alternateBy similarity1
Modified residuei114N6-acetyllysine; alternateBy similarity1
Modified residuei114N6-succinyllysine; alternateBy similarity1
Modified residuei148N6-acetyllysine; alternateBy similarity1
Modified residuei148N6-succinyllysine; alternateBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei201PhosphoserineCombined sources1

Post-translational modificationi

During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP07203
PaxDbiP07203
PeptideAtlasiP07203
PRIDEiP07203
ProteomicsDBi51972

2D gel databases

OGPiP07203
SWISS-2DPAGEiP07203

PTM databases

iPTMnetiP07203
PhosphoSitePlusiP07203
SwissPalmiP07203

Expressioni

Gene expression databases

BgeeiENSG00000233276 Expressed in 91 organ(s), highest expression level in left adrenal gland
CleanExiHS_GPX1
ExpressionAtlasiP07203 baseline and differential
GenevisibleiP07203 HS

Organism-specific databases

HPAiCAB011582
HPA044758

Interactioni

Subunit structurei

Homotetramer. Interacts with MIEN1.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109134, 15 interactors
CORUMiP07203
IntActiP07203, 10 interactors
MINTiP07203
STRINGi9606.ENSP00000407375

Chemistry databases

BindingDBiP07203

Structurei

Secondary structure

1203
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07203
SMRiP07203
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07203

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277055
HOVERGENiHBG004333
InParanoidiP07203
KOiK00432
OMAiRDYTEMN
OrthoDBiEOG091G10LN
PhylomeDBiP07203
TreeFamiTF105318

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P07203-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLUG
60 70 80 90 100
TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR
110 120 130 140 150
PGGGFEPNFM LFEKCEVNGA GAHPLFAFLR EALPAPSDDA TALMTDPKLI
160 170 180 190 200
TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS RRFQTIDIEP DIEALLSQGP

SCA
Length:203
Mass (Da):22,088
Last modified:November 2, 2010 - v4
Checksum:i5DB11579C66FE8E5
GO
Isoform 2 (identifier: P07203-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-98: ENAKNEEILNSLKY → VRRAERGGAGADVQ
     99-203: Missing.

Note: Gene prediction based on EST data.
Show »
Length:98
Mass (Da):10,289
Checksum:i9AD713E53537E4A0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUQ6A0A087WUQ6_HUMAN
Glutathione peroxidase
GPX1
202Annotation score:
A0A2R8Y6B6A0A2R8Y6B6_HUMAN
Glutathione peroxidase 1
GPX1
157Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93L → Q in CAA31992 (PubMed:2955287).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0209125R → P1 PublicationCorresponds to variant dbSNP:rs8179169Ensembl.1
Natural variantiVAR_0209137 – 8Missing 5 Publications2
Natural variantiVAR_0209148Missing 3 Publications1
Natural variantiVAR_020915194A → T1 PublicationCorresponds to variant dbSNP:rs6446261Ensembl.1
Natural variantiVAR_007904200P → L Frequent polymorphism. 4 PublicationsCorresponds to variant dbSNP:rs1050450EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04736985 – 98ENAKN…NSLKY → VRRAERGGAGADVQ in isoform 2. CuratedAdd BLAST14
Alternative sequenceiVSP_04737099 – 203Missing in isoform 2. CuratedAdd BLAST105

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei49Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00433 mRNA Translation: CAA68491.1
Y00483 Genomic DNA Translation: CAB37833.1
X13709 mRNA Translation: CAA31992.1
X13710 mRNA Translation: CAA31993.1
M21304 mRNA Translation: AAA75389.2
M83094 Genomic DNA Translation: AAA67540.2
AY327818 Genomic DNA Translation: AAP80181.1
AC121247 Genomic DNA No translation available.
BC000742 mRNA Translation: AAH00742.3
CCDSiCCDS43091.1 [P07203-1]
CCDS54582.1 [P07203-2]
PIRiA42152 OPHUE
RefSeqiNP_000572.2, NM_000581.3 [P07203-1]
UniGeneiHs.76686

Genome annotation databases

EnsembliENST00000419349; ENSP00000391316; ENSG00000233276 [P07203-2]
ENST00000419783; ENSP00000407375; ENSG00000233276 [P07203-1]
GeneIDi2876
KEGGihsa:2876
UCSCiuc021wxw.2 human [P07203-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, Selenocysteine

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Glutathione peroxidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00433 mRNA Translation: CAA68491.1
Y00483 Genomic DNA Translation: CAB37833.1
X13709 mRNA Translation: CAA31992.1
X13710 mRNA Translation: CAA31993.1
M21304 mRNA Translation: AAA75389.2
M83094 Genomic DNA Translation: AAA67540.2
AY327818 Genomic DNA Translation: AAP80181.1
AC121247 Genomic DNA No translation available.
BC000742 mRNA Translation: AAH00742.3
CCDSiCCDS43091.1 [P07203-1]
CCDS54582.1 [P07203-2]
PIRiA42152 OPHUE
RefSeqiNP_000572.2, NM_000581.3 [P07203-1]
UniGeneiHs.76686

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F8AX-ray1.50A/B14-198[»]
ProteinModelPortaliP07203
SMRiP07203
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109134, 15 interactors
CORUMiP07203
IntActiP07203, 10 interactors
MINTiP07203
STRINGi9606.ENSP00000407375

Chemistry databases

BindingDBiP07203
ChEMBLiCHEMBL2163186
DrugBankiDB00143 Glutathione
SwissLipidsiSLP:000001632

Protein family/group databases

PeroxiBasei3600 HsGPx01-A

PTM databases

iPTMnetiP07203
PhosphoSitePlusiP07203
SwissPalmiP07203

Polymorphism and mutation databases

BioMutaiGPX1
DMDMi311033481

2D gel databases

OGPiP07203
SWISS-2DPAGEiP07203

Proteomic databases

EPDiP07203
PaxDbiP07203
PeptideAtlasiP07203
PRIDEiP07203
ProteomicsDBi51972

Protocols and materials databases

DNASUi2876
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419349; ENSP00000391316; ENSG00000233276 [P07203-2]
ENST00000419783; ENSP00000407375; ENSG00000233276 [P07203-1]
GeneIDi2876
KEGGihsa:2876
UCSCiuc021wxw.2 human [P07203-1]

Organism-specific databases

CTDi2876
DisGeNETi2876
EuPathDBiHostDB:ENSG00000233276.3
GeneCardsiGPX1
H-InvDBiHIX0003298
HGNCiHGNC:4553 GPX1
HPAiCAB011582
HPA044758
MalaCardsiGPX1
MIMi138320 gene+phenotype
neXtProtiNX_P07203
OpenTargetsiENSG00000233276
PharmGKBiPA28949
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277055
HOVERGENiHBG004333
InParanoidiP07203
KOiK00432
OMAiRDYTEMN
OrthoDBiEOG091G10LN
PhylomeDBiP07203
TreeFamiTF105318

Enzyme and pathway databases

BioCyciMetaCyc:HS00019-MONOMER
BRENDAi1.11.1.9 2681
ReactomeiR-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-74259 Purine catabolism
SIGNORiP07203

Miscellaneous databases

ChiTaRSiGPX1 human
EvolutionaryTraceiP07203
GeneWikiiGPX1
GenomeRNAii2876
PROiPR:P07203
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000233276 Expressed in 91 organ(s), highest expression level in left adrenal gland
CleanExiHS_GPX1
ExpressionAtlasiP07203 baseline and differential
GenevisibleiP07203 HS

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPX1_HUMAN
AccessioniPrimary (citable) accession number: P07203
Secondary accession number(s): E9PAS1, Q7Z5H1, Q9BW12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 208 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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