GPX1

BioCycⁱ	MetaCyc:HS00019-MONOMER
BRENDAⁱ	1.11.1.9 2681
Reactomeⁱ	R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-3299685 Detoxification of Reactive Oxygen Species R-HSA-74259 Purine catabolism
SIGNORⁱ	P07203

Protein family/group databases

PeroxiBaseⁱ	3600 HsGPx01-A

PeroxiBaseⁱ

3600 HsGPx01-A

Chemistry databases

SwissLipidsⁱ	SLP:000001632

SwissLipidsⁱ

SLP:000001632

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutathione peroxidase 1 (EC:1.11.1.9) Short name: GPx-1 Short name: GSHPx-1 Alternative name(s): Cellular glutathione peroxidase
Gene namesⁱ	Name:GPX1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000233276.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4553 GPX1
MIMⁱ	138320 gene+phenotype
neXtProtⁱ	NX_P07203

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2876
MalaCards human disease database More...MalaCardsⁱ	GPX1
MIMⁱ	138320 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000233276
PharmGKBⁱ	PA28949

Chemistry databases

ChEMBLⁱ	CHEMBL2163186
Drug and drug target database More...DrugBankⁱ	DB00143 Glutathione

Polymorphism and mutation databases

BioMutaⁱ	GPX1
DMDMⁱ	311033481

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066610	1 – 203	Glutathione peroxidase 1Add BLAST		203

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	34	PhosphoserineBy similarity	1
Modified residueⁱ	88	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	88	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	114	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	114	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	148	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	148	N6-succinyllysine; alternateBy similarity	1
Modified residueⁱ	197	PhosphoserineBy similarity	1
Modified residueⁱ	201	PhosphoserineCombined sources	1

Post-translational modificationⁱ

During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P07203
PaxDbⁱ	P07203
PeptideAtlas More...PeptideAtlasⁱ	P07203
PRIDEⁱ	P07203
ProteomicsDBⁱ	51972

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P07203
SWISS-2DPAGEⁱ	P07203

PTM databases

iPTMnetⁱ	P07203
PhosphoSitePlusⁱ	P07203
SwissPalmⁱ	P07203

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000233276 Expressed in 91 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_GPX1
ExpressionAtlasⁱ	P07203 baseline and differential
Genevisibleⁱ	P07203 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB011582 HPA044758

HPAⁱ

CAB011582
HPA044758

Interactionⁱ

Subunit structureⁱ

Homotetramer. Interacts with MIEN1.

GO - Molecular functionⁱ

SH3 domain binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12893824

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109134, 15 interactors
CORUMⁱ	P07203
IntActⁱ	P07203, 10 interactors
Molecular INTeraction database More...MINTⁱ	P07203
STRINGⁱ	9606.ENSP00000407375

Chemistry databases

BindingDBⁱ

P07203

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	16 – 18	Combined sources	3
Helixⁱ	32 – 35	Combined sources	4
Beta strandⁱ	38 – 45	Combined sources	8
Beta strandⁱ	47 – 49	Combined sources	3
Helixⁱ	52 – 66	Combined sources	15
Helixⁱ	67 – 69	Combined sources	3
Beta strandⁱ	71 – 77	Combined sources	7
Turnⁱ	82 – 85	Combined sources	4
Helixⁱ	89 – 91	Combined sources	3
Helixⁱ	92 – 98	Combined sources	7
Beta strandⁱ	108 – 112	Combined sources	5
Helixⁱ	124 – 132	Combined sources	9
Helixⁱ	147 – 149	Combined sources	3
Beta strandⁱ	152 – 154	Combined sources	3
Beta strandⁱ	166 – 169	Combined sources	4
Beta strandⁱ	175 – 179	Combined sources	5
Helixⁱ	185 – 188	Combined sources	4
Helixⁱ	189 – 196	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P07203
SMRⁱ	P07203
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P07203

EvolutionaryTraceⁱ

P07203

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1651 Eukaryota COG0386 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119230
HOGENOMⁱ	HOG000277055
HOVERGENⁱ	HBG004333
InParanoidⁱ	P07203
KEGG Orthology (KO) More...KOⁱ	K00432
OMAⁱ	RDYTEMN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10LN
PhylomeDBⁱ	P07203
TreeFamⁱ	TF105318

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00340 GSH_Peroxidase, 1 hit
InterProⁱ	View protein in InterPro IPR000889 Glutathione_peroxidase IPR029759 GPX_AS IPR029760 GPX_CS IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR11592 PTHR11592, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00255 GSHPx, 1 hit
PIRSFⁱ	PIRSF000303 Glutathion_perox, 1 hit
PRINTSⁱ	PR01011 GLUTPROXDASE
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS00460 GLUTATHIONE_PEROXID_1, 1 hit PS00763 GLUTATHIONE_PEROXID_2, 1 hit PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P07203-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLUG 
        60         70         80         90        100
TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR 
       110        120        130        140        150
PGGGFEPNFM LFEKCEVNGA GAHPLFAFLR EALPAPSDDA TALMTDPKLI 
       160        170        180        190        200
TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS RRFQTIDIEP DIEALLSQGP 

SCA

Length:203

Mass (Da):22,088

Last modified:November 2, 2010 - v4

Checksum:ⁱ5DB11579C66FE8E5

GO

Isoform 2 (identifier: P07203-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
85-98: ENAKNEEILNSLKY → VRRAERGGAGADVQ
99-203: Missing.

« Hide

        10         20         30         40         50
MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLUG 
        60         70         80         90 
TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQVRRAER GGAGADVQ

Note: Gene prediction based on EST data.

Show »

Length:98

Mass (Da):10,289

Checksum:ⁱ9AD713E53537E4A0

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WUQ6	A0A087WUQ6_HUMAN	Glutathione peroxidase Glutathione peroxidase	GPX1	202	Annotation score:
A0A2R8Y6B6	A0A2R8Y6B6_HUMAN	Glutathione peroxidase 1 Glutathione peroxidase 1	GPX1	157	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	93	L → Q in CAA31992 (PubMed:2955287).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_020912	5	R → P1 PublicationCorresponds to variant dbSNP:rs8179169Ensembl.	1
Natural variantⁱVAR_020913	7 – 8	Missing 5 Publications	2
Natural variantⁱVAR_020914	8	Missing 3 Publications	1
Natural variantⁱVAR_020915	194	A → T1 PublicationCorresponds to variant dbSNP:rs6446261Ensembl.	1
Natural variantⁱVAR_007904	200	P → L Frequent polymorphism. 4 PublicationsCorresponds to variant dbSNP:rs1050450EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047369	85 – 98	ENAKN…NSLKY → VRRAERGGAGADVQ in isoform 2. CuratedAdd BLAST		14
Alternative sequenceⁱVSP_047370	99 – 203	Missing in isoform 2. CuratedAdd BLAST		105

Non-standard residue

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-standard residueⁱ	49	Selenocysteine		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00433 mRNA Translation: CAA68491.1 Y00483 Genomic DNA Translation: CAB37833.1 X13709 mRNA Translation: CAA31992.1 X13710 mRNA Translation: CAA31993.1 M21304 mRNA Translation: AAA75389.2 M83094 Genomic DNA Translation: AAA67540.2 AY327818 Genomic DNA Translation: AAP80181.1 AC121247 Genomic DNA No translation available. BC000742 mRNA Translation: AAH00742.3
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43091.1 [P07203-1] CCDS54582.1 [P07203-2]
PIRⁱ	A42152 OPHUE
NCBI Reference Sequences More...RefSeqⁱ	NP_000572.2, NM_000581.3 [P07203-1]
UniGeneⁱ	Hs.76686

Genome annotation databases

Ensemblⁱ	ENST00000419349; ENSP00000391316; ENSG00000233276 [P07203-2] ENST00000419783; ENSP00000407375; ENSG00000233276 [P07203-1]
GeneIDⁱ	2876
KEGGⁱ	hsa:2876
UCSC genome browser More...UCSCⁱ	uc021wxw.2 human [P07203-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism, Selenocysteine

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P07203	Glutathione peroxidase		HUMAN		203	UniRef100_P07203
Glutathione peroxidase		PANTR		145
Glutathione peroxidase		NOMLE		145
Glutathione peroxidase 1 isoform A		HUMAN		48

Protein	Similar proteins		Species	Score	Length	Source
P07203	Glutathione peroxidase 1		PIG		206	UniRef90_P07203
Glutathione peroxidase 1	)	BOVIN		205
Glutathione peroxidase 1		PONPY		201
Glutathione peroxidase 1		PANTR		201
Glutathione peroxidase 1		MACFU		201
+91

Protein	Similar proteins		Species	Score	Length	Source
P07203	Glutathione peroxidase 1		PIG		206	UniRef50_P07203
Glutathione peroxidase 1	)	BOVIN		205
Glutathione peroxidase 1		MACFU		201
Glutathione peroxidase 1		PONPY		201
Glutathione peroxidase 1		HYLLA		201
+112
P07203-2	Glutathione peroxidase 1 (Fragment)		MUSSP		99	UniRef50_P07203-2
UPI0004F50089		PYGAD		85
UPI00051EE820		EGRGA		77
UPI0005226CB9		LEPDC		74
UPI0008082CA7		HUMAN		104
+1

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Wikipedia

Glutathione peroxidase entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00433 mRNA Translation: CAA68491.1 Y00483 Genomic DNA Translation: CAB37833.1 X13709 mRNA Translation: CAA31992.1 X13710 mRNA Translation: CAA31993.1 M21304 mRNA Translation: AAA75389.2 M83094 Genomic DNA Translation: AAA67540.2 AY327818 Genomic DNA Translation: AAP80181.1 AC121247 Genomic DNA No translation available. BC000742 mRNA Translation: AAH00742.3
CCDSⁱ	CCDS43091.1 [P07203-1] CCDS54582.1 [P07203-2]
PIRⁱ	A42152 OPHUE
RefSeqⁱ	NP_000572.2, NM_000581.3 [P07203-1]
UniGeneⁱ	Hs.76686

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2F8A	X-ray	1.50	A/B	14-198	[»]
ProteinModelPortalⁱ	P07203
SMRⁱ	P07203
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109134, 15 interactors
CORUMⁱ	P07203
IntActⁱ	P07203, 10 interactors
MINTⁱ	P07203
STRINGⁱ	9606.ENSP00000407375

Chemistry databases

BindingDBⁱ	P07203
ChEMBLⁱ	CHEMBL2163186
DrugBankⁱ	DB00143 Glutathione
SwissLipidsⁱ	SLP:000001632

Protein family/group databases

PeroxiBaseⁱ	3600 HsGPx01-A

PeroxiBaseⁱ

3600 HsGPx01-A

PTM databases

iPTMnetⁱ	P07203
PhosphoSitePlusⁱ	P07203
SwissPalmⁱ	P07203

Polymorphism and mutation databases

BioMutaⁱ	GPX1
DMDMⁱ	311033481

2D gel databases

OGPⁱ	P07203
SWISS-2DPAGEⁱ	P07203

Proteomic databases

EPDⁱ	P07203
PaxDbⁱ	P07203
PeptideAtlasⁱ	P07203
PRIDEⁱ	P07203
ProteomicsDBⁱ	51972

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2876
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000419349; ENSP00000391316; ENSG00000233276 [P07203-2] ENST00000419783; ENSP00000407375; ENSG00000233276 [P07203-1]
GeneIDⁱ	2876
KEGGⁱ	hsa:2876
UCSCⁱ	uc021wxw.2 human [P07203-1]

Organism-specific databases

CTDⁱ	2876
DisGeNETⁱ	2876
EuPathDBⁱ	HostDB:ENSG00000233276.3
GeneCardsⁱ	GPX1
H-InvDBⁱ	HIX0003298
HGNCⁱ	HGNC:4553 GPX1
HPAⁱ	CAB011582 HPA044758
MalaCardsⁱ	GPX1
MIMⁱ	138320 gene+phenotype
neXtProtⁱ	NX_P07203
OpenTargetsⁱ	ENSG00000233276
PharmGKBⁱ	PA28949
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1651 Eukaryota COG0386 LUCA
GeneTreeⁱ	ENSGT00760000119230
HOGENOMⁱ	HOG000277055
HOVERGENⁱ	HBG004333
InParanoidⁱ	P07203
KOⁱ	K00432
OMAⁱ	RDYTEMN
OrthoDBⁱ	EOG091G10LN
PhylomeDBⁱ	P07203
TreeFamⁱ	TF105318

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS00019-MONOMER
BRENDAⁱ	1.11.1.9 2681
Reactomeⁱ	R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-3299685 Detoxification of Reactive Oxygen Species R-HSA-74259 Purine catabolism
SIGNORⁱ	P07203

Miscellaneous databases

ChiTaRSⁱ	GPX1 human
EvolutionaryTraceⁱ	P07203
GeneWikiⁱ	GPX1
GenomeRNAiⁱ	2876
Protein Ontology More...PROⁱ	PR:P07203
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000233276 Expressed in 91 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_GPX1
ExpressionAtlasⁱ	P07203 baseline and differential
Genevisibleⁱ	P07203 HS

Family and domain databases

CDDⁱ	cd00340 GSH_Peroxidase, 1 hit
InterProⁱ	View protein in InterPro IPR000889 Glutathione_peroxidase IPR029759 GPX_AS IPR029760 GPX_CS IPR036249 Thioredoxin-like_sf
PANTHERⁱ	PTHR11592 PTHR11592, 1 hit
Pfamⁱ	View protein in Pfam PF00255 GSHPx, 1 hit
PIRSFⁱ	PIRSF000303 Glutathion_perox, 1 hit
PRINTSⁱ	PR01011 GLUTPROXDASE
SUPFAMⁱ	SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS00460 GLUTATHIONE_PEROXID_1, 1 hit PS00763 GLUTATHIONE_PEROXID_2, 1 hit PS51355 GLUTATHIONE_PEROXID_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPX1_HUMAN
Accessionⁱ	P07203Primary (citable) accession number: P07203 Secondary accession number(s): E9PAS1, Q7Z5H1, Q9BW12
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
	Last sequence update:	November 2, 2010
	Last modified:	November 7, 2018
	This is version 208 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniProtKB - P07203 (GPX1_HUMAN)

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Glutathione peroxidase 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Non-standard residue

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ