Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P07203 (GPX1_HUMAN)

Entry version 225 (10 Feb 2021)
Sequence version 4 (02 Nov 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Glutathione peroxidase 1

Gene

GPX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism (PubMed:11115402).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei491
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei49Subject to oxidation and hydroselenide loss to dehydroalanineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS00019-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.11.1.9, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P07203

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2142688, Synthesis of 5-eicosatetraenoic acids
R-HSA-2142712, Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2142770, Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-3299685, Detoxification of Reactive Oxygen Species
R-HSA-74259, Purine catabolism

SIGNOR Signaling Network Open Resource

More...SIGNORi		P07203

Protein family/group databases

PeroxiBase, a peroxidase database

More...PeroxiBasei		3600, HsGPx01-A

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001632

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutathione peroxidase 1Curated (EC:1.11.1.91 Publication)
Short name:
GPx-11 Publication
Short name:
GSHPx-1
Alternative name(s):
Cellular glutathione peroxidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPX1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4553, GPX1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		138320, gene+phenotype

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07203

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000233276.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		2876

MalaCards human disease database

More...MalaCardsi		GPX1
MIMi138320, gene+phenotype

Open Targets

More...OpenTargetsi		ENSG00000233276

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28949

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P07203, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2163186

Drug and drug target database

More...DrugBanki		DB09061, Cannabidiol
DB00143, Glutathione
DB03310, Glutathione disulfide
DB11091, Hydrogen peroxide
DB14009, Medical Cannabis
DB14011, Nabiximols
DB09221, Polaprezinc
DB11127, Selenious acid
DB11590, Thimerosal

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPX1

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033481

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000666101 – 203Glutathione peroxidase 1Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphoserineBy similarity1
Modified residuei88N6-acetyllysine; alternateBy similarity1
Modified residuei88N6-succinyllysine; alternateBy similarity1
Modified residuei114N6-acetyllysine; alternateBy similarity1
Modified residuei114N6-succinyllysine; alternateBy similarity1
Modified residuei148N6-acetyllysine; alternateBy similarity1
Modified residuei148N6-succinyllysine; alternateBy similarity1
Modified residuei197PhosphoserineBy similarity1
Modified residuei201PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P07203

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P07203

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P07203

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07203

PeptideAtlas

More...PeptideAtlasi		P07203

PRoteomics IDEntifications database

More...PRIDEi		P07203

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19069
51972 [P07203-1]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P07203

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P07203

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07203

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P07203

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P07203

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P07203

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in platelets (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000233276, Expressed in monocyte and 113 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P07203, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07203, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Interacts with MIEN1.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109134, 43 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P07203

Protein interaction database and analysis system

More...IntActi		P07203, 15 interactors

Molecular INTeraction database

More...MINTi		P07203

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000407375

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P07203

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P07203, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1203
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07203

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P07203

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1651, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156150

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029507_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07203

Identification of Orthologs from Complete Genome Data

More...OMAi		MNDLQRR

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07203

TreeFam database of animal gene trees

More...TreeFami		TF105318

Family and domain databases

Conserved Domains Database

More...CDDi		cd00340, GSH_Peroxidase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000889, Glutathione_peroxidase
IPR029759, GPX_AS
IPR029760, GPX_CS
IPR036249, Thioredoxin-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR11592, PTHR11592, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00255, GSHPx, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000303, Glutathion_perox, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01011, GLUTPROXDASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52833, SSF52833, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00460, GLUTATHIONE_PEROXID_1, 1 hit
PS00763, GLUTATHIONE_PEROXID_2, 1 hit
PS51355, GLUTATHIONE_PEROXID_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P07203-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCAARLAAAA AAAQSVYAFS ARPLAGGEPV SLGSLRGKVL LIENVASLUG 
        60         70         80         90        100
TTVRDYTQMN ELQRRLGPRG LVVLGFPCNQ FGHQENAKNE EILNSLKYVR 
       110        120        130        140        150
PGGGFEPNFM LFEKCEVNGA GAHPLFAFLR EALPAPSDDA TALMTDPKLI 
       160        170        180        190        200
TWSPVCRNDV AWNFEKFLVG PDGVPLRRYS RRFQTIDIEP DIEALLSQGP 

SCA
Length:203
Mass (Da):22,088
Last modified:November 2, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DB11579C66FE8E5
GO
Isoform 2 (identifier: P07203-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-98: ENAKNEEILNSLKY → VRRAERGGAGADVQ
     99-203: Missing.

Show »
Length:98
Mass (Da):10,289
Checksum:i9AD713E53537E4A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUQ6A0A087WUQ6_HUMAN
Glutathione peroxidase
GPX1
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6B6A0A2R8Y6B6_HUMAN
Glutathione peroxidase 1
GPX1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti93L → Q in CAA31992 (PubMed:2955287).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0209125R → P1 PublicationCorresponds to variant dbSNP:rs8179169Ensembl.1
Natural variantiVAR_0209137 – 8Missing 5 Publications2
Natural variantiVAR_0209148Missing 3 Publications1
Natural variantiVAR_020915194A → T1 PublicationCorresponds to variant dbSNP:rs6446261Ensembl.1
Natural variantiVAR_007904200P → L4 PublicationsCorresponds to variant dbSNP:rs1050450EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04736985 – 98ENAKN…NSLKY → VRRAERGGAGADVQ in isoform 2. CuratedAdd BLAST14
Alternative sequenceiVSP_04737099 – 203Missing in isoform 2. CuratedAdd BLAST105

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the occurrence of non-standard amino acids selenocysteine (Sec) or pyrrolysine (Pyl) in the protein sequence.<p><a href='/help/non_std' target='_top'>More...</a></p>Non-standard residuei49Selenocysteine1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y00433 mRNA Translation: CAA68491.1
Y00483 Genomic DNA Translation: CAB37833.1
X13709 mRNA Translation: CAA31992.1
X13710 mRNA Translation: CAA31993.1
M21304 mRNA Translation: AAA75389.2
M83094 Genomic DNA Translation: AAA67540.2
AY327818 Genomic DNA Translation: AAP80181.1
AC121247 Genomic DNA No translation available.
BC000742 mRNA Translation: AAH00742.3

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43091.1 [P07203-1]
CCDS54582.1 [P07203-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A42152, OPHUE

NCBI Reference Sequences

More...RefSeqi		NP_000572.2, NM_000581.3 [P07203-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000419349; ENSP00000391316; ENSG00000233276 [P07203-2]
ENST00000419783; ENSP00000407375; ENSG00000233276 [P07203-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2876

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2876

UCSC genome browser

More...UCSCi		uc021wxw.2, human [P07203-1]

Keywords - Coding sequence diversityi

Alternative splicing, Selenocysteine

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Glutathione peroxidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00433 mRNA Translation: CAA68491.1
Y00483 Genomic DNA Translation: CAB37833.1
X13709 mRNA Translation: CAA31992.1
X13710 mRNA Translation: CAA31993.1
M21304 mRNA Translation: AAA75389.2
M83094 Genomic DNA Translation: AAA67540.2
AY327818 Genomic DNA Translation: AAP80181.1
AC121247 Genomic DNA No translation available.
BC000742 mRNA Translation: AAH00742.3
CCDSiCCDS43091.1 [P07203-1]
CCDS54582.1 [P07203-2]
PIRiA42152, OPHUE
RefSeqiNP_000572.2, NM_000581.3 [P07203-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F8AX-ray1.50A/B14-198[»]
SMRiP07203
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109134, 43 interactors
CORUMiP07203
IntActiP07203, 15 interactors
MINTiP07203
STRINGi9606.ENSP00000407375

Chemistry databases

BindingDBiP07203
ChEMBLiCHEMBL2163186
DrugBankiDB09061, Cannabidiol
DB00143, Glutathione
DB03310, Glutathione disulfide
DB11091, Hydrogen peroxide
DB14009, Medical Cannabis
DB14011, Nabiximols
DB09221, Polaprezinc
DB11127, Selenious acid
DB11590, Thimerosal
SwissLipidsiSLP:000001632

Protein family/group databases

PeroxiBasei3600, HsGPx01-A

PTM databases

iPTMnetiP07203
MetOSiteiP07203
PhosphoSitePlusiP07203
SwissPalmiP07203

Genetic variation databases

BioMutaiGPX1
DMDMi311033481

2D gel databases

OGPiP07203
SWISS-2DPAGEiP07203

Proteomic databases

EPDiP07203
jPOSTiP07203
MassIVEiP07203
PaxDbiP07203
PeptideAtlasiP07203
PRIDEiP07203
ProteomicsDBi19069
51972 [P07203-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		39716, 521 antibodies

The DNASU plasmid repository

More...DNASUi		2876

Genome annotation databases

EnsembliENST00000419349; ENSP00000391316; ENSG00000233276 [P07203-2]
ENST00000419783; ENSP00000407375; ENSG00000233276 [P07203-1]
GeneIDi2876
KEGGihsa:2876
UCSCiuc021wxw.2, human [P07203-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2876
DisGeNETi2876

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPX1
HGNCiHGNC:4553, GPX1
MalaCardsiGPX1
MIMi138320, gene+phenotype
neXtProtiNX_P07203
OpenTargetsiENSG00000233276
PharmGKBiPA28949
VEuPathDBiHostDB:ENSG00000233276.3

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1651, Eukaryota
GeneTreeiENSGT00940000156150
HOGENOMiCLU_029507_2_0_1
InParanoidiP07203
OMAiMNDLQRR
PhylomeDBiP07203
TreeFamiTF105318

Enzyme and pathway databases

BioCyciMetaCyc:HS00019-MONOMER
BRENDAi1.11.1.9, 2681
PathwayCommonsiP07203
ReactomeiR-HSA-2142688, Synthesis of 5-eicosatetraenoic acids
R-HSA-2142712, Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2142770, Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-3299685, Detoxification of Reactive Oxygen Species
R-HSA-74259, Purine catabolism
SIGNORiP07203

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2876, 3 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GPX1, human
EvolutionaryTraceiP07203

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GPX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2876
PharosiP07203, Tbio

Protein Ontology

More...PROi		PR:P07203
RNActiP07203, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000233276, Expressed in monocyte and 113 other tissues
ExpressionAtlasiP07203, baseline and differential
GenevisibleiP07203, HS

Family and domain databases

CDDicd00340, GSH_Peroxidase, 1 hit
Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR000889, Glutathione_peroxidase
IPR029759, GPX_AS
IPR029760, GPX_CS
IPR036249, Thioredoxin-like_sf
PANTHERiPTHR11592, PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255, GSHPx, 1 hit
PIRSFiPIRSF000303, Glutathion_perox, 1 hit
PRINTSiPR01011, GLUTPROXDASE
SUPFAMiSSF52833, SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460, GLUTATHIONE_PEROXID_1, 1 hit
PS00763, GLUTATHIONE_PEROXID_2, 1 hit
PS51355, GLUTATHIONE_PEROXID_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07203
Secondary accession number(s): E9PAS1, Q7Z5H1, Q9BW12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 2, 2010
Last modified: February 10, 2021
This is version 225 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again