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UniProtKB - P07202 (PERT_HUMAN)

Protein

Thyroid peroxidase

Gene

TPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.By similarity

Catalytic activityi

2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O.By similarity
[Thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O.By similarity
[Thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O.By similarity
2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O.By similarity
[Thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O.By similarity

Cofactori

Protein has several cofactor binding sites:
  • Ca2+PROSITE-ProRule annotationNote: Binds 1 Ca2+ ion per heterodimer.PROSITE-ProRule annotation
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.PROSITE-ProRule annotation

Pathwayi: thyroid hormone biosynthesis

This protein is involved in the pathway thyroid hormone biosynthesis, which is part of Hormone biosynthesis.
View all proteins of this organism that are known to be involved in the pathway thyroid hormone biosynthesis and in Hormone biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei238Heme (covalent; via 2 links)By similarity1
Active sitei239Proton acceptorPROSITE-ProRule annotation1
Metal bindingi240CalciumPROSITE-ProRule annotation1
Metal bindingi321CalciumPROSITE-ProRule annotation1
Metal bindingi323Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi325CalciumPROSITE-ProRule annotation1
Metal bindingi327CalciumPROSITE-ProRule annotation1
Sitei396Transition state stabilizerPROSITE-ProRule annotation1
Binding sitei399Heme (covalent; via 2 links)By similarity1
Metal bindingi494Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • heme binding Source: InterPro
  • iodide peroxidase activity Source: UniProtKB-EC
  • peroxidase activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide, Thyroid hormones biosynthesis
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.52 2681
ReactomeiR-HSA-209968 Thyroxine biosynthesis
UniPathwayi
UPA00194

Protein family/group databases

PeroxiBasei3318 HsTPO01

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid peroxidaseCurated (EC:1.11.1.8By similarity)
Short name:
TPO
Gene namesi
Name:TPOImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115705.20
HGNCiHGNC:12015 TPO
MIMi606765 gene
neXtProtiNX_P07202

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 846ExtracellularSequence analysisAdd BLAST828
Transmembranei847 – 871HelicalSequence analysisAdd BLAST25
Topological domaini872 – 933CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
Thyroid dyshormonogenesis 2A (TDH2A)17 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
See also OMIM:274500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02162253A → P in TDH2A. 1 Publication1
Natural variantiVAR_021623240D → N in TDH2A; loss of activity. 1 Publication1
Natural variantiVAR_021624307N → T in TDH2A. 1 Publication1
Natural variantiVAR_021625326A → T in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs371367459Ensembl.1
Natural variantiVAR_025784378E → K in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1297312788Ensembl.1
Natural variantiVAR_078336412R → H in TDH2A; unknown pathological significance. 1 Publication1
Natural variantiVAR_021626433V → M in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1035791118Ensembl.1
Natural variantiVAR_015375447I → F in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs104893669EnsemblClinVar.1
Natural variantiVAR_006060453Y → D in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908083EnsemblClinVar.1
Natural variantiVAR_021627458L → P in TDH2A. 1 Publication1
Natural variantiVAR_021628491R → H in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs201165648EnsemblClinVar.1
Natural variantiVAR_021629493G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs778515113Ensembl.1
Natural variantiVAR_021630499P → L in TDH2A. 1 Publication1
Natural variantiVAR_021631527W → C in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs779434941Ensembl.1
Natural variantiVAR_027229533G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication1
Natural variantiVAR_027230574 – 575Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme. 2
Natural variantiVAR_027231590G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908084EnsemblClinVar.1
Natural variantiVAR_078337596 – 933Missing in TDH2A; unknown pathological significance. 1 PublicationAdd BLAST338
Natural variantiVAR_013138648R → Q in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908086EnsemblClinVar.1
Natural variantiVAR_021632660Q → E in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908088EnsemblClinVar.1
Natural variantiVAR_021633665R → W in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs776742629Ensembl.1
Natural variantiVAR_021634693R → W in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs121908087EnsemblClinVar.1
Natural variantiVAR_021635771G → R in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs138931129Ensembl.1
Natural variantiVAR_021636796D → Y in TDH2A. 1 Publication1
Natural variantiVAR_006062799E → K in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908085EnsemblClinVar.1
Natural variantiVAR_021637808C → R in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs935058009Ensembl.1
Natural variantiVAR_027235839V → I in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs146351101Ensembl.1

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

DisGeNETi7173
MalaCardsiTPO
MIMi274500 phenotype
OpenTargetsiENSG00000115705
Orphaneti95716 Familial thyroid dyshormonogenesis
PharmGKBiPA36694

Protein family/group databases

Allergomei9554 Hom s TPO

Chemistry databases

ChEMBLiCHEMBL1839
DrugBankiDB00389 Carbimazole
DB00509 Dextrothyroxine
DB00763 Methimazole
DB00550 Propylthiouracil

Polymorphism and mutation databases

BioMutaiTPO
DMDMi160281455

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002366219 – 933Thyroid peroxidaseAdd BLAST915

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi142 ↔ 158By similarity
Disulfide bondi259 ↔ 269By similarity
Disulfide bondi263 ↔ 286By similarity
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi569N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi598 ↔ 655By similarity
Disulfide bondi696 ↔ 721By similarity
Disulfide bondi800 ↔ 814By similarity
Disulfide bondi808 ↔ 823By similarity
Disulfide bondi825 ↔ 838By similarity

Post-translational modificationi

Glycosylated.
Heme is covalently bound through a H2O2-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07202
PeptideAtlasiP07202
PRIDEiP07202
ProteomicsDBi51964
51965 [P07202-2]
51966 [P07202-3]
51967 [P07202-4]
51968 [P07202-5]
51969 [P07202-6]
51970 [P07202-7]
51971 [P07202-8]

PTM databases

iPTMnetiP07202
PhosphoSitePlusiP07202

Expressioni

Gene expression databases

BgeeiENSG00000115705 Expressed in 86 organ(s), highest expression level in right lobe of thyroid gland
ExpressionAtlasiP07202 baseline and differential
GenevisibleiP07202 HS

Organism-specific databases

HPAiCAB009587
HPA007987

Interactioni

Subunit structurei

Interacts with DUOX1, DUOX2 and CYBA.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000318820

Chemistry databases

BindingDBiP07202

Structurei

3D structure databases

ProteinModelPortaliP07202
SMRiP07202
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini740 – 795SushiPROSITE-ProRule annotationAdd BLAST56
Domaini796 – 839EGF-like; calcium-bindingPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00550000074325
HOVERGENiHBG000071
InParanoidiP07202
KOiK00431
OMAiMVWGQYI
OrthoDBiEOG091G0236
PhylomeDBiP07202
TreeFamiTF314316

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR029589 TPO
PANTHERiPTHR11475:SF60 PTHR11475:SF60, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF07645 EGF_CA, 1 hit
PF00084 Sushi, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SUPFAMiSSF48113 SSF48113, 1 hit
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit
PS00435 PEROXIDASE_1, 1 hit
PS50292 PEROXIDASE_3, 1 hit
PS50923 SUSHI, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 8 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P07202-1) [UniParc]FASTAAdd to basket
Also known as: TPO1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV 
        60         70         80         90        100
DTAMYATMQR NLKKRGILSP AQLLSFSKLP EPTSGVIARA AEIMETSIQA 
       110        120        130        140        150
MKRKVNLKTQ QSQHPTDALS EDLLSIIANM SGCLPYMLPP KCPNTCLANK 
       160        170        180        190        200
YRPITGACNN RDHPRWGASN TALARWLPPV YEDGFSQPRG WNPGFLYNGF 
       210        220        230        240        250
PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD IAFTPQSTSK 
       260        270        280        290        300
AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD 
       310        320        330        340        350
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL 
       360        370        380        390        400
RVHARLRDSG RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV 
       410        420        430        440        450
PSLTALHTLW LREHNRLAAA LKALNAHWSA DAVYQEARKV VGALHQIITL 
       460        470        480        490        500
RDYIPRILGP EAFQQYVGPY EGYDSTANPT VSNVFSTAAF RFGHATIHPL 
       510        520        530        540        550
VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR GLLARPAKLQ 
       560        570        580        590        600
VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL 
       610        620        630        640        650
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG 
       660        670        680        690        700
PLFACLIGKQ MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG 
       710        720        730        740        750
LTRVPMDAFQ VGKFPEDFES CDSITGMNLE AWRETFPQDD KCGFPESVEN 
       760        770        780        790        800
GDFVHCEESG RRVLVYSCRH GYELQGREQL TCTQEGWDFQ PPLCKDVNEC 
       810        820        830        840        850
ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD SGRLPRVTWI 
       860        870        880        890        900
SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ 
       910        920        930 
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL
Length:933
Mass (Da):102,963
Last modified:November 13, 2007 - v4
Checksum:iF67C5F1A4AEE0B29
GO
Isoform 2 (identifier: P07202-2) [UniParc]FASTAAdd to basket
Also known as: TPO2

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.

Note: Lacks exon 10. Found in normal thyroid tissues as well as Graves'tissues. Rapidly degraded after synthesis, does not reach the cell surface. Inactive.
Show »
Length:876
Mass (Da):96,699
Checksum:iF4CF0D050608F808
GO
Isoform 3 (identifier: P07202-3) [UniParc]FASTAAdd to basket
Also known as: TPO3, Graves' disease, TPOzaninelli

The sequence of this isoform differs from the canonical sequence as follows:
     874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG

Note: Lacks exon 16. Found in normal thyroid tissues as well as Graves'tissues. Active.
Show »
Length:929
Mass (Da):102,771
Checksum:i423AC29EEB27277B
GO
Isoform 4 (identifier: P07202-4) [UniParc]FASTAAdd to basket
Also known as: TPO4

The sequence of this isoform differs from the canonical sequence as follows:
     796-839: Missing.

Note: Lacks exon 14. Active.
Show »
Length:889
Mass (Da):98,327
Checksum:iF9C575FC93A450C8
GO
Isoform 5 (identifier: P07202-5) [UniParc]FASTAAdd to basket
Also known as: TPO5

The sequence of this isoform differs from the canonical sequence as follows:
     274-446: Missing.

Note: Lacks exon 8. Does not fold correctly. Does not reach the cell surface.
Show »
Length:760
Mass (Da):84,581
Checksum:i3C6150EA7E602B78
GO
Isoform 6 (identifier: P07202-6) [UniParc]FASTAAdd to basket
Also known as: TPO6

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     669-933: Missing.

Note: Lacks exons 10, 12, 13, 14 and 16.
Show »
Length:611
Mass (Da):67,293
Checksum:i7AD0B6FA3206066A
GO
Isoform 2-3 (identifier: P07202-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG

Note: Lacks exons 10 and 16.
Show »
Length:872
Mass (Da):96,507
Checksum:i3EDC31BFE86C24E2
GO
Isoform 2-4 (identifier: P07202-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     796-839: Missing.

Note: Lacks exons 10 and 14.
Show »
Length:832
Mass (Da):92,063
Checksum:i7C6D17A3B62C1D7D
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JP53A0A0G2JP53_HUMAN
Thyroid peroxidase
TPO
933Annotation score:
A0A0G2JRZ1A0A0G2JRZ1_HUMAN
Thyroid peroxidase
TPO
916Annotation score:
A0A0G2JR31A0A0G2JR31_HUMAN
Thyroid peroxidase
TPO
859Annotation score:
A0A0G2JR90A0A0G2JR90_HUMAN
Thyroid peroxidase
TPO
743Annotation score:
A0A0G2JNN7A0A0G2JNN7_HUMAN
Thyroid peroxidase
TPO
889Annotation score:
H7C1F5H7C1F5_HUMAN
Thyroid peroxidase
TPO
404Annotation score:
A0A0G2JRX3A0A0G2JRX3_HUMAN
Thyroid peroxidase
TPO
347Annotation score:
H0Y6H4H0Y6H4_HUMAN
Thyroid peroxidase
TPO
864Annotation score:
H7C5B6H7C5B6_HUMAN
Thyroid peroxidase
TPO
363Annotation score:
A0A0G2JR79A0A0G2JR79_HUMAN
Thyroid peroxidase
TPO
864Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70P → G in AAA61217 (Ref. 5) Curated1
Sequence conflicti354A → G (Ref. 5) Curated1
Sequence conflicti354A → G (PubMed:3654979).Curated1
Sequence conflicti371A → R in AAA61215 (PubMed:3475693).Curated1
Sequence conflicti371A → R in AAA61216 (PubMed:3475693).Curated1
Sequence conflicti381I → N (Ref. 5) Curated1
Sequence conflicti381I → N (PubMed:3654979).Curated1
Sequence conflicti574D → N in CAA68467 (PubMed:3453124).Curated1
Sequence conflicti732W → C in AAN11302 (PubMed:12454013).Curated1
Sequence conflicti748V → M (PubMed:3453124).Curated1
Sequence conflicti748V → M (PubMed:12454013).Curated1
Sequence conflicti816N → S in AAL74416 (Ref. 6) Curated1
Sequence conflicti872R → K (PubMed:3453124).Curated1
Sequence conflicti872R → K (PubMed:12454013).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02162253A → P in TDH2A. 1 Publication1
Natural variantiVAR_021623240D → N in TDH2A; loss of activity. 1 Publication1
Natural variantiVAR_006057257A → S3 PublicationsCorresponds to variant dbSNP:rs4927611EnsemblClinVar.1
Natural variantiVAR_021624307N → T in TDH2A. 1 Publication1
Natural variantiVAR_021625326A → T in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs371367459Ensembl.1
Natural variantiVAR_006058373A → S1 PublicationCorresponds to variant dbSNP:rs2280132EnsemblClinVar.1
Natural variantiVAR_025784378E → K in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1297312788Ensembl.1
Natural variantiVAR_006059398S → T1 PublicationCorresponds to variant dbSNP:rs2175977EnsemblClinVar.1
Natural variantiVAR_078336412R → H in TDH2A; unknown pathological significance. 1 Publication1
Natural variantiVAR_021626433V → M in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1035791118Ensembl.1
Natural variantiVAR_015375447I → F in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs104893669EnsemblClinVar.1
Natural variantiVAR_006060453Y → D in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908083EnsemblClinVar.1
Natural variantiVAR_021627458L → P in TDH2A. 1 Publication1
Natural variantiVAR_021628491R → H in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs201165648EnsemblClinVar.1
Natural variantiVAR_021629493G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs778515113Ensembl.1
Natural variantiVAR_021630499P → L in TDH2A. 1 Publication1
Natural variantiVAR_021631527W → C in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs779434941Ensembl.1
Natural variantiVAR_027229533G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication1
Natural variantiVAR_027230574 – 575Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme. 2
Natural variantiVAR_027231590G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908084EnsemblClinVar.1
Natural variantiVAR_078337596 – 933Missing in TDH2A; unknown pathological significance. 1 PublicationAdd BLAST338
Natural variantiVAR_027232618V → M. Corresponds to variant dbSNP:rs10189135EnsemblClinVar.1
Natural variantiVAR_013138648R → Q in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908086EnsemblClinVar.1
Natural variantiVAR_021632660Q → E in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908088EnsemblClinVar.1
Natural variantiVAR_021633665R → W in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs776742629Ensembl.1
Natural variantiVAR_021634693R → W in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs121908087EnsemblClinVar.1
Natural variantiVAR_027233706M → V. Corresponds to variant dbSNP:rs13431173EnsemblClinVar.1
Natural variantiVAR_006061725T → P5 PublicationsCorresponds to variant dbSNP:rs732609EnsemblClinVar.1
Natural variantiVAR_021635771G → R in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs138931129Ensembl.1
Natural variantiVAR_027234793L → P. Corresponds to variant dbSNP:rs28991293Ensembl.1
Natural variantiVAR_021636796D → Y in TDH2A. 1 Publication1
Natural variantiVAR_006062799E → K in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908085EnsemblClinVar.1
Natural variantiVAR_021637808C → R in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs935058009Ensembl.1
Natural variantiVAR_027235839V → I in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs146351101Ensembl.1
Natural variantiVAR_027236846R → W. Corresponds to variant dbSNP:rs28913014Ensembl.1
Natural variantiVAR_027237847V → A4 PublicationsCorresponds to variant dbSNP:rs1126799EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007268274 – 446Missing in isoform 5. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_004665534 – 590Missing in isoform 2, isoform 2-3, isoform 2-4 and isoform 6. 2 PublicationsAdd BLAST57
Alternative sequenceiVSP_007270669 – 933Missing in isoform 6. CuratedAdd BLAST265
Alternative sequenceiVSP_007269796 – 839Missing in isoform 4 and isoform 2-4. CuratedAdd BLAST44
Alternative sequenceiVSP_004666874 – 933TRTGT…LPRAL → RVLGWKAGILTGCREPSEGK VAGHCRTASCSQNHRTTLFQ TQANRKSAGRLFSQHG in isoform 3 and isoform 2-3. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02969 mRNA Translation: AAA61215.1
J02970 mRNA Translation: AAA61216.1
Y00406 mRNA Translation: CAA68467.1
M25715
, M25702, M25703, M25704, M25705, M25706, M25707, M25708, M25709, M25710, M25711, M25712, M25713, M25714 Genomic DNA Translation: AAA97517.1
X17358 mRNA Translation: CAA35235.1
M17755 mRNA Translation: AAA61217.2
AF439430 mRNA Translation: AAL74416.1
AF533528 mRNA Translation: AAN04471.1
AY136822 mRNA Translation: AAN11302.1
AF533529 mRNA Translation: AAN04472.1
AF533530 mRNA Translation: AAN04473.1
AF533531 mRNA Translation: AAN04474.1
M55702 mRNA Translation: AAA61219.1
M55702 mRNA Translation: AAA61218.1
CCDSiCCDS1643.1 [P07202-1]
CCDS1644.1 [P07202-2]
CCDS1646.1 [P07202-5]
PIRiA32413 OPHUIT
RefSeqiNP_000538.3, NM_000547.5 [P07202-1]
NP_001193673.1, NM_001206744.1 [P07202-1]
NP_001193674.1, NM_001206745.1 [P07202-2]
NP_783650.1, NM_175719.3 [P07202-2]
NP_783652.1, NM_175721.3 [P07202-4]
NP_783653.1, NM_175722.3 [P07202-5]
XP_011508683.1, XM_011510381.2
UniGeneiHs.467554

Genome annotation databases

EnsembliENST00000329066; ENSP00000329869; ENSG00000115705 [P07202-1]
ENST00000345913; ENSP00000318820; ENSG00000115705 [P07202-1]
ENST00000346956; ENSP00000263886; ENSG00000115705 [P07202-4]
ENST00000382198; ENSP00000371633; ENSG00000115705 [P07202-5]
ENST00000382201; ENSP00000371636; ENSG00000115705 [P07202-2]
GeneIDi7173
KEGGihsa:7173
UCSCiuc002qwr.4 human [P07202-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Thyroid peroxidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02969 mRNA Translation: AAA61215.1
J02970 mRNA Translation: AAA61216.1
Y00406 mRNA Translation: CAA68467.1
M25715
, M25702, M25703, M25704, M25705, M25706, M25707, M25708, M25709, M25710, M25711, M25712, M25713, M25714 Genomic DNA Translation: AAA97517.1
X17358 mRNA Translation: CAA35235.1
M17755 mRNA Translation: AAA61217.2
AF439430 mRNA Translation: AAL74416.1
AF533528 mRNA Translation: AAN04471.1
AY136822 mRNA Translation: AAN11302.1
AF533529 mRNA Translation: AAN04472.1
AF533530 mRNA Translation: AAN04473.1
AF533531 mRNA Translation: AAN04474.1
M55702 mRNA Translation: AAA61219.1
M55702 mRNA Translation: AAA61218.1
CCDSiCCDS1643.1 [P07202-1]
CCDS1644.1 [P07202-2]
CCDS1646.1 [P07202-5]
PIRiA32413 OPHUIT
RefSeqiNP_000538.3, NM_000547.5 [P07202-1]
NP_001193673.1, NM_001206744.1 [P07202-1]
NP_001193674.1, NM_001206745.1 [P07202-2]
NP_783650.1, NM_175719.3 [P07202-2]
NP_783652.1, NM_175721.3 [P07202-4]
NP_783653.1, NM_175722.3 [P07202-5]
XP_011508683.1, XM_011510381.2
UniGeneiHs.467554

3D structure databases

ProteinModelPortaliP07202
SMRiP07202
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318820

Chemistry databases

BindingDBiP07202
ChEMBLiCHEMBL1839
DrugBankiDB00389 Carbimazole
DB00509 Dextrothyroxine
DB00763 Methimazole
DB00550 Propylthiouracil

Protein family/group databases

Allergomei9554 Hom s TPO
PeroxiBasei3318 HsTPO01

PTM databases

iPTMnetiP07202
PhosphoSitePlusiP07202

Polymorphism and mutation databases

BioMutaiTPO
DMDMi160281455

Proteomic databases

PaxDbiP07202
PeptideAtlasiP07202
PRIDEiP07202
ProteomicsDBi51964
51965 [P07202-2]
51966 [P07202-3]
51967 [P07202-4]
51968 [P07202-5]
51969 [P07202-6]
51970 [P07202-7]
51971 [P07202-8]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329066; ENSP00000329869; ENSG00000115705 [P07202-1]
ENST00000345913; ENSP00000318820; ENSG00000115705 [P07202-1]
ENST00000346956; ENSP00000263886; ENSG00000115705 [P07202-4]
ENST00000382198; ENSP00000371633; ENSG00000115705 [P07202-5]
ENST00000382201; ENSP00000371636; ENSG00000115705 [P07202-2]
GeneIDi7173
KEGGihsa:7173
UCSCiuc002qwr.4 human [P07202-1]

Organism-specific databases

CTDi7173
DisGeNETi7173
EuPathDBiHostDB:ENSG00000115705.20
GeneCardsiTPO
H-InvDBiHIX0029848
HGNCiHGNC:12015 TPO
HPAiCAB009587
HPA007987
MalaCardsiTPO
MIMi274500 phenotype
606765 gene
neXtProtiNX_P07202
OpenTargetsiENSG00000115705
Orphaneti95716 Familial thyroid dyshormonogenesis
PharmGKBiPA36694
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00550000074325
HOVERGENiHBG000071
InParanoidiP07202
KOiK00431
OMAiMVWGQYI
OrthoDBiEOG091G0236
PhylomeDBiP07202
TreeFamiTF314316

Enzyme and pathway databases

UniPathwayi
UPA00194

BRENDAi3.6.1.52 2681
ReactomeiR-HSA-209968 Thyroxine biosynthesis

Miscellaneous databases

ChiTaRSiTPO human
GenomeRNAii7173
PROiPR:P07202
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115705 Expressed in 86 organ(s), highest expression level in right lobe of thyroid gland
ExpressionAtlasiP07202 baseline and differential
GenevisibleiP07202 HS

Family and domain databases

CDDicd00033 CCP, 1 hit
Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR029589 TPO
PANTHERiPTHR11475:SF60 PTHR11475:SF60, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF07645 EGF_CA, 1 hit
PF00084 Sushi, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00032 CCP, 1 hit
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SUPFAMiSSF48113 SSF48113, 1 hit
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit
PS00435 PEROXIDASE_1, 1 hit
PS50292 PEROXIDASE_3, 1 hit
PS50923 SUSHI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPERT_HUMAN
AccessioniPrimary (citable) accession number: P07202
Secondary accession number(s): P09934
, P09935, Q8IUL0, Q8NF94, Q8NF95, Q8NF96, Q8NF97, Q8TCI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 228 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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