UniProtKB - P07202 (PERT_HUMAN)
Thyroid peroxidase
TPO
Functioni
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.
By similarityCatalytic activityi
- EC:1.11.1.8By similarity
- [thyroglobulin]-L-tyrosine + H+ + H2O2 + iodide = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2OBy similarityEC:1.11.1.8By similarity
- [thyroglobulin]-3-iodo-L-tyrosine + H+ + H2O2 + iodide = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2OBy similarityEC:1.11.1.8By similarity
- 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-dehydroalanine + [thyroglobulin]-L-thyroxine + 2 H2OBy similarityEC:1.11.1.8By similarity
- [thyroglobulin]-3,5-diiodo-L-tyrosine + [thyroglobulin]-3-iodo-L-tyrosine + H2O2 = [thyroglobulin]-3,3',5-triiodo-L-thyronine + [thyroglobulin]-dehydroalanine + 2 H2OBy similarityEC:1.11.1.8By similarity
Cofactori
Protein has several cofactor binding sites:- Ca2+PROSITE-ProRule annotationNote: Binds 1 Ca2+ ion per heterodimer.PROSITE-ProRule annotation
- heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.PROSITE-ProRule annotation
: thyroid hormone biosynthesis Pathwayi
This protein is involved in the pathway thyroid hormone biosynthesis, which is part of Hormone biosynthesis.View all proteins of this organism that are known to be involved in the pathway thyroid hormone biosynthesis and in Hormone biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 238 | Heme; covalent, via 2 linksBy similarity | 1 | |
Active sitei | 239 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Metal bindingi | 240 | CalciumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 321 | CalciumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 323 | Calcium; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 325 | CalciumPROSITE-ProRule annotation | 1 | |
Metal bindingi | 327 | CalciumPROSITE-ProRule annotation | 1 | |
Sitei | 396 | Transition state stabilizerPROSITE-ProRule annotation | 1 | |
Binding sitei | 399 | Heme; covalent, via 2 linksBy similarity | 1 | |
Metal bindingi | 494 | Iron (heme axial ligand)PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- heme binding Source: InterPro
- iodide peroxidase activity Source: UniProtKB-EC
- peroxidase activity Source: GO_Central
GO - Biological processi
- embryonic hemopoiesis Source: DFLAT
- hormone biosynthetic process Source: UniProtKB-KW
- hydrogen peroxide catabolic process Source: UniProtKB-KW
- response to oxidative stress Source: InterPro
- thyroid hormone generation Source: Reactome
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Biological process | Hydrogen peroxide, Thyroid hormones biosynthesis |
Ligand | Calcium, Heme, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.11.1.8, 2681 3.6.1.52, 2681 |
PathwayCommonsi | P07202 |
Reactomei | R-HSA-209968, Thyroxine biosynthesis |
SignaLinki | P07202 |
SIGNORi | P07202 |
UniPathwayi | UPA00194 |
Protein family/group databases
PeroxiBasei | 3318, HsTPO01 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TPOImported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12015, TPO |
MIMi | 606765, gene |
neXtProti | NX_P07202 |
VEuPathDBi | HostDB:ENSG00000115705 |
Subcellular locationi
Other locations
Other locations
Extracellular region or secreted
- extracellular space Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- cell surface Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 846 | ExtracellularSequence analysisAdd BLAST | 828 | |
Transmembranei | 847 – 871 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 872 – 933 | CytoplasmicSequence analysisAdd BLAST | 62 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Thyroid dyshormonogenesis 2A (TDH2A)17 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021622 | 53 | A → P in TDH2A. 1 Publication | 1 | |
Natural variantiVAR_021623 | 240 | D → N in TDH2A; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1427024341Ensembl. | 1 | |
Natural variantiVAR_021624 | 307 | N → T in TDH2A. 1 Publication | 1 | |
Natural variantiVAR_021625 | 326 | A → T in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs371367459Ensembl. | 1 | |
Natural variantiVAR_025784 | 378 | E → K in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1297312788Ensembl. | 1 | |
Natural variantiVAR_078336 | 412 | R → H in TDH2A; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1173922703Ensembl. | 1 | |
Natural variantiVAR_021626 | 433 | V → M in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1035791118Ensembl. | 1 | |
Natural variantiVAR_015375 | 447 | I → F in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs104893669EnsemblClinVar. | 1 | |
Natural variantiVAR_006060 | 453 | Y → D in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908083EnsemblClinVar. | 1 | |
Natural variantiVAR_021627 | 458 | L → P in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1231870370Ensembl. | 1 | |
Natural variantiVAR_021628 | 491 | R → H in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs201165648EnsemblClinVar. | 1 | |
Natural variantiVAR_021629 | 493 | G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs778515113Ensembl. | 1 | |
Natural variantiVAR_021630 | 499 | P → L in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1169072188Ensembl. | 1 | |
Natural variantiVAR_021631 | 527 | W → C in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs779434941Ensembl. | 1 | |
Natural variantiVAR_027229 | 533 | G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication | 1 | |
Natural variantiVAR_027230 | 574 – 575 | Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme. | 2 | |
Natural variantiVAR_027231 | 590 | G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908084EnsemblClinVar. | 1 | |
Natural variantiVAR_078337 | 596 – 933 | Missing in TDH2A; unknown pathological significance. 1 PublicationAdd BLAST | 338 | |
Natural variantiVAR_013138 | 648 | R → Q in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908086EnsemblClinVar. | 1 | |
Natural variantiVAR_021632 | 660 | Q → E in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908088EnsemblClinVar. | 1 | |
Natural variantiVAR_021633 | 665 | R → W in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs776742629Ensembl. | 1 | |
Natural variantiVAR_021634 | 693 | R → W in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs121908087EnsemblClinVar. | 1 | |
Natural variantiVAR_021635 | 771 | G → R in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs138931129Ensembl. | 1 | |
Natural variantiVAR_021636 | 796 | D → Y in TDH2A. 1 Publication | 1 | |
Natural variantiVAR_006062 | 799 | E → K in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908085EnsemblClinVar. | 1 | |
Natural variantiVAR_021637 | 808 | C → R in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs935058009Ensembl. | 1 | |
Natural variantiVAR_027235 | 839 | V → I in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs146351101Ensembl. | 1 |
Keywords - Diseasei
Congenital hypothyroidism, Disease variantOrganism-specific databases
DisGeNETi | 7173 |
MalaCardsi | TPO |
MIMi | 274500, phenotype |
OpenTargetsi | ENSG00000115705 |
Orphaneti | 95716, Familial thyroid dyshormonogenesis |
PharmGKBi | PA36694 |
Miscellaneous databases
Pharosi | P07202, Tclin |
Protein family/group databases
Allergomei | 9554, Hom s TPO |
Chemistry databases
ChEMBLi | CHEMBL1839 |
DrugBanki | DB11496, 2-mercaptobenzothiazole DB00389, Carbimazole DB00509, Dextrothyroxine DB05382, Iodine DB00763, Methimazole DB00550, Propylthiouracil DB11085, Resorcinol DB08604, Triclosan |
DrugCentrali | P07202 |
Genetic variation databases
BioMutai | TPO |
DMDMi | 160281455 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000023662 | 19 – 933 | Thyroid peroxidaseAdd BLAST | 915 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 129 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 142 ↔ 158 | By similarity | ||
Disulfide bondi | 259 ↔ 269 | By similarity | ||
Disulfide bondi | 263 ↔ 286 | By similarity | ||
Glycosylationi | 307 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 342 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 569 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 598 ↔ 655 | By similarity | ||
Disulfide bondi | 696 ↔ 721 | By similarity | ||
Disulfide bondi | 800 ↔ 814 | By similarity | ||
Disulfide bondi | 808 ↔ 823 | By similarity | ||
Disulfide bondi | 825 ↔ 838 | By similarity |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P07202 |
PaxDbi | P07202 |
PeptideAtlasi | P07202 |
PRIDEi | P07202 |
ProteomicsDBi | 51964 [P07202-1] 51965 [P07202-2] 51966 [P07202-3] 51967 [P07202-4] 51968 [P07202-5] 51969 [P07202-6] 51970 [P07202-7] 51971 [P07202-8] |
PTM databases
GlyGeni | P07202, 4 sites |
iPTMneti | P07202 |
PhosphoSitePlusi | P07202 |
Expressioni
Gene expression databases
Bgeei | ENSG00000115705, Expressed in right lobe of thyroid gland and 104 other tissues |
ExpressionAtlasi | P07202, baseline and differential |
Genevisiblei | P07202, HS |
Organism-specific databases
HPAi | ENSG00000115705, Tissue enriched (thyroid) |
Interactioni
Subunit structurei
Interacts with DUOX1, DUOX2 and CYBA.
1 PublicationProtein-protein interaction databases
STRINGi | 9606.ENSP00000318820 |
Chemistry databases
BindingDBi | P07202 |
Miscellaneous databases
RNActi | P07202, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 740 – 795 | SushiPROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 796 – 839 | EGF-like; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 881 – 933 | DisorderedSequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 918 – 933 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Signal, Sushi, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2408, Eukaryota |
GeneTreei | ENSGT00940000158104 |
InParanoidi | P07202 |
OMAi | DSLCMPF |
OrthoDBi | 276568at2759 |
PhylomeDBi | P07202 |
TreeFami | TF314316 |
Family and domain databases
CDDi | cd00033, CCP, 1 hit |
Gene3Di | 1.10.640.10, 1 hit |
InterProi | View protein in InterPro IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR019791, Haem_peroxidase_animal IPR010255, Haem_peroxidase_sf IPR037120, Haem_peroxidase_sf_animal IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom IPR029589, TPO |
PANTHERi | PTHR11475:SF60, PTHR11475:SF60, 1 hit |
Pfami | View protein in Pfam PF03098, An_peroxidase, 1 hit PF07645, EGF_CA, 1 hit PF00084, Sushi, 1 hit |
PRINTSi | PR00457, ANPEROXIDASE |
SMARTi | View protein in SMART SM00032, CCP, 1 hit SM00181, EGF, 1 hit SM00179, EGF_CA, 1 hit |
SUPFAMi | SSF48113, SSF48113, 1 hit SSF57535, SSF57535, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00435, PEROXIDASE_1, 1 hit PS50292, PEROXIDASE_3, 1 hit PS50923, SUSHI, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV
60 70 80 90 100
DTAMYATMQR NLKKRGILSP AQLLSFSKLP EPTSGVIARA AEIMETSIQA
110 120 130 140 150
MKRKVNLKTQ QSQHPTDALS EDLLSIIANM SGCLPYMLPP KCPNTCLANK
160 170 180 190 200
YRPITGACNN RDHPRWGASN TALARWLPPV YEDGFSQPRG WNPGFLYNGF
210 220 230 240 250
PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD IAFTPQSTSK
260 270 280 290 300
AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD
310 320 330 340 350
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL
360 370 380 390 400
RVHARLRDSG RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV
410 420 430 440 450
PSLTALHTLW LREHNRLAAA LKALNAHWSA DAVYQEARKV VGALHQIITL
460 470 480 490 500
RDYIPRILGP EAFQQYVGPY EGYDSTANPT VSNVFSTAAF RFGHATIHPL
510 520 530 540 550
VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR GLLARPAKLQ
560 570 580 590 600
VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL
610 620 630 640 650
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG
660 670 680 690 700
PLFACLIGKQ MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG
710 720 730 740 750
LTRVPMDAFQ VGKFPEDFES CDSITGMNLE AWRETFPQDD KCGFPESVEN
760 770 780 790 800
GDFVHCEESG RRVLVYSCRH GYELQGREQL TCTQEGWDFQ PPLCKDVNEC
810 820 830 840 850
ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD SGRLPRVTWI
860 870 880 890 900
SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ
910 920 930
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL
The sequence of this isoform differs from the canonical sequence as follows:
534-590: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG
The sequence of this isoform differs from the canonical sequence as follows:
534-590: Missing.
874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG
The sequence of this isoform differs from the canonical sequence as follows:
534-590: Missing.
796-839: Missing.
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JP53 | A0A0G2JP53_HUMAN | Thyroid peroxidase | TPO | 933 | Annotation score: | ||
A0A0G2JRZ1 | A0A0G2JRZ1_HUMAN | Thyroid peroxidase | TPO | 916 | Annotation score: | ||
A0A0G2JR31 | A0A0G2JR31_HUMAN | Thyroid peroxidase | TPO | 859 | Annotation score: | ||
A0A0G2JR90 | A0A0G2JR90_HUMAN | Thyroid peroxidase | TPO | 743 | Annotation score: | ||
H7C1F5 | H7C1F5_HUMAN | Thyroid peroxidase | TPO | 404 | Annotation score: | ||
A0A0G2JRX3 | A0A0G2JRX3_HUMAN | Thyroid peroxidase | TPO | 347 | Annotation score: | ||
A0A0G2JNN7 | A0A0G2JNN7_HUMAN | Thyroid peroxidase | TPO | 889 | Annotation score: | ||
H7C5B6 | H7C5B6_HUMAN | Thyroid peroxidase | TPO | 363 | Annotation score: | ||
A0A0G2JS21 | A0A0G2JS21_HUMAN | Thyroid peroxidase | TPO | 346 | Annotation score: | ||
H0Y6H4 | H0Y6H4_HUMAN | Thyroid peroxidase | TPO | 864 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 70 | P → G in AAA61217 (Ref. 5) Curated | 1 | |
Sequence conflicti | 354 | A → G (Ref. 5) Curated | 1 | |
Sequence conflicti | 354 | A → G (PubMed:3654979).Curated | 1 | |
Sequence conflicti | 371 | A → R in AAA61215 (PubMed:3475693).Curated | 1 | |
Sequence conflicti | 371 | A → R in AAA61216 (PubMed:3475693).Curated | 1 | |
Sequence conflicti | 381 | I → N (Ref. 5) Curated | 1 | |
Sequence conflicti | 381 | I → N (PubMed:3654979).Curated | 1 | |
Sequence conflicti | 574 | D → N in CAA68467 (PubMed:3453124).Curated | 1 | |
Sequence conflicti | 732 | W → C in AAN11302 (PubMed:12454013).Curated | 1 | |
Sequence conflicti | 748 | V → M (PubMed:3453124).Curated | 1 | |
Sequence conflicti | 748 | V → M (PubMed:12454013).Curated | 1 | |
Sequence conflicti | 816 | N → S in AAL74416 (Ref. 6) Curated | 1 | |
Sequence conflicti | 872 | R → K (PubMed:3453124).Curated | 1 | |
Sequence conflicti | 872 | R → K (PubMed:12454013).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021622 | 53 | A → P in TDH2A. 1 Publication | 1 | |
Natural variantiVAR_021623 | 240 | D → N in TDH2A; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1427024341Ensembl. | 1 | |
Natural variantiVAR_006057 | 257 | A → S3 PublicationsCorresponds to variant dbSNP:rs4927611EnsemblClinVar. | 1 | |
Natural variantiVAR_021624 | 307 | N → T in TDH2A. 1 Publication | 1 | |
Natural variantiVAR_021625 | 326 | A → T in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs371367459Ensembl. | 1 | |
Natural variantiVAR_006058 | 373 | A → S1 PublicationCorresponds to variant dbSNP:rs2280132EnsemblClinVar. | 1 | |
Natural variantiVAR_025784 | 378 | E → K in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1297312788Ensembl. | 1 | |
Natural variantiVAR_006059 | 398 | S → T1 PublicationCorresponds to variant dbSNP:rs2175977EnsemblClinVar. | 1 | |
Natural variantiVAR_078336 | 412 | R → H in TDH2A; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1173922703Ensembl. | 1 | |
Natural variantiVAR_021626 | 433 | V → M in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1035791118Ensembl. | 1 | |
Natural variantiVAR_015375 | 447 | I → F in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs104893669EnsemblClinVar. | 1 | |
Natural variantiVAR_006060 | 453 | Y → D in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908083EnsemblClinVar. | 1 | |
Natural variantiVAR_021627 | 458 | L → P in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1231870370Ensembl. | 1 | |
Natural variantiVAR_021628 | 491 | R → H in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs201165648EnsemblClinVar. | 1 | |
Natural variantiVAR_021629 | 493 | G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs778515113Ensembl. | 1 | |
Natural variantiVAR_021630 | 499 | P → L in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1169072188Ensembl. | 1 | |
Natural variantiVAR_021631 | 527 | W → C in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs779434941Ensembl. | 1 | |
Natural variantiVAR_027229 | 533 | G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication | 1 | |
Natural variantiVAR_027230 | 574 – 575 | Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme. | 2 | |
Natural variantiVAR_027231 | 590 | G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908084EnsemblClinVar. | 1 | |
Natural variantiVAR_078337 | 596 – 933 | Missing in TDH2A; unknown pathological significance. 1 PublicationAdd BLAST | 338 | |
Natural variantiVAR_027232 | 618 | V → M. Corresponds to variant dbSNP:rs10189135EnsemblClinVar. | 1 | |
Natural variantiVAR_013138 | 648 | R → Q in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908086EnsemblClinVar. | 1 | |
Natural variantiVAR_021632 | 660 | Q → E in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908088EnsemblClinVar. | 1 | |
Natural variantiVAR_021633 | 665 | R → W in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs776742629Ensembl. | 1 | |
Natural variantiVAR_021634 | 693 | R → W in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs121908087EnsemblClinVar. | 1 | |
Natural variantiVAR_027233 | 706 | M → V. Corresponds to variant dbSNP:rs13431173EnsemblClinVar. | 1 | |
Natural variantiVAR_006061 | 725 | T → P5 PublicationsCorresponds to variant dbSNP:rs732609EnsemblClinVar. | 1 | |
Natural variantiVAR_021635 | 771 | G → R in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs138931129Ensembl. | 1 | |
Natural variantiVAR_027234 | 793 | L → P. Corresponds to variant dbSNP:rs28991293Ensembl. | 1 | |
Natural variantiVAR_021636 | 796 | D → Y in TDH2A. 1 Publication | 1 | |
Natural variantiVAR_006062 | 799 | E → K in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908085EnsemblClinVar. | 1 | |
Natural variantiVAR_021637 | 808 | C → R in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs935058009Ensembl. | 1 | |
Natural variantiVAR_027235 | 839 | V → I in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs146351101Ensembl. | 1 | |
Natural variantiVAR_027236 | 846 | R → W. Corresponds to variant dbSNP:rs28913014EnsemblClinVar. | 1 | |
Natural variantiVAR_027237 | 847 | V → A4 PublicationsCorresponds to variant dbSNP:rs1126799EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007268 | 274 – 446 | Missing in isoform 5. 1 PublicationAdd BLAST | 173 | |
Alternative sequenceiVSP_004665 | 534 – 590 | Missing in isoform 2, isoform 2-3, isoform 2-4 and isoform 6. 2 PublicationsAdd BLAST | 57 | |
Alternative sequenceiVSP_007270 | 669 – 933 | Missing in isoform 6. CuratedAdd BLAST | 265 | |
Alternative sequenceiVSP_007269 | 796 – 839 | Missing in isoform 4 and isoform 2-4. CuratedAdd BLAST | 44 | |
Alternative sequenceiVSP_004666 | 874 – 933 | TRTGT…LPRAL → RVLGWKAGILTGCREPSEGK VAGHCRTASCSQNHRTTLFQ TQANRKSAGRLFSQHG in isoform 3 and isoform 2-3. 1 PublicationAdd BLAST | 60 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000329066; ENSP00000329869; ENSG00000115705 ENST00000345913; ENSP00000318820; ENSG00000115705 ENST00000346956; ENSP00000263886; ENSG00000115705 [P07202-4] ENST00000382198; ENSP00000371633; ENSG00000115705 [P07202-5] ENST00000382201; ENSP00000371636; ENSG00000115705 [P07202-2] |
GeneIDi | 7173 |
KEGGi | hsa:7173 |
MANE-Selecti | ENST00000329066.9; ENSP00000329869.4; NM_001206744.2; NP_001193673.1 |
UCSCi | uc002qwr.4, human [P07202-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Thyroid peroxidase entry |
Sequence databases
3D structure databases
SMRi | P07202 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000318820 |
Chemistry databases
BindingDBi | P07202 |
ChEMBLi | CHEMBL1839 |
DrugBanki | DB11496, 2-mercaptobenzothiazole DB00389, Carbimazole DB00509, Dextrothyroxine DB05382, Iodine DB00763, Methimazole DB00550, Propylthiouracil DB11085, Resorcinol DB08604, Triclosan |
DrugCentrali | P07202 |
Protein family/group databases
Allergomei | 9554, Hom s TPO |
PeroxiBasei | 3318, HsTPO01 |
PTM databases
GlyGeni | P07202, 4 sites |
iPTMneti | P07202 |
PhosphoSitePlusi | P07202 |
Genetic variation databases
BioMutai | TPO |
DMDMi | 160281455 |
Proteomic databases
MassIVEi | P07202 |
PaxDbi | P07202 |
PeptideAtlasi | P07202 |
PRIDEi | P07202 |
ProteomicsDBi | 51964 [P07202-1] 51965 [P07202-2] 51966 [P07202-3] 51967 [P07202-4] 51968 [P07202-5] 51969 [P07202-6] 51970 [P07202-7] 51971 [P07202-8] |
Protocols and materials databases
ABCDi | P07202, 56 sequenced antibodies |
Antibodypediai | 2364, 608 antibodies from 34 providers |
DNASUi | 7173 |
Genome annotation databases
Ensembli | ENST00000329066; ENSP00000329869; ENSG00000115705 ENST00000345913; ENSP00000318820; ENSG00000115705 ENST00000346956; ENSP00000263886; ENSG00000115705 [P07202-4] ENST00000382198; ENSP00000371633; ENSG00000115705 [P07202-5] ENST00000382201; ENSP00000371636; ENSG00000115705 [P07202-2] |
GeneIDi | 7173 |
KEGGi | hsa:7173 |
MANE-Selecti | ENST00000329066.9; ENSP00000329869.4; NM_001206744.2; NP_001193673.1 |
UCSCi | uc002qwr.4, human [P07202-1] |
Organism-specific databases
CTDi | 7173 |
DisGeNETi | 7173 |
GeneCardsi | TPO |
HGNCi | HGNC:12015, TPO |
HPAi | ENSG00000115705, Tissue enriched (thyroid) |
MalaCardsi | TPO |
MIMi | 274500, phenotype 606765, gene |
neXtProti | NX_P07202 |
OpenTargetsi | ENSG00000115705 |
Orphaneti | 95716, Familial thyroid dyshormonogenesis |
PharmGKBi | PA36694 |
VEuPathDBi | HostDB:ENSG00000115705 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2408, Eukaryota |
GeneTreei | ENSGT00940000158104 |
InParanoidi | P07202 |
OMAi | DSLCMPF |
OrthoDBi | 276568at2759 |
PhylomeDBi | P07202 |
TreeFami | TF314316 |
Enzyme and pathway databases
UniPathwayi | UPA00194 |
BRENDAi | 1.11.1.8, 2681 3.6.1.52, 2681 |
PathwayCommonsi | P07202 |
Reactomei | R-HSA-209968, Thyroxine biosynthesis |
SignaLinki | P07202 |
SIGNORi | P07202 |
Miscellaneous databases
BioGRID-ORCSi | 7173, 2 hits in 1034 CRISPR screens |
ChiTaRSi | TPO, human |
GenomeRNAii | 7173 |
Pharosi | P07202, Tclin |
PROi | PR:P07202 |
RNActi | P07202, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115705, Expressed in right lobe of thyroid gland and 104 other tissues |
ExpressionAtlasi | P07202, baseline and differential |
Genevisiblei | P07202, HS |
Family and domain databases
CDDi | cd00033, CCP, 1 hit |
Gene3Di | 1.10.640.10, 1 hit |
InterProi | View protein in InterPro IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR019791, Haem_peroxidase_animal IPR010255, Haem_peroxidase_sf IPR037120, Haem_peroxidase_sf_animal IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom IPR029589, TPO |
PANTHERi | PTHR11475:SF60, PTHR11475:SF60, 1 hit |
Pfami | View protein in Pfam PF03098, An_peroxidase, 1 hit PF07645, EGF_CA, 1 hit PF00084, Sushi, 1 hit |
PRINTSi | PR00457, ANPEROXIDASE |
SMARTi | View protein in SMART SM00032, CCP, 1 hit SM00181, EGF, 1 hit SM00179, EGF_CA, 1 hit |
SUPFAMi | SSF48113, SSF48113, 1 hit SSF57535, SSF57535, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01186, EGF_2, 1 hit PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS00435, PEROXIDASE_1, 1 hit PS50292, PEROXIDASE_3, 1 hit PS50923, SUSHI, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PERT_HUMAN | |
Accessioni | P07202Primary (citable) accession number: P07202 Secondary accession number(s): P09934 Q8TCI9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 23, 2022 | |
This is version 248 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families