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UniProtKB - P07202 (PERT_HUMAN)

Entry version 248 (23 Feb 2022)
Sequence version 4 (13 Nov 2007)
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Protein

Thyroid peroxidase

Gene

TPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: thyroid hormone biosynthesis

This protein is involved in the pathway thyroid hormone biosynthesis, which is part of Hormone biosynthesis.
View all proteins of this organism that are known to be involved in the pathway thyroid hormone biosynthesis and in Hormone biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei238Heme; covalent, via 2 linksBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei239Proton acceptorPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi240CalciumPROSITE-ProRule annotation1
Metal bindingi321CalciumPROSITE-ProRule annotation1
Metal bindingi323Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi325CalciumPROSITE-ProRule annotation1
Metal bindingi327CalciumPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei396Transition state stabilizerPROSITE-ProRule annotation1
Binding sitei399Heme; covalent, via 2 linksBy similarity1
Metal bindingi494Iron (heme axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide, Thyroid hormones biosynthesis
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.11.1.8, 2681
3.6.1.52, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P07202

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-209968, Thyroxine biosynthesis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P07202

SIGNOR Signaling Network Open Resource

More...SIGNORi		P07202

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00194

Protein family/group databases

PeroxiBase, a peroxidase database

More...PeroxiBasei		3318, HsTPO01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroid peroxidaseCurated (EC:1.11.1.8By similarity)
Short name:
TPO
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPOImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12015, TPO

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606765, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P07202

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000115705

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 846ExtracellularSequence analysisAdd BLAST828
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei847 – 871HelicalSequence analysisAdd BLAST25
Topological domaini872 – 933CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
Thyroid dyshormonogenesis 2A (TDH2A)17 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02162253A → P in TDH2A. 1 Publication1
Natural variantiVAR_021623240D → N in TDH2A; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1427024341Ensembl.1
Natural variantiVAR_021624307N → T in TDH2A. 1 Publication1
Natural variantiVAR_021625326A → T in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs371367459Ensembl.1
Natural variantiVAR_025784378E → K in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1297312788Ensembl.1
Natural variantiVAR_078336412R → H in TDH2A; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1173922703Ensembl.1
Natural variantiVAR_021626433V → M in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1035791118Ensembl.1
Natural variantiVAR_015375447I → F in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs104893669EnsemblClinVar.1
Natural variantiVAR_006060453Y → D in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908083EnsemblClinVar.1
Natural variantiVAR_021627458L → P in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1231870370Ensembl.1
Natural variantiVAR_021628491R → H in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs201165648EnsemblClinVar.1
Natural variantiVAR_021629493G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs778515113Ensembl.1
Natural variantiVAR_021630499P → L in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1169072188Ensembl.1
Natural variantiVAR_021631527W → C in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs779434941Ensembl.1
Natural variantiVAR_027229533G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication1
Natural variantiVAR_027230574 – 575Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme. 2
Natural variantiVAR_027231590G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908084EnsemblClinVar.1
Natural variantiVAR_078337596 – 933Missing in TDH2A; unknown pathological significance. 1 PublicationAdd BLAST338
Natural variantiVAR_013138648R → Q in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908086EnsemblClinVar.1
Natural variantiVAR_021632660Q → E in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908088EnsemblClinVar.1
Natural variantiVAR_021633665R → W in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs776742629Ensembl.1
Natural variantiVAR_021634693R → W in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs121908087EnsemblClinVar.1
Natural variantiVAR_021635771G → R in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs138931129Ensembl.1
Natural variantiVAR_021636796D → Y in TDH2A. 1 Publication1
Natural variantiVAR_006062799E → K in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908085EnsemblClinVar.1
Natural variantiVAR_021637808C → R in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs935058009Ensembl.1
Natural variantiVAR_027235839V → I in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs146351101Ensembl.1

Keywords - Diseasei

Congenital hypothyroidism, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		7173

MalaCards human disease database

More...MalaCardsi		TPO
MIMi274500, phenotype

Open Targets

More...OpenTargetsi		ENSG00000115705

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		95716, Familial thyroid dyshormonogenesis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36694

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P07202, Tclin

Protein family/group databases

Allergome; a platform for allergen knowledge

More...Allergomei		9554, Hom s TPO

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1839

Drug and drug target database

More...DrugBanki		DB11496, 2-mercaptobenzothiazole
DB00389, Carbimazole
DB00509, Dextrothyroxine
DB05382, Iodine
DB00763, Methimazole
DB00550, Propylthiouracil
DB11085, Resorcinol
DB08604, Triclosan

DrugCentral

More...DrugCentrali		P07202

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TPO

Domain mapping of disease mutations (DMDM)

More...DMDMi		160281455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002366219 – 933Thyroid peroxidaseAdd BLAST915

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi142 ↔ 158By similarity
Disulfide bondi259 ↔ 269By similarity
Disulfide bondi263 ↔ 286By similarity
Glycosylationi307N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi569N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi598 ↔ 655By similarity
Disulfide bondi696 ↔ 721By similarity
Disulfide bondi800 ↔ 814By similarity
Disulfide bondi808 ↔ 823By similarity
Disulfide bondi825 ↔ 838By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.
Heme is covalently bound through a H2O2-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
Cleaved in its N-terminal part.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P07202

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07202

PeptideAtlas

More...PeptideAtlasi		P07202

PRoteomics IDEntifications database

More...PRIDEi		P07202

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51964 [P07202-1]
51965 [P07202-2]
51966 [P07202-3]
51967 [P07202-4]
51968 [P07202-5]
51969 [P07202-6]
51970 [P07202-7]
51971 [P07202-8]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P07202, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P07202

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P07202

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000115705, Expressed in right lobe of thyroid gland and 104 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P07202, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P07202, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000115705, Tissue enriched (thyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DUOX1, DUOX2 and CYBA.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000318820

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P07202

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P07202, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07202

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini740 – 795SushiPROSITE-ProRule annotationAdd BLAST56
Domaini796 – 839EGF-like; calcium-bindingPROSITE-ProRule annotationAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni881 – 933DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi918 – 933Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2408, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158104

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07202

Identification of Orthologs from Complete Genome Data

More...OMAi		DSLCMPF

Database of Orthologous Groups

More...OrthoDBi		276568at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07202

TreeFam database of animal gene trees

More...TreeFami		TF314316

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.640.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR029589, TPO

The PANTHER Classification System

More...PANTHERi		PTHR11475:SF60, PTHR11475:SF60, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF07645, EGF_CA, 1 hit
PF00084, Sushi, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00457, ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 1 hit
SM00181, EGF, 1 hit
SM00179, EGF_CA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48113, SSF48113, 1 hit
SSF57535, SSF57535, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS01187, EGF_CA, 1 hit
PS00435, PEROXIDASE_1, 1 hit
PS50292, PEROXIDASE_3, 1 hit
PS50923, SUSHI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 8 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P07202-1) [UniParc]FASTAAdd to basket
Also known as: TPO1

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV 
        60         70         80         90        100
DTAMYATMQR NLKKRGILSP AQLLSFSKLP EPTSGVIARA AEIMETSIQA 
       110        120        130        140        150
MKRKVNLKTQ QSQHPTDALS EDLLSIIANM SGCLPYMLPP KCPNTCLANK 
       160        170        180        190        200
YRPITGACNN RDHPRWGASN TALARWLPPV YEDGFSQPRG WNPGFLYNGF 
       210        220        230        240        250
PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD IAFTPQSTSK 
       260        270        280        290        300
AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD 
       310        320        330        340        350
QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL 
       360        370        380        390        400
RVHARLRDSG RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRASEV 
       410        420        430        440        450
PSLTALHTLW LREHNRLAAA LKALNAHWSA DAVYQEARKV VGALHQIITL 
       460        470        480        490        500
RDYIPRILGP EAFQQYVGPY EGYDSTANPT VSNVFSTAAF RFGHATIHPL 
       510        520        530        540        550
VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR GLLARPAKLQ 
       560        570        580        590        600
VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL 
       610        620        630        640        650
PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG 
       660        670        680        690        700
PLFACLIGKQ MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG 
       710        720        730        740        750
LTRVPMDAFQ VGKFPEDFES CDSITGMNLE AWRETFPQDD KCGFPESVEN 
       760        770        780        790        800
GDFVHCEESG RRVLVYSCRH GYELQGREQL TCTQEGWDFQ PPLCKDVNEC 
       810        820        830        840        850
ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD SGRLPRVTWI 
       860        870        880        890        900
SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ 
       910        920        930 
AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL
Length:933
Mass (Da):102,963
Last modified:November 13, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF67C5F1A4AEE0B29
GO
Isoform 2 (identifier: P07202-2) [UniParc]FASTAAdd to basket
Also known as: TPO2

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.

Note: Lacks exon 10. Found in normal thyroid tissues as well as Graves'tissues. Rapidly degraded after synthesis, does not reach the cell surface. Inactive.Curated
Show »
Length:876
Mass (Da):96,699
Checksum:iF4CF0D050608F808
GO
Isoform 3 (identifier: P07202-3) [UniParc]FASTAAdd to basket
Also known as: TPO3, Graves' disease, TPOzaninelli

The sequence of this isoform differs from the canonical sequence as follows:
     874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG

Note: Lacks exon 16. Found in normal thyroid tissues as well as Graves'tissues. Active.Curated
Show »
Length:929
Mass (Da):102,771
Checksum:i423AC29EEB27277B
GO
Isoform 4 (identifier: P07202-4) [UniParc]FASTAAdd to basket
Also known as: TPO4

The sequence of this isoform differs from the canonical sequence as follows:
     796-839: Missing.

Note: Lacks exon 14. Active.Curated
Show »
Length:889
Mass (Da):98,327
Checksum:iF9C575FC93A450C8
GO
Isoform 5 (identifier: P07202-5) [UniParc]FASTAAdd to basket
Also known as: TPO5

The sequence of this isoform differs from the canonical sequence as follows:
     274-446: Missing.

Note: Lacks exon 8. Does not fold correctly. Does not reach the cell surface.Curated
Show »
Length:760
Mass (Da):84,581
Checksum:i3C6150EA7E602B78
GO
Isoform 6 (identifier: P07202-6) [UniParc]FASTAAdd to basket
Also known as: TPO6

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     669-933: Missing.

Note: Lacks exons 10, 12, 13, 14 and 16.Curated
Show »
Length:611
Mass (Da):67,293
Checksum:i7AD0B6FA3206066A
GO
Isoform 2-3 (identifier: P07202-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     874-933: TRTGTKSTLP...RDTHRLPRAL → RVLGWKAGIL...SAGRLFSQHG

Note: Lacks exons 10 and 16.Curated
Show »
Length:872
Mass (Da):96,507
Checksum:i3EDC31BFE86C24E2
GO
Isoform 2-4 (identifier: P07202-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-590: Missing.
     796-839: Missing.

Note: Lacks exons 10 and 14.Curated
Show »
Length:832
Mass (Da):92,063
Checksum:i7C6D17A3B62C1D7D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JP53A0A0G2JP53_HUMAN
Thyroid peroxidase
TPO
933Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRZ1A0A0G2JRZ1_HUMAN
Thyroid peroxidase
TPO
916Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JR31A0A0G2JR31_HUMAN
Thyroid peroxidase
TPO
859Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JR90A0A0G2JR90_HUMAN
Thyroid peroxidase
TPO
743Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1F5H7C1F5_HUMAN
Thyroid peroxidase
TPO
404Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JRX3A0A0G2JRX3_HUMAN
Thyroid peroxidase
TPO
347Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNN7A0A0G2JNN7_HUMAN
Thyroid peroxidase
TPO
889Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5B6H7C5B6_HUMAN
Thyroid peroxidase
TPO
363Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JS21A0A0G2JS21_HUMAN
Thyroid peroxidase
TPO
346Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6H4H0Y6H4_HUMAN
Thyroid peroxidase
TPO
864Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70P → G in AAA61217 (Ref. 5) Curated1
Sequence conflicti354A → G (Ref. 5) Curated1
Sequence conflicti354A → G (PubMed:3654979).Curated1
Sequence conflicti371A → R in AAA61215 (PubMed:3475693).Curated1
Sequence conflicti371A → R in AAA61216 (PubMed:3475693).Curated1
Sequence conflicti381I → N (Ref. 5) Curated1
Sequence conflicti381I → N (PubMed:3654979).Curated1
Sequence conflicti574D → N in CAA68467 (PubMed:3453124).Curated1
Sequence conflicti732W → C in AAN11302 (PubMed:12454013).Curated1
Sequence conflicti748V → M (PubMed:3453124).Curated1
Sequence conflicti748V → M (PubMed:12454013).Curated1
Sequence conflicti816N → S in AAL74416 (Ref. 6) Curated1
Sequence conflicti872R → K (PubMed:3453124).Curated1
Sequence conflicti872R → K (PubMed:12454013).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02162253A → P in TDH2A. 1 Publication1
Natural variantiVAR_021623240D → N in TDH2A; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1427024341Ensembl.1
Natural variantiVAR_006057257A → S3 PublicationsCorresponds to variant dbSNP:rs4927611EnsemblClinVar.1
Natural variantiVAR_021624307N → T in TDH2A. 1 Publication1
Natural variantiVAR_021625326A → T in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs371367459Ensembl.1
Natural variantiVAR_006058373A → S1 PublicationCorresponds to variant dbSNP:rs2280132EnsemblClinVar.1
Natural variantiVAR_025784378E → K in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1297312788Ensembl.1
Natural variantiVAR_006059398S → T1 PublicationCorresponds to variant dbSNP:rs2175977EnsemblClinVar.1
Natural variantiVAR_078336412R → H in TDH2A; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1173922703Ensembl.1
Natural variantiVAR_021626433V → M in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1035791118Ensembl.1
Natural variantiVAR_015375447I → F in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs104893669EnsemblClinVar.1
Natural variantiVAR_006060453Y → D in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908083EnsemblClinVar.1
Natural variantiVAR_021627458L → P in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1231870370Ensembl.1
Natural variantiVAR_021628491R → H in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs201165648EnsemblClinVar.1
Natural variantiVAR_021629493G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs778515113Ensembl.1
Natural variantiVAR_021630499P → L in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs1169072188Ensembl.1
Natural variantiVAR_021631527W → C in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs779434941Ensembl.1
Natural variantiVAR_027229533G → C in TDH2A; partial defect; expression slightly lower in efficiency and more degenerative than wild-type enzyme. 1 Publication1
Natural variantiVAR_027230574 – 575Missing in TDH2A; partial defect; expressed on the plasma membrane surface at less than half the rate of wild-type enzyme. 2
Natural variantiVAR_027231590G → S in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908084EnsemblClinVar.1
Natural variantiVAR_078337596 – 933Missing in TDH2A; unknown pathological significance. 1 PublicationAdd BLAST338
Natural variantiVAR_027232618V → M. Corresponds to variant dbSNP:rs10189135EnsemblClinVar.1
Natural variantiVAR_013138648R → Q in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908086EnsemblClinVar.1
Natural variantiVAR_021632660Q → E in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs121908088EnsemblClinVar.1
Natural variantiVAR_021633665R → W in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs776742629Ensembl.1
Natural variantiVAR_021634693R → W in TDH2A. 2 PublicationsCorresponds to variant dbSNP:rs121908087EnsemblClinVar.1
Natural variantiVAR_027233706M → V. Corresponds to variant dbSNP:rs13431173EnsemblClinVar.1
Natural variantiVAR_006061725T → P5 PublicationsCorresponds to variant dbSNP:rs732609EnsemblClinVar.1
Natural variantiVAR_021635771G → R in TDH2A; fails to localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs138931129Ensembl.1
Natural variantiVAR_027234793L → P. Corresponds to variant dbSNP:rs28991293Ensembl.1
Natural variantiVAR_021636796D → Y in TDH2A. 1 Publication1
Natural variantiVAR_006062799E → K in TDH2A. 3 PublicationsCorresponds to variant dbSNP:rs121908085EnsemblClinVar.1
Natural variantiVAR_021637808C → R in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs935058009Ensembl.1
Natural variantiVAR_027235839V → I in TDH2A. 1 PublicationCorresponds to variant dbSNP:rs146351101Ensembl.1
Natural variantiVAR_027236846R → W. Corresponds to variant dbSNP:rs28913014EnsemblClinVar.1
Natural variantiVAR_027237847V → A4 PublicationsCorresponds to variant dbSNP:rs1126799EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007268274 – 446Missing in isoform 5. 1 PublicationAdd BLAST173
Alternative sequenceiVSP_004665534 – 590Missing in isoform 2, isoform 2-3, isoform 2-4 and isoform 6. 2 PublicationsAdd BLAST57
Alternative sequenceiVSP_007270669 – 933Missing in isoform 6. CuratedAdd BLAST265
Alternative sequenceiVSP_007269796 – 839Missing in isoform 4 and isoform 2-4. CuratedAdd BLAST44
Alternative sequenceiVSP_004666874 – 933TRTGT…LPRAL → RVLGWKAGILTGCREPSEGK VAGHCRTASCSQNHRTTLFQ TQANRKSAGRLFSQHG in isoform 3 and isoform 2-3. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J02969 mRNA Translation: AAA61215.1
J02970 mRNA Translation: AAA61216.1
Y00406 mRNA Translation: CAA68467.1
M25715 M25714 Genomic DNA Translation: AAA97517.1
X17358 mRNA Translation: CAA35235.1
M17755 mRNA Translation: AAA61217.2
AF439430 mRNA Translation: AAL74416.1
AF533528 mRNA Translation: AAN04471.1
AY136822 mRNA Translation: AAN11302.1
AF533529 mRNA Translation: AAN04472.1
AF533530 mRNA Translation: AAN04473.1
AF533531 mRNA Translation: AAN04474.1
M55702 mRNA Translation: AAA61219.1
M55702 mRNA Translation: AAA61218.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1643.1 [P07202-1]
CCDS1644.1 [P07202-2]
CCDS1646.1 [P07202-5]

Protein sequence database of the Protein Information Resource

More...PIRi		A32413, OPHUIT

NCBI Reference Sequences

More...RefSeqi		NP_000538.3, NM_000547.5 [P07202-1]
NP_001193673.1, NM_001206744.1 [P07202-1]
NP_001193674.1, NM_001206745.1 [P07202-2]
NP_783650.1, NM_175719.3 [P07202-2]
NP_783652.1, NM_175721.3 [P07202-4]
NP_783653.1, NM_175722.3 [P07202-5]
XP_011508683.1, XM_011510381.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329066; ENSP00000329869; ENSG00000115705
ENST00000345913; ENSP00000318820; ENSG00000115705
ENST00000346956; ENSP00000263886; ENSG00000115705 [P07202-4]
ENST00000382198; ENSP00000371633; ENSG00000115705 [P07202-5]
ENST00000382201; ENSP00000371636; ENSG00000115705 [P07202-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7173

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7173

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000329066.9; ENSP00000329869.4; NM_001206744.2; NP_001193673.1

UCSC genome browser

More...UCSCi		uc002qwr.4, human [P07202-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Thyroid peroxidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02969 mRNA Translation: AAA61215.1
J02970 mRNA Translation: AAA61216.1
Y00406 mRNA Translation: CAA68467.1
M25715 M25714 Genomic DNA Translation: AAA97517.1
X17358 mRNA Translation: CAA35235.1
M17755 mRNA Translation: AAA61217.2
AF439430 mRNA Translation: AAL74416.1
AF533528 mRNA Translation: AAN04471.1
AY136822 mRNA Translation: AAN11302.1
AF533529 mRNA Translation: AAN04472.1
AF533530 mRNA Translation: AAN04473.1
AF533531 mRNA Translation: AAN04474.1
M55702 mRNA Translation: AAA61219.1
M55702 mRNA Translation: AAA61218.1
CCDSiCCDS1643.1 [P07202-1]
CCDS1644.1 [P07202-2]
CCDS1646.1 [P07202-5]
PIRiA32413, OPHUIT
RefSeqiNP_000538.3, NM_000547.5 [P07202-1]
NP_001193673.1, NM_001206744.1 [P07202-1]
NP_001193674.1, NM_001206745.1 [P07202-2]
NP_783650.1, NM_175719.3 [P07202-2]
NP_783652.1, NM_175721.3 [P07202-4]
NP_783653.1, NM_175722.3 [P07202-5]
XP_011508683.1, XM_011510381.2

3D structure databases

SMRiP07202
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000318820

Chemistry databases

BindingDBiP07202
ChEMBLiCHEMBL1839
DrugBankiDB11496, 2-mercaptobenzothiazole
DB00389, Carbimazole
DB00509, Dextrothyroxine
DB05382, Iodine
DB00763, Methimazole
DB00550, Propylthiouracil
DB11085, Resorcinol
DB08604, Triclosan
DrugCentraliP07202

Protein family/group databases

Allergomei9554, Hom s TPO
PeroxiBasei3318, HsTPO01

PTM databases

GlyGeniP07202, 4 sites
iPTMnetiP07202
PhosphoSitePlusiP07202

Genetic variation databases

BioMutaiTPO
DMDMi160281455

Proteomic databases

MassIVEiP07202
PaxDbiP07202
PeptideAtlasiP07202
PRIDEiP07202
ProteomicsDBi51964 [P07202-1]
51965 [P07202-2]
51966 [P07202-3]
51967 [P07202-4]
51968 [P07202-5]
51969 [P07202-6]
51970 [P07202-7]
51971 [P07202-8]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P07202, 56 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2364, 608 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		7173

Genome annotation databases

EnsembliENST00000329066; ENSP00000329869; ENSG00000115705
ENST00000345913; ENSP00000318820; ENSG00000115705
ENST00000346956; ENSP00000263886; ENSG00000115705 [P07202-4]
ENST00000382198; ENSP00000371633; ENSG00000115705 [P07202-5]
ENST00000382201; ENSP00000371636; ENSG00000115705 [P07202-2]
GeneIDi7173
KEGGihsa:7173
MANE-SelectiENST00000329066.9; ENSP00000329869.4; NM_001206744.2; NP_001193673.1
UCSCiuc002qwr.4, human [P07202-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7173
DisGeNETi7173

GeneCards: human genes, protein and diseases

More...GeneCardsi		TPO
HGNCiHGNC:12015, TPO
HPAiENSG00000115705, Tissue enriched (thyroid)
MalaCardsiTPO
MIMi274500, phenotype
606765, gene
neXtProtiNX_P07202
OpenTargetsiENSG00000115705
Orphaneti95716, Familial thyroid dyshormonogenesis
PharmGKBiPA36694
VEuPathDBiHostDB:ENSG00000115705

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2408, Eukaryota
GeneTreeiENSGT00940000158104
InParanoidiP07202
OMAiDSLCMPF
OrthoDBi276568at2759
PhylomeDBiP07202
TreeFamiTF314316

Enzyme and pathway databases

UniPathwayiUPA00194
BRENDAi1.11.1.8, 2681
3.6.1.52, 2681
PathwayCommonsiP07202
ReactomeiR-HSA-209968, Thyroxine biosynthesis
SignaLinkiP07202
SIGNORiP07202

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7173, 2 hits in 1034 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TPO, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7173
PharosiP07202, Tclin

Protein Ontology

More...PROi		PR:P07202
RNActiP07202, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000115705, Expressed in right lobe of thyroid gland and 104 other tissues
ExpressionAtlasiP07202, baseline and differential
GenevisibleiP07202, HS

Family and domain databases

CDDicd00033, CCP, 1 hit
Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR029589, TPO
PANTHERiPTHR11475:SF60, PTHR11475:SF60, 1 hit
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF07645, EGF_CA, 1 hit
PF00084, Sushi, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SMARTiView protein in SMART
SM00032, CCP, 1 hit
SM00181, EGF, 1 hit
SM00179, EGF_CA, 1 hit
SUPFAMiSSF48113, SSF48113, 1 hit
SSF57535, SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS01187, EGF_CA, 1 hit
PS00435, PEROXIDASE_1, 1 hit
PS50292, PEROXIDASE_3, 1 hit
PS50923, SUSHI, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPERT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07202
Secondary accession number(s): P09934
, P09935, Q8IUL0, Q8NF94, Q8NF95, Q8NF96, Q8NF97, Q8TCI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 13, 2007
Last modified: February 23, 2022
This is version 248 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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