UniProtKB - P07197 (NFM_HUMAN)

BLAST

>sp|P07197|NFM_HUMAN Neurofilament medium polypeptide OS=Homo sapiens OX=9606 GN=NEFM PE=1 SV=3
MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPR
LAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVH
YLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEE
DIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEE
EVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLT
EAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQ
DTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSIT
GPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEEL
AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEED
EGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE
LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP
VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK
KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE
GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD
EKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKV
EKVTSHAIVKEVTQSD

Align

Format
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History
Entry version 190 (07 Nov 2018)
Sequence version 3 (15 Dec 2009)
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Protein

Neurofilament medium polypeptide

Gene

NEFM

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.

GO - Molecular functionⁱ

microtubule binding
Source: BHF-UCL
Traceable author statementⁱ
- 17498690
structural constituent of cytoskeleton
Source: ProtInc
Traceable author statementⁱ
- 3608989

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon development Source: InterPro
neurofilament bundle assembly
Source: BHF-UCL
Traceable author statementⁱ
- 17498690

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SIGNORⁱ	P07197

SIGNORⁱ

P07197

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neurofilament medium polypeptide Short name: NF-M Alternative name(s): 160 kDa neurofilament protein Neurofilament 3 Neurofilament triplet M protein
Gene namesⁱ	Name:NEFM Synonyms:NEF3, NFM
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104722.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7734 NEFM
MIMⁱ	162250 gene
neXtProtⁱ	NX_P07197

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

Intermediate filament

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4741
Open Targets More...OpenTargetsⁱ	ENSG00000104722
PharmGKBⁱ	PA162397442

Polymorphism and mutation databases

BioMutaⁱ	NEFM
DMDMⁱ	281185500

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000063794	2 – 916	Neurofilament medium polypeptideAdd BLAST		915

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineBy similarity	1
Modified residueⁱ	30	PhosphoserineBy similarity	1
Modified residueⁱ	42	Omega-N-methylarginineBy similarity	1
Glycosylationⁱ	47	O-linked (GlcNAc) threonineBy similarity	1
Modified residueⁱ	99	PhosphoserineBy similarity	1
Modified residueⁱ	226	PhosphoserineBy similarity	1
Modified residueⁱ	320	PhosphotyrosineBy similarity	1
Modified residueⁱ	346	PhosphoserineBy similarity	1
Modified residueⁱ	418	PhosphoserineBy similarity	1
Glycosylationⁱ	431	O-linked (GlcNAc) threonineBy similarity	1
Modified residueⁱ	467	PhosphoserineBy similarity	1
Modified residueⁱ	483	PhosphoserineBy similarity	1
Modified residueⁱ	511	PhosphoserineBy similarity	1
Modified residueⁱ	545	PhosphoserineBy similarity	1
Modified residueⁱ	553	PhosphoserineBy similarity	1
Modified residueⁱ	558	PhosphoserineBy similarity	1
Modified residueⁱ	559	PhosphoserineBy similarity	1
Modified residueⁱ	571	PhosphothreonineBy similarity	1
Modified residueⁱ	641	PhosphoserineBy similarity	1
Modified residueⁱ	646	PhosphoserineBy similarity	1
Modified residueⁱ	680	PhosphoserineBy similarity	1
Modified residueⁱ	685	PhosphoserineBy similarity	1
Modified residueⁱ	736	PhosphoserineBy similarity	1
Modified residueⁱ	783	PhosphoserineBy similarity	1
Modified residueⁱ	821	PhosphoserineBy similarity	1
Modified residueⁱ	837	PhosphoserineCombined sources	1

Post-translational modificationⁱ

There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.

Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.

Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.

Keywords - PTMⁱ

Acetylation, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	P07197
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P07197
PaxDbⁱ	P07197
PeptideAtlas More...PeptideAtlasⁱ	P07197
PRIDEⁱ	P07197
ProteomicsDBⁱ	51962

2D gel databases

UCD-2DPAGEⁱ	P07197

UCD-2DPAGEⁱ

P07197

PTM databases

iPTMnetⁱ	P07197
PhosphoSitePlusⁱ	P07197
SwissPalmⁱ	P07197

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000104722 Expressed in 159 organ(s), highest expression level in dorsal root ganglion
CleanExⁱ	HS_NEFM
ExpressionAtlasⁱ	P07197 baseline and differential
Genevisibleⁱ	P07197 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010900 CAB012976 HPA022845 HPA023138

HPAⁱ

CAB010900
CAB012976
HPA022845
HPA023138

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
JUN	P05412	2	EBI-1105035,EBI-852823
RB1	P06400	2	EBI-1105035,EBI-491274
SMAD2	Q15796	3	EBI-1105035,EBI-1040141
VIM	P08670	3	EBI-1105035,EBI-353844

GO - Molecular functionⁱ

microtubule binding
Source: BHF-UCL
Traceable author statementⁱ
- 17498690

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110818, 50 interactors
IntActⁱ	P07197, 24 interactors
Molecular INTeraction database More...MINTⁱ	P07197
STRINGⁱ	9606.ENSP00000221166

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P07197
SMRⁱ	P07197
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	101 – 412	IF rodPROSITE-ProRule annotationAdd BLAST	312
Repeatⁱ	614 – 626	1Add BLAST	13
Repeatⁱ	627 – 639	2Add BLAST	13
Repeatⁱ	640 – 652	3Add BLAST	13
Repeatⁱ	653 – 665	4Add BLAST	13
Repeatⁱ	666 – 678	5Add BLAST	13
Repeatⁱ	679 – 691	6Add BLAST	13

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2 – 104	HeadAdd BLAST	103
Regionⁱ	105 – 136	Coil 1AAdd BLAST	32
Regionⁱ	137 – 149	Linker 1Add BLAST	13
Regionⁱ	150 – 248	Coil 1BAdd BLAST	99
Regionⁱ	249 – 265	Linker 12Add BLAST	17
Regionⁱ	266 – 287	Coil 2AAdd BLAST	22
Regionⁱ	288 – 291	Linker 2	4
Regionⁱ	292 – 412	Coil 2BAdd BLAST	121
Regionⁱ	413 – 916	TailAdd BLAST	504
Regionⁱ	614 – 691	6 X 13 AA approximate tandem repeats of K-S-P-V-[PS]-K-S-P-V-E-E-[KA]-[GAK]Add BLAST	78

Sequence similaritiesⁱ

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IGME Eukaryota ENOG410XPTM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143989
HOGENOMⁱ	HOG000230977
HOVERGENⁱ	HBG013015
InParanoidⁱ	P07197
KEGG Orthology (KO) More...KOⁱ	K04573
OMAⁱ	EERHNND
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G12MK
PhylomeDBⁱ	P07197
TreeFamⁱ	TF330122

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR006821 Intermed_filament_DNA-bd IPR002957 Keratin_I IPR027697 NF-M
PANTHERⁱ	PTHR23239 PTHR23239, 2 hits PTHR23239:SF19 PTHR23239:SF19, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF04732 Filament_head, 1 hit
PRINTSⁱ	PR01248 TYPE1KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P07197-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYTLDSLGN PSAYRRVTET RSSFSRVSGS PSSGFRSQSW SRGSPSTVSS 
        60         70         80         90        100
SYKRSMLAPR LAYSSAMLSS AESSLDFSQS SSLLNGGSGP GGDYKLSRSN 
       110        120        130        140        150
EKEQLQGLND RFAGYIEKVH YLEQQNKEIE AEIQALRQKQ ASHAQLGDAY 
       160        170        180        190        200
DQEIRELRAT LEMVNHEKAQ VQLDSDHLEE DIHRLKERFE EEARLRDDTE 
       210        220        230        240        250
AAIRALRKDI EEASLVKVEL DKKVQSLQDE VAFLRSNHEE EVADLLAQIQ 
       260        270        280        290        300
ASHITVERKD YLKTDISTAL KEIRSQLESH SDQNMHQAEE WFKCRYAKLT 
       310        320        330        340        350
EAAEQNKEAI RSAKEEIAEY RRQLQSKSIE LESVRGTKES LERQLSDIEE 
       360        370        380        390        400
RHNHDLSSYQ DTIQQLENEL RGTKWEMARH LREYQDLLNV KMALDIEIAA 
       410        420        430        440        450
YRKLLEGEET RFSTFAGSIT GPLYTHRPPI TISSKIQKPK VEAPKLKVQH 
       460        470        480        490        500
KFVEEIIEET KVEDEKSEME EALTAITEEL AVSMKEEKKE AAEEKEEEPE 
       510        520        530        540        550
AEEEEVAAKK SPVKATAPEV KEEEGEKEEE EGQEEEEEED EGAKSDQAEE 
       560        570        580        590        600
GGSEKEGSSE KEEGEQEEGE TEAEAEGEEA EAKEEKKVEE KSEEVATKEE 
       610        620        630        640        650
LVADAKVEKP EKAKSPVPKS PVEEKGKSPV PKSPVEEKGK SPVPKSPVEE 
       660        670        680        690        700
KGKSPVPKSP VEEKGKSPVS KSPVEEKAKS PVPKSPVEEA KSKAEVGKGE 
       710        720        730        740        750
QKEEEEKEVK EAPKEEKVEK KEEKPKDVPE KKKAESPVKE EAVAEVVTIT 
       760        770        780        790        800
KSVKVHLEKE TKEEGKPLQQ EKEKEKAGGE GGSEEEGSDK GAKGSRKEDI 
       810        820        830        840        850
AVNGEVEGKE EVEQETKEKG SGREEEKGVV TNGLDLSPAD EKKGGDKSEE 
       860        870        880        890        900
KVVVTKTVEK ITSEGGDGAT KYITKSVTVT QKVEEHEETF EEKLVSTKKV 
       910 
EKVTSHAIVK EVTQSD

Length:916

Mass (Da):102,472

Last modified:December 15, 2009 - v3

Checksum:ⁱ187B16CA6C6BF092

Isoform 2 (identifier: P07197-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-376: Missing.

« Hide

        10         20         30         40         50
MARHLREYQD LLNVKMALDI EIAAYRKLLE GEETRFSTFA GSITGPLYTH 
        60         70         80         90        100
RPPITISSKI QKPKVEAPKL KVQHKFVEEI IEETKVEDEK SEMEEALTAI 
       110        120        130        140        150
TEELAVSMKE EKKEAAEEKE EEPEAEEEEV AAKKSPVKAT APEVKEEEGE 
       160        170        180        190        200
KEEEEGQEEE EEEDEGAKSD QAEEGGSEKE GSSEKEEGEQ EEGETEAEAE 
       210        220        230        240        250
GEEAEAKEEK KVEEKSEEVA TKEELVADAK VEKPEKAKSP VPKSPVEEKG 
       260        270        280        290        300
KSPVPKSPVE EKGKSPVPKS PVEEKGKSPV PKSPVEEKGK SPVSKSPVEE 
       310        320        330        340        350
KAKSPVPKSP VEEAKSKAEV GKGEQKEEEE KEVKEAPKEE KVEKKEEKPK 
       360        370        380        390        400
DVPEKKKAES PVKEEAVAEV VTITKSVKVH LEKETKEEGK PLQQEKEKEK 
       410        420        430        440        450
AGGEGGSEEE GSDKGAKGSR KEDIAVNGEV EGKEEVEQET KEKGSGREEE 
       460        470        480        490        500
KGVVTNGLDL SPADEKKGGD KSEEKVVVTK TVEKITSEGG DGATKYITKS 
       510        520        530        540
VTVTQKVEEH EETFEEKLVS TKKVEKVTSH AIVKEVTQSD

Note: No experimental confirmation available.

Show »

Length:540

Mass (Da):59,468

Checksum:ⁱ8CBBDA0C4D31F90F

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7ESP9	E7ESP9_HUMAN	Neurofilament medium polypeptide Neurofilament medium polypeptide	NEFM	877	Annotation score:
E7EMV2	E7EMV2_HUMAN	Neurofilament medium polypeptide Neurofilament medium polypeptide	NEFM	698	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	482	V → A in CAA68276 (PubMed:3608989).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_060732	439	P → TCombined sources5 PublicationsCorresponds to variant dbSNP:rs196864Ensembl.		1
Natural variantⁱVAR_056024	725	P → Q. Corresponds to variant dbSNP:rs196863EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046306	1 – 376	Missing in isoform 2. 1 PublicationAdd BLAST		376

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00067 Genomic DNA Translation: CAA68276.1 EF560736 mRNA Translation: ABQ59046.1 AK294681 mRNA Translation: BAG57843.1 AF106564 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63602.1 BC096757 mRNA Translation: AAH96757.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47831.1 [P07197-2] CCDS6046.1 [P07197-1]
PIRⁱ	A27864
NCBI Reference Sequences More...RefSeqⁱ	NP_005373.2, NM_005382.2 [P07197-1]
UniGeneⁱ	Hs.458657 Hs.730072

Genome annotation databases

Ensemblⁱ	ENST00000221166; ENSP00000221166; ENSG00000104722 [P07197-1] ENST00000433454; ENSP00000412295; ENSG00000104722 [P07197-2]
GeneIDⁱ	4741
KEGGⁱ	hsa:4741
UCSC genome browser More...UCSCⁱ	uc003xed.5 human [P07197-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P07197	Isoform 2 of Neurofilament medium polypeptide		HUMAN		540	UniRef90_P07197
Uncharacterized protein		PAPAN		932
Uncharacterized protein		CERAT		931
Uncharacterized protein		MACMU		919
Uncharacterized protein		CHLSB		919
+12

Protein	Similar proteins		Species	Score	Length	Source
P07197	Neurofilament medium polypeptide		RAT		846	UniRef50_P12839
Neurofilament medium polypeptide		MOUSE		848
Neurofilament medium polypeptide		BOVIN		926
Uncharacterized protein		RHIRO		880
NEFM isoform 3		PANTR		877
+120

Cross-referencesⁱ

Web resourcesⁱ

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00067 Genomic DNA Translation: CAA68276.1 EF560736 mRNA Translation: ABQ59046.1 AK294681 mRNA Translation: BAG57843.1 AF106564 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63602.1 BC096757 mRNA Translation: AAH96757.1
CCDSⁱ	CCDS47831.1 [P07197-2] CCDS6046.1 [P07197-1]
PIRⁱ	A27864
RefSeqⁱ	NP_005373.2, NM_005382.2 [P07197-1]
UniGeneⁱ	Hs.458657 Hs.730072

3D structure databases

ProteinModelPortalⁱ	P07197
SMRⁱ	P07197
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110818, 50 interactors
IntActⁱ	P07197, 24 interactors
MINTⁱ	P07197
STRINGⁱ	9606.ENSP00000221166

PTM databases

iPTMnetⁱ	P07197
PhosphoSitePlusⁱ	P07197
SwissPalmⁱ	P07197

Polymorphism and mutation databases

BioMutaⁱ	NEFM
DMDMⁱ	281185500

2D gel databases

UCD-2DPAGEⁱ	P07197

UCD-2DPAGEⁱ

P07197

Proteomic databases

EPDⁱ	P07197
MaxQBⁱ	P07197
PaxDbⁱ	P07197
PeptideAtlasⁱ	P07197
PRIDEⁱ	P07197
ProteomicsDBⁱ	51962

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4741
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000221166; ENSP00000221166; ENSG00000104722 [P07197-1] ENST00000433454; ENSP00000412295; ENSG00000104722 [P07197-2]
GeneIDⁱ	4741
KEGGⁱ	hsa:4741
UCSCⁱ	uc003xed.5 human [P07197-1]

Organism-specific databases

CTDⁱ	4741
DisGeNETⁱ	4741
EuPathDBⁱ	HostDB:ENSG00000104722.13
GeneCardsⁱ	NEFM
H-InvDBⁱ	HIX0034266 HIX0034491
HGNCⁱ	HGNC:7734 NEFM
HPAⁱ	CAB010900 CAB012976 HPA022845 HPA023138
MIMⁱ	162250 gene
neXtProtⁱ	NX_P07197
OpenTargetsⁱ	ENSG00000104722
PharmGKBⁱ	PA162397442
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGME Eukaryota ENOG410XPTM LUCA
GeneTreeⁱ	ENSGT00910000143989
HOGENOMⁱ	HOG000230977
HOVERGENⁱ	HBG013015
InParanoidⁱ	P07197
KOⁱ	K04573
OMAⁱ	EERHNND
OrthoDBⁱ	EOG091G12MK
PhylomeDBⁱ	P07197
TreeFamⁱ	TF330122

Enzyme and pathway databases

SIGNORⁱ	P07197

SIGNORⁱ

P07197

Miscellaneous databases

ChiTaRSⁱ	NEFM human
GeneWikiⁱ	NEFM
GenomeRNAiⁱ	4741
Protein Ontology More...PROⁱ	PR:P07197
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104722 Expressed in 159 organ(s), highest expression level in dorsal root ganglion
CleanExⁱ	HS_NEFM
ExpressionAtlasⁱ	P07197 baseline and differential
Genevisibleⁱ	P07197 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001664 IF IPR018039 IF_conserved IPR039008 IF_rod_dom IPR006821 Intermed_filament_DNA-bd IPR002957 Keratin_I IPR027697 NF-M
PANTHERⁱ	PTHR23239 PTHR23239, 2 hits PTHR23239:SF19 PTHR23239:SF19, 2 hits
Pfamⁱ	View protein in Pfam PF00038 Filament, 1 hit PF04732 Filament_head, 1 hit
PRINTSⁱ	PR01248 TYPE1KERATIN
SMARTⁱ	View protein in SMART SM01391 Filament, 1 hit
PROSITEⁱ	View protein in PROSITE PS00226 IF_ROD_1, 1 hit PS51842 IF_ROD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NFM_HUMAN
Accessionⁱ	P07197Primary (citable) accession number: P07197 Secondary accession number(s): B4DGN2, E9PBF7, Q4QRK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
	Last sequence update:	December 15, 2009
	Last modified:	November 7, 2018
	This is version 190 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - P07197 (NFM_HUMAN)

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Neurofilament medium polypeptide

NEFM

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ