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Protein

L-lactate dehydrogenase B chain

Gene

LDHB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (HEL-S-133P), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase, L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHAL6A), L-lactate dehydrogenase, L-lactate dehydrogenase, L-lactate dehydrogenase (LDHB), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase (LDHAL6A), L-lactate dehydrogenase (HEL-S-281), L-lactate dehydrogenase (LDHC), L-lactate dehydrogenase A-like 6A (LDHAL6A), L-lactate dehydrogenase B chain (LDHB), L-lactate dehydrogenase C chain (LDHC), L-lactate dehydrogenase A-like 6B (LDHAL6B), L-lactate dehydrogenase A chain (LDHA)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei100NAD1 Publication1
Binding sitei107Substrate1
Binding sitei139NAD or substrate1 Publication1
Binding sitei170Substrate1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei194Proton acceptor1
Binding sitei249Substrate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi31 – 53NADBy similarityAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • L-lactate dehydrogenase activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.1.27 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70268 Pyruvate metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P07195

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00554;UER00611

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
L-lactate dehydrogenase B chain (EC:1.1.1.27)
Short name:
LDH-B
Alternative name(s):
LDH heart subunit
Short name:
LDH-H
Renal carcinoma antigen NY-REN-46
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LDHB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000111716.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6541 LDHB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
150100 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07195

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lactate dehydrogenase B deficiency (LDHBD)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition with no deleterious effects on health. LDHBD is of interest to laboratory medicine mainly because it can cause misdiagnosis in those disorders in which elevation of serum LDH is expected.
See also OMIM:614128
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0041737K → E in LDHBD; slightly decreased activity. 1 PublicationCorresponds to variant dbSNP:rs118203897EnsemblClinVar.1
Natural variantiVAR_00417435A → E in LDHBD. 1 Publication1
Natural variantiVAR_01163469G → E in LDHBD. 1 Publication1
Natural variantiVAR_011635107R → W in LDHBD; inactive. 1 PublicationCorresponds to variant dbSNP:rs777954556Ensembl.1
Natural variantiVAR_004175129S → R in LDHBD. 1 PublicationCorresponds to variant dbSNP:rs118203896EnsemblClinVar.1
Natural variantiVAR_004176171F → V in LDHBD. 1 Publication1
Natural variantiVAR_004177172R → H in LDHBD. 2 PublicationsCorresponds to variant dbSNP:rs118203895EnsemblClinVar.1
Natural variantiVAR_011636172R → P in LDHBD. 1 Publication1
Natural variantiVAR_004178175M → L in LDHBD. 1 Publication1
Natural variantiVAR_011637223Missing in LDHBD. 1 Publication1
Natural variantiVAR_004179322D → V in LDHBD. 1 Publication1
Natural variantiVAR_011638325W → R in LDHBD. Corresponds to variant dbSNP:rs267607212EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3945

MalaCards human disease database

More...
MalaCardsi
LDHB
MIMi614128 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000111716

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
284435 Glycogen storage disease due to lactate dehydrogenase H-subunit deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30325

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4940

Drug and drug target database

More...
DrugBanki
DB00157 NADH
DB03940 Oxamic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LDHB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126041

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001684592 – 334L-lactate dehydrogenase B chainAdd BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei7N6-acetyllysineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei58N6-acetyllysineCombined sources1
Modified residuei119N6-acetyllysineCombined sources1
Modified residuei240PhosphotyrosineCombined sources1
Modified residuei329N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P07195

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07195

PeptideAtlas

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PeptideAtlasi
P07195

PRoteomics IDEntifications database

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PRIDEi
P07195

ProteomicsDB human proteome resource

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ProteomicsDBi
51960

Consortium for Top Down Proteomics

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TopDownProteomicsi
P07195

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P07195

USC-OGP 2-DE database

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OGPi
P07195

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00219217

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P07195

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P07195

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P07195

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P07195

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P07195

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111716 Expressed in 233 organ(s), highest expression level in cortex of kidney

CleanEx database of gene expression profiles

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CleanExi
HS_LDHB

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P07195 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P07195 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004641
HPA019007

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110137, 148 interactors

Protein interaction database and analysis system

More...
IntActi
P07195, 40 interactors

Molecular INTeraction database

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MINTi
P07195

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000229319

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P07195

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P07195

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07195

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P07195

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1495 Eukaryota
COG0039 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153525

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000213793

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000462

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P07195

KEGG Orthology (KO)

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KOi
K00016

Identification of Orthologs from Complete Genome Data

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OMAi
RQPGQTR

Database of Orthologous Groups

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OrthoDBi
EOG091G0HME

Database for complete collections of gene phylogenies

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PhylomeDBi
P07195

TreeFam database of animal gene trees

More...
TreeFami
TF314963

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.90.110.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00488 Lactate_dehydrog, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000102 Lac_mal_DH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00086 LLDHDRGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01771 L-LDH-NAD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00064 L_LDH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P07195-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLKEKLIA PVAEEEATVP NNKITVVGVG QVGMACAISI LGKSLADELA
60 70 80 90 100
LVDVLEDKLK GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR
110 120 130 140 150
QQEGESRLNL VQRNVNVFKF IIPQIVKYSP DCIIIVVSNP VDILTYVTWK
160 170 180 190 200
LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG IHPSSCHGWI LGEHGDSSVA
210 220 230 240 250
VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVESAY EVIKLKGYTN
260 270 280 290 300
WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG
310 320 330
LTSVINQKLK DDEVAQLKKS ADTLWDIQKD LKDL
Length:334
Mass (Da):36,638
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AD605DEED0D54A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MW50A8MW50_HUMAN
L-lactate dehydrogenase
LDHB
232Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7H8C9J7H8_HUMAN
L-lactate dehydrogenase B chain
LDHB
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H793F5H793_HUMAN
L-lactate dehydrogenase B chain
LDHB
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0041737K → E in LDHBD; slightly decreased activity. 1 PublicationCorresponds to variant dbSNP:rs118203897EnsemblClinVar.1
Natural variantiVAR_00417435A → E in LDHBD. 1 Publication1
Natural variantiVAR_01163469G → E in LDHBD. 1 Publication1
Natural variantiVAR_011635107R → W in LDHBD; inactive. 1 PublicationCorresponds to variant dbSNP:rs777954556Ensembl.1
Natural variantiVAR_004175129S → R in LDHBD. 1 PublicationCorresponds to variant dbSNP:rs118203896EnsemblClinVar.1
Natural variantiVAR_004176171F → V in LDHBD. 1 Publication1
Natural variantiVAR_004177172R → H in LDHBD. 2 PublicationsCorresponds to variant dbSNP:rs118203895EnsemblClinVar.1
Natural variantiVAR_011636172R → P in LDHBD. 1 Publication1
Natural variantiVAR_004178175M → L in LDHBD. 1 Publication1
Natural variantiVAR_049758175M → V. Corresponds to variant dbSNP:rs7966339Ensembl.1
Natural variantiVAR_011637223Missing in LDHBD. 1 Publication1
Natural variantiVAR_004179322D → V in LDHBD. 1 Publication1
Natural variantiVAR_011638325W → R in LDHBD. Corresponds to variant dbSNP:rs267607212EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X13794
, X13795, X13796, X13797, X13798, X13799, X13800 Genomic DNA Translation: CAA32033.1
Y00711 mRNA Translation: CAA68701.1
BC002362 mRNA Translation: AAH02362.1
BC015122 mRNA Translation: AAH15122.1
BC071860 mRNA Translation: AAH71860.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8691.1

Protein sequence database of the Protein Information Resource

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PIRi
S02795 DEHULH

NCBI Reference Sequences

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RefSeqi
NP_001167568.1, NM_001174097.2
NP_001302466.1, NM_001315537.1
NP_002291.1, NM_002300.7

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.446149

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000350669; ENSP00000229319; ENSG00000111716
ENST00000396076; ENSP00000379386; ENSG00000111716

Database of genes from NCBI RefSeq genomes

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GeneIDi
3945

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3945

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Lactate dehydrogenase entry

Protein Spotlight

Another dark horse - Issue 109 of September 2009

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13794
, X13795, X13796, X13797, X13798, X13799, X13800 Genomic DNA Translation: CAA32033.1
Y00711 mRNA Translation: CAA68701.1
BC002362 mRNA Translation: AAH02362.1
BC015122 mRNA Translation: AAH15122.1
BC071860 mRNA Translation: AAH71860.1
CCDSiCCDS8691.1
PIRiS02795 DEHULH
RefSeqiNP_001167568.1, NM_001174097.2
NP_001302466.1, NM_001315537.1
NP_002291.1, NM_002300.7
UniGeneiHs.446149

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I0ZX-ray2.10A/B2-334[»]
1T2FX-ray3.00A/B/C/D2-332[»]
ProteinModelPortaliP07195
SMRiP07195
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110137, 148 interactors
IntActiP07195, 40 interactors
MINTiP07195
STRINGi9606.ENSP00000229319

Chemistry databases

BindingDBiP07195
ChEMBLiCHEMBL4940
DrugBankiDB00157 NADH
DB03940 Oxamic Acid

PTM databases

iPTMnetiP07195
PhosphoSitePlusiP07195
SwissPalmiP07195

Polymorphism and mutation databases

BioMutaiLDHB
DMDMi126041

2D gel databases

DOSAC-COBS-2DPAGEiP07195
OGPiP07195
REPRODUCTION-2DPAGEiIPI00219217
SWISS-2DPAGEiP07195
UCD-2DPAGEiP07195

Proteomic databases

EPDiP07195
PaxDbiP07195
PeptideAtlasiP07195
PRIDEiP07195
ProteomicsDBi51960
TopDownProteomicsiP07195

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3945
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350669; ENSP00000229319; ENSG00000111716
ENST00000396076; ENSP00000379386; ENSG00000111716
GeneIDi3945
KEGGihsa:3945

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3945
DisGeNETi3945
EuPathDBiHostDB:ENSG00000111716.12

GeneCards: human genes, protein and diseases

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GeneCardsi
LDHB
HGNCiHGNC:6541 LDHB
HPAiCAB004641
HPA019007
MalaCardsiLDHB
MIMi150100 gene
614128 phenotype
neXtProtiNX_P07195
OpenTargetsiENSG00000111716
Orphaneti284435 Glycogen storage disease due to lactate dehydrogenase H-subunit deficiency
PharmGKBiPA30325

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00940000153525
HOGENOMiHOG000213793
HOVERGENiHBG000462
InParanoidiP07195
KOiK00016
OMAiRQPGQTR
OrthoDBiEOG091G0HME
PhylomeDBiP07195
TreeFamiTF314963

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

BRENDAi1.1.1.27 2681
ReactomeiR-HSA-70268 Pyruvate metabolism
SABIO-RKiP07195

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LDHB human
EvolutionaryTraceiP07195

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3945

Protein Ontology

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PROi
PR:P07195

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111716 Expressed in 233 organ(s), highest expression level in cortex of kidney
CleanExiHS_LDHB
ExpressionAtlasiP07195 baseline and differential
GenevisibleiP07195 HS

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLDHB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07195
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 221 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  8. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
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