UniProtKB - P07172 (HIS8_YEAST)
Protein
Histidinol-phosphate aminotransferase
Gene
HIS5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalytic activityi
- EC:2.6.1.9
Cofactori
: L-histidine biosynthesis Pathwayi
This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.Proteins known to be involved in the 9 steps of the subpathway in this organism are:
- ATP phosphoribosyltransferase (HIS1)
- Histidine biosynthesis trifunctional protein (HIS4)
- Histidine biosynthesis trifunctional protein (HIS4)
- 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (HIS6)
- Imidazole glycerol phosphate synthase hisHF (HIS7)
- Imidazoleglycerol-phosphate dehydratase (HIS3)
- Histidinol-phosphate aminotransferase (HIS5)
- Histidinol-phosphatase (HIS2)
- Histidine biosynthesis trifunctional protein (HIS4)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- histidinol-phosphate transaminase activity Source: SGD
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- histidine biosynthetic process Source: SGD
Keywordsi
Molecular function | Aminotransferase, Transferase |
Biological process | Amino-acid biosynthesis, Histidine biosynthesis |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
UniPathwayi | UPA00031;UER00012 |
Names & Taxonomyi
Protein namesi | Recommended name: Histidinol-phosphate aminotransferase (EC:2.6.1.9)Alternative name(s): Imidazole acetol-phosphate transaminase |
Gene namesi | Name:HIS5 Ordered Locus Names:YIL116W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YIL116W |
SGDi | S000001378, HIS5 |
Subcellular locationi
Other locations
- cytoplasm Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153509 | 1 – 385 | Histidinol-phosphate aminotransferaseAdd BLAST | 385 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 230 | N6-(pyridoxal phosphate)lysineCurated | 1 |
Proteomic databases
MaxQBi | P07172 |
PaxDbi | P07172 |
PRIDEi | P07172 |
TopDownProteomicsi | P07172 |
PTM databases
iPTMneti | P07172 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34875, 16 interactors |
STRINGi | 4932.YIL116W |
Miscellaneous databases
RNActi | P07172, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.Curated
Phylogenomic databases
eggNOGi | KOG0633, Eukaryota |
HOGENOMi | CLU_017584_3_1_1 |
InParanoidi | P07172 |
OMAi | IWLNANE |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_01023, HisC_aminotrans_2, 1 hit |
InterProi | View protein in InterPro IPR001917, Aminotrans_II_pyridoxalP_BS IPR004839, Aminotransferase_I/II IPR005861, HisP_aminotrans IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR01141, hisC, 1 hit |
PROSITEi | View protein in PROSITE PS00599, AA_TRANSFER_CLASS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P07172-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVFDLKRIVR PKIYNLEPYR CARDDFTEGI LLDANENAHG PTPVELSKTN
60 70 80 90 100
LHRYPDPHQL EFKTAMTKYR NKTSSYANDP EVKPLTADNL CLGVGSDESI
110 120 130 140 150
DAIIRACCVP GKEKILVLPP TYSMYSVCAN INDIEVVQCP LTVSDGSFQM
160 170 180 190 200
DTEAVLTILK NDSLIKLMFV TSPGNPTGAK IKTSLIEKVL QNWDNGLVVV
210 220 230 240 250
DEAYVDFCGG STAPLVTKYP NLVTLQTLSK SFGLAGIRLG MTYATAELAR
260 270 280 290 300
ILNAMKAPYN ISSLASEYAL KAVQDSNLKK MEATSKIINE EKMRLLKELT
310 320 330 340 350
ALDYVDDQYV GGLDANFLLI RINGGDNVLA KKLYYQLATQ SGVVVRFRGN
360 370 380
ELGCSGCLRI TVGTHEENTH LIKYFKETLY KLANE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 110 – 112 | PGK → RE in CAA29139 (PubMed:3302607).Curated | 3 | |
Sequence conflicti | 125 | Y → S in CAA29139 (PubMed:3302607).Curated | 1 | |
Sequence conflicti | 142 | T → I in CAA29139 (PubMed:3302607).Curated | 1 | |
Sequence conflicti | 294 | R → L in CAA29139 (PubMed:3302607).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38125 Genomic DNA Translation: CAA86264.1 X05650 Genomic DNA Translation: CAA29139.1 M38613 Genomic DNA Translation: AAA34675.1 BK006942 Genomic DNA Translation: DAA08437.1 |
PIRi | S48456 |
RefSeqi | NP_012150.1, NM_001179464.1 |
Genome annotation databases
EnsemblFungii | YIL116W_mRNA; YIL116W; YIL116W |
GeneIDi | 854690 |
KEGGi | sce:YIL116W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z38125 Genomic DNA Translation: CAA86264.1 X05650 Genomic DNA Translation: CAA29139.1 M38613 Genomic DNA Translation: AAA34675.1 BK006942 Genomic DNA Translation: DAA08437.1 |
PIRi | S48456 |
RefSeqi | NP_012150.1, NM_001179464.1 |
3D structure databases
SMRi | P07172 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34875, 16 interactors |
STRINGi | 4932.YIL116W |
PTM databases
iPTMneti | P07172 |
Proteomic databases
MaxQBi | P07172 |
PaxDbi | P07172 |
PRIDEi | P07172 |
TopDownProteomicsi | P07172 |
Genome annotation databases
EnsemblFungii | YIL116W_mRNA; YIL116W; YIL116W |
GeneIDi | 854690 |
KEGGi | sce:YIL116W |
Organism-specific databases
EuPathDBi | FungiDB:YIL116W |
SGDi | S000001378, HIS5 |
Phylogenomic databases
eggNOGi | KOG0633, Eukaryota |
HOGENOMi | CLU_017584_3_1_1 |
InParanoidi | P07172 |
OMAi | IWLNANE |
Enzyme and pathway databases
UniPathwayi | UPA00031;UER00012 |
Miscellaneous databases
PROi | PR:P07172 |
RNActi | P07172, protein |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_01023, HisC_aminotrans_2, 1 hit |
InterProi | View protein in InterPro IPR001917, Aminotrans_II_pyridoxalP_BS IPR004839, Aminotransferase_I/II IPR005861, HisP_aminotrans IPR015424, PyrdxlP-dep_Trfase IPR015422, PyrdxlP-dep_Trfase_dom1 IPR015421, PyrdxlP-dep_Trfase_major |
Pfami | View protein in Pfam PF00155, Aminotran_1_2, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
TIGRFAMsi | TIGR01141, hisC, 1 hit |
PROSITEi | View protein in PROSITE PS00599, AA_TRANSFER_CLASS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HIS8_YEAST | |
Accessioni | P07172Primary (citable) accession number: P07172 Secondary accession number(s): D6VVH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IX
Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names