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Protein

Calbindin

Gene

Calb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 351Add BLAST12
Calcium bindingi111 – 1222Add BLAST12
Calcium bindingi155 – 1663Add BLAST12
Calcium bindingi199 – 2104Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Calbindin
Alternative name(s):
Calbindin D28
D-28K
Spot 35 protein
Vitamin D-dependent calcium-binding protein, avian-type
Gene namesi
Name:Calb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi69340 Calb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000734752 – 261CalbindinAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP07171
PRIDEiP07171

PTM databases

iPTMnetiP07171
PhosphoSitePlusiP07171

Expressioni

Gene expression databases

BgeeiENSRNOG00000007456 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
GenevisibleiP07171 RN

Interactioni

Subunit structurei

Interacts with RANBP9.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010845

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07171
SMRiP07171
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07171

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 46EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini53 – 88EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini98 – 133EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini142 – 177EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini186 – 221EF-hand 5PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 7Interaction with RANBP9By similarity6

Domaini

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Sequence similaritiesi

Belongs to the calbindin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000013118
HOGENOMiHOG000231866
HOVERGENiHBG000855
InParanoidiP07171
KOiK14757
OMAiMQTWRKY
OrthoDBiEOG091G0GNH
PhylomeDBiP07171
TreeFamiTF325083

Family and domain databases

InterProiView protein in InterPro
IPR029634 Calbindin
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR19972:SF3 PTHR19972:SF3, 1 hit
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07171-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELLQARKKA
60 70 80 90 100
GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC
110 120 130 140 150
EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM
160 170 180 190 200
LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ
210 220 230 240 250
DGNGYIDENE LDALLKDLCE KNKQELDINN ISTYKKNIMA LSDGGKLYRT
260
DLALILSAGD N
Length:261
Mass (Da):29,994
Last modified:January 23, 2007 - v2
Checksum:iB9C58D75C4D252C1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139D → H in AAA40852 (PubMed:2792772).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31178 mRNA Translation: AAA40851.1
X04280 mRNA Translation: CAA27828.1
M27839 Genomic DNA Translation: AAA40852.1
BC081764 mRNA Translation: AAH81764.1
PIRiA30808 KLRTB
RefSeqiNP_114190.1, NM_031984.2
UniGeneiRn.3908

Genome annotation databases

EnsembliENSRNOT00000010845; ENSRNOP00000010845; ENSRNOG00000007456
GeneIDi83839
KEGGirno:83839
UCSCiRGD:69340 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31178 mRNA Translation: AAA40851.1
X04280 mRNA Translation: CAA27828.1
M27839 Genomic DNA Translation: AAA40852.1
BC081764 mRNA Translation: AAH81764.1
PIRiA30808 KLRTB
RefSeqiNP_114190.1, NM_031984.2
UniGeneiRn.3908

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F33NMR-A1-261[»]
2G9BNMR-A1-261[»]
ProteinModelPortaliP07171
SMRiP07171
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010845

PTM databases

iPTMnetiP07171
PhosphoSitePlusiP07171

Proteomic databases

PaxDbiP07171
PRIDEiP07171

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010845; ENSRNOP00000010845; ENSRNOG00000007456
GeneIDi83839
KEGGirno:83839
UCSCiRGD:69340 rat

Organism-specific databases

CTDi793
RGDi69340 Calb1

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000013118
HOGENOMiHOG000231866
HOVERGENiHBG000855
InParanoidiP07171
KOiK14757
OMAiMQTWRKY
OrthoDBiEOG091G0GNH
PhylomeDBiP07171
TreeFamiTF325083

Miscellaneous databases

EvolutionaryTraceiP07171
PROiPR:P07171

Gene expression databases

BgeeiENSRNOG00000007456 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
GenevisibleiP07171 RN

Family and domain databases

InterProiView protein in InterPro
IPR029634 Calbindin
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR19972:SF3 PTHR19972:SF3, 1 hit
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCALB1_RAT
AccessioniPrimary (citable) accession number: P07171
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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