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UniProtKB - P07149 (FAS1_YEAST)
Protein
Fatty acid synthase subunit beta
Gene
FAS1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
Miscellaneous
Present with 91800 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- acetyl-CoA + 2n H+ + n malonyl-CoA + 2n NADPH = a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP+EC:2.3.1.86
- EC:2.3.1.38
- EC:2.3.1.39
- EC:4.2.1.59
- EC:1.3.1.9
- EC:3.1.2.14
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 274 | For acetyltransferase activityBy similarity | 1 | |
Active sitei | 1808 | For malonyltransferase activityBy similarity | 1 |
GO - Molecular functioni
- (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
- [acyl-carrier-protein] S-acetyltransferase activity Source: SGD
- [acyl-carrier-protein] S-malonyltransferase activity Source: SGD
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity Source: SGD
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
- 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
- 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC
- enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB-EC
- enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Source: SGD
- enoyl-[acyl-carrier-protein] reductase activity Source: UniProtKB-EC
- fatty-acyl-CoA synthase activity Source: UniProtKB-EC
- myristoyl-[acyl-carrier-protein] hydrolase activity Source: UniProtKB-EC
- oleoyl-[acyl-carrier-protein] hydrolase activity Source: UniProtKB-EC
- palmitoyl-[acyl-carrier-protein] hydrolase activity Source: UniProtKB-EC
- palmitoyltransferase activity Source: SGD
GO - Biological processi
- long-chain fatty acid biosynthetic process Source: ComplexPortal
Keywordsi
Molecular function | Hydrolase, Lyase, Multifunctional enzyme, Oxidoreductase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | NAD, NADP |
Enzyme and pathway databases
BRENDAi | 2.3.1.86, 984 |
SABIO-RKi | P07149 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:FAS1 Ordered Locus Names:YKL182W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000001665, FAS1 |
VEuPathDBi | FungiDB:YKL182W |
Subcellular locationi
Cytosol
- cytosol Source: SGD
- fatty acid synthase complex Source: SGD
Mitochondrion
- mitochondrion Source: SGD
Other locations
- cytoplasm Source: SGD
- lipid droplet Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180282 | 1 – 2051 | Fatty acid synthase subunit betaAdd BLAST | 2051 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 733 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1121 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1364 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P07149 |
PaxDbi | P07149 |
PRIDEi | P07149 |
PTM databases
CarbonylDBi | P07149 |
iPTMneti | P07149 |
Interactioni
Subunit structurei
[Alpha6beta6] hexamers of two multifunctional subunits (alpha and beta).
Binary interactionsi
P07149
With | #Exp. | IntAct |
---|---|---|
FAS2 [P19097] | 9 | EBI-6795,EBI-6806 |
Protein-protein interaction databases
BioGRIDi | 33940, 126 interactors |
ComplexPortali | CPX-1162, Fatty-acyl-CoA synthase |
DIPi | DIP-742N |
IntActi | P07149, 101 interactors |
MINTi | P07149 |
STRINGi | 4932.YKL182W |
Miscellaneous databases
RNActi | P07149, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P07149 |
SMRi | P07149 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P07149 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1523 – 1648 | MaoC-likeAdd BLAST | 126 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 468 | AcetyltransferaseAdd BLAST | 468 | |
Regioni | 480 – 868 | Enoyl reductaseAdd BLAST | 389 | |
Regioni | 1144 – 1626 | DehydrataseAdd BLAST | 483 | |
Regioni | 1627 – 1845 | Malonyl/palmitoyl transferaseAdd BLAST | 219 |
Sequence similaritiesi
Belongs to the fungal fatty acid synthetase subunit beta family.Curated
Phylogenomic databases
eggNOGi | ENOG502QQJX, Eukaryota |
GeneTreei | ENSGT00940000176444 |
HOGENOMi | CLU_000114_5_0_1 |
InParanoidi | P07149 |
OMAi | LTHRNKD |
Family and domain databases
Gene3Di | 3.20.20.70, 2 hits 3.40.366.10, 3 hits |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013785, Aldolase_TIM IPR016452, Fas1/AflB-like IPR013565, Fas1/AflB-like_central IPR041099, FAS1_N IPR040883, FAS_meander IPR003965, Fatty_acid_synthase IPR029069, HotDog_dom_sf IPR039569, MaoC-like_dehydrat_N IPR002539, MaoC-like_dom IPR032088, SAT |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08354, DUF1729, 1 hit PF17951, FAS_meander, 1 hit PF17828, FAS_N, 1 hit PF13452, MaoC_dehydrat_N, 1 hit PF01575, MaoC_dehydratas, 1 hit PF16073, SAT, 1 hit |
PIRSFi | PIRSF005562, FAS_yeast_beta, 1 hit |
PRINTSi | PR01483, FASYNTHASE |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit |
SUPFAMi | SSF52151, SSF52151, 2 hits SSF54637, SSF54637, 2 hits |
i Sequence
Sequence statusi: Complete.
P07149-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDAYSTRPLT LSHGSLEHVL LVPTASFFIA SQLQEQFNKI LPEPTEGFAA
60 70 80 90 100
DDEPTTPAEL VGKFLGYVSS LVEPSKVGQF DQVLNLCLTE FENCYLEGND
110 120 130 140 150
IHALAAKLLQ ENDTTLVKTK ELIKNYITAR IMAKRPFDKK SNSALFRAVG
160 170 180 190 200
EGNAQLVAIF GGQGNTDDYF EELRDLYQTY HVLVGDLIKF SAETLSELIR
210 220 230 240 250
TTLDAEKVFT QGLNILEWLE NPSNTPDKDY LLSIPISCPL IGVIQLAHYV
260 270 280 290 300
VTAKLLGFTP GELRSYLKGA TGHSQGLVTA VAIAETDSWE SFFVSVRKAI
310 320 330 340 350
TVLFFIGVRC YEAYPNTSLP PSILEDSLEN NEGVPSPMLS ISNLTQEQVQ
360 370 380 390 400
DYVNKTNSHL PAGKQVEISL VNGAKNLVVS GPPQSLYGLN LTLRKAKAPS
410 420 430 440 450
GLDQSRIPFS ERKLKFSNRF LPVASPFHSH LLVPASDLIN KDLVKNNVSF
460 470 480 490 500
NAKDIQIPVY DTFDGSDLRV LSGSISERIV DCIIRLPVKW ETTTQFKATH
510 520 530 540 550
ILDFGPGGAS GLGVLTHRNK DGTGVRVIVA GTLDINPDDD YGFKQEIFDV
560 570 580 590 600
TSNGLKKNPN WLEEYHPKLI KNKSGKIFVE TKFSKLIGRP PLLVPGMTPC
610 620 630 640 650
TVSPDFVAAT TNAGYTIELA GGGYFSAAGM TAAIDSVVSQ IEKGSTFGIN
660 670 680 690 700
LIYVNPFMLQ WGIPLIKELR SKGYPIQFLT IGAGVPSLEV ASEYIETLGL
710 720 730 740 750
KYLGLKPGSI DAISQVINIA KAHPNFPIAL QWTGGRGGGH HSFEDAHTPM
760 770 780 790 800
LQMYSKIRRH PNIMLIFGSG FGSADDTYPY LTGEWSTKFD YPPMPFDGFL
810 820 830 840 850
FGSRVMIAKE VKTSPDAKKC IAACTGVPDD KWEQTYKKPT GGIVTVRSEM
860 870 880 890 900
GEPIHKIATR GVMLWKEFDE TIFNLPKNKL VPTLEAKRDY IISRLNADFQ
910 920 930 940 950
KPWFATVNGQ ARDLATMTYE EVAKRLVELM FIRSTNSWFD VTWRTFTGDF
960 970 980 990 1000
LRRVEERFTK SKTLSLIQSY SLLDKPDEAI EKVFNAYPAA REQFLNAQDI
1010 1020 1030 1040 1050
DHFLSMCQNP MQKPVPFVPV LDRRFEIFFK KDSLWQSEHL EAVVDQDVQR
1060 1070 1080 1090 1100
TCILHGPVAA QFTKVIDEPI KSIMDGIHDG HIKKLLHQYY GDDESKIPAV
1110 1120 1130 1140 1150
EYFGGESPVD VQSQVDSSSV SEDSAVFKAT SSTDEESWFK ALAGSEINWR
1160 1170 1180 1190 1200
HASFLCSFIT QDKMFVSNPI RKVFKPSQGM VVEISNGNTS SKTVVTLSEP
1210 1220 1230 1240 1250
VQGELKPTVI LKLLKENIIQ MEMIENRTMD GKPVSLPLLY NFNPDNGFAP
1260 1270 1280 1290 1300
ISEVMEDRNQ RIKEMYWKLW IDEPFNLDFD PRDVIKGKDF EITAKEVYDF
1310 1320 1330 1340 1350
THAVGNNCED FVSRPDRTML APMDFAIVVG WRAIIKAIFP NTVDGDLLKL
1360 1370 1380 1390 1400
VHLSNGYKMI PGAKPLQVGD VVSTTAVIES VVNQPTGKIV DVVGTLSRNG
1410 1420 1430 1440 1450
KPVMEVTSSF FYRGNYTDFE NTFQKTVEPV YQMHIKTSKD IAVLRSKEWF
1460 1470 1480 1490 1500
QLDDEDFDLL NKTLTFETET EVTFKNANIF SSVKCFGPIK VELPTKETVE
1510 1520 1530 1540 1550
IGIVDYEAGA SHGNPVVDFL KRNGSTLEQK VNLENPIPIA VLDSYTPSTN
1560 1570 1580 1590 1600
EPYARVSGDL NPIHVSRHFA SYANLPGTIT HGMFSSASVR ALIENWAADS
1610 1620 1630 1640 1650
VSSRVRGYTC QFVDMVLPNT ALKTSIQHVG MINGRKLIKF ETRNEDDVVV
1660 1670 1680 1690 1700
LTGEAEIEQP VTTFVFTGQG SQEQGMGMDL YKTSKAAQDV WNRADNHFKD
1710 1720 1730 1740 1750
TYGFSILDIV INNPVNLTIH FGGEKGKRIR ENYSAMIFET IVDGKLKTEK
1760 1770 1780 1790 1800
IFKEINEHST SYTFRSEKGL LSATQFTQPA LTLMEKAAFE DLKSKGLIPA
1810 1820 1830 1840 1850
DATFAGHSLG EYAALASLAD VMSIESLVEV VFYRGMTMQV AVPRDELGRS
1860 1870 1880 1890 1900
NYGMIAINPG RVAASFSQEA LQYVVERVGK RTGWLVEIVN YNVENQQYVA
1910 1920 1930 1940 1950
AGDLRALDTV TNVLNFIKLQ KIDIIELQKS LSLEEVEGHL FEIIDEASKK
1960 1970 1980 1990 2000
SAVKPRPLKL ERGFACIPLV GISVPFHSTY LMNGVKPFKS FLKKNIIKEN
2010 2020 2030 2040 2050
VKVARLAGKY IPNLTAKPFQ VTKEYFQDVY DLTGSEPIKE IIDNWEKYEQ
S
Sequence cautioni
The sequence CAA27616 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 191 | S → F in AAB59310 (PubMed:2034224).Curated | 1 | |
Sequence conflicti | 191 | S → F in CAA27616 (PubMed:3528750).Curated | 1 | |
Sequence conflicti | 212 | G → D in AAA34602 (PubMed:3031066).Curated | 1 | |
Sequence conflicti | 403 | D → G in AAA34602 (PubMed:3031066).Curated | 1 | |
Sequence conflicti | 1039 | H → Q in AAB59310 (PubMed:2034224).Curated | 1 | |
Sequence conflicti | 1039 | H → Q in CAA27616 (PubMed:3528750).Curated | 1 | |
Sequence conflicti | 1149 | W → R in AAA34602 (PubMed:3031066).Curated | 1 | |
Sequence conflicti | 1184 | I → F in AAB59310 (PubMed:2034224).Curated | 1 | |
Sequence conflicti | 1184 | I → F in CAA27616 (PubMed:3528750).Curated | 1 | |
Sequence conflicti | 1290 – 1292 | FEI → SET in AAA34602 (PubMed:3031066).Curated | 3 | |
Sequence conflicti | 1331 – 1333 | WRA → LRG in AAB59310 (PubMed:2034224).Curated | 3 | |
Sequence conflicti | 1331 – 1333 | WRA → LRG in CAA27616 (PubMed:3528750).Curated | 3 | |
Sequence conflicti | 1407 – 1411 | TSSFF → IFLFL in AAA34602 (PubMed:3031066).Curated | 5 | |
Sequence conflicti | 1559 | D → H in AAB59310 (PubMed:2034224).Curated | 1 | |
Sequence conflicti | 1559 | D → H in CAA27616 (PubMed:3528750).Curated | 1 | |
Sequence conflicti | 1576 | P → L in AAA34602 (PubMed:3031066).Curated | 1 | |
Sequence conflicti | 1587 | A → T in AAA34602 (PubMed:3031066).Curated | 1 | |
Sequence conflicti | 1631 | M → T in AAA34602 (PubMed:3031066).Curated | 1 | |
Sequence conflicti | 1647 | D → H in CAA27616 (PubMed:3528750).Curated | 1 | |
Sequence conflicti | 1661 | V → G in AAB59310 (PubMed:2034224).Curated | 1 | |
Sequence conflicti | 1661 | V → G in CAA27616 (PubMed:3528750).Curated | 1 | |
Sequence conflicti | 1876 | E → K in AAA34602 (PubMed:3031066).Curated | 1 | |
Sequence conflicti | 1980 | Y → T in AAA34602 (PubMed:3031066).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30162 Genomic DNA Translation: AAB59310.1 X74151 Genomic DNA Translation: CAA52256.1 Z28182 Genomic DNA Translation: CAA82025.1 X03977 Genomic DNA Translation: CAA27616.1 Frameshift. M31034 Genomic DNA Translation: AAA34602.1 X70069 Genomic DNA Translation: CAA49673.1 BK006944 Genomic DNA Translation: DAA08985.1 |
PIRi | S34688 |
RefSeqi | NP_012739.1, NM_001179748.1 |
Genome annotation databases
EnsemblFungii | YKL182W_mRNA; YKL182W; YKL182W |
GeneIDi | 853653 |
KEGGi | sce:YKL182W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M30162 Genomic DNA Translation: AAB59310.1 X74151 Genomic DNA Translation: CAA52256.1 Z28182 Genomic DNA Translation: CAA82025.1 X03977 Genomic DNA Translation: CAA27616.1 Frameshift. M31034 Genomic DNA Translation: AAA34602.1 X70069 Genomic DNA Translation: CAA49673.1 BK006944 Genomic DNA Translation: DAA08985.1 |
PIRi | S34688 |
RefSeqi | NP_012739.1, NM_001179748.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2PFF | X-ray | 4.00 | B/E/H | 1-545 | [»] | |
B/E/H | 1669-1940 | [»] | ||||
2UV8 | X-ray | 3.10 | G/H/I | 1-2051 | [»] | |
2VKZ | X-ray | 4.00 | G/H/I | 1-2051 | [»] | |
3HMJ | X-ray | 4.00 | G/H/I | 1-2051 | [»] | |
6JSH | electron microscopy | 5.10 | B/F/G | 1-2051 | [»] | |
6JSI | electron microscopy | 4.70 | B/F/G | 1-2051 | [»] | |
6QL5 | electron microscopy | 2.80 | G/H/I/J/K/L | 5-2050 | [»] | |
6QL6 | electron microscopy | 2.90 | G/H/I/J/K/L | 5-2050 | [»] | |
6QL7 | X-ray | 4.60 | G/H/I/J/K/L/g/h/i/j/k/l | 1-2051 | [»] | |
6QL9 | X-ray | 2.82 | G/H/I/J/K/L | 1-2051 | [»] | |
6TA1 | electron microscopy | 3.10 | C/E/G/H/J/L | 1-2051 | [»] | |
6U5T | electron microscopy | 2.90 | G | 1-2051 | [»] | |
6U5U | electron microscopy | 2.80 | G | 1-2051 | [»] | |
6WC7 | electron microscopy | 5.80 | G | 1-2051 | [»] | |
AlphaFoldDBi | P07149 | |||||
SMRi | P07149 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33940, 126 interactors |
ComplexPortali | CPX-1162, Fatty-acyl-CoA synthase |
DIPi | DIP-742N |
IntActi | P07149, 101 interactors |
MINTi | P07149 |
STRINGi | 4932.YKL182W |
PTM databases
CarbonylDBi | P07149 |
iPTMneti | P07149 |
Proteomic databases
MaxQBi | P07149 |
PaxDbi | P07149 |
PRIDEi | P07149 |
Genome annotation databases
EnsemblFungii | YKL182W_mRNA; YKL182W; YKL182W |
GeneIDi | 853653 |
KEGGi | sce:YKL182W |
Organism-specific databases
SGDi | S000001665, FAS1 |
VEuPathDBi | FungiDB:YKL182W |
Phylogenomic databases
eggNOGi | ENOG502QQJX, Eukaryota |
GeneTreei | ENSGT00940000176444 |
HOGENOMi | CLU_000114_5_0_1 |
InParanoidi | P07149 |
OMAi | LTHRNKD |
Enzyme and pathway databases
BRENDAi | 2.3.1.86, 984 |
SABIO-RKi | P07149 |
Miscellaneous databases
EvolutionaryTracei | P07149 |
PROi | PR:P07149 |
RNActi | P07149, protein |
Family and domain databases
Gene3Di | 3.20.20.70, 2 hits 3.40.366.10, 3 hits |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR013785, Aldolase_TIM IPR016452, Fas1/AflB-like IPR013565, Fas1/AflB-like_central IPR041099, FAS1_N IPR040883, FAS_meander IPR003965, Fatty_acid_synthase IPR029069, HotDog_dom_sf IPR039569, MaoC-like_dehydrat_N IPR002539, MaoC-like_dom IPR032088, SAT |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF08354, DUF1729, 1 hit PF17951, FAS_meander, 1 hit PF17828, FAS_N, 1 hit PF13452, MaoC_dehydrat_N, 1 hit PF01575, MaoC_dehydratas, 1 hit PF16073, SAT, 1 hit |
PIRSFi | PIRSF005562, FAS_yeast_beta, 1 hit |
PRINTSi | PR01483, FASYNTHASE |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit |
SUPFAMi | SSF52151, SSF52151, 2 hits SSF54637, SSF54637, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FAS1_YEAST | |
Accessioni | P07149Primary (citable) accession number: P07149 Secondary accession number(s): D6VX19, Q05747 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | February 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 213 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families