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Protein

Fatty acid-binding protein, liver

Gene

FABP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-163560 Triglyceride catabolism
R-HSA-1989781 PPARA activates gene expression
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Chemistry databases

SwissLipidsiSLP:000001516

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, liver
Alternative name(s):
Fatty acid-binding protein 1
Liver-type fatty acid-binding protein
Short name:
L-FABP
Gene namesi
Name:FABP1
Synonyms:FABPL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163586.9
HGNCiHGNC:3555 FABP1
MIMi134650 gene
neXtProtiNX_P07148

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2168
OpenTargetsiENSG00000163586
PharmGKBiPA27956

Chemistry databases

ChEMBLiCHEMBL5421
DrugBankiDB02074 Butenoic Acid
DB02659 Cholic Acid
DB04224 Oleic Acid
DB02216 S-Methylcysteine

Polymorphism and mutation databases

BioMutaiFABP1
DMDMi119808

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000673341 – 127Fatty acid-binding protein, liverAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei11PhosphoserineCombined sources1
Modified residuei31N6-succinyllysineBy similarity1
Modified residuei36N6-succinyllysineBy similarity1
Modified residuei39PhosphoserineBy similarity1
Modified residuei46N6-succinyllysineBy similarity1
Modified residuei51PhosphothreonineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei57N6-succinyllysineBy similarity1
Modified residuei78N6-succinyllysineBy similarity1
Modified residuei90N6-succinyllysineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei121N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP07148
PeptideAtlasiP07148
PRIDEiP07148
ProteomicsDBi51959

2D gel databases

SWISS-2DPAGEiP07148

PTM databases

iPTMnetiP07148
PhosphoSitePlusiP07148

Expressioni

Gene expression databases

BgeeiENSG00000163586 Expressed in 105 organ(s), highest expression level in colonic mucosa
CleanExiHS_FABP1
ExpressionAtlasiP07148 baseline and differential
GenevisibleiP07148 HS

Organism-specific databases

HPAiCAB002305
HPA028275

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNAP21333-23EBI-2115989,EBI-9641086

Protein-protein interaction databases

BioGridi108466, 8 interactors
IntActiP07148, 2 interactors
STRINGi9606.ENSP00000295834

Chemistry databases

BindingDBiP07148

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP07148
SMRiP07148
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07148

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00390000012034
HOVERGENiHBG005633
InParanoidiP07148
KOiK08750
OMAiFTLGEEC
OrthoDBiEOG091G16BV
PhylomeDBiP07148
TreeFamiTF330348

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR031276 Lb-FABP
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF96 PTHR11955:SF96, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P07148-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFSGKYQLQ SQENFEAFMK AIGLPEELIQ KGKDIKGVSE IVQNGKHFKF
60 70 80 90 100
TITAGSKVIQ NEFTVGEECE LETMTGEKVK TVVQLEGDNK LVTTFKNIKS
110 120
VTELNGDIIT NTMTLGDIVF KRISKRI
Length:127
Mass (Da):14,208
Last modified:April 1, 1988 - v1
Checksum:i065DCEFB08DAB6B6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MW49A8MW49_HUMAN
Fatty acid-binding protein, liver
FABP1
124Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01466254A → T. Corresponds to variant dbSNP:rs1801273Ensembl.1
Natural variantiVAR_02209394T → A Polymorphism; increases the binding for cholesterol; increases high density lipoprotein (HDL)- and low density lipoprotein (LDL)-mediated cholesterol uptake. 1 PublicationCorresponds to variant dbSNP:rs2241883Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10617 mRNA Translation: AAA52419.1
M10050 mRNA Translation: AAA52418.1
BC032801 mRNA Translation: AAH32801.1
CCDSiCCDS2001.1
PIRiA22289 FZHUL
RefSeqiNP_001434.1, NM_001443.2
UniGeneiHs.380135

Genome annotation databases

EnsembliENST00000295834; ENSP00000295834; ENSG00000163586
GeneIDi2168
KEGGihsa:2168

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10617 mRNA Translation: AAA52419.1
M10050 mRNA Translation: AAA52418.1
BC032801 mRNA Translation: AAH32801.1
CCDSiCCDS2001.1
PIRiA22289 FZHUL
RefSeqiNP_001434.1, NM_001443.2
UniGeneiHs.380135

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F73X-ray2.50A/B/C/D/E/F/G/H1-127[»]
2L67NMR-A2-127[»]
2L68NMR-A2-127[»]
2LKKNMR-A2-127[»]
2PY1NMR-A1-127[»]
3B2HX-ray1.55A2-127[»]
3B2IX-ray1.86A2-127[»]
3B2JX-ray2.00A2-127[»]
3B2KX-ray1.73A2-127[»]
3B2LX-ray2.25A2-127[»]
3STKX-ray1.55A2-127[»]
3STMX-ray2.22X2-127[»]
3STNX-ray2.60A2-127[»]
3VG2X-ray2.40A2-127[»]
3VG3X-ray2.22A2-127[»]
3VG4X-ray2.50A2-127[»]
3VG5X-ray2.00A2-127[»]
3VG6X-ray2.22A2-127[»]
3VG7X-ray1.44A2-127[»]
ProteinModelPortaliP07148
SMRiP07148
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108466, 8 interactors
IntActiP07148, 2 interactors
STRINGi9606.ENSP00000295834

Chemistry databases

BindingDBiP07148
ChEMBLiCHEMBL5421
DrugBankiDB02074 Butenoic Acid
DB02659 Cholic Acid
DB04224 Oleic Acid
DB02216 S-Methylcysteine
SwissLipidsiSLP:000001516

PTM databases

iPTMnetiP07148
PhosphoSitePlusiP07148

Polymorphism and mutation databases

BioMutaiFABP1
DMDMi119808

2D gel databases

SWISS-2DPAGEiP07148

Proteomic databases

PaxDbiP07148
PeptideAtlasiP07148
PRIDEiP07148
ProteomicsDBi51959

Protocols and materials databases

DNASUi2168
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295834; ENSP00000295834; ENSG00000163586
GeneIDi2168
KEGGihsa:2168

Organism-specific databases

CTDi2168
DisGeNETi2168
EuPathDBiHostDB:ENSG00000163586.9
GeneCardsiFABP1
HGNCiHGNC:3555 FABP1
HPAiCAB002305
HPA028275
MIMi134650 gene
neXtProtiNX_P07148
OpenTargetsiENSG00000163586
PharmGKBiPA27956
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00390000012034
HOVERGENiHBG005633
InParanoidiP07148
KOiK08750
OMAiFTLGEEC
OrthoDBiEOG091G16BV
PhylomeDBiP07148
TreeFamiTF330348

Enzyme and pathway databases

ReactomeiR-HSA-163560 Triglyceride catabolism
R-HSA-1989781 PPARA activates gene expression
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Miscellaneous databases

ChiTaRSiFABP1 human
EvolutionaryTraceiP07148
GeneWikiiFABP1
GenomeRNAii2168
PROiPR:P07148
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163586 Expressed in 105 organ(s), highest expression level in colonic mucosa
CleanExiHS_FABP1
ExpressionAtlasiP07148 baseline and differential
GenevisibleiP07148 HS

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR031276 Lb-FABP
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF96 PTHR11955:SF96, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFABPL_HUMAN
AccessioniPrimary (citable) accession number: P07148
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 10, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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