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Protein

5,6-dihydroxyindole-2-carboxylic acid oxidase

Gene

Tyrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid (PubMed:7813420). May regulate or influence the type of melanin synthesized (PubMed:7813420, PubMed:2245916). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (PubMed:1537333).3 Publications

Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Pathwayi: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi192Copper ABy similarity1
Metal bindingi215Copper ABy similarity1
Metal bindingi224Copper ABy similarity1
Metal bindingi377Copper BBy similarity1
Metal bindingi381Copper BBy similarity1
Metal bindingi404Copper BBy similarity1

GO - Molecular functioni

GO - Biological processi

  • acetoacetic acid metabolic process Source: MGI
  • melanin biosynthetic process from tyrosine Source: UniProtKB
  • melanin metabolic process Source: MGI
  • melanocyte differentiation Source: MGI
  • melanosome organization Source: MGI
  • pigmentation Source: MGI
  • positive regulation of melanin biosynthetic process Source: CACAO

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processMelanin biosynthesis
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15620
ReactomeiR-MMU-5662702 Melanin biosynthesis
UniPathwayi
UPA00785

Names & Taxonomyi

Protein namesi
Recommended name:
5,6-dihydroxyindole-2-carboxylic acid oxidase (EC:1.14.18.-)
Short name:
DHICA oxidase
Alternative name(s):
Brown locus protein
Catalase B
Tyrosinase-related protein 1
Short name:
TRP
Short name:
TRP-1
Short name:
TRP1
Gene namesi
Name:Tyrp1
Synonyms:Tyrp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98881 Tyrp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 477Lumenal, melanosomeSequence analysisAdd BLAST453
Transmembranei478 – 501HelicalSequence analysisAdd BLAST24
Topological domaini502 – 537CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Tyrp1 are the cause of the brown (b) phenotype. Brown mice have a brown or hypopigmented coat.1 Publication

Keywords - Diseasei

Albinism, Disease mutation

Chemistry databases

ChEMBLiCHEMBL3638355

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000003589025 – 5375,6-dihydroxyindole-2-carboxylic acid oxidaseAdd BLAST513

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 41By similarity
Disulfide bondi42 ↔ 65By similarity
Disulfide bondi56 ↔ 99By similarity
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 110By similarity
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 122By similarity
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi258 ↔ 261By similarity
Disulfide bondi290 ↔ 303By similarity
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07147
PRIDEiP07147

PTM databases

iPTMnetiP07147
PhosphoSitePlusiP07147

Expressioni

Tissue specificityi

Pigment cells.

Gene expression databases

BgeeiENSMUSG00000005994 Expressed in 73 organ(s), highest expression level in iris
CleanExiMM_TYRP1
ExpressionAtlasiP07147 baseline and differential
GenevisibleiP07147 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TyrP113442EBI-821614,EBI-821603

GO - Molecular functioni

Protein-protein interaction databases

IntActiP07147, 1 interactor
STRINGi10090.ENSMUSP00000006151

Chemistry databases

BindingDBiP07147

Structurei

3D structure databases

ProteinModelPortaliP07147
SMRiP07147
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEEB Eukaryota
ENOG410XSJD LUCA
GeneTreeiENSGT00500000044790
HOGENOMiHOG000118376
HOVERGENiHBG003553
InParanoidiP07147
KOiK00506
OMAiWRVVCES
OrthoDBiEOG091G03YR
PhylomeDBiP07147
TreeFamiTF315865

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
InterProiView protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF00264 Tyrosinase, 1 hit
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 1 hit
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P07147-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSYNVLPLA YISLFLMLFY QVWAQFPREC ANIEALRRGV CCPDLLPSSG
60 70 80 90 100
PGTDPCGSSS GRGRCVAVIA DSRPHSRHYP HDGKDDREAW PLRFFNRTCQ
110 120 130 140 150
CNDNFSGHNC GTCRPGWRGA ACNQKILTVR RNLLDLSPEE KSHFVRALDM
160 170 180 190 200
AKRTTHPQFV IATRRLEDIL GPDGNTPQFE NISVYNYFVW THYYSVKKTF
210 220 230 240 250
LGTGQESFGD VDFSHEGPAF LTWHRYHLLQ LERDMQEMLQ EPSFSLPYWN
260 270 280 290 300
FATGKNVCDV CTDDLMGSRS NFDSTLISPN SVFSQWRVVC ESLEEYDTLG
310 320 330 340 350
TLCNSTEGGP IRRNPAGNVG RPAVQRLPEP QDVTQCLEVR VFDTPPFYSN
360 370 380 390 400
STDSFRNTVE GYSAPTGKYD PAVRSLHNLA HLFLNGTGGQ THLSPNDPIF
410 420 430 440 450
VLLHTFTDAV FDEWLRRYNA DISTFPLENA PIGHNRQYNM VPFWPPVTNT
460 470 480 490 500
EMFVTAPDNL GYAYEVQWPG QEFTVSEIIT IAVVAALLLV AAIFGVASCL
510 520 530
IRSRSTKNEA NQPLLTDHYQ RYAEDYEELP NPNHSMV
Length:537
Mass (Da):60,761
Last modified:April 1, 1988 - v1
Checksum:i86570998AA9EB0BC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ADJ4A2ADJ4_MOUSE
5,6-dihydroxyindole-2-carboxylic ac...
Tyrp1 RP23-372M15.1-003
229Annotation score:
A2ADJ6A2ADJ6_MOUSE
5,6-dihydroxyindole-2-carboxylic ac...
Tyrp1 RP23-372M15.1-002
176Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti110C → Y in brown. 1 Publication1
Natural varianti326R → H in brown. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03687 mRNA Translation: CAA27323.1
BC076598 mRNA Translation: AAH76598.1
CCDSiCCDS18290.1
PIRiA24933 YRMSB6
RefSeqiNP_001268943.1, NM_001282014.1
NP_001268944.1, NM_001282015.1
NP_112479.1, NM_031202.3
UniGeneiMm.30438

Genome annotation databases

EnsembliENSMUST00000006151; ENSMUSP00000006151; ENSMUSG00000005994
ENSMUST00000102831; ENSMUSP00000099895; ENSMUSG00000005994
GeneIDi22178
KEGGimmu:22178
UCSCiuc008tjq.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03687 mRNA Translation: CAA27323.1
BC076598 mRNA Translation: AAH76598.1
CCDSiCCDS18290.1
PIRiA24933 YRMSB6
RefSeqiNP_001268943.1, NM_001282014.1
NP_001268944.1, NM_001282015.1
NP_112479.1, NM_031202.3
UniGeneiMm.30438

3D structure databases

ProteinModelPortaliP07147
SMRiP07147
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP07147, 1 interactor
STRINGi10090.ENSMUSP00000006151

Chemistry databases

BindingDBiP07147
ChEMBLiCHEMBL3638355

PTM databases

iPTMnetiP07147
PhosphoSitePlusiP07147

Proteomic databases

PaxDbiP07147
PRIDEiP07147

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006151; ENSMUSP00000006151; ENSMUSG00000005994
ENSMUST00000102831; ENSMUSP00000099895; ENSMUSG00000005994
GeneIDi22178
KEGGimmu:22178
UCSCiuc008tjq.3 mouse

Organism-specific databases

CTDi7306
MGIiMGI:98881 Tyrp1

Phylogenomic databases

eggNOGiENOG410IEEB Eukaryota
ENOG410XSJD LUCA
GeneTreeiENSGT00500000044790
HOGENOMiHOG000118376
HOVERGENiHBG003553
InParanoidiP07147
KOiK00506
OMAiWRVVCES
OrthoDBiEOG091G03YR
PhylomeDBiP07147
TreeFamiTF315865

Enzyme and pathway databases

UniPathwayi
UPA00785

BioCyciMetaCyc:MONOMER-15620
ReactomeiR-MMU-5662702 Melanin biosynthesis

Miscellaneous databases

ChiTaRSiTyrp1 mouse
PROiPR:P07147
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005994 Expressed in 73 organ(s), highest expression level in iris
CleanExiMM_TYRP1
ExpressionAtlasiP07147 baseline and differential
GenevisibleiP07147 MM

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
InterProiView protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF00264 Tyrosinase, 1 hit
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 1 hit
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTYRP1_MOUSE
AccessioniPrimary (citable) accession number: P07147
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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