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Protein

Anionic trypsin-2

Gene

Prss2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Charge relay systemBy similarity1
Metal bindingi75CalciumBy similarity1
Metal bindingi77Calcium; via carbonyl oxygenBy similarity1
Metal bindingi80Calcium; via carbonyl oxygenBy similarity1
Metal bindingi85CalciumBy similarity1
Active sitei107Charge relay systemBy similarity1
Sitei194Required for specificityBy similarity1
Active sitei200Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processDigestion
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1592389 Activation of Matrix Metalloproteinases
R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-MMU-6798695 Neutrophil degranulation
R-MMU-6803157 Antimicrobial peptides

Protein family/group databases

MEROPSiS01.064

Names & Taxonomyi

Protein namesi
Recommended name:
Anionic trypsin-2 (EC:3.4.21.4)
Alternative name(s):
Anionic trypsin II
Pretrypsinogen II
Serine protease 2
Gene namesi
Name:Prss2
Synonyms:Try2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:102759 Prss2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Add BLAST15
PropeptideiPRO_000002820316 – 23Activation peptide8
ChainiPRO_000002820424 – 246Anionic trypsin-2Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 160PROSITE-ProRule annotation
Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
Disulfide bondi132 ↔ 233PROSITE-ProRule annotation
Disulfide bondi139 ↔ 206PROSITE-ProRule annotation
Disulfide bondi171 ↔ 185PROSITE-ProRule annotation
Disulfide bondi196 ↔ 220PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP07146
PeptideAtlasiP07146
PRIDEiP07146

PTM databases

PhosphoSitePlusiP07146

Expressioni

Gene expression databases

BgeeiENSMUSG00000057163 Expressed in 161 organ(s), highest expression level in stomach
CleanExiMM_PRSS2
ExpressionAtlasiP07146 baseline and differential
GenevisibleiP07146 MM

Interactioni

Protein-protein interaction databases

BioGridi204335, 1 interactor
STRINGi10090.ENSMUSP00000065393

Structurei

3D structure databases

ProteinModelPortaliP07146
SMRiP07146
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 244Peptidase S1PROSITE-ProRule annotationAdd BLAST221

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP07146
KOiK01312
OMAiQNTIADN
OrthoDBiEOG091G0DF7
PhylomeDBiP07146
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07146-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALLILALV GAAVAFPVDD DDKIVGGYTC RESSVPYQVS LNAGYHFCGG
60 70 80 90 100
SLINDQWVVS AAHCYKYRIQ VRLGEHNINV LEGNEQFVDS AKIIRHPNYN
110 120 130 140 150
SWTLDNDIML IKLASPVTLN ARVASVPLPS SCAPAGTQCL ISGWGNTLSN
160 170 180 190 200
GVNNPDLLQC VDAPVLPQAD CEASYPGDIT NNMICVGFLE GGKDSCQGDS
210 220 230 240
GGPVVCNGEL QGIVSWGYGC AQPDAPGVYT KVCNYVDWIQ NTIADN
Length:246
Mass (Da):26,204
Last modified:April 1, 1988 - v1
Checksum:iCEF8C97AAC2D07AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04574 mRNA Translation: CAA28243.1
X04577 Genomic DNA Translation: CAA28245.1
CCDSiCCDS20050.1
PIRiB25528
RefSeqiNP_033456.1, NM_009430.2
UniGeneiMm.276926

Genome annotation databases

EnsembliENSMUST00000070380; ENSMUSP00000065393; ENSMUSG00000057163
GeneIDi22072
KEGGimmu:22072
UCSCiuc009boz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04574 mRNA Translation: CAA28243.1
X04577 Genomic DNA Translation: CAA28245.1
CCDSiCCDS20050.1
PIRiB25528
RefSeqiNP_033456.1, NM_009430.2
UniGeneiMm.276926

3D structure databases

ProteinModelPortaliP07146
SMRiP07146
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204335, 1 interactor
STRINGi10090.ENSMUSP00000065393

Protein family/group databases

MEROPSiS01.064

PTM databases

PhosphoSitePlusiP07146

Proteomic databases

PaxDbiP07146
PeptideAtlasiP07146
PRIDEiP07146

Protocols and materials databases

DNASUi22072
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070380; ENSMUSP00000065393; ENSMUSG00000057163
GeneIDi22072
KEGGimmu:22072
UCSCiuc009boz.2 mouse

Organism-specific databases

CTDi5645
MGIiMGI:102759 Prss2

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118862
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP07146
KOiK01312
OMAiQNTIADN
OrthoDBiEOG091G0DF7
PhylomeDBiP07146
TreeFamiTF331065

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1592389 Activation of Matrix Metalloproteinases
R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-MMU-6798695 Neutrophil degranulation
R-MMU-6803157 Antimicrobial peptides

Miscellaneous databases

ChiTaRSiPrss2 mouse
PROiPR:P07146
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057163 Expressed in 161 organ(s), highest expression level in stomach
CleanExiMM_PRSS2
ExpressionAtlasiP07146 baseline and differential
GenevisibleiP07146 MM

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRY2_MOUSE
AccessioniPrimary (citable) accession number: P07146
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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