CYT1

Functionⁱ

Heme-containing component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c.

Miscellaneous

Present with 39900 molecules/cell in log phase SD medium.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	101	Heme (covalent)	1
Binding siteⁱ	104	Heme (covalent)	1
Metal bindingⁱ	105	Iron (heme axial ligand)	1
Metal bindingⁱ	225	Iron (heme axial ligand)	1

GO - Molecular functionⁱ

electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity Source: GO_Central
electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
Source: SGD
Inferred from mutant phenotypeⁱ
- 11279090
heme binding Source: InterPro
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial ATP synthesis coupled proton transport Source: GO_Central
mitochondrial electron transport, ubiquinol to cytochrome c
Source: SGD
Inferred from mutant phenotypeⁱ
- 11279090
oxidative phosphorylation
Source: SGD
Traceable author statementⁱ
- 11279090

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Electron transport, Respiratory chain, Transport
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:MONOMER3O-103

BioCycⁱ

YEAST:MONOMER3O-103

Protein family/group databases

TCDBⁱ	3.D.3.3.1 the proton-translocating quinol:cytochrome c reductase (qcr) superfamily

TCDBⁱ

3.D.3.3.1 the proton-translocating quinol:cytochrome c reductase (qcr) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome c1, heme protein, mitochondrial Alternative name(s): Complex III subunit 4 Complex III subunit IV Cytochrome b-c1 complex subunit 4 Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit Short name: Cytochrome c-1
Gene namesⁱ	Name:CYT1 Synonyms:CTC1 Ordered Locus Names:YOR065W ORF Names:YOR29-16
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XV

Organism-specific databases

EuPathDBⁱ	FungiDB:YOR065W
Saccharomyces Genome Database More...SGDⁱ	S000005591 CYT1

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	273 – 287	Helical; Note=Anchors to the membraneSequence analysisAdd BLAST		15

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	272	K → A: Loss of RIP1 from the bc1 complex.	1
Mutagenesisⁱ	288	K → L: Loss of CYT1 and COB from the bc1 complex; when associated with L-289 and L-296. 1 Publication	1
Mutagenesisⁱ	289	K → L: Loss of CYT1 and COB from the bc1 complex; when associated with L-288 and L-296. 1 Publication	1
Mutagenesisⁱ	296	K → L: Loss of CYT1 and COB from the bc1 complex; when associated with L-288 and L-289. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 61	MitochondrionAdd BLAST		61
ChainⁱPRO_0000006566	62 – 309	Cytochrome c1, heme protein, mitochondrialAdd BLAST		248

Post-translational modificationⁱ

Binds 1 heme group per subunit.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P07143
PaxDbⁱ	P07143
PRIDEⁱ	P07143

Interactionⁱ

Subunit structureⁱ

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Protein-protein interaction databases

BioGridⁱ	34464, 480 interactors
ComplexPortalⁱ	CPX-567 Mitochondrial electron transport complex III
Database of interacting proteins More...DIPⁱ	DIP-4166N
IntActⁱ	P07143, 14 interactors
Molecular INTeraction database More...MINTⁱ	P07143
STRINGⁱ	4932.YOR065W

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	64 – 67	Combined sources	4
Helixⁱ	87 – 99	Combined sources	13
Helixⁱ	101 – 103	Combined sources	3
Helixⁱ	112 – 115	Combined sources	4
Turnⁱ	116 – 118	Combined sources	3
Helixⁱ	122 – 129	Combined sources	8
Beta strandⁱ	132 – 135	Combined sources	4
Beta strandⁱ	140 – 142	Combined sources	3
Beta strandⁱ	146 – 148	Combined sources	3
Beta strandⁱ	158 – 161	Combined sources	4
Helixⁱ	162 – 167	Combined sources	6
Turnⁱ	168 – 171	Combined sources	4
Turnⁱ	180 – 182	Combined sources	3
Beta strandⁱ	183 – 186	Combined sources	4
Helixⁱ	187 – 196	Combined sources	10
Beta strandⁱ	216 – 218	Combined sources	3
Beta strandⁱ	221 – 225	Combined sources	5
Helixⁱ	244 – 259	Combined sources	16
Helixⁱ	263 – 296	Combined sources	34
Beta strandⁱ	299 – 302	Combined sources	4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1EZV	X-ray	2.30	D	62-306	[»]
	1KB9	X-ray	2.30	D	62-307	[»]
	1KYO	X-ray	2.97	D/O	62-309	[»]
	1P84	X-ray	2.50	D	62-307	[»]
	2IBZ	X-ray	2.30	D	62-309	[»]
	3CX5	X-ray	1.90	D/O	62-309	[»]
	3CXH	X-ray	2.50	D/O	62-309	[»]
	4PD4	X-ray	3.04	D	62-309	[»]
ProteinModelPortalⁱ	P07143
SMRⁱ	P07143
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P07143

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	88 – 241	Cytochrome cPROSITE-ProRule annotationAdd BLAST		154

Sequence similaritiesⁱ

Belongs to the cytochrome c family.Curated

Keywords - Domainⁱ

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012445
HOGENOMⁱ	HOG000003867
InParanoidⁱ	P07143
KEGG Orthology (KO) More...KOⁱ	K00413
OMAⁱ	SRKIAYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3Y24

Family and domain databases

Gene3Dⁱ	1.10.760.10, 1 hit
InterProⁱ	View protein in InterPro IPR009056 Cyt_c-like_dom IPR036909 Cyt_c-like_dom_sf IPR002326 Cyt_c1 IPR021157 Cyt_c1_TM_anchor_C
PANTHERⁱ	PTHR10266 PTHR10266, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02167 Cytochrom_C1, 1 hit
PRINTSⁱ	PR00603 CYTOCHROMEC1
SUPFAMⁱ	SSF46626 SSF46626, 1 hit SSF81496 SSF81496, 1 hit
PROSITEⁱ	View protein in PROSITE PS51007 CYTC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P07143-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFSNLSKRWA QRTLSKSFYS TATGAASKSG KLTQKLVTAG VAAAGITAST 
        60         70         80         90        100
LLYADSLTAE AMTAAEHGLH APAYAWSHNG PFETFDHASI RRGYQVYREV 
       110        120        130        140        150
CAACHSLDRV AWRTLVGVSH TNEEVRNMAE EFEYDDEPDE QGNPKKRPGK 
       160        170        180        190        200
LSDYIPGPYP NEQAARAANQ GALPPDLSLI VKARHGGCDY IFSLLTGYPD 
       210        220        230        240        250
EPPAGVALPP GSNYNPYFPG GSIAMARVLF DDMVEYEDGT PATTSQMAKD 
       260        270        280        290        300
VTTFLNWCAE PEHDERKRLG LKTVIILSSL YLLSIWVKKF KWAGIKTRKF 

VFNPPKPRK

Length:309

Mass (Da):34,055

Last modified:April 1, 1988 - v1

Checksum:ⁱ6CB7A0813AA06AF5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00791 Genomic DNA Translation: CAA25375.1 Z74973 Genomic DNA Translation: CAA99258.1 Z70678 Genomic DNA Translation: CAA94550.1 BK006948 Genomic DNA Translation: DAA10844.1
PIRⁱ	A22737 CCBY1H
NCBI Reference Sequences More...RefSeqⁱ	NP_014708.1, NM_001183484.1

Genome annotation databases

EnsemblFungiⁱ	YOR065W; YOR065W; YOR065W
GeneIDⁱ	854231
KEGGⁱ	sce:YOR065W

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P07143	Cytochrome c1		YEAS1		309
Cyt1p		SACCK		309
CYT1p Cytochrome c1		Saccharomyces sp. 'boulardii'		309
Cyt1p		YEASC		309
YOR065Wp-like protein		YEAS6		309
+30

Protein	Similar proteins		Species	Score	Length
P07143	Cytochrome c1		YEAS1		309
Cyt1p		SACCK		309
CYT1p Cytochrome c1		Saccharomyces sp. 'boulardii'		309
Cyt1p		YEASC		309
YOR065Wp-like protein		YEAS6		309
+162

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X00791 Genomic DNA Translation: CAA25375.1 Z74973 Genomic DNA Translation: CAA99258.1 Z70678 Genomic DNA Translation: CAA94550.1 BK006948 Genomic DNA Translation: DAA10844.1
PIRⁱ	A22737 CCBY1H
NCBI Reference Sequences More...RefSeqⁱ	NP_014708.1, NM_001183484.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1EZV	X-ray	2.30	D	62-306	[»]
	1KB9	X-ray	2.30	D	62-307	[»]
	1KYO	X-ray	2.97	D/O	62-309	[»]
	1P84	X-ray	2.50	D	62-307	[»]
	2IBZ	X-ray	2.30	D	62-309	[»]
	3CX5	X-ray	1.90	D/O	62-309	[»]
	3CXH	X-ray	2.50	D/O	62-309	[»]
	4PD4	X-ray	3.04	D	62-309	[»]
ProteinModelPortalⁱ	P07143
SMRⁱ	P07143
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	34464, 480 interactors
ComplexPortalⁱ	CPX-567 Mitochondrial electron transport complex III
Database of interacting proteins More...DIPⁱ	DIP-4166N
IntActⁱ	P07143, 14 interactors
Molecular INTeraction database More...MINTⁱ	P07143
STRINGⁱ	4932.YOR065W

Protein family/group databases

TCDBⁱ	3.D.3.3.1 the proton-translocating quinol:cytochrome c reductase (qcr) superfamily

TCDBⁱ

3.D.3.3.1 the proton-translocating quinol:cytochrome c reductase (qcr) superfamily

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P07143
PaxDbⁱ	P07143
PRIDEⁱ	P07143

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YOR065W; YOR065W; YOR065W
GeneIDⁱ	854231
KEGGⁱ	sce:YOR065W

Organism-specific databases

EuPathDBⁱ	FungiDB:YOR065W
Saccharomyces Genome Database More...SGDⁱ	S000005591 CYT1

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012445
HOGENOMⁱ	HOG000003867
InParanoidⁱ	P07143
KEGG Orthology (KO) More...KOⁱ	K00413
OMAⁱ	SRKIAYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3Y24

Enzyme and pathway databases

BioCycⁱ	YEAST:MONOMER3O-103

BioCycⁱ

YEAST:MONOMER3O-103

Miscellaneous databases

EvolutionaryTraceⁱ	P07143
Protein Ontology More...PROⁱ	PR:P07143

Family and domain databases

Gene3Dⁱ	1.10.760.10, 1 hit
InterProⁱ	View protein in InterPro IPR009056 Cyt_c-like_dom IPR036909 Cyt_c-like_dom_sf IPR002326 Cyt_c1 IPR021157 Cyt_c1_TM_anchor_C
PANTHERⁱ	PTHR10266 PTHR10266, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02167 Cytochrom_C1, 1 hit
PRINTSⁱ	PR00603 CYTOCHROMEC1
SUPFAMⁱ	SSF46626 SSF46626, 1 hit SSF81496 SSF81496, 1 hit
PROSITEⁱ	View protein in PROSITE PS51007 CYTC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CY1_YEAST
Accessionⁱ	P07143Primary (citable) accession number: P07143 Secondary accession number(s): D6W2C8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
	Last sequence update:	April 1, 1988
	Last modified:	June 20, 2018
	This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P07143 (CY1_YEAST)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cytochrome c1, heme protein, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ