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UniProtKB - P07118 (SYV_ECOLI)

Entry version 188 (23 Feb 2022)
Sequence version 2 (01 Nov 1997)
Previous versions | rss
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Protein

Valine--tRNA ligase

Gene

valS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.1 µM for tRNA1 Publication
  2. KM=47 µM for valine1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei557ATPBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:VALS-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.1.1.9, 2026

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P07118

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Valine--tRNA ligase (EC:6.1.1.9)
Alternative name(s):
Valyl-tRNA synthetase
Short name:
ValRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:valS
Ordered Locus Names:b4258, JW4215
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi222T → P: Produces mischarged Thr-tRNA(Val) and Cys-tRNA(Val). 1 Publication1
Mutagenesisi277K → A: Reduces posttransfer Thr-tRNA(Val) editing rate significantly and alters amino acid discrimination in the editing site, resulting in hydrolysis of the correctly charged cognate product. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001062241 – 951Valine--tRNA ligaseAdd BLAST951

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P07118

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P07118

PRoteomics IDEntifications database

More...PRIDEi		P07118

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4262724, 7 interactors
853071, 1 interactor

Database of interacting proteins

More...DIPi		DIP-11112N

Protein interaction database and analysis system

More...IntActi		P07118, 6 interactors

STRING: functional protein association networks

More...STRINGi		511145.b4258

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P07118

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili880 – 944Sequence analysisAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi42 – 52'HIGH' regionAdd BLAST11
Motifi554 – 558'KMSKS' region5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.
The C-terminal coiled-coil domain is crucial for aminoacylation activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0525, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001493_0_2_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P07118

Database for complete collections of gene phylogenies

More...PhylomeDBi		P07118

Family and domain databases

Conserved Domains Database

More...CDDi		cd07962, Anticodon_Ia_Val, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.287.380, 1 hit
3.40.50.620, 2 hits
3.90.740.10, 2 hits

HAMAP database of protein families

More...HAMAPi		MF_02004, Val_tRNA_synth_type1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR002300, aa-tRNA-synth_Ia
IPR033705, Anticodon_Ia_Val
IPR013155, M/V/L/I-tRNA-synth_anticd-bd
IPR014729, Rossmann-like_a/b/a_fold
IPR010978, tRNA-bd_arm
IPR009080, tRNAsynth_Ia_anticodon-bd
IPR037118, Val-tRNA_synth_C_sf
IPR019499, Val-tRNA_synth_tRNA-bd
IPR009008, Val/Leu/Ile-tRNA-synth_edit
IPR002303, Valyl-tRNA_ligase

The PANTHER Classification System

More...PANTHERi		PTHR11946, PTHR11946, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08264, Anticodon_1, 1 hit
PF00133, tRNA-synt_1, 1 hit
PF10458, Val_tRNA-synt_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00986, TRNASYNTHVAL

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46589, SSF46589, 1 hit
SSF47323, SSF47323, 1 hit
SSF50677, SSF50677, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00422, valS, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P07118-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKTYNPQDI EQPLYEHWEK QGYFKPNGDE SQESFCIMIP PPNVTGSLHM 
        60         70         80         90        100
GHAFQQTIMD TMIRYQRMQG KNTLWQVGTD HAGIATQMVV ERKIAAEEGK 
       110        120        130        140        150
TRHDYGREAF IDKIWEWKAE SGGTITRQMR RLGNSVDWER ERFTMDEGLS 
       160        170        180        190        200
NAVKEVFVRL YKEDLIYRGK RLVNWDPKLR TAISDLEVEN RESKGSMWHI 
       210        220        230        240        250
RYPLADGAKT ADGKDYLVVA TTRPETLLGD TGVAVNPEDP RYKDLIGKYV 
       260        270        280        290        300
ILPLVNRRIP IVGDEHADME KGTGCVKITP AHDFNDYEVG KRHALPMINI 
       310        320        330        340        350
LTFDGDIRES AQVFDTKGNE SDVYSSEIPA EFQKLERFAA RKAVVAAVDA 
       360        370        380        390        400
LGLLEEIKPH DLTVPYGDRG GVVIEPMLTD QWYVRADVLA KPAVEAVENG 
       410        420        430        440        450
DIQFVPKQYE NMYFSWMRDI QDWCISRQLW WGHRIPAWYD EAGNVYVGRN 
       460        470        480        490        500
EDEVRKENNL GADVVLRQDE DVLDTWFSSA LWTFSTLGWP ENTDALRQFH 
       510        520        530        540        550
PTSVMVSGFD IIFFWIARMI MMTMHFIKDE NGKPQVPFHT VYMTGLIRDD 
       560        570        580        590        600
EGQKMSKSKG NVIDPLDMVD GISLPELLEK RTGNMMQPQL ADKIRKRTEK 
       610        620        630        640        650
QFPNGIEPHG TDALRFTLAA LASTGRDINW DMKRLEGYRN FCNKLWNASR 
       660        670        680        690        700
FVLMNTEGQD CGFNGGEMTL SLADRWILAE FNQTIKAYRE ALDSFRFDIA 
       710        720        730        740        750
AGILYEFTWN QFCDWYLELT KPVMNGGTEA ELRGTRHTLV TVLEGLLRLA 
       760        770        780        790        800
HPIIPFITET IWQRVKVLCG ITADTIMLQP FPQYDASQVD EAALADTEWL 
       810        820        830        840        850
KQAIVAVRNI RAEMNIAPGK PLELLLRGCS ADAERRVNEN RGFLQTLARL 
       860        870        880        890        900
ESITVLPADD KGPVSVTKII DGAELLIPMA GLINKEDELA RLAKEVAKIE 
       910        920        930        940        950
GEISRIENKL ANEGFVARAP EAVIAKEREK LEGYAEAKAK LIEQQAVIAA 

L
Length:951
Mass (Da):108,192
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FBE09CF1E7D40BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107R → A in AAA24657 (PubMed:3275660).Curated1
Sequence conflicti148G → D in AAP43521 (Ref. 6) Curated1
Sequence conflicti452D → E in AAP43521 (Ref. 6) Curated1
Sequence conflicti465V → A in AAP43521 (Ref. 6) Curated1
Sequence conflicti694S → T in CAA29322 (PubMed:3317277).Curated1
Sequence conflicti833A → R in AAA24657 (PubMed:3275660).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X05891 Genomic DNA Translation: CAA29322.1
J03497 Genomic DNA Translation: AAA24657.1
U14003 Genomic DNA Translation: AAA97155.1
U00096 Genomic DNA Translation: AAC77215.1
AP009048 Genomic DNA Translation: BAE78255.1
AY283771 Genomic DNA Translation: AAP43521.1

Protein sequence database of the Protein Information Resource

More...PIRi		E65238, SYECVT

NCBI Reference Sequences

More...RefSeqi		NP_418679.1, NC_000913.3
WP_000416392.1, NZ_STEB01000013.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC77215; AAC77215; b4258
BAE78255; BAE78255; BAE78255

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948785

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW4215
eco:b4258

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.2446

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05891 Genomic DNA Translation: CAA29322.1
J03497 Genomic DNA Translation: AAA24657.1
U14003 Genomic DNA Translation: AAA97155.1
U00096 Genomic DNA Translation: AAC77215.1
AP009048 Genomic DNA Translation: BAE78255.1
AY283771 Genomic DNA Translation: AAP43521.1
PIRiE65238, SYECVT
RefSeqiNP_418679.1, NC_000913.3
WP_000416392.1, NZ_STEB01000013.1

3D structure databases

SMRiP07118
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4262724, 7 interactors
853071, 1 interactor
DIPiDIP-11112N
IntActiP07118, 6 interactors
STRINGi511145.b4258

Proteomic databases

jPOSTiP07118
PaxDbiP07118
PRIDEiP07118

Genome annotation databases

EnsemblBacteriaiAAC77215; AAC77215; b4258
BAE78255; BAE78255; BAE78255
GeneIDi948785
KEGGiecj:JW4215
eco:b4258
PATRICifig|1411691.4.peg.2446

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1060

Phylogenomic databases

eggNOGiCOG0525, Bacteria
HOGENOMiCLU_001493_0_2_6
InParanoidiP07118
PhylomeDBiP07118

Enzyme and pathway databases

BioCyciEcoCyc:VALS-MONOMER
BRENDAi6.1.1.9, 2026
SABIO-RKiP07118

Miscellaneous databases

Protein Ontology

More...PROi		PR:P07118

Family and domain databases

CDDicd07962, Anticodon_Ia_Val, 1 hit
Gene3Di1.10.287.380, 1 hit
3.40.50.620, 2 hits
3.90.740.10, 2 hits
HAMAPiMF_02004, Val_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR002300, aa-tRNA-synth_Ia
IPR033705, Anticodon_Ia_Val
IPR013155, M/V/L/I-tRNA-synth_anticd-bd
IPR014729, Rossmann-like_a/b/a_fold
IPR010978, tRNA-bd_arm
IPR009080, tRNAsynth_Ia_anticodon-bd
IPR037118, Val-tRNA_synth_C_sf
IPR019499, Val-tRNA_synth_tRNA-bd
IPR009008, Val/Leu/Ile-tRNA-synth_edit
IPR002303, Valyl-tRNA_ligase
PANTHERiPTHR11946, PTHR11946, 1 hit
PfamiView protein in Pfam
PF08264, Anticodon_1, 1 hit
PF00133, tRNA-synt_1, 1 hit
PF10458, Val_tRNA-synt_C, 1 hit
PRINTSiPR00986, TRNASYNTHVAL
SUPFAMiSSF46589, SSF46589, 1 hit
SSF47323, SSF47323, 1 hit
SSF50677, SSF50677, 1 hit
TIGRFAMsiTIGR00422, valS, 1 hit
PROSITEiView protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYV_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07118
Secondary accession number(s): P78142, Q2M651, Q7X4V7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1997
Last modified: February 23, 2022
This is version 188 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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