UniProtKB - P07109 (HISP_ECOLI)
Protein
Histidine transport ATP-binding protein HisP
Gene
hisP
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 38 – 45 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled amino acid transmembrane transporter activity Source: InterPro
- ATP binding Source: EcoCyc
- high-affinity L-histidine transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- histidine transport Source: EcoliWiki
- L-histidine import across plasma membrane Source: EcoCyc
- L-histidine transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Amino-acid transport, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:HISP-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.3.29, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Histidine transport ATP-binding protein HisP |
Gene namesi | Name:hisP Ordered Locus Names:b2306, JW2303 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000092341 | 1 – 257 | Histidine transport ATP-binding protein HisPAdd BLAST | 257 |
Proteomic databases
jPOSTi | P07109 |
PaxDbi | P07109 |
PRIDEi | P07109 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).
By similarityProtein-protein interaction databases
BioGRIDi | 4263202, 13 interactors 851130, 2 interactors |
ComplexPortali | CPX-4328, Histidine ABC transporter complex CPX-4329, Polar amino acid ABC transporter complex |
IntActi | P07109, 5 interactors |
STRINGi | 511145.b2306 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 252 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 247 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily.Curated
Phylogenomic databases
eggNOGi | COG4598, Bacteria |
HOGENOMi | CLU_000604_1_22_6 |
InParanoidi | P07109 |
PhylomeDBi | P07109 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR030679, ABC_ATPase_HisP-typ IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
PIRSFi | PIRSF039085, ABC_ATPase_HisP, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P07109-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSENKLNVID LHKRYGEHEV LKGVSLQANA GDVISIIGSS GSGKSTFLRC
60 70 80 90 100
INFLEKPSEG SIVVNGQTIN LVRDKDGQLK VADKNQLRLL RTRLTMVFQH
110 120 130 140 150
FNLWSHMTVL ENVMEAPIQV LGLSKQEARE RAVKYLAKVG IDERAQGKYP
160 170 180 190 200
VHLSGGQQQR VSIARALAME PEVLLFDEPT SALDPELVGE VLRIMQQLAE
210 220 230 240 250
EGKTMVVVTH EMGFARHVST HVIFLHQGKI EEEGAPEQLF GNPQSPRLQR
FLKGSLK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | E → G AA sequence (PubMed:2246240).Curated | 1 | |
Sequence conflicti | 191 | V → L in CAA68511 (PubMed:3313284).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00455 Genomic DNA Translation: CAA68511.1 U00096 Genomic DNA Translation: AAC75366.1 AP009048 Genomic DNA Translation: BAA16143.1 |
PIRi | H65002 |
RefSeqi | NP_416809.1, NC_000913.3 WP_001293613.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75366; AAC75366; b2306 BAA16143; BAA16143; BAA16143 |
GeneIDi | 946789 |
KEGGi | ecj:JW2303 eco:b2306 |
PATRICi | fig|1411691.4.peg.4428 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00455 Genomic DNA Translation: CAA68511.1 U00096 Genomic DNA Translation: AAC75366.1 AP009048 Genomic DNA Translation: BAA16143.1 |
PIRi | H65002 |
RefSeqi | NP_416809.1, NC_000913.3 WP_001293613.1, NZ_LN832404.1 |
3D structure databases
SMRi | P07109 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263202, 13 interactors 851130, 2 interactors |
ComplexPortali | CPX-4328, Histidine ABC transporter complex CPX-4329, Polar amino acid ABC transporter complex |
IntActi | P07109, 5 interactors |
STRINGi | 511145.b2306 |
Protein family/group databases
TCDBi | 3.A.1.3.29, the atp-binding cassette (abc) superfamily |
Proteomic databases
jPOSTi | P07109 |
PaxDbi | P07109 |
PRIDEi | P07109 |
Genome annotation databases
EnsemblBacteriai | AAC75366; AAC75366; b2306 BAA16143; BAA16143; BAA16143 |
GeneIDi | 946789 |
KEGGi | ecj:JW2303 eco:b2306 |
PATRICi | fig|1411691.4.peg.4428 |
Organism-specific databases
EchoBASEi | EB0447 |
Phylogenomic databases
eggNOGi | COG4598, Bacteria |
HOGENOMi | CLU_000604_1_22_6 |
InParanoidi | P07109 |
PhylomeDBi | P07109 |
Enzyme and pathway databases
BioCyci | EcoCyc:HISP-MONOMER |
Miscellaneous databases
PROi | PR:P07109 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR030679, ABC_ATPase_HisP-typ IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
PIRSFi | PIRSF039085, ABC_ATPase_HisP, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HISP_ECOLI | |
Accessioni | P07109Primary (citable) accession number: P07109 Secondary accession number(s): P77299 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families