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Entry version 196 (16 Oct 2019)
Sequence version 1 (01 Nov 1988)
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Protein

Epoxide hydrolase 1

Gene

EPHX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.8 µM for 8,9-EET1 Publication
  2. KM=0.4 µM for 11,12-EET1 Publication
  3. KM=0.9 µM for 14,15-EET1 Publication
  4. KM=5.8 µM for leukotoxin1 Publication
  1. Vmax=0.12 µmol/min/mg enzyme with 8,9-EET as substrate1 Publication
  2. Vmax=0.6 µmol/min/mg enzyme with 11,12-EET as substrate1 Publication
  3. Vmax=0.04 µmol/min/mg enzyme with 14,15-EET as substrate1 Publication
  4. Vmax=0.008 µmol/min/mg enzyme with leukotoxin as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei226NucleophileBy similarity1
Active sitei374Proton donorBy similarity1
Active sitei431Proton acceptorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processAromatic hydrocarbons catabolism, Detoxification

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS07112-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.3.2.9 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-211945 Phase I - Functionalization of compounds

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P07099

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-EPHX1 Epoxide_hydrolase

MEROPS protease database

More...
MEROPSi
S33.971

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001117

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epoxide hydrolase 1 (EC:3.3.2.9By similarity)
Alternative name(s):
Epoxide hydratase
Microsomal epoxide hydrolase
Short name:
mEHCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPHX1
Synonyms:EPHX, EPOX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:3401 EPHX1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
132810 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P07099

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 21Helical; Signal-anchor for type III membrane proteinBy similarityAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 455CytoplasmicBy similarityAdd BLAST434

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls.1 Publication
Familial hypercholanemia (FHCA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
Related information in OMIM

Organism-specific databases

DisGeNET

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DisGeNETi
2052

MalaCards human disease database

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MalaCardsi
EPHX1
MIMi132810 gene+phenotype
607748 phenotype

Open Targets

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OpenTargetsi
ENSG00000143819

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
238475 Familial hypercholanemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27829

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P07099

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1968

DrugCentral

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DrugCentrali
P07099

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
EPHX1

Domain mapping of disease mutations (DMDM)

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DMDMi
123926

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000808551 – 455Epoxide hydrolase 1Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei295Dimethylated arginine; alternateBy similarity1
Modified residuei295Omega-N-methylated arginine; alternateBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-359
CPTAC-360

Encyclopedia of Proteome Dynamics

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EPDi
P07099

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P07099

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P07099

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P07099

PeptideAtlas

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PeptideAtlasi
P07099

PRoteomics IDEntifications database

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PRIDEi
P07099

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51949

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P07099

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P07099

SwissPalm database of S-palmitoylation events

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SwissPalmi
P07099

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000143819 Expressed in 218 organ(s), highest expression level in adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P07099 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P07099 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020593
HPA048847

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108366, 35 interactors

Protein interaction database and analysis system

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IntActi
P07099, 16 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000480004

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P07099

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P07099

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S33 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2565 Eukaryota
COG0596 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002210

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P07099

KEGG Orthology (KO)

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KOi
K01253

Identification of Orthologs from Complete Genome Data

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OMAi
HIFEVIC

Database of Orthologous Groups

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OrthoDBi
898504at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P07099

TreeFam database of animal gene trees

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TreeFami
TF313813

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR000639 Epox_hydrolase-like
IPR010497 Epoxide_hydro_N
IPR016292 Epoxide_hydrolase

Pfam protein domain database

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Pfami
View protein in Pfam
PF06441 EHN, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001112 Epoxide_hydrolase, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00412 EPOXHYDRLASE

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P07099-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLEILLTSV LGFAIYWFIS RDKEETLPLE DGWWGPGTRS AAREDDSIRP
60 70 80 90 100
FKVETSDEEI HDLHQRIDKF RFTPPLEDSC FHYGFNSNYL KKVISYWRNE
110 120 130 140 150
FDWKKQVEIL NRYPHFKTKI EGLDIHFIHV KPPQLPAGHT PKPLLMVHGW
160 170 180 190 200
PGSFYEFYKI IPLLTDPKNH GLSDEHVFEV ICPSIPGYGF SEASSKKGFN
210 220 230 240 250
SVATARIFYK LMLRLGFQEF YIQGGDWGSL ICTNMAQLVP SHVKGLHLNM
260 270 280 290 300
ALVLSNFSTL TLLLGQRFGR FLGLTERDVE LLYPVKEKVF YSLMRESGYM
310 320 330 340 350
HIQCTKPDTV GSALNDSPVG LAAYILEKFS TWTNTEFRYL EDGGLERKFS
360 370 380 390 400
LDDLLTNVML YWTTGTIISS QRFYKENLGQ GWMTQKHERM KVYVPTGFSA
410 420 430 440 450
FPFELLHTPE KWVRFKYPKL ISYSYMVRGG HFAAFEEPEL LAQDIRKFLS

VLERQ
Length:455
Mass (Da):52,949
Last modified:November 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88E333838C841390
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AQP8B1AQP8_HUMAN
Epoxide hydrolase 1
EPHX1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AQP9B1AQP9_HUMAN
Epoxide hydrolase 1
EPHX1
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15I → V in BAG36227 (PubMed:14702039).Curated1
Sequence conflicti112R → K (Ref. 10) Curated1
Sequence conflicti148H → N (PubMed:3502697).Curated1
Sequence conflicti148H → N (Ref. 10) Curated1
Sequence conflicti243V → L (Ref. 10) Curated1
Sequence conflicti348K → S in CAA68486 (PubMed:3502697).Curated1
Sequence conflicti406L → F in CAA68486 (PubMed:3502697).Curated1
Sequence conflicti420L → V in CAA68486 (PubMed:3502697).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02330343R → T1 PublicationCorresponds to variant dbSNP:rs3738046Ensembl.1
Natural variantiVAR_01834744E → Q1 PublicationCorresponds to variant dbSNP:rs745306359Ensembl.1
Natural variantiVAR_01329849R → C in allele EPHX1*2. 1 PublicationCorresponds to variant dbSNP:rs2234697Ensembl.1
Natural variantiVAR_005295113Y → H in allele EPHX1*3; 55% of wild type enzyme activity. 5 PublicationsCorresponds to variant dbSNP:rs1051740EnsemblClinVar.1
Natural variantiVAR_005296139H → R in allele EPHX1*4; 62% of wild type enzyme activity. 5 PublicationsCorresponds to variant dbSNP:rs2234922EnsemblClinVar.1
Natural variantiVAR_013299260L → P in allele EPHX1*1G. 1 Publication1
Natural variantiVAR_051828275T → A. Corresponds to variant dbSNP:rs35073925Ensembl.1
Natural variantiVAR_023304285V → L1 PublicationCorresponds to variant dbSNP:rs45449793Ensembl.1
Natural variantiVAR_005297396T → I Either a rare polymorphism or a sequencing error. 1 Publication1
Natural variantiVAR_023305408T → M1 PublicationCorresponds to variant dbSNP:rs45495897Ensembl.1
Natural variantiVAR_023306452L → Q1 PublicationCorresponds to variant dbSNP:rs45563137Ensembl.1
Natural variantiVAR_013300454R → Q in allele EPHX1*5. 1 PublicationCorresponds to variant dbSNP:rs2234701Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
J03518 mRNA Translation: AAA61305.1
X07936 mRNA Translation: CAA30759.1
Y00424 mRNA Translation: CAA68486.1
L25878 mRNA Translation: AAA52389.1
L25879 mRNA Translation: AAA52390.1
U06661
, U06656, U06657, U06658, U06659, U06660 Genomic DNA Translation: AAB60649.1
AK313436 mRNA Translation: BAG36227.1
AY948961 Genomic DNA Translation: AAX81410.1
AL591895 Genomic DNA No translation available.
BC003567 mRNA Translation: AAH03567.1
BC008291 mRNA Translation: AAH08291.1
BC095430 mRNA Translation: AAH95430.1
M36374 mRNA Translation: AAA59580.1
AF253417 Genomic DNA Translation: AAC41694.1
AF276626 Genomic DNA Translation: AAF87726.1
AF276627 Genomic DNA Translation: AAF87727.1
AF276628 Genomic DNA Translation: AAF87728.1
AF276629 Genomic DNA Translation: AAF87729.1
AF276630 Genomic DNA Translation: AAF87730.1
AF276631 Genomic DNA Translation: AAF87731.1
AF276632 Genomic DNA Translation: AAF87732.1
AF276633 Genomic DNA Translation: AAF87733.1
AF276634 Genomic DNA Translation: AAF87734.1
AF276635 Genomic DNA Translation: AAF87735.1
AF276636 Genomic DNA Translation: AAF87736.1
AF276637 Genomic DNA Translation: AAF87737.1
AF276638 Genomic DNA Translation: AAF87738.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1547.1

Protein sequence database of the Protein Information Resource

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PIRi
A29939

NCBI Reference Sequences

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RefSeqi
NP_000111.1, NM_000120.3
NP_001129490.1, NM_001136018.3
NP_001278092.1, NM_001291163.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272167; ENSP00000272167; ENSG00000143819
ENST00000366837; ENSP00000355802; ENSG00000143819
ENST00000614058; ENSP00000480004; ENSG00000143819

Database of genes from NCBI RefSeq genomes

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GeneIDi
2052

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2052

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03518 mRNA Translation: AAA61305.1
X07936 mRNA Translation: CAA30759.1
Y00424 mRNA Translation: CAA68486.1
L25878 mRNA Translation: AAA52389.1
L25879 mRNA Translation: AAA52390.1
U06661
, U06656, U06657, U06658, U06659, U06660 Genomic DNA Translation: AAB60649.1
AK313436 mRNA Translation: BAG36227.1
AY948961 Genomic DNA Translation: AAX81410.1
AL591895 Genomic DNA No translation available.
BC003567 mRNA Translation: AAH03567.1
BC008291 mRNA Translation: AAH08291.1
BC095430 mRNA Translation: AAH95430.1
M36374 mRNA Translation: AAA59580.1
AF253417 Genomic DNA Translation: AAC41694.1
AF276626 Genomic DNA Translation: AAF87726.1
AF276627 Genomic DNA Translation: AAF87727.1
AF276628 Genomic DNA Translation: AAF87728.1
AF276629 Genomic DNA Translation: AAF87729.1
AF276630 Genomic DNA Translation: AAF87730.1
AF276631 Genomic DNA Translation: AAF87731.1
AF276632 Genomic DNA Translation: AAF87732.1
AF276633 Genomic DNA Translation: AAF87733.1
AF276634 Genomic DNA Translation: AAF87734.1
AF276635 Genomic DNA Translation: AAF87735.1
AF276636 Genomic DNA Translation: AAF87736.1
AF276637 Genomic DNA Translation: AAF87737.1
AF276638 Genomic DNA Translation: AAF87738.1
CCDSiCCDS1547.1
PIRiA29939
RefSeqiNP_000111.1, NM_000120.3
NP_001129490.1, NM_001136018.3
NP_001278092.1, NM_001291163.1

3D structure databases

SMRiP07099
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108366, 35 interactors
IntActiP07099, 16 interactors
STRINGi9606.ENSP00000480004

Chemistry databases

BindingDBiP07099
ChEMBLiCHEMBL1968
DrugCentraliP07099
SwissLipidsiSLP:000001117

Protein family/group databases

ESTHERihuman-EPHX1 Epoxide_hydrolase
MEROPSiS33.971

PTM databases

iPTMnetiP07099
PhosphoSitePlusiP07099
SwissPalmiP07099

Polymorphism and mutation databases

BioMutaiEPHX1
DMDMi123926

Proteomic databases

CPTACiCPTAC-359
CPTAC-360
EPDiP07099
jPOSTiP07099
MassIVEiP07099
PaxDbiP07099
PeptideAtlasiP07099
PRIDEiP07099
ProteomicsDBi51949

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2052

Genome annotation databases

EnsembliENST00000272167; ENSP00000272167; ENSG00000143819
ENST00000366837; ENSP00000355802; ENSG00000143819
ENST00000614058; ENSP00000480004; ENSG00000143819
GeneIDi2052
KEGGihsa:2052

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2052
DisGeNETi2052

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EPHX1
HGNCiHGNC:3401 EPHX1
HPAiHPA020593
HPA048847
MalaCardsiEPHX1
MIMi132810 gene+phenotype
607748 phenotype
neXtProtiNX_P07099
OpenTargetsiENSG00000143819
Orphaneti238475 Familial hypercholanemia
PharmGKBiPA27829

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2565 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00390000002210
InParanoidiP07099
KOiK01253
OMAiHIFEVIC
OrthoDBi898504at2759
PhylomeDBiP07099
TreeFamiTF313813

Enzyme and pathway databases

BioCyciMetaCyc:HS07112-MONOMER
BRENDAi3.3.2.9 2681
ReactomeiR-HSA-211945 Phase I - Functionalization of compounds
SABIO-RKiP07099

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EPHX1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
EPHX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2052
PharosiP07099

Protein Ontology

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PROi
PR:P07099

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143819 Expressed in 218 organ(s), highest expression level in adrenal gland
ExpressionAtlasiP07099 baseline and differential
GenevisibleiP07099 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000639 Epox_hydrolase-like
IPR010497 Epoxide_hydro_N
IPR016292 Epoxide_hydrolase
PfamiView protein in Pfam
PF06441 EHN, 1 hit
PIRSFiPIRSF001112 Epoxide_hydrolase, 1 hit
PRINTSiPR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHYEP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07099
Secondary accession number(s): B2R8N0
, Q5VTJ6, Q9NP75, Q9NPE7, Q9NQU6, Q9NQU7, Q9NQU8, Q9NQU9, Q9NQV0, Q9NQV1, Q9NQV2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1988
Last modified: October 16, 2019
This is version 196 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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