UniProtKB - P07093 (GDN_HUMAN)
Protein
Glia-derived nexin
Gene
SERPINE2
Organism
Homo sapiens (Human)
Status
Functioni
Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 365 – 366 | Reactive bondSequence analysis | 2 |
GO - Molecular functioni
- glycosaminoglycan binding Source: BHF-UCL
- heparin binding Source: BHF-UCL
- serine-type endopeptidase inhibitor activity Source: BHF-UCL
- signaling receptor binding Source: BHF-UCL
GO - Biological processi
- blood coagulation Source: Reactome
- cerebellar granular layer morphogenesis Source: Ensembl
- detection of mechanical stimulus involved in sensory perception Source: Ensembl
- innervation Source: Ensembl
- long-term synaptic potentiation Source: Ensembl
- mating plug formation Source: Ensembl
- negative regulation of blood coagulation Source: BHF-UCL
- negative regulation of cell growth Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of endopeptidase activity Source: GO_Central
- negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
- negative regulation of plasminogen activation Source: BHF-UCL
- negative regulation of platelet aggregation Source: BHF-UCL
- negative regulation of protein catabolic process Source: Ensembl
- negative regulation of protein processing Source: BHF-UCL
- negative regulation of proteolysis Source: BHF-UCL
- negative regulation of smoothened signaling pathway Source: Ensembl
- negative regulation of sodium ion transport Source: Ensembl
- positive regulation of astrocyte differentiation Source: BHF-UCL
- regulation of cell migration Source: UniProtKB
- regulation of synaptic transmission, glutamatergic Source: Ensembl
- regulation of timing of cell differentiation Source: Ensembl
- secretion by cell Source: Ensembl
- secretory granule organization Source: Ensembl
- seminal vesicle epithelium development Source: Ensembl
Keywordsi
Molecular function | Developmental protein, Heparin-binding, Protease inhibitor, Serine protease inhibitor |
Biological process | Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | P07093 |
Reactomei | R-HSA-140837, Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-75205, Dissolution of Fibrin Clot |
Protein family/group databases
MEROPSi | I04.021 |
Names & Taxonomyi
Protein namesi | Recommended name: Glia-derived nexinShort name: GDN Alternative name(s): Peptidase inhibitor 7 Short name: PI-7 Protease nexin 1 Short name: PN-1 Protease nexin I Serpin E2 |
Gene namesi | Name:SERPINE2 Synonyms:PI7, PN1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000135919.12 |
HGNCi | HGNC:8951, SERPINE2 |
MIMi | 177010, gene |
neXtProti | NX_P07093 |
Subcellular locationi
Extracellular region or secreted
Cytosol
- cytosol Source: BHF-UCL
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular region Source: BHF-UCL
- extracellular space Source: GO_Central
- extracellular vesicle Source: UniProtKB
Plasma Membrane
- extrinsic component of external side of plasma membrane Source: BHF-UCL
Other locations
- neuromuscular junction Source: BHF-UCL
- platelet alpha granule Source: MGI
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5270 |
OpenTargetsi | ENSG00000135919 |
PharmGKBi | PA269 |
Miscellaneous databases
Pharosi | P07093, Tbio |
Polymorphism and mutation databases
BioMutai | SERPINE2 |
DMDMi | 121110 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 2 PublicationsAdd BLAST | 19 | |
ChainiPRO_0000032504 | 20 – 398 | Glia-derived nexinAdd BLAST | 379 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 118 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | P07093 |
jPOSTi | P07093 |
MassIVEi | P07093 |
MaxQBi | P07093 |
PaxDbi | P07093 |
PeptideAtlasi | P07093 |
PRIDEi | P07093 |
ProteomicsDBi | 51945 [P07093-1] 51946 [P07093-2] 51947 [P07093-3] |
PTM databases
CarbonylDBi | P07093 |
GlyGeni | P07093, 4 sites, 1 O-linked glycan (1 site) |
iPTMneti | P07093 |
PhosphoSitePlusi | P07093 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135919, Expressed in decidua and 242 other tissues |
ExpressionAtlasi | P07093, baseline and differential |
Genevisiblei | P07093, HS |
Organism-specific databases
HPAi | ENSG00000135919, Tissue enriched (placenta) |
Interactioni
Binary interactionsi
P07093
With | #Exp. | IntAct |
---|---|---|
FAM9B [Q8IZU0] | 3 | EBI-10195168,EBI-10175124 |
GO - Molecular functioni
- signaling receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111288, 29 interactors |
IntActi | P07093, 17 interactors |
MINTi | P07093 |
STRINGi | 9606.ENSP00000415786 |
Miscellaneous databases
RNActi | P07093, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P07093 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the serpin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000158424 |
HOGENOMi | CLU_023330_0_4_1 |
InParanoidi | P07093 |
OMAi | ALRYKKN |
OrthoDBi | 1124079at2759 |
PhylomeDBi | P07093 |
TreeFami | TF352620 |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P07093-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN
60 70 80 90 100
IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV
110 120 130 140 150
SKKNKDIVTV ANAVFVKNAS EIEVPFVTRN KDVFQCEVRN VNFEDPASAC
160 170 180 190 200
DSINAWVKNE TRDMIDNLLS PDLIDGVLTR LVLVNAVYFK GLWKSRFQPE
210 220 230 240 250
NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN FIELPYHGES
260 270 280 290 300
ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA
310 320 330 340 350
QTDLKEPLKV LGITDMFDSS KANFAKITTG SENLHVSHIL QKAKIEVSED
360 370 380 390
GTKASAATTA ILIARSSPPW FIVDRPFLFF IRHNPTGAVL FMGQINKP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JN98 | C9JN98_HUMAN | Glia-derived nexin | SERPINE2 | 275 | Annotation score: | ||
C9K031 | C9K031_HUMAN | Glia-derived nexin | SERPINE2 | 86 | Annotation score: | ||
C9JRK5 | C9JRK5_HUMAN | Glia-derived nexin | SERPINE2 | 42 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 159 | N → D in BAG35401 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 261 | S → E (PubMed:2877744).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051955 | 51 | I → M. Corresponds to variant dbSNP:rs3795875Ensembl. | 1 | |
Natural variantiVAR_036027 | 204 | K → N in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043668 | 1 | M → MSDCRSSLVEGTM in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_038367 | 329 – 330 | TG → R in isoform 2 and isoform 3. 3 Publications | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17783 mRNA Translation: AAA35883.1 AK295564 mRNA Translation: BAG58464.1 AK312499 mRNA Translation: BAG35401.1 AC073641 Genomic DNA Translation: AAY14926.1 CH471063 Genomic DNA Translation: EAW70821.1 CH471063 Genomic DNA Translation: EAW70823.1 BC015663 mRNA Translation: AAH15663.1 BC042628 mRNA Translation: AAH42628.1 |
CCDSi | CCDS2460.1 [P07093-1] CCDS46525.1 [P07093-3] CCDS46526.1 [P07093-2] |
PIRi | A37274 |
RefSeqi | NP_001130000.1, NM_001136528.1 [P07093-2] NP_001130002.1, NM_001136530.1 [P07093-3] NP_006207.1, NM_006216.3 [P07093-1] XP_016859818.1, XM_017004329.1 XP_016859819.1, XM_017004330.1 [P07093-1] XP_016859820.1, XM_017004331.1 XP_016859821.1, XM_017004332.1 [P07093-2] |
Genome annotation databases
Ensembli | ENST00000258405; ENSP00000258405; ENSG00000135919 [P07093-1] ENST00000409304; ENSP00000386412; ENSG00000135919 [P07093-2] ENST00000409840; ENSP00000386969; ENSG00000135919 [P07093-2] ENST00000447280; ENSP00000415786; ENSG00000135919 [P07093-3] |
GeneIDi | 5270 |
KEGGi | hsa:5270 |
UCSCi | uc002vnu.3, human [P07093-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17783 mRNA Translation: AAA35883.1 AK295564 mRNA Translation: BAG58464.1 AK312499 mRNA Translation: BAG35401.1 AC073641 Genomic DNA Translation: AAY14926.1 CH471063 Genomic DNA Translation: EAW70821.1 CH471063 Genomic DNA Translation: EAW70823.1 BC015663 mRNA Translation: AAH15663.1 BC042628 mRNA Translation: AAH42628.1 |
CCDSi | CCDS2460.1 [P07093-1] CCDS46525.1 [P07093-3] CCDS46526.1 [P07093-2] |
PIRi | A37274 |
RefSeqi | NP_001130000.1, NM_001136528.1 [P07093-2] NP_001130002.1, NM_001136530.1 [P07093-3] NP_006207.1, NM_006216.3 [P07093-1] XP_016859818.1, XM_017004329.1 XP_016859819.1, XM_017004330.1 [P07093-1] XP_016859820.1, XM_017004331.1 XP_016859821.1, XM_017004332.1 [P07093-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4DY0 | X-ray | 2.35 | A/B | 20-398 | [»] | |
4DY7 | X-ray | 2.80 | C/F | 20-398 | [»] | |
SMRi | P07093 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111288, 29 interactors |
IntActi | P07093, 17 interactors |
MINTi | P07093 |
STRINGi | 9606.ENSP00000415786 |
Protein family/group databases
MEROPSi | I04.021 |
PTM databases
CarbonylDBi | P07093 |
GlyGeni | P07093, 4 sites, 1 O-linked glycan (1 site) |
iPTMneti | P07093 |
PhosphoSitePlusi | P07093 |
Polymorphism and mutation databases
BioMutai | SERPINE2 |
DMDMi | 121110 |
Proteomic databases
EPDi | P07093 |
jPOSTi | P07093 |
MassIVEi | P07093 |
MaxQBi | P07093 |
PaxDbi | P07093 |
PeptideAtlasi | P07093 |
PRIDEi | P07093 |
ProteomicsDBi | 51945 [P07093-1] 51946 [P07093-2] 51947 [P07093-3] |
Protocols and materials databases
ABCDi | P07093, 4 sequenced antibodies |
Antibodypediai | 34366, 363 antibodies |
DNASUi | 5270 |
Genome annotation databases
Ensembli | ENST00000258405; ENSP00000258405; ENSG00000135919 [P07093-1] ENST00000409304; ENSP00000386412; ENSG00000135919 [P07093-2] ENST00000409840; ENSP00000386969; ENSG00000135919 [P07093-2] ENST00000447280; ENSP00000415786; ENSG00000135919 [P07093-3] |
GeneIDi | 5270 |
KEGGi | hsa:5270 |
UCSCi | uc002vnu.3, human [P07093-1] |
Organism-specific databases
CTDi | 5270 |
DisGeNETi | 5270 |
EuPathDBi | HostDB:ENSG00000135919.12 |
GeneCardsi | SERPINE2 |
HGNCi | HGNC:8951, SERPINE2 |
HPAi | ENSG00000135919, Tissue enriched (placenta) |
MIMi | 177010, gene |
neXtProti | NX_P07093 |
OpenTargetsi | ENSG00000135919 |
PharmGKBi | PA269 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000158424 |
HOGENOMi | CLU_023330_0_4_1 |
InParanoidi | P07093 |
OMAi | ALRYKKN |
OrthoDBi | 1124079at2759 |
PhylomeDBi | P07093 |
TreeFami | TF352620 |
Enzyme and pathway databases
PathwayCommonsi | P07093 |
Reactomei | R-HSA-140837, Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-75205, Dissolution of Fibrin Clot |
Miscellaneous databases
BioGRID-ORCSi | 5270, 4 hits in 848 CRISPR screens |
ChiTaRSi | SERPINE2, human |
GeneWikii | SERPINE2 |
GenomeRNAii | 5270 |
Pharosi | P07093, Tbio |
PROi | PR:P07093 |
RNActi | P07093, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135919, Expressed in decidua and 242 other tissues |
ExpressionAtlasi | P07093, baseline and differential |
Genevisiblei | P07093, HS |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GDN_HUMAN | |
Accessioni | P07093Primary (citable) accession number: P07093 Secondary accession number(s): B2R6A4 Q5D0C4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | April 1, 1988 | |
Last modified: | December 2, 2020 | |
This is version 202 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations