Glia-derived nexin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• glycosaminoglycan binding Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Anticoagulant and antithrombotic properties of platelet protease nexin-1."
    Boulaftali Y., Adam F., Venisse L., Ollivier V., Richard B., Taieb S., Monard D., Favier R., Alessi M.C., Bryckaert M., Arocas V., Jandrot-Perrus M., Bouton M.C.
    Blood 115:97-106(2010) [PubMed] [Europe PMC] [Abstract]
• heparin binding Source: BHF-UCLInferred from direct assayⁱ
  • "Protease specificity and heparin binding and activation of recombinant protease nexin I."
    Evans D.L., McGrogan M., Scott R.W., Carrell R.W.
    J. Biol. Chem. 266:22307-22312(1991) [PubMed] [Europe PMC] [Abstract]
  • Ref.8

    "Protease nexin. Properties and a modified purification procedure."
    Scott R.W., Bergman B.L., Bajpai A., Hersh R.T., Rodriguez H., Jones B.N., Barreda C., Watts S., Baker J.B.
    J. Biol. Chem. 260:7029-7034(1985) [PubMed] [Europe PMC] [Abstract]

    Cited for: PROTEIN SEQUENCE OF 20-47, CHARACTERIZATION.
• serine-type endopeptidase inhibitor activity Source: BHF-UCLInferred from direct assayⁱ
  • "Nexin-1 inhibits the activity of human brain trypsin."
    Koistinen H., Koistinen R., Zhang W.M., Valmu L., Stenman U.H.
    Neuroscience 160:97-102(2009) [PubMed] [Europe PMC] [Abstract]
  • Ref.8

    "Protease nexin. Properties and a modified purification procedure."
    Scott R.W., Bergman B.L., Bajpai A., Hersh R.T., Rodriguez H., Jones B.N., Barreda C., Watts S., Baker J.B.
    J. Biol. Chem. 260:7029-7034(1985) [PubMed] [Europe PMC] [Abstract]

    Cited for: PROTEIN SEQUENCE OF 20-47, CHARACTERIZATION.
• signaling receptor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect."
    Bouton M.C., Venisse L., Richard B., Pouzet C., Arocas V., Jandrot-Perrus M.
    Circ. Res. 100:1174-1181(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• blood coagulation Source: Reactome
• cerebellar granular layer morphogenesis Source: Ensembl
• detection of mechanical stimulus involved in sensory perception Source: Ensembl
• innervation Source: Ensembl
• long-term synaptic potentiation Source: Ensembl
• mating plug formation Source: Ensembl
• negative regulation of blood coagulation Source: BHF-UCLInferred from direct assayⁱ
  • "Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect."
    Bouton M.C., Venisse L., Richard B., Pouzet C., Arocas V., Jandrot-Perrus M.
    Circ. Res. 100:1174-1181(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell growth Source: Ensembl
• negative regulation of cell population proliferation Source: Ensembl
• negative regulation of endopeptidase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
• negative regulation of plasminogen activation Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Anticoagulant and antithrombotic properties of platelet protease nexin-1."
    Boulaftali Y., Adam F., Venisse L., Ollivier V., Richard B., Taieb S., Monard D., Favier R., Alessi M.C., Bryckaert M., Arocas V., Jandrot-Perrus M., Bouton M.C.
    Blood 115:97-106(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of platelet aggregation Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "Anticoagulant and antithrombotic properties of platelet protease nexin-1."
    Boulaftali Y., Adam F., Venisse L., Ollivier V., Richard B., Taieb S., Monard D., Favier R., Alessi M.C., Bryckaert M., Arocas V., Jandrot-Perrus M., Bouton M.C.
    Blood 115:97-106(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein catabolic process Source: Ensembl
• negative regulation of protein processing Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Anticoagulant and antithrombotic properties of platelet protease nexin-1."
    Boulaftali Y., Adam F., Venisse L., Ollivier V., Richard B., Taieb S., Monard D., Favier R., Alessi M.C., Bryckaert M., Arocas V., Jandrot-Perrus M., Bouton M.C.
    Blood 115:97-106(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of proteolysis Source: BHF-UCLInferred from direct assayⁱ
  • "Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect."
    Bouton M.C., Venisse L., Richard B., Pouzet C., Arocas V., Jandrot-Perrus M.
    Circ. Res. 100:1174-1181(2007) [PubMed] [Europe PMC] [Abstract]
  • Ref.8

    "Protease nexin. Properties and a modified purification procedure."
    Scott R.W., Bergman B.L., Bajpai A., Hersh R.T., Rodriguez H., Jones B.N., Barreda C., Watts S., Baker J.B.
    J. Biol. Chem. 260:7029-7034(1985) [PubMed] [Europe PMC] [Abstract]

    Cited for: PROTEIN SEQUENCE OF 20-47, CHARACTERIZATION.
• negative regulation of smoothened signaling pathway Source: Ensembl
• negative regulation of sodium ion transport Source: Ensembl
• positive regulation of astrocyte differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1."
    Cavanaugh K.P., Gurwitz D., Cunningham D.D., Bradshaw R.A.
    J. Neurochem. 54:1735-1743(1990) [PubMed] [Europe PMC] [Abstract]
• regulation of cell migration Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.2

    "A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins."
    Gloor S.M., Odink K., Guenther J., Nick H., Monard D.
    Cell 47:687-693(1986) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• regulation of synaptic transmission, glutamatergic Source: Ensembl
• regulation of timing of cell differentiation Source: Ensembl
• secretion by cell Source: Ensembl
• secretory granule organization Source: Ensembl
• seminal vesicle epithelium development Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• signaling receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect."
    Bouton M.C., Venisse L., Richard B., Pouzet C., Arocas V., Jandrot-Perrus M.
    Circ. Res. 100:1174-1181(2007) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN 
        60         70         80         90        100
IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV 
       110        120        130        140        150
SKKNKDIVTV ANAVFVKNAS EIEVPFVTRN KDVFQCEVRN VNFEDPASAC 
       160        170        180        190        200
DSINAWVKNE TRDMIDNLLS PDLIDGVLTR LVLVNAVYFK GLWKSRFQPE 
       210        220        230        240        250
NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN FIELPYHGES 
       260        270        280        290        300
ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA 
       310        320        330        340        350
QTDLKEPLKV LGITDMFDSS KANFAKITTG SENLHVSHIL QKAKIEVSED 
       360        370        380        390 
GTKASAATTA ILIARSSPPW FIVDRPFLFF IRHNPTGAVL FMGQINKP   

        10         20         30         40         50
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN 
        60         70         80         90        100
IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV 
       110        120        130        140        150
SKKNKDIVTV ANAVFVKNAS EIEVPFVTRN KDVFQCEVRN VNFEDPASAC 
       160        170        180        190        200
DSINAWVKNE TRDMIDNLLS PDLIDGVLTR LVLVNAVYFK GLWKSRFQPE 
       210        220        230        240        250
NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN FIELPYHGES 
       260        270        280        290        300
ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA 
       310        320        330        340        350
QTDLKEPLKV LGITDMFDSS KANFAKITRS ENLHVSHILQ KAKIEVSEDG 
       360        370        380        390 
TKASAATTAI LIARSSPPWF IVDRPFLFFI RHNPTGAVLF MGQINKP    

        10         20         30         40         50
MSDCRSSLVE GTMNWHLPLF LLASVTLPSI CSHFNPLSLE ELGSNTGIQV 
        60         70         80         90        100
FNQIVKSRPH DNIVISPHGI ASVLGMLQLG ADGRTKKQLA MVMRYGVNGV 
       110        120        130        140        150
GKILKKINKA IVSKKNKDIV TVANAVFVKN ASEIEVPFVT RNKDVFQCEV 
       160        170        180        190        200
RNVNFEDPAS ACDSINAWVK NETRDMIDNL LSPDLIDGVL TRLVLVNAVY 
       210        220        230        240        250
FKGLWKSRFQ PENTKKRTFV AADGKSYQVP MLAQLSVFRC GSTSAPNDLW 
       260        270        280        290        300
YNFIELPYHG ESISMLIALP TESSTPLSAI IPHISTKTID SWMSIMVPKR 
       310        320        330        340        350
VQVILPKFTA VAQTDLKEPL KVLGITDMFD SSKANFAKIT RSENLHVSHI 
       360        370        380        390        400
LQKAKIEVSE DGTKASAATT AILIARSSPP WFIVDRPFLF FIRHNPTGAV 

LFMGQINKP                                              

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. Human chromosome 2
   Human chromosome 2: entries, gene names and cross-references to MIM
4. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
5. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
6. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot