SERPINE2

Functionⁱ

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	365 – 366	Reactive bondSequence analysis		2

GO - Molecular functionⁱ

glycosaminoglycan binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19855083
heparin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 1939253
- 3997857
serine-type endopeptidase inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 19249338
- 3997857
signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17379830

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blood coagulation Source: Reactome
cerebellar granular layer morphogenesis Source: Ensembl
detection of mechanical stimulus involved in sensory perception Source: Ensembl
innervation Source: Ensembl
long-term synaptic potentiation Source: Ensembl
mating plug formation Source: Ensembl
negative regulation of blood coagulation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17379830
negative regulation of cell growth Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
negative regulation of endopeptidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
negative regulation of plasminogen activation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19855083
negative regulation of platelet aggregation
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 19855083
negative regulation of protein catabolic process Source: Ensembl
negative regulation of protein processing
Source: BHF-UCL
Inferred by curatorⁱ
- 19855083
negative regulation of proteolysis
Source: BHF-UCL
Inferred from direct assayⁱ
- 17379830
- 3997857
negative regulation of smoothened signaling pathway Source: Ensembl
negative regulation of sodium ion transport Source: Ensembl
positive regulation of astrocyte differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 1691280
regulation of cell migration
Source: UniProtKB
Non-traceable author statementⁱ
- 2877744
regulation of synaptic transmission, glutamatergic Source: Ensembl
regulation of timing of cell differentiation Source: Ensembl
secretion by cell Source: Ensembl
secretory granule organization Source: Ensembl
seminal vesicle epithelium development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Heparin-binding, Protease inhibitor, Serine protease inhibitor
Biological process	Differentiation, Neurogenesis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875 Common Pathway of Fibrin Clot Formation R-HSA-75205 Dissolution of Fibrin Clot

Reactomeⁱ

R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-75205 Dissolution of Fibrin Clot

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I04.021

MEROPSⁱ

I04.021

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glia-derived nexin Short name: GDN Alternative name(s): Peptidase inhibitor 7 Short name: PI-7 Protease nexin 1 Short name: PN-1 Protease nexin I Serpin E2
Gene namesⁱ	Name:SERPINE2 Synonyms:PI7, PN1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000135919.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8951 SERPINE2
MIMⁱ	177010 gene
neXtProtⁱ	NX_P07093

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5270
Open Targets More...OpenTargetsⁱ	ENSG00000135919
PharmGKBⁱ	PA269

Polymorphism and mutation databases

BioMutaⁱ	SERPINE2
DMDMⁱ	121110

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	2 PublicationsAdd BLAST		19
ChainⁱPRO_0000032504	20 – 398	Glia-derived nexinAdd BLAST		379

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	118	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	159	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	P07093
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P07093
PaxDbⁱ	P07093
PeptideAtlas More...PeptideAtlasⁱ	P07093
PRIDEⁱ	P07093
ProteomicsDBⁱ	51945 51946 [P07093-2] 51947 [P07093-3]

PTM databases

CarbonylDBⁱ	P07093
iPTMnetⁱ	P07093
PhosphoSitePlusⁱ	P07093

Miscellaneous databases

PMAP-CutDBⁱ	P07093

PMAP-CutDBⁱ

P07093

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000135919 Expressed in 232 organ(s), highest expression level in decidua
CleanExⁱ	HS_SERPINE2
ExpressionAtlasⁱ	P07093 baseline and differential
Genevisibleⁱ	P07093 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FAM9B	Q8IZU0	3	EBI-10195168,EBI-10175124

With

Entry

#Exp.

IntAct

Notes

FAM9B

Q8IZU0

3

EBI-10195168,EBI-10175124

GO - Molecular functionⁱ

signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17379830

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111288, 27 interactors
IntActⁱ	P07093, 8 interactors
Molecular INTeraction database More...MINTⁱ	P07093
STRINGⁱ	9606.ENSP00000415786

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	24 – 45	Combined sources	22
Beta strandⁱ	51 – 53	Combined sources	3
Helixⁱ	55 – 66	Combined sources	12
Helixⁱ	71 – 81	Combined sources	11
Turnⁱ	86 – 88	Combined sources	3
Helixⁱ	89 – 100	Combined sources	12
Helixⁱ	102 – 104	Combined sources	3
Beta strandⁱ	109 – 117	Combined sources	9
Helixⁱ	124 – 134	Combined sources	11
Beta strandⁱ	136 – 140	Combined sources	5
Helixⁱ	146 – 160	Combined sources	15
Turnⁱ	161 – 163	Combined sources	3
Helixⁱ	171 – 173	Combined sources	3
Turnⁱ	176 – 178	Combined sources	3
Beta strandⁱ	181 – 189	Combined sources	9
Beta strandⁱ	193 – 195	Combined sources	3
Helixⁱ	199 – 201	Combined sources	3
Beta strandⁱ	203 – 208	Combined sources	6
Beta strandⁱ	210 – 212	Combined sources	3
Beta strandⁱ	214 – 232	Combined sources	19
Beta strandⁱ	238 – 246	Combined sources	9
Beta strandⁱ	249 – 260	Combined sources	12
Helixⁱ	265 – 267	Combined sources	3
Helixⁱ	269 – 271	Combined sources	3
Helixⁱ	274 – 281	Combined sources	8
Beta strandⁱ	285 – 294	Combined sources	10
Beta strandⁱ	296 – 303	Combined sources	8
Helixⁱ	305 – 310	Combined sources	6
Helixⁱ	315 – 317	Combined sources	3
Turnⁱ	319 – 321	Combined sources	3
Turnⁱ	325 – 327	Combined sources	3
Beta strandⁱ	328 – 330	Combined sources	3
Beta strandⁱ	338 – 347	Combined sources	10
Beta strandⁱ	354 – 356	Combined sources	3
Helixⁱ	357 – 360	Combined sources	4
Beta strandⁱ	370 – 372	Combined sources	3
Beta strandⁱ	377 – 383	Combined sources	7
Turnⁱ	384 – 387	Combined sources	4
Beta strandⁱ	388 – 396	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P07093
SMRⁱ	P07093
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the serpin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150820
HOGENOMⁱ	HOG000238519
HOVERGENⁱ	HBG106493
InParanoidⁱ	P07093
KEGG Orthology (KO) More...KOⁱ	K16643
OMAⁱ	KANFQCE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ION
PhylomeDBⁱ	P07093
TreeFamⁱ	TF352620

Family and domain databases

InterProⁱ	View protein in InterPro IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P07093-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN 
        60         70         80         90        100
IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV 
       110        120        130        140        150
SKKNKDIVTV ANAVFVKNAS EIEVPFVTRN KDVFQCEVRN VNFEDPASAC 
       160        170        180        190        200
DSINAWVKNE TRDMIDNLLS PDLIDGVLTR LVLVNAVYFK GLWKSRFQPE 
       210        220        230        240        250
NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN FIELPYHGES 
       260        270        280        290        300
ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA 
       310        320        330        340        350
QTDLKEPLKV LGITDMFDSS KANFAKITTG SENLHVSHIL QKAKIEVSED 
       360        370        380        390 
GTKASAATTA ILIARSSPPW FIVDRPFLFF IRHNPTGAVL FMGQINKP

Length:398

Mass (Da):44,002

Last modified:April 1, 1988 - v1

Checksum:ⁱ2A165604E2CBE6B8

GO

Isoform 2 (identifier: P07093-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
329-330: TG → R

« Hide

        10         20         30         40         50
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN 
        60         70         80         90        100
IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV 
       110        120        130        140        150
SKKNKDIVTV ANAVFVKNAS EIEVPFVTRN KDVFQCEVRN VNFEDPASAC 
       160        170        180        190        200
DSINAWVKNE TRDMIDNLLS PDLIDGVLTR LVLVNAVYFK GLWKSRFQPE 
       210        220        230        240        250
NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN FIELPYHGES 
       260        270        280        290        300
ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA 
       310        320        330        340        350
QTDLKEPLKV LGITDMFDSS KANFAKITRS ENLHVSHILQ KAKIEVSEDG 
       360        370        380        390 
TKASAATTAI LIARSSPPWF IVDRPFLFFI RHNPTGAVLF MGQINKP

Show »

Length:397

Mass (Da):44,000

Checksum:ⁱ45A9C934A800D7EB

GO

Isoform 3 (identifier: P07093-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSDCRSSLVEGTM
329-330: TG → R

« Hide

        10         20         30         40         50
MSDCRSSLVE GTMNWHLPLF LLASVTLPSI CSHFNPLSLE ELGSNTGIQV 
        60         70         80         90        100
FNQIVKSRPH DNIVISPHGI ASVLGMLQLG ADGRTKKQLA MVMRYGVNGV 
       110        120        130        140        150
GKILKKINKA IVSKKNKDIV TVANAVFVKN ASEIEVPFVT RNKDVFQCEV 
       160        170        180        190        200
RNVNFEDPAS ACDSINAWVK NETRDMIDNL LSPDLIDGVL TRLVLVNAVY 
       210        220        230        240        250
FKGLWKSRFQ PENTKKRTFV AADGKSYQVP MLAQLSVFRC GSTSAPNDLW 
       260        270        280        290        300
YNFIELPYHG ESISMLIALP TESSTPLSAI IPHISTKTID SWMSIMVPKR 
       310        320        330        340        350
VQVILPKFTA VAQTDLKEPL KVLGITDMFD SSKANFAKIT RSENLHVSHI 
       360        370        380        390        400
LQKAKIEVSE DGTKASAATT AILIARSSPP WFIVDRPFLF FIRHNPTGAV 

LFMGQINKP

Note: No experimental confirmation available.

Show »

Length:409

Mass (Da):45,267

Checksum:ⁱ6315691891B53A7B

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JN98	C9JN98_HUMAN	Glia-derived nexin Glia-derived nexin	SERPINE2	275	Annotation score:
C9K031	C9K031_HUMAN	Glia-derived nexin Glia-derived nexin	SERPINE2	86	Annotation score:
C9JRK5	C9JRK5_HUMAN	Glia-derived nexin Glia-derived nexin	SERPINE2	42	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	159	N → D in BAG35401 (PubMed:14702039).Curated		1
Sequence conflictⁱ	261	S → E (PubMed:2877744).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051955	51	I → M. Corresponds to variant dbSNP:rs3795875Ensembl.		1
Natural variantⁱVAR_036027	204	K → N in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043668	1	M → MSDCRSSLVEGTM in isoform 3. 1 Publication		1
Alternative sequenceⁱVSP_038367	329 – 330	TG → R in isoform 2 and isoform 3. 3 Publications		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M17783 mRNA Translation: AAA35883.1 AK295564 mRNA Translation: BAG58464.1 AK312499 mRNA Translation: BAG35401.1 AC073641 Genomic DNA Translation: AAY14926.1 CH471063 Genomic DNA Translation: EAW70821.1 CH471063 Genomic DNA Translation: EAW70823.1 BC015663 mRNA Translation: AAH15663.1 BC042628 mRNA Translation: AAH42628.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2460.1 [P07093-1] CCDS46525.1 [P07093-3] CCDS46526.1 [P07093-2]
PIRⁱ	A37274
NCBI Reference Sequences More...RefSeqⁱ	NP_001130000.1, NM_001136528.1 [P07093-2] NP_001130002.1, NM_001136530.1 [P07093-3] NP_006207.1, NM_006216.3 [P07093-1] XP_016859818.1, XM_017004329.1 XP_016859819.1, XM_017004330.1 [P07093-1] XP_016859820.1, XM_017004331.1 XP_016859821.1, XM_017004332.1 [P07093-2]
UniGeneⁱ	Hs.38449 Hs.708453

Genome annotation databases

Ensemblⁱ	ENST00000258405; ENSP00000258405; ENSG00000135919 [P07093-1] ENST00000409304; ENSP00000386412; ENSG00000135919 [P07093-2] ENST00000409840; ENSP00000386969; ENSG00000135919 [P07093-2] ENST00000447280; ENSP00000415786; ENSG00000135919 [P07093-3]
GeneIDⁱ	5270
KEGGⁱ	hsa:5270
UCSC genome browser More...UCSCⁱ	uc002vnu.3 human [P07093-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P07093	Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_a		HUMAN		398	UniRef100_P07093
SERPINE2 isoform 1		PANTR		398
SERPINE2 isoform 2 (Fragment)		PANTR		87
Glia-derived nexin (Fragment)		HUMAN		86
Glia-derived nexin (Fragment)		HUMAN		275
+2
P07093-2	Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_b		HUMAN		397	UniRef100_A0A024R498
SERPINE2 isoform 5		PANTR		409
Uncharacterized protein		PANPA		409
SERPINE2 isoform 4		PANTR		397
Uncharacterized protein		PANPA		397
+1

Protein	Similar proteins		Species	Score	Length	Source
P07093	Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_a		HUMAN		398	UniRef90_P07093
SERPINE2 isoform 1		PANTR		398
glia-derived nexin isoform X1		DELLE		427
glia-derived nexin		BALAS		415
SERPINE2		CEREH		415
+148

Protein	Similar proteins		Species	Score	Length	Source
P07093	Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_a		HUMAN		398	UniRef50_P07093
SERPINE2 isoform 1		PANTR		398
glia-derived nexin isoform X1		DELLE		427
glia-derived nexin		BALAS		415
SERPINE2		CEREH		415
+314

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M17783 mRNA Translation: AAA35883.1 AK295564 mRNA Translation: BAG58464.1 AK312499 mRNA Translation: BAG35401.1 AC073641 Genomic DNA Translation: AAY14926.1 CH471063 Genomic DNA Translation: EAW70821.1 CH471063 Genomic DNA Translation: EAW70823.1 BC015663 mRNA Translation: AAH15663.1 BC042628 mRNA Translation: AAH42628.1
CCDSⁱ	CCDS2460.1 [P07093-1] CCDS46525.1 [P07093-3] CCDS46526.1 [P07093-2]
PIRⁱ	A37274
RefSeqⁱ	NP_001130000.1, NM_001136528.1 [P07093-2] NP_001130002.1, NM_001136530.1 [P07093-3] NP_006207.1, NM_006216.3 [P07093-1] XP_016859818.1, XM_017004329.1 XP_016859819.1, XM_017004330.1 [P07093-1] XP_016859820.1, XM_017004331.1 XP_016859821.1, XM_017004332.1 [P07093-2]
UniGeneⁱ	Hs.38449 Hs.708453

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4DY0	X-ray	2.35	A/B	20-398	[»]
	4DY7	X-ray	2.80	C/F	20-398	[»]
ProteinModelPortalⁱ	P07093
SMRⁱ	P07093
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111288, 27 interactors
IntActⁱ	P07093, 8 interactors
MINTⁱ	P07093
STRINGⁱ	9606.ENSP00000415786

Protein family/group databases

MEROPSⁱ	I04.021

MEROPSⁱ

I04.021

PTM databases

CarbonylDBⁱ	P07093
iPTMnetⁱ	P07093
PhosphoSitePlusⁱ	P07093

Polymorphism and mutation databases

BioMutaⁱ	SERPINE2
DMDMⁱ	121110

Proteomic databases

EPDⁱ	P07093
MaxQBⁱ	P07093
PaxDbⁱ	P07093
PeptideAtlasⁱ	P07093
PRIDEⁱ	P07093
ProteomicsDBⁱ	51945 51946 [P07093-2] 51947 [P07093-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5270
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000258405; ENSP00000258405; ENSG00000135919 [P07093-1] ENST00000409304; ENSP00000386412; ENSG00000135919 [P07093-2] ENST00000409840; ENSP00000386969; ENSG00000135919 [P07093-2] ENST00000447280; ENSP00000415786; ENSG00000135919 [P07093-3]
GeneIDⁱ	5270
KEGGⁱ	hsa:5270
UCSCⁱ	uc002vnu.3 human [P07093-1]

Organism-specific databases

CTDⁱ	5270
DisGeNETⁱ	5270
EuPathDBⁱ	HostDB:ENSG00000135919.12
GeneCardsⁱ	SERPINE2
HGNCⁱ	HGNC:8951 SERPINE2
MIMⁱ	177010 gene
neXtProtⁱ	NX_P07093
OpenTargetsⁱ	ENSG00000135919
PharmGKBⁱ	PA269
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
GeneTreeⁱ	ENSGT00930000150820
HOGENOMⁱ	HOG000238519
HOVERGENⁱ	HBG106493
InParanoidⁱ	P07093
KOⁱ	K16643
OMAⁱ	KANFQCE
OrthoDBⁱ	EOG091G0ION
PhylomeDBⁱ	P07093
TreeFamⁱ	TF352620

Enzyme and pathway databases

Reactomeⁱ	R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875 Common Pathway of Fibrin Clot Formation R-HSA-75205 Dissolution of Fibrin Clot

Reactomeⁱ

R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-75205 Dissolution of Fibrin Clot

Miscellaneous databases

ChiTaRSⁱ	SERPINE2 human
GeneWikiⁱ	SERPINE2
GenomeRNAiⁱ	5270
PMAP-CutDBⁱ	P07093
Protein Ontology More...PROⁱ	PR:P07093
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135919 Expressed in 232 organ(s), highest expression level in decidua
CleanExⁱ	HS_SERPINE2
ExpressionAtlasⁱ	P07093 baseline and differential
Genevisibleⁱ	P07093 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GDN_HUMAN
Accessionⁱ	P07093Primary (citable) accession number: P07093 Secondary accession number(s): B2R6A4 , B4DIF2, Q53S15, Q5D0C4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
	Last sequence update:	April 1, 1988
	Last modified:	November 7, 2018
	This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Proteomes

Annotation systems

Supporting data

UniProtKB - P07093 (GDN_HUMAN)

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Glia-derived nexin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytosol

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ