SERPINE2

Functionⁱ

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	365 – 366	Reactive bondSequence analysis		2

GO - Molecular functionⁱ

glycosaminoglycan binding
Source: BHF-UCL
Inferred from direct assayⁱ
- "Anticoagulant and antithrombotic properties of platelet protease nexin-1."
  Boulaftali Y., Adam F., Venisse L., Ollivier V., Richard B., Taieb S., Monard D., Favier R., Alessi M.C., Bryckaert M., Arocas V., Jandrot-Perrus M., Bouton M.C.
  Blood 115:97-106(2010) [PubMed] [Europe PMC] [Abstract]
heparin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- "Protease specificity and heparin binding and activation of recombinant protease nexin I."
  Evans D.L., McGrogan M., Scott R.W., Carrell R.W.
  J Biol Chem 266:22307-22312(1991) [PubMed] [Europe PMC] [Abstract]
- Ref.8
  "Protease nexin. Properties and a modified purification procedure."
  Scott R.W., Bergman B.L., Bajpai A., Hersh R.T., Rodriguez H., Jones B.N., Barreda C., Watts S., Baker J.B.
  J. Biol. Chem. 260:7029-7034(1985) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE OF 20-47, CHARACTERIZATION.
serine-type endopeptidase inhibitor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- "Nexin-1 inhibits the activity of human brain trypsin."
  Koistinen H., Koistinen R., Zhang W.M., Valmu L., Stenman U.H.
  Neuroscience 160:97-102(2009) [PubMed] [Europe PMC] [Abstract]
- Ref.8
  "Protease nexin. Properties and a modified purification procedure."
  Scott R.W., Bergman B.L., Bajpai A., Hersh R.T., Rodriguez H., Jones B.N., Barreda C., Watts S., Baker J.B.
  J. Biol. Chem. 260:7029-7034(1985) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE OF 20-47, CHARACTERIZATION.
signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- "Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect."
  Bouton M.C., Venisse L., Richard B., Pouzet C., Arocas V., Jandrot-Perrus M.
  Circ Res 100:1174-1181(2007) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Heparin-binding, Protease inhibitor, Serine protease inhibitor
Biological process	Differentiation, Neurogenesis

Enzyme and pathway databases

PathwayCommonsⁱ	P07093
Reactomeⁱ	R-HSA-140837, Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-75205, Dissolution of Fibrin Clot

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I04.021

MEROPSⁱ

I04.021

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glia-derived nexin Short name: GDN Alternative name(s): Peptidase inhibitor 7 Short name: PI-7 Protease nexin 1 Short name: PN-1 Protease nexin I Serpin E2
Gene namesⁱ	Name:SERPINE2 Synonyms:PI7, PN1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8951, SERPINE2
MIMⁱ	177010, gene
neXtProtⁱ	NX_P07093
VEuPathDBⁱ	HostDB:ENSG00000135919.12

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5270
Open Targets More...OpenTargetsⁱ	ENSG00000135919
PharmGKBⁱ	PA269

Miscellaneous databases

Pharosⁱ	P07093, Tbio

Pharosⁱ

P07093, Tbio

Genetic variation databases

BioMutaⁱ	SERPINE2
DMDMⁱ	121110

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	2 PublicationsAdd BLAST		19
ChainⁱPRO_0000032504	20 – 398	Glia-derived nexinAdd BLAST		379

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	118	N-linked (GlcNAc...) asparagineSequence analysis		1
Glycosylationⁱ	159	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	P07093
jPOSTⁱ	P07093
MassIVEⁱ	P07093
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P07093
PaxDbⁱ	P07093
PeptideAtlas More...PeptideAtlasⁱ	P07093
PRIDEⁱ	P07093
ProteomicsDBⁱ	51945 [P07093-1] 51946 [P07093-2] 51947 [P07093-3]

PTM databases

CarbonylDBⁱ	P07093
GlyGenⁱ	P07093, 4 sites, 1 O-linked glycan (1 site)
iPTMnetⁱ	P07093
PhosphoSitePlusⁱ	P07093

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000135919, Expressed in decidua and 243 other tissues
ExpressionAtlasⁱ	P07093, baseline and differential
Genevisibleⁱ	P07093, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000135919, Tissue enriched (placenta)

HPAⁱ

ENSG00000135919, Tissue enriched (placenta)

Interactionⁱ

Binary interactionsⁱ

P07093

With	#Exp.	IntAct
FAM9B [Q8IZU0]	3	EBI-10195168,EBI-10175124

GO - Molecular functionⁱ

signaling receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- "Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect."
  Bouton M.C., Venisse L., Richard B., Pouzet C., Arocas V., Jandrot-Perrus M.
  Circ Res 100:1174-1181(2007) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	111288, 32 interactors
IntActⁱ	P07093, 18 interactors
Molecular INTeraction database More...MINTⁱ	P07093
STRINGⁱ	9606.ENSP00000415786

Miscellaneous databases

RNActⁱ	P07093, protein

RNActⁱ

P07093, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	24 – 45	Combined sources	22
Beta strandⁱ	51 – 53	Combined sources	3
Helixⁱ	55 – 66	Combined sources	12
Helixⁱ	71 – 81	Combined sources	11
Turnⁱ	86 – 88	Combined sources	3
Helixⁱ	89 – 100	Combined sources	12
Helixⁱ	102 – 104	Combined sources	3
Beta strandⁱ	109 – 117	Combined sources	9
Helixⁱ	124 – 134	Combined sources	11
Beta strandⁱ	136 – 140	Combined sources	5
Helixⁱ	146 – 160	Combined sources	15
Turnⁱ	161 – 163	Combined sources	3
Helixⁱ	171 – 173	Combined sources	3
Turnⁱ	176 – 178	Combined sources	3
Beta strandⁱ	181 – 189	Combined sources	9
Beta strandⁱ	193 – 195	Combined sources	3
Helixⁱ	199 – 201	Combined sources	3
Beta strandⁱ	203 – 208	Combined sources	6
Beta strandⁱ	210 – 212	Combined sources	3
Beta strandⁱ	214 – 232	Combined sources	19
Beta strandⁱ	238 – 246	Combined sources	9
Beta strandⁱ	249 – 260	Combined sources	12
Helixⁱ	265 – 267	Combined sources	3
Helixⁱ	269 – 271	Combined sources	3
Helixⁱ	274 – 281	Combined sources	8
Beta strandⁱ	285 – 294	Combined sources	10
Beta strandⁱ	296 – 303	Combined sources	8
Helixⁱ	305 – 310	Combined sources	6
Helixⁱ	315 – 317	Combined sources	3
Turnⁱ	319 – 321	Combined sources	3
Turnⁱ	325 – 327	Combined sources	3
Beta strandⁱ	328 – 330	Combined sources	3
Beta strandⁱ	338 – 347	Combined sources	10
Beta strandⁱ	354 – 356	Combined sources	3
Helixⁱ	357 – 360	Combined sources	4
Beta strandⁱ	370 – 372	Combined sources	3
Beta strandⁱ	377 – 383	Combined sources	7
Turnⁱ	384 – 387	Combined sources	4
Beta strandⁱ	388 – 396	Combined sources	9

Show more details

3D structure databases

SMRⁱ	P07093
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the serpin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG2392, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158424
HOGENOMⁱ	CLU_023330_0_4_1
InParanoidⁱ	P07093
OMAⁱ	ALRYKKN
Database of Orthologous Groups More...OrthoDBⁱ	1124079at2759
PhylomeDBⁱ	P07093
TreeFamⁱ	TF352620

Family and domain databases

Gene3Dⁱ	2.30.39.10, 1 hit 3.30.497.10, 1 hit
InterProⁱ	View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2
PANTHERⁱ	PTHR11461, PTHR11461, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00079, Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093, SERPIN, 1 hit
SUPFAMⁱ	SSF56574, SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284, SERPIN, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P07093-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN 
        60         70         80         90        100
IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV 
       110        120        130        140        150
SKKNKDIVTV ANAVFVKNAS EIEVPFVTRN KDVFQCEVRN VNFEDPASAC 
       160        170        180        190        200
DSINAWVKNE TRDMIDNLLS PDLIDGVLTR LVLVNAVYFK GLWKSRFQPE 
       210        220        230        240        250
NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN FIELPYHGES 
       260        270        280        290        300
ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA 
       310        320        330        340        350
QTDLKEPLKV LGITDMFDSS KANFAKITTG SENLHVSHIL QKAKIEVSED 
       360        370        380        390 
GTKASAATTA ILIARSSPPW FIVDRPFLFF IRHNPTGAVL FMGQINKP

Length:398

Mass (Da):44,002

Last modified:April 1, 1988 - v1

Checksum:ⁱ2A165604E2CBE6B8

GO

Isoform 2 (identifier: P07093-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
329-330: TG → R

« Hide

        10         20         30         40         50
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN 
        60         70         80         90        100
IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV 
       110        120        130        140        150
SKKNKDIVTV ANAVFVKNAS EIEVPFVTRN KDVFQCEVRN VNFEDPASAC 
       160        170        180        190        200
DSINAWVKNE TRDMIDNLLS PDLIDGVLTR LVLVNAVYFK GLWKSRFQPE 
       210        220        230        240        250
NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN FIELPYHGES 
       260        270        280        290        300
ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA 
       310        320        330        340        350
QTDLKEPLKV LGITDMFDSS KANFAKITRS ENLHVSHILQ KAKIEVSEDG 
       360        370        380        390 
TKASAATTAI LIARSSPPWF IVDRPFLFFI RHNPTGAVLF MGQINKP

Show »

Length:397

Mass (Da):44,000

Checksum:ⁱ45A9C934A800D7EB

GO

Isoform 3 (identifier: P07093-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MSDCRSSLVEGTM
329-330: TG → R

« Hide

        10         20         30         40         50
MSDCRSSLVE GTMNWHLPLF LLASVTLPSI CSHFNPLSLE ELGSNTGIQV 
        60         70         80         90        100
FNQIVKSRPH DNIVISPHGI ASVLGMLQLG ADGRTKKQLA MVMRYGVNGV 
       110        120        130        140        150
GKILKKINKA IVSKKNKDIV TVANAVFVKN ASEIEVPFVT RNKDVFQCEV 
       160        170        180        190        200
RNVNFEDPAS ACDSINAWVK NETRDMIDNL LSPDLIDGVL TRLVLVNAVY 
       210        220        230        240        250
FKGLWKSRFQ PENTKKRTFV AADGKSYQVP MLAQLSVFRC GSTSAPNDLW 
       260        270        280        290        300
YNFIELPYHG ESISMLIALP TESSTPLSAI IPHISTKTID SWMSIMVPKR 
       310        320        330        340        350
VQVILPKFTA VAQTDLKEPL KVLGITDMFD SSKANFAKIT RSENLHVSHI 
       360        370        380        390        400
LQKAKIEVSE DGTKASAATT AILIARSSPP WFIVDRPFLF FIRHNPTGAV 

LFMGQINKP

Show »

Length:409

Mass (Da):45,267

Checksum:ⁱ6315691891B53A7B

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JN98	C9JN98_HUMAN	Glia-derived nexin Glia-derived nexin	SERPINE2	275	Annotation score:
C9K031	C9K031_HUMAN	Glia-derived nexin Glia-derived nexin	SERPINE2	86	Annotation score:
C9JRK5	C9JRK5_HUMAN	Glia-derived nexin Glia-derived nexin	SERPINE2	42	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	159	N → D in BAG35401 (PubMed:14702039).Curated		1
Sequence conflictⁱ	261	S → E (PubMed:2877744).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051955	51	I → M. Corresponds to variant dbSNP:rs3795875Ensembl.		1
Natural variantⁱVAR_036027	204	K → N in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043668	1	M → MSDCRSSLVEGTM in isoform 3. 1 Publication		1
Alternative sequenceⁱVSP_038367	329 – 330	TG → R in isoform 2 and isoform 3. 3 Publications		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M17783 mRNA Translation: AAA35883.1 AK295564 mRNA Translation: BAG58464.1 AK312499 mRNA Translation: BAG35401.1 AC073641 Genomic DNA Translation: AAY14926.1 CH471063 Genomic DNA Translation: EAW70821.1 CH471063 Genomic DNA Translation: EAW70823.1 BC015663 mRNA Translation: AAH15663.1 BC042628 mRNA Translation: AAH42628.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2460.1 [P07093-1] CCDS46525.1 [P07093-3] CCDS46526.1 [P07093-2]
PIRⁱ	A37274
NCBI Reference Sequences More...RefSeqⁱ	NP_001130000.1, NM_001136528.1 [P07093-2] NP_001130002.1, NM_001136530.1 [P07093-3] NP_006207.1, NM_006216.3 [P07093-1] XP_016859818.1, XM_017004329.1 XP_016859819.1, XM_017004330.1 [P07093-1] XP_016859820.1, XM_017004331.1 XP_016859821.1, XM_017004332.1 [P07093-2]

Genome annotation databases

Ensemblⁱ	ENST00000258405; ENSP00000258405; ENSG00000135919 [P07093-1] ENST00000409304; ENSP00000386412; ENSG00000135919 [P07093-2] ENST00000409840; ENSP00000386969; ENSG00000135919 [P07093-2] ENST00000447280; ENSP00000415786; ENSG00000135919 [P07093-3]
GeneIDⁱ	5270
KEGGⁱ	hsa:5270
UCSC genome browser More...UCSCⁱ	uc002vnu.3, human [P07093-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P07093	Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_a		HUMAN		398	UniRef100_P07093
SERPINE2 isoform 1		PANTR		398
Glia-derived nexin (Fragment)		HUMAN		86
Glia-derived nexin (Fragment)		HUMAN		275
SERPINE2 isoform 2 (Fragment)		PANTR		87
+2
P07093-2	Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_b		HUMAN		397	UniRef100_A0A024R498
SERPINE2 isoform 5		PANTR		409
Serpin family E member 2		PANPA		409
Serpin family E member 2		PANTR		409
SERPINE2 isoform 4		PANTR		397
+1

Protein	Similar proteins		Species	Score	Length	Source
P07093	Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_a		HUMAN		398	UniRef90_P07093
SERPINE2 isoform 1		PANTR		398
SERPIN domain-containing protein		RHIRO		413
SERPIN domain-containing protein		RHIBE		397
Serpin family E member 2		CALJA		409
+74

Protein	Similar proteins		Species	Score	Length	Source
P07093	Glia-derived nexin		MOUSE		397	UniRef50_Q07235
Glia-derived nexin		RAT		397
glia-derived nexin		MUSCR		397
glia-derived nexin		MESAU		397
glia-derived nexin		PERMB		397
+266

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M17783 mRNA Translation: AAA35883.1 AK295564 mRNA Translation: BAG58464.1 AK312499 mRNA Translation: BAG35401.1 AC073641 Genomic DNA Translation: AAY14926.1 CH471063 Genomic DNA Translation: EAW70821.1 CH471063 Genomic DNA Translation: EAW70823.1 BC015663 mRNA Translation: AAH15663.1 BC042628 mRNA Translation: AAH42628.1
CCDSⁱ	CCDS2460.1 [P07093-1] CCDS46525.1 [P07093-3] CCDS46526.1 [P07093-2]
PIRⁱ	A37274
RefSeqⁱ	NP_001130000.1, NM_001136528.1 [P07093-2] NP_001130002.1, NM_001136530.1 [P07093-3] NP_006207.1, NM_006216.3 [P07093-1] XP_016859818.1, XM_017004329.1 XP_016859819.1, XM_017004330.1 [P07093-1] XP_016859820.1, XM_017004331.1 XP_016859821.1, XM_017004332.1 [P07093-2]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4DY0	X-ray	2.35	A/B	20-398	[»]
	4DY7	X-ray	2.80	C/F	20-398	[»]
SMRⁱ	P07093
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	111288, 32 interactors
IntActⁱ	P07093, 18 interactors
MINTⁱ	P07093
STRINGⁱ	9606.ENSP00000415786

Protein family/group databases

MEROPSⁱ	I04.021

MEROPSⁱ

I04.021

PTM databases

CarbonylDBⁱ	P07093
GlyGenⁱ	P07093, 4 sites, 1 O-linked glycan (1 site)
iPTMnetⁱ	P07093
PhosphoSitePlusⁱ	P07093

Genetic variation databases

BioMutaⁱ	SERPINE2
DMDMⁱ	121110

Proteomic databases

EPDⁱ	P07093
jPOSTⁱ	P07093
MassIVEⁱ	P07093
MaxQBⁱ	P07093
PaxDbⁱ	P07093
PeptideAtlasⁱ	P07093
PRIDEⁱ	P07093
ProteomicsDBⁱ	51945 [P07093-1] 51946 [P07093-2] 51947 [P07093-3]

Protocols and materials databases

ABCDⁱ	P07093, 4 sequenced antibodies
Antibodypediaⁱ	34366, 371 antibodies
The DNASU plasmid repository More...DNASUⁱ	5270

Genome annotation databases

Ensemblⁱ	ENST00000258405; ENSP00000258405; ENSG00000135919 [P07093-1] ENST00000409304; ENSP00000386412; ENSG00000135919 [P07093-2] ENST00000409840; ENSP00000386969; ENSG00000135919 [P07093-2] ENST00000447280; ENSP00000415786; ENSG00000135919 [P07093-3]
GeneIDⁱ	5270
KEGGⁱ	hsa:5270
UCSCⁱ	uc002vnu.3, human [P07093-1]

Organism-specific databases

CTDⁱ	5270
DisGeNETⁱ	5270
GeneCardsⁱ	SERPINE2
HGNCⁱ	HGNC:8951, SERPINE2
HPAⁱ	ENSG00000135919, Tissue enriched (placenta)
MIMⁱ	177010, gene
neXtProtⁱ	NX_P07093
OpenTargetsⁱ	ENSG00000135919
PharmGKBⁱ	PA269
VEuPathDBⁱ	HostDB:ENSG00000135919.12
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2392, Eukaryota
GeneTreeⁱ	ENSGT00940000158424
HOGENOMⁱ	CLU_023330_0_4_1
InParanoidⁱ	P07093
OMAⁱ	ALRYKKN
OrthoDBⁱ	1124079at2759
PhylomeDBⁱ	P07093
TreeFamⁱ	TF352620

Enzyme and pathway databases

PathwayCommonsⁱ	P07093
Reactomeⁱ	R-HSA-140837, Intrinsic Pathway of Fibrin Clot Formation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-75205, Dissolution of Fibrin Clot

Miscellaneous databases

BioGRID-ORCSⁱ	5270, 6 hits in 992 CRISPR screens
ChiTaRSⁱ	SERPINE2, human
GeneWikiⁱ	SERPINE2
GenomeRNAiⁱ	5270
Pharosⁱ	P07093, Tbio
Protein Ontology More...PROⁱ	PR:P07093
RNActⁱ	P07093, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000135919, Expressed in decidua and 243 other tissues
ExpressionAtlasⁱ	P07093, baseline and differential
Genevisibleⁱ	P07093, HS

Family and domain databases

Gene3Dⁱ	2.30.39.10, 1 hit 3.30.497.10, 1 hit
InterProⁱ	View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2
PANTHERⁱ	PTHR11461, PTHR11461, 1 hit
Pfamⁱ	View protein in Pfam PF00079, Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093, SERPIN, 1 hit
SUPFAMⁱ	SSF56574, SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284, SERPIN, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GDN_HUMAN
Accessionⁱ	P07093Primary (citable) accession number: P07093 Secondary accession number(s): B2R6A4 , B4DIF2, Q53S15, Q5D0C4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
	Last sequence update:	April 1, 1988
	Last modified:	June 2, 2021
	This is version 205 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P07093 (GDN_HUMAN)

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Glia-derived nexin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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P07093

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Miscellaneous databases

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<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ