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Protein

Protein S100-A4

Gene

S100a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: MGI
  • calcium-dependent protein binding Source: MGI
  • calcium ion binding Source: MGI
  • identical protein binding Source: IntAct
  • RAGE receptor binding Source: MGI
  • transition metal ion binding Source: InterPro

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A4
Alternative name(s):
Metastasin
Metastatic cell protein
PEL98
Placental calcium-binding protein
Protein 18A2
Protein Mts1
S100 calcium-binding protein A4
Gene namesi
Name:S100a4
Synonyms:Capl, Mts1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1330282 S100a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001439782 – 101Protein S100-A4Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei35N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP07091
PaxDbiP07091
PeptideAtlasiP07091
PRIDEiP07091

PTM databases

iPTMnetiP07091
PhosphoSitePlusiP07091
SwissPalmiP07091

Expressioni

Tissue specificityi

Specifically expressed in different metastatic cells.

Inductioni

The mRNA coding for this protein increases in abundance after serum stimulation of quiescent mouse fibroblasts.

Gene expression databases

BgeeiENSMUSG00000001020 Expressed in 25 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_S100A4
ExpressionAtlasiP07091 baseline and differential
GenevisibleiP07091 MM

Interactioni

Subunit structurei

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203053, 2 interactors
IntActiP07091, 4 interactors
MINTiP07091
STRINGi10090.ENSMUSP00000001046

Structurei

3D structure databases

ProteinModelPortaliP07091
SMRiP07091
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYVZ Eukaryota
ENOG4111DV3 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP07091
OMAiCVAMMCN
OrthoDBiEOG091G10JX
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P07091-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPLEEALD VIVSTFHKYS GKEGDKFKLN KTELKELLTR ELPSFLGKRT
60 70 80 90 100
DEAAFQKVMS NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGCPDKEPRK

K
Length:101
Mass (Da):11,721
Last modified:April 1, 1988 - v1
Checksum:i2302254B67A4C873
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGD2A0A0G2JGD2_MOUSE
Protein S100-A4
S100a4
78Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47G → GVSGSXFNGQ in CAA34224 (PubMed:8423998).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05835 mRNA Translation: CAA29282.1
D00208 mRNA Translation: BAA00148.1
X16190 mRNA Translation: CAA34316.1
M36578 Genomic DNA Translation: AAA39749.1
M36579 Genomic DNA Translation: AAA39750.1
X16094 Genomic DNA Translation: CAA34224.1
CCDSiCCDS17538.1
PIRiS06207
RefSeqiNP_035441.1, NM_011311.2
XP_006501240.1, XM_006501177.3
XP_006501241.1, XM_006501178.2
UniGeneiMm.3925

Genome annotation databases

EnsembliENSMUST00000001046; ENSMUSP00000001046; ENSMUSG00000001020
GeneIDi20198
KEGGimmu:20198
UCSCiuc008qcz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05835 mRNA Translation: CAA29282.1
D00208 mRNA Translation: BAA00148.1
X16190 mRNA Translation: CAA34316.1
M36578 Genomic DNA Translation: AAA39749.1
M36579 Genomic DNA Translation: AAA39750.1
X16094 Genomic DNA Translation: CAA34224.1
CCDSiCCDS17538.1
PIRiS06207
RefSeqiNP_035441.1, NM_011311.2
XP_006501240.1, XM_006501177.3
XP_006501241.1, XM_006501178.2
UniGeneiMm.3925

3D structure databases

ProteinModelPortaliP07091
SMRiP07091
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203053, 2 interactors
IntActiP07091, 4 interactors
MINTiP07091
STRINGi10090.ENSMUSP00000001046

PTM databases

iPTMnetiP07091
PhosphoSitePlusiP07091
SwissPalmiP07091

Proteomic databases

EPDiP07091
PaxDbiP07091
PeptideAtlasiP07091
PRIDEiP07091

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001046; ENSMUSP00000001046; ENSMUSG00000001020
GeneIDi20198
KEGGimmu:20198
UCSCiuc008qcz.2 mouse

Organism-specific databases

CTDi6275
MGIiMGI:1330282 S100a4

Phylogenomic databases

eggNOGiENOG410IYVZ Eukaryota
ENOG4111DV3 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP07091
OMAiCVAMMCN
OrthoDBiEOG091G10JX
TreeFamiTF332727

Miscellaneous databases

PROiPR:P07091
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001020 Expressed in 25 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_S100A4
ExpressionAtlasiP07091 baseline and differential
GenevisibleiP07091 MM

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10A4_MOUSE
AccessioniPrimary (citable) accession number: P07091
Secondary accession number(s): P20066
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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