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Protein

Methyl-accepting chemotaxis protein IV

Gene

tap

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates taxis toward dipeptides via an interaction with the periplasmic dipeptide-binding protein.
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: EcoCyc

GO - Biological processi

  • chemotaxis Source: EcoCyc

Keywordsi

Molecular functionTransducer
Biological processChemotaxis

Enzyme and pathway databases

BioCyciEcoCyc:TAP-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-accepting chemotaxis protein IV
Short name:
MCP-IV
Alternative name(s):
Dipeptide chemoreceptor protein
Gene namesi
Name:tap
Ordered Locus Names:b1885, JW1874
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10987 tap

Subcellular locationi

  • Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
  • Note: Found predominantly at cell poles.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 33HelicalSequence analysisAdd BLAST27
Topological domaini34 – 188PeriplasmicSequence analysisAdd BLAST155
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 533CytoplasmicSequence analysisAdd BLAST324

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105411 – 533Methyl-accepting chemotaxis protein IVAdd BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei293Glutamate methyl ester (Gln)By similarity1
Modified residuei300Glutamate methyl ester (Gln)By similarity1
Modified residuei307Glutamate methyl ester (Gln)By similarity1
Modified residuei489Glutamate methyl ester (Glu)By similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP07018
PRIDEiP07018

Interactioni

Protein-protein interaction databases

BioGridi4262072, 172 interactors
DIPiDIP-10955N
IntActiP07018, 2 interactors
STRINGi316385.ECDH10B_2026

Structurei

3D structure databases

ProteinModelPortaliP07018
SMRiP07018
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 264HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini269 – 498Methyl-accepting transducerPROSITE-ProRule annotationAdd BLAST230

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C8Q Bacteria
COG0840 LUCA
HOGENOMiHOG000148074
InParanoidiP07018
KOiK05877
OMAiQATWLEN
PhylomeDBiP07018

Family and domain databases

CDDicd06225 HAMP, 1 hit
cd00181 Tar_Tsr_LBD, 1 hit
InterProiView protein in InterPro
IPR035440 4HB_MCP_dom_sf
IPR004090 Chemotax_Me-accpt_rcpt
IPR004091 Chemotax_Me-accpt_rcpt_Me-site
IPR003660 HAMP_dom
IPR004089 MCPsignal_dom
IPR003122 Tar_rcpt_lig-bd
PfamiView protein in Pfam
PF00672 HAMP, 1 hit
PF00015 MCPsignal, 1 hit
PF02203 TarH, 1 hit
PRINTSiPR00260 CHEMTRNSDUCR
SMARTiView protein in SMART
SM00304 HAMP, 1 hit
SM00283 MA, 1 hit
SM00319 TarH, 1 hit
SUPFAMiSSF47170 SSF47170, 1 hit
PROSITEiView protein in PROSITE
PS00538 CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111 CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885 HAMP, 1 hit

Sequencei

Sequence statusi: Complete.

P07018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNRIRISTT LFLILILCGI LQIGSNGMSF WAFRDDLQRL NQVEQSNQQR
60 70 80 90 100
AALAQTRAVM LQASTALNKA GTLTALSYPA DDIKTLMTTA RASLTQSTTL
110 120 130 140 150
FKSFMAMTAG NEHVRGLQKE TEKSFARWHN DLEHQATWLE SNQLSDFLTA
160 170 180 190 200
PVQGSQNAFD VNFEAWQLEI NHVLEAASAQ SQRNYQISAL VFISMIIVAA
210 220 230 240 250
IYISSALWWT RKMIVQPLAI IGSHFDSIAA GNLARPIAVY GRNEITAIFA
260 270 280 290 300
SLKTMQQALR GTVSDVRKGS QEMHIGIAEI VAGNNDLSSR TEQQAASLAQ
310 320 330 340 350
TAASMEQLTA TVGQNADNAR QASELAKNAA TTAQAGGVQV STMTHTMQEI
360 370 380 390 400
ATSSQKIGDI ISVIDGIAFQ TNILALNAAV EAARAGEQGR GFAVVAGEVR
410 420 430 440 450
NLASRSAQAA KEIKGLIEES VNRVQQGSKL VNNAAATMID IVSSVTRVND
460 470 480 490 500
IMGEIASASE EQQRGIEQVA QAVSQMDQVT QQNASLVEEA AVATEQLANQ
510 520 530
ADHLSSRVAV FTLEEHEVAR HESVQLQIAP VVS
Length:533
Mass (Da):57,512
Last modified:November 1, 1997 - v2
Checksum:i632570BE1E45DA38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335A → G in AAA23567 (PubMed:6305515).Curated1
Sequence conflicti503H → R in AAA23567 (PubMed:6305515).Curated1
Sequence conflicti527 – 533QIAPVVS → TNCASGILK in AAA23567 (PubMed:6305515).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01705 Genomic DNA Translation: AAA23567.1
U00096 Genomic DNA Translation: AAC74955.1
AP009048 Genomic DNA Translation: BAA15701.1
PIRiE64951 QRECM2
RefSeqiNP_416399.1, NC_000913.3
WP_000483239.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74955; AAC74955; b1885
BAA15701; BAA15701; BAA15701
GeneIDi946397
KEGGiecj:JW1874
eco:b1885
PATRICifig|1411691.4.peg.362

Similar proteinsi

Entry informationi

Entry nameiMCP4_ECOLI
AccessioniPrimary (citable) accession number: P07018
Secondary accession number(s): P76300
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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