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Entry version 166 (13 Nov 2019)
Sequence version 2 (01 Nov 1997)
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Protein

Methyl-accepting chemotaxis protein IV

Gene

tap

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates taxis toward dipeptides via an interaction with the periplasmic dipeptide-binding protein.
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transmembrane signaling receptor activity Source: EcoCyc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer
Biological processChemotaxis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:TAP-MONOMER
ECOL316407:JW1874-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methyl-accepting chemotaxis protein IV
Short name:
MCP-IV
Alternative name(s):
Dipeptide chemoreceptor protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tap
Ordered Locus Names:b1885, JW1874
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 33HelicalSequence analysisAdd BLAST27
Topological domaini34 – 188PeriplasmicSequence analysisAdd BLAST155
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 533CytoplasmicSequence analysisAdd BLAST324

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001105411 – 533Methyl-accepting chemotaxis protein IVAdd BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei293Glutamate methyl ester (Gln)By similarity1
Modified residuei300Glutamate methyl ester (Gln)By similarity1
Modified residuei307Glutamate methyl ester (Gln)By similarity1
Modified residuei489Glutamate methyl ester (Glu)By similarity1

Keywords - PTMi

Methylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P07018

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P07018

PRoteomics IDEntifications database

More...
PRIDEi
P07018

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4262072, 172 interactors

Database of interacting proteins

More...
DIPi
DIP-10955N

Protein interaction database and analysis system

More...
IntActi
P07018, 2 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b1885

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P07018

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini212 – 264HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini269 – 498Methyl-accepting transducerPROSITE-ProRule annotationAdd BLAST230

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105C8Q Bacteria
COG0840 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000148074

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P07018

KEGG Orthology (KO)

More...
KOi
K05877

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P07018

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06225 HAMP, 1 hit
cd00181 Tar_Tsr_LBD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035440 4HB_MCP_dom_sf
IPR004090 Chemotax_Me-accpt_rcpt
IPR004091 Chemotax_Me-accpt_rcpt_Me-site
IPR003660 HAMP_dom
IPR004089 MCPsignal_dom
IPR003122 Tar_rcpt_lig-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00672 HAMP, 1 hit
PF00015 MCPsignal, 1 hit
PF02203 TarH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00260 CHEMTRNSDUCR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00304 HAMP, 1 hit
SM00283 MA, 1 hit
SM00319 TarH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47170 SSF47170, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00538 CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111 CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885 HAMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P07018-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFNRIRISTT LFLILILCGI LQIGSNGMSF WAFRDDLQRL NQVEQSNQQR
60 70 80 90 100
AALAQTRAVM LQASTALNKA GTLTALSYPA DDIKTLMTTA RASLTQSTTL
110 120 130 140 150
FKSFMAMTAG NEHVRGLQKE TEKSFARWHN DLEHQATWLE SNQLSDFLTA
160 170 180 190 200
PVQGSQNAFD VNFEAWQLEI NHVLEAASAQ SQRNYQISAL VFISMIIVAA
210 220 230 240 250
IYISSALWWT RKMIVQPLAI IGSHFDSIAA GNLARPIAVY GRNEITAIFA
260 270 280 290 300
SLKTMQQALR GTVSDVRKGS QEMHIGIAEI VAGNNDLSSR TEQQAASLAQ
310 320 330 340 350
TAASMEQLTA TVGQNADNAR QASELAKNAA TTAQAGGVQV STMTHTMQEI
360 370 380 390 400
ATSSQKIGDI ISVIDGIAFQ TNILALNAAV EAARAGEQGR GFAVVAGEVR
410 420 430 440 450
NLASRSAQAA KEIKGLIEES VNRVQQGSKL VNNAAATMID IVSSVTRVND
460 470 480 490 500
IMGEIASASE EQQRGIEQVA QAVSQMDQVT QQNASLVEEA AVATEQLANQ
510 520 530
ADHLSSRVAV FTLEEHEVAR HESVQLQIAP VVS
Length:533
Mass (Da):57,512
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i632570BE1E45DA38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti335A → G in AAA23567 (PubMed:6305515).Curated1
Sequence conflicti503H → R in AAA23567 (PubMed:6305515).Curated1
Sequence conflicti527 – 533QIAPVVS → TNCASGILK in AAA23567 (PubMed:6305515).Curated7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J01705 Genomic DNA Translation: AAA23567.1
U00096 Genomic DNA Translation: AAC74955.1
AP009048 Genomic DNA Translation: BAA15701.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E64951 QRECM2

NCBI Reference Sequences

More...
RefSeqi
NP_416399.1, NC_000913.3
WP_000483239.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74955; AAC74955; b1885
BAA15701; BAA15701; BAA15701

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946397

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1874
eco:b1885

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.362

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01705 Genomic DNA Translation: AAA23567.1
U00096 Genomic DNA Translation: AAC74955.1
AP009048 Genomic DNA Translation: BAA15701.1
PIRiE64951 QRECM2
RefSeqiNP_416399.1, NC_000913.3
WP_000483239.1, NZ_LN832404.1

3D structure databases

SMRiP07018
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4262072, 172 interactors
DIPiDIP-10955N
IntActiP07018, 2 interactors
STRINGi511145.b1885

Proteomic databases

jPOSTiP07018
PaxDbiP07018
PRIDEiP07018

Genome annotation databases

EnsemblBacteriaiAAC74955; AAC74955; b1885
BAA15701; BAA15701; BAA15701
GeneIDi946397
KEGGiecj:JW1874
eco:b1885
PATRICifig|1411691.4.peg.362

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0980

Phylogenomic databases

eggNOGiENOG4105C8Q Bacteria
COG0840 LUCA
HOGENOMiHOG000148074
InParanoidiP07018
KOiK05877
PhylomeDBiP07018

Enzyme and pathway databases

BioCyciEcoCyc:TAP-MONOMER
ECOL316407:JW1874-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P07018

Family and domain databases

CDDicd06225 HAMP, 1 hit
cd00181 Tar_Tsr_LBD, 1 hit
InterProiView protein in InterPro
IPR035440 4HB_MCP_dom_sf
IPR004090 Chemotax_Me-accpt_rcpt
IPR004091 Chemotax_Me-accpt_rcpt_Me-site
IPR003660 HAMP_dom
IPR004089 MCPsignal_dom
IPR003122 Tar_rcpt_lig-bd
PfamiView protein in Pfam
PF00672 HAMP, 1 hit
PF00015 MCPsignal, 1 hit
PF02203 TarH, 1 hit
PRINTSiPR00260 CHEMTRNSDUCR
SMARTiView protein in SMART
SM00304 HAMP, 1 hit
SM00283 MA, 1 hit
SM00319 TarH, 1 hit
SUPFAMiSSF47170 SSF47170, 1 hit
PROSITEiView protein in PROSITE
PS00538 CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111 CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885 HAMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCP4_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P07018
Secondary accession number(s): P76300
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 1, 1997
Last modified: November 13, 2019
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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