UniProtKB - P06996 (OMPC_ECOLI)

BLAST

>sp|P06996|OMPC_ECOLI Outer membrane protein C OS=Escherichia coli (strain K12) OX=83333 GN=ompC PE=1 SV=1
MKVKVLSLLVPALLVAGAANAAEVYNKDGNKLDLYGKVDGLHYFSDNKDVDGDQTYMRLG
FKGETQVTDQLTGYGQWEYQIQGNSAENENNSWTRVAFAGLKFQDVGSFDYGRNYGVVYD
VTSWTDVLPEFGGDTYGSDNFMQQRGNGFATYRNTDFFGLVDGLNFAVQYQGKNGNPSGE
GFTSGVTNNGRDALRQNGDGVGGSITYDYEGFGIGGAISSSKRTDAQNTAAYIGNGDRAE
TYTGGLKYDANNIYLAAQYTQTYNATRVGSLGWANKAQNFEAVAQYQFDFGLRPSLAYLQ
SKGKNLGRGYDDEDILKYVDVGATYYFNKNMSTYVDYKINLLDDNQFTRDAGINTDNIVA
LGLVYQF

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History
Entry version 168 (10 Oct 2018)
Sequence version 1 (01 Apr 1988)
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Protein

Outer membrane protein C

Gene

ompC

Organism

Escherichia coli (strain K12)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Forms pores that allow passive diffusion of small molecules across the outer membrane.

Miscellaneous

Binds 1 Mg²⁺ per subunit; could be Ca²⁺ in vivo.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	340	Magnesium; via carbonyl oxygen	1
Metal bindingⁱ	342	Magnesium; via carbonyl oxygen	1
Metal bindingⁱ	355	Magnesium; via carbonyl oxygen	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
porin activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus
Source: EcoliWiki
Inferred from expression patternⁱ
- 11967071
phospholipid transport
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 26314242

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Porin
Biological process	Ion transport, Transport
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG10670-MONOMER MetaCyc:EG10670-MONOMER

BioCycⁱ

EcoCyc:EG10670-MONOMER
MetaCyc:EG10670-MONOMER

Protein family/group databases

TCDBⁱ	1.B.1.1.3 the general bacterial porin (gbp) family

TCDBⁱ

1.B.1.1.3 the general bacterial porin (gbp) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Outer membrane protein C Alternative name(s): Outer membrane protein 1B Porin OmpC
Gene namesⁱ	Name:ompC Synonyms:meoA, par Ordered Locus Names:b2215, JW2203
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10670 ompC

EcoGeneⁱ

EG10670 ompC

Subcellular locationⁱ

Cell outer membrane ; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 33	Periplasmic1 PublicationAdd BLAST	12
Transmembraneⁱ	34 – 42	Beta stranded	9
Topological domainⁱ	43 – 53	Extracellular1 PublicationAdd BLAST	11
Transmembraneⁱ	54 – 63	Beta stranded	10
Topological domainⁱ	64 – 73	Periplasmic1 Publication	10
Transmembraneⁱ	74 – 84	Beta strandedAdd BLAST	11
Topological domainⁱ	85 – 91	Extracellular1 Publication	7
Transmembraneⁱ	92 – 101	Beta stranded	10
Topological domainⁱ	102 – 106	Periplasmic1 Publication	5
Transmembraneⁱ	107 – 115	Beta stranded	9
Topological domainⁱ	116 – 141	Extracellular1 PublicationAdd BLAST	26
Transmembraneⁱ	142 – 154	Beta strandedAdd BLAST	13
Topological domainⁱ	155 – 163	Periplasmic1 Publication	9
Transmembraneⁱ	164 – 171	Beta stranded	8
Topological domainⁱ	172 – 200	Extracellular1 PublicationAdd BLAST	29
Transmembraneⁱ	201 – 207	Beta stranded	7
Topological domainⁱ	208 – 211	Periplasmic1 Publication	4
Transmembraneⁱ	212 – 219	Beta stranded	8
Topological domainⁱ	220 – 241	Extracellular1 PublicationAdd BLAST	22
Transmembraneⁱ	242 – 248	Beta stranded	7
Topological domainⁱ	249 – 252	Periplasmic1 Publication	4
Transmembraneⁱ	253 – 260	Beta stranded	8
Topological domainⁱ	261 – 269	Extracellular1 Publication	9
Transmembraneⁱ	270 – 286	Beta strandedAdd BLAST	17
Topological domainⁱ	287 – 291	Periplasmic1 Publication	5
Transmembraneⁱ	292 – 299	Beta stranded	8
Topological domainⁱ	300 – 318	Extracellular1 PublicationAdd BLAST	19
Transmembraneⁱ	319 – 326	Beta stranded	8
Topological domainⁱ	327 – 330	Periplasmic1 Publication	4
Transmembraneⁱ	331 – 338	Beta stranded	8
Topological domainⁱ	339 – 358	Extracellular1 PublicationAdd BLAST	20
Transmembraneⁱ	359 – 366	Beta stranded	8
Topological domainⁱ	367	Periplasmic1 Publication	1

GO - Cellular componentⁱ

cell outer membrane
Source: EcoCyc
Inferred from direct assayⁱ
integral component of cell outer membrane
Source: EcoliWiki
Inferred from direct assayⁱ
- 16949612
pore complex Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell outer membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	3 PublicationsAdd BLAST		21
ChainⁱPRO_0000025230	22 – 367	Outer membrane protein CAdd BLAST		346

Proteomic databases

PaxDbⁱ	P06996
PRIDEⁱ	P06996

Interactionⁱ

Subunit structureⁱ

Homotrimer.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
degP	P0C0V0	7	EBI-371155,EBI-547165
mlaA	P76506	4	EBI-371155,EBI-1128511

Protein-protein interaction databases

BioGridⁱ	4261917, 276 interactors
Database of interacting proteins More...DIPⁱ	DIP-10397N
IntActⁱ	P06996, 9 interactors
Molecular INTeraction database More...MINTⁱ	P06996
STRINGⁱ	316385.ECDH10B_2372

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	23 – 27	Combined sources	5
Beta strandⁱ	30 – 44	Combined sources	15
Turnⁱ	48 – 50	Combined sources	3
Beta strandⁱ	56 – 85	Combined sources	30
Beta strandⁱ	92 – 103	Combined sources	12
Turnⁱ	104 – 106	Combined sources	3
Beta strandⁱ	107 – 115	Combined sources	9
Helixⁱ	119 – 122	Combined sources	4
Helixⁱ	123 – 125	Combined sources	3
Beta strandⁱ	129 – 131	Combined sources	3
Beta strandⁱ	138 – 140	Combined sources	3
Beta strandⁱ	143 – 155	Combined sources	13
Helixⁱ	156 – 159	Combined sources	4
Beta strandⁱ	164 – 171	Combined sources	8
Beta strandⁱ	176 – 182	Combined sources	7
Beta strandⁱ	184 – 186	Combined sources	3
Helixⁱ	193 – 195	Combined sources	3
Beta strandⁱ	200 – 209	Combined sources	10
Beta strandⁱ	212 – 222	Combined sources	11
Turnⁱ	225 – 227	Combined sources	3
Beta strandⁱ	229 – 233	Combined sources	5
Beta strandⁱ	237 – 250	Combined sources	14
Beta strandⁱ	253 – 264	Combined sources	12
Beta strandⁱ	271 – 273	Combined sources	3
Beta strandⁱ	275 – 286	Combined sources	12
Beta strandⁱ	291 – 305	Combined sources	15
Turnⁱ	308 – 310	Combined sources	3
Beta strandⁱ	312 – 340	Combined sources	29
Helixⁱ	346 – 351	Combined sources	6
Beta strandⁱ	358 – 367	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	P06996
SMRⁱ	P06996
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P06996

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	116 – 133	Loop L3; may constrict the poreAdd BLAST		18

Domainⁱ

Loop L3 (residues 116-133) extends along the inner side of the beta barrel wall and may constrict the pore mid-length.1 Publication

Sequence similaritiesⁱ

Belongs to the Gram-negative porin family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGⁱ	ENOG4105FCK Bacteria COG3203 LUCA
HOGENOMⁱ	HOG000272406
InParanoidⁱ	P06996
KEGG Orthology (KO) More...KOⁱ	K09475
OMAⁱ	YTQSYNA
PhylomeDBⁱ	P06996

Family and domain databases

Gene3Dⁱ	2.40.160.10, 1 hit
InterProⁱ	View protein in InterPro IPR023614 Porin_dom_sf IPR001897 Porin_gammaproteobac IPR001702 Porin_Gram-ve IPR013793 Porin_Gram-ve_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00267 Porin_1, 1 hit
PRINTSⁱ	PR00183 ECOLIPORIN PR00182 ECOLNEIPORIN
PROSITEⁱ	View protein in PROSITE PS00576 GRAM_NEG_PORIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P06996-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKVKVLSLLV PALLVAGAAN AAEVYNKDGN KLDLYGKVDG LHYFSDNKDV 
        60         70         80         90        100
DGDQTYMRLG FKGETQVTDQ LTGYGQWEYQ IQGNSAENEN NSWTRVAFAG 
       110        120        130        140        150
LKFQDVGSFD YGRNYGVVYD VTSWTDVLPE FGGDTYGSDN FMQQRGNGFA 
       160        170        180        190        200
TYRNTDFFGL VDGLNFAVQY QGKNGNPSGE GFTSGVTNNG RDALRQNGDG 
       210        220        230        240        250
VGGSITYDYE GFGIGGAISS SKRTDAQNTA AYIGNGDRAE TYTGGLKYDA 
       260        270        280        290        300
NNIYLAAQYT QTYNATRVGS LGWANKAQNF EAVAQYQFDF GLRPSLAYLQ 
       310        320        330        340        350
SKGKNLGRGY DDEDILKYVD VGATYYFNKN MSTYVDYKIN LLDDNQFTRD 
       360 
AGINTDNIVA LGLVYQF

Length:367

Mass (Da):40,368

Last modified:April 1, 1988 - v1

Checksum:ⁱ6A49370CC8A1A225

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K00541 Genomic DNA Translation: AAA24243.1 U00096 Genomic DNA Translation: AAC75275.1 AP009048 Genomic DNA Translation: BAA15998.1 U00008 Genomic DNA Translation: AAA16412.1
PIRⁱ	A20867 MMECPC
NCBI Reference Sequences More...RefSeqⁱ	NP_416719.1, NC_000913.3 WP_000865568.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC75275; AAC75275; b2215 BAA15998; BAA15998; BAA15998
GeneIDⁱ	946716
KEGGⁱ	ecj:JW2203 eco:b2215
PATRICⁱ	fig\|1411691.4.peg.20

Protein	Similar proteins		Species	Score	Length	Source
P06996	Outer membrane protein C		Klebsiella pneumoniae IS22		367	UniRef100_P06996
Membrane protein		ECOLX		367
Outer membrane protein C		Escherichia coli 1-110-08_S3_C1		367
Outer membrane protein C		Escherichia coli 2-210-07_S3_C3		367
Phosphoporin PhoE		SHISO		367
+14

Protein	Similar proteins		Species	Score	Length	Source
P06996	Outer membrane protein C	)	ECOL6		375	UniRef90_P06996
Outer membrane protein C		Klebsiella pneumoniae IS22		367
Membrane protein		ECOLX		367
Outer membrane protein C		Escherichia coli 1-110-08_S3_C1		367
Outer membrane protein C		Escherichia coli 2-210-07_S3_C3		367
+339

Protein	Similar proteins		Species	Score	Length	Source
P06996	Outer membrane protein F	)	ECOLI		362	UniRef50_P02931
Outer membrane protein S2		SALTI		383
Outer membrane protein F		SERMA		374
Outer membrane protein C	)	ECOL6		375
Outer membrane porin 1a (IabF)		Escherichia coli NCCP15648		362
+3286

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K00541 Genomic DNA Translation: AAA24243.1 U00096 Genomic DNA Translation: AAC75275.1 AP009048 Genomic DNA Translation: BAA15998.1 U00008 Genomic DNA Translation: AAA16412.1
PIRⁱ	A20867 MMECPC
RefSeqⁱ	NP_416719.1, NC_000913.3 WP_000865568.1, NZ_LN832404.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2J1N	X-ray	2.00	A/B/C	22-367	[»]
	2J4U	X-ray	2.99	P/Q/R/U/V/W	22-367	[»]
	2ZLE	electron microscopy	28.00	D	22-367	[»]
	3NB3	electron microscopy	-	D	22-367	[»]
	4A8D	electron microscopy	28.00	M	22-366	[»]
ProteinModelPortalⁱ	P06996
SMRⁱ	P06996
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4261917, 276 interactors
DIPⁱ	DIP-10397N
IntActⁱ	P06996, 9 interactors
MINTⁱ	P06996
STRINGⁱ	316385.ECDH10B_2372

Protein family/group databases

TCDBⁱ	1.B.1.1.3 the general bacterial porin (gbp) family

TCDBⁱ

1.B.1.1.3 the general bacterial porin (gbp) family

Proteomic databases

PaxDbⁱ	P06996
PRIDEⁱ	P06996

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC75275; AAC75275; b2215 BAA15998; BAA15998; BAA15998
GeneIDⁱ	946716
KEGGⁱ	ecj:JW2203 eco:b2215
PATRICⁱ	fig\|1411691.4.peg.20

Organism-specific databases

EchoBASEⁱ	EB0664
EcoGeneⁱ	EG10670 ompC

Phylogenomic databases

eggNOGⁱ	ENOG4105FCK Bacteria COG3203 LUCA
HOGENOMⁱ	HOG000272406
InParanoidⁱ	P06996
KOⁱ	K09475
OMAⁱ	YTQSYNA
PhylomeDBⁱ	P06996

Enzyme and pathway databases

BioCycⁱ	EcoCyc:EG10670-MONOMER MetaCyc:EG10670-MONOMER

BioCycⁱ

EcoCyc:EG10670-MONOMER
MetaCyc:EG10670-MONOMER

Miscellaneous databases

EvolutionaryTraceⁱ	P06996
Protein Ontology More...PROⁱ	PR:P06996

Family and domain databases

Gene3Dⁱ	2.40.160.10, 1 hit
InterProⁱ	View protein in InterPro IPR023614 Porin_dom_sf IPR001897 Porin_gammaproteobac IPR001702 Porin_Gram-ve IPR013793 Porin_Gram-ve_CS
Pfamⁱ	View protein in Pfam PF00267 Porin_1, 1 hit
PRINTSⁱ	PR00183 ECOLIPORIN PR00182 ECOLNEIPORIN
PROSITEⁱ	View protein in PROSITE PS00576 GRAM_NEG_PORIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OMPC_ECOLI
Accessionⁱ	P06996Primary (citable) accession number: P06996
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
	Last sequence update:	April 1, 1988
	Last modified:	October 10, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

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Supporting data

UniProtKB - P06996 (OMPC_ECOLI)

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Outer membrane protein C

ompC

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ