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UniProtKB - P06996 (OMPC_ECOLI)
Protein
Outer membrane porin C
Gene
ompC
Organism
Escherichia coli (strain K12)
Status
Functioni
Forms pores that allow passive diffusion of small molecules across the outer membrane.
(Microbial infection) Supports colicin E5 entry in the absence of its major receptor OmpF.
1 Publication(Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA-EC536-mediated toxicity.
1 PublicationMiscellaneous
Binds 1 Mg2+ per subunit; could be Ca2+ in vivo.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 340 | Magnesium; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 342 | Magnesium; via carbonyl oxygenCombined sources | 1 | |
Metal bindingi | 355 | Magnesium; via carbonyl oxygenCombined sources | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- porin activity Source: UniProtKB-KW
- virus receptor activity Source: CACAO
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- ion transmembrane transport Source: InterPro
- phospholipid transport Source: EcoCyc
- receptor-mediated virion attachment to host cell Source: CACAO
Keywordsi
Molecular function | Porin |
Biological process | Ion transport, Stress response, Transport |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10670-MONOMER |
Protein family/group databases
TCDBi | 1.B.1.1.3, the general bacterial porin (gbp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Outer membrane porin CAlternative name(s): Outer membrane protein 1B Outer membrane protein C Porin OmpC |
Gene namesi | Name:ompC Synonyms:meoA, par Ordered Locus Names:b2215, JW2203 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
- Cell outer membrane 1 Publication; Multi-pass membrane protein 1 Publication
Other locations
- cell outer membrane Source: EcoCyc
- integral component of cell outer membrane Source: EcoliWiki
- pore complex Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 33 | Periplasmic1 PublicationAdd BLAST | 12 | |
Transmembranei | 34 – 42 | Beta stranded | 9 | |
Topological domaini | 43 – 53 | Extracellular1 PublicationAdd BLAST | 11 | |
Transmembranei | 54 – 63 | Beta stranded | 10 | |
Topological domaini | 64 – 73 | Periplasmic1 Publication | 10 | |
Transmembranei | 74 – 84 | Beta strandedAdd BLAST | 11 | |
Topological domaini | 85 – 91 | Extracellular1 Publication | 7 | |
Transmembranei | 92 – 101 | Beta stranded | 10 | |
Topological domaini | 102 – 106 | Periplasmic1 Publication | 5 | |
Transmembranei | 107 – 115 | Beta stranded | 9 | |
Topological domaini | 116 – 141 | Extracellular1 PublicationAdd BLAST | 26 | |
Transmembranei | 142 – 154 | Beta strandedAdd BLAST | 13 | |
Topological domaini | 155 – 163 | Periplasmic1 Publication | 9 | |
Transmembranei | 164 – 171 | Beta stranded | 8 | |
Topological domaini | 172 – 200 | Extracellular1 PublicationAdd BLAST | 29 | |
Transmembranei | 201 – 207 | Beta stranded | 7 | |
Topological domaini | 208 – 211 | Periplasmic1 Publication | 4 | |
Transmembranei | 212 – 219 | Beta stranded | 8 | |
Topological domaini | 220 – 241 | Extracellular1 PublicationAdd BLAST | 22 | |
Transmembranei | 242 – 248 | Beta stranded | 7 | |
Topological domaini | 249 – 252 | Periplasmic1 Publication | 4 | |
Transmembranei | 253 – 260 | Beta stranded | 8 | |
Topological domaini | 261 – 269 | Extracellular1 Publication | 9 | |
Transmembranei | 270 – 286 | Beta strandedAdd BLAST | 17 | |
Topological domaini | 287 – 291 | Periplasmic1 Publication | 5 | |
Transmembranei | 292 – 299 | Beta stranded | 8 | |
Topological domaini | 300 – 318 | Extracellular1 PublicationAdd BLAST | 19 | |
Transmembranei | 319 – 326 | Beta stranded | 8 | |
Topological domaini | 327 – 330 | Periplasmic1 Publication | 4 | |
Transmembranei | 331 – 338 | Beta stranded | 8 | |
Topological domaini | 339 – 358 | Extracellular1 PublicationAdd BLAST | 20 | |
Transmembranei | 359 – 366 | Beta stranded | 8 | |
Topological domaini | 367 | Periplasmic1 Publication | 1 |
Keywords - Cellular componenti
Cell outer membrane, MembranePathology & Biotechi
Disruption phenotypei
Deletion of both ompC and ompF confers resistance to colicin E5 and to the toxic activity of CdiA-EC536.1 Publication
Miscellaneous databases
PHI-basei | PHI:7024 |
Chemistry databases
DrugBanki | DB01017, Minocycline |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 3 PublicationsAdd BLAST | 21 | |
ChainiPRO_0000025230 | 22 – 367 | Outer membrane porin CAdd BLAST | 346 |
Proteomic databases
jPOSTi | P06996 |
PaxDbi | P06996 |
PRIDEi | P06996 |
Expressioni
Inductioni
By growth in high osmolarity conditions (high sugar or salt) under control of OmpR (at protein level) (PubMed:3010044, PubMed:2464593). In the presence of 0.2 M NaCl, 2.0 mM sodium cholate (bile salts) decreases expression from the ompC promoter; how this is mediated is unknown (PubMed:28423182).3 Publications
Interactioni
Subunit structurei
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 4261917, 276 interactors |
DIPi | DIP-10397N |
IntActi | P06996, 9 interactors |
MINTi | P06996 |
STRINGi | 511145.b2215 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P06996 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06996 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 116 – 133 | Loop L3; may constrict the poreAdd BLAST | 18 |
Domaini
Loop L3 (residues 116-133) extends along the inner side of the beta barrel wall and may constrict the pore mid-length.1 Publication
Sequence similaritiesi
Belongs to the Gram-negative porin family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane beta strandPhylogenomic databases
eggNOGi | COG3203, Bacteria |
HOGENOMi | CLU_058202_0_0_6 |
InParanoidi | P06996 |
PhylomeDBi | P06996 |
Family and domain databases
Gene3Di | 2.40.160.10, 1 hit |
InterProi | View protein in InterPro IPR023614, Porin_dom_sf IPR001897, Porin_gammaproteobac IPR001702, Porin_Gram-ve IPR013793, Porin_Gram-ve_CS |
Pfami | View protein in Pfam PF00267, Porin_1, 1 hit |
PRINTSi | PR00183, ECOLIPORIN PR00182, ECOLNEIPORIN |
PROSITEi | View protein in PROSITE PS00576, GRAM_NEG_PORIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P06996-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVKVLSLLV PALLVAGAAN AAEVYNKDGN KLDLYGKVDG LHYFSDNKDV
60 70 80 90 100
DGDQTYMRLG FKGETQVTDQ LTGYGQWEYQ IQGNSAENEN NSWTRVAFAG
110 120 130 140 150
LKFQDVGSFD YGRNYGVVYD VTSWTDVLPE FGGDTYGSDN FMQQRGNGFA
160 170 180 190 200
TYRNTDFFGL VDGLNFAVQY QGKNGNPSGE GFTSGVTNNG RDALRQNGDG
210 220 230 240 250
VGGSITYDYE GFGIGGAISS SKRTDAQNTA AYIGNGDRAE TYTGGLKYDA
260 270 280 290 300
NNIYLAAQYT QTYNATRVGS LGWANKAQNF EAVAQYQFDF GLRPSLAYLQ
310 320 330 340 350
SKGKNLGRGY DDEDILKYVD VGATYYFNKN MSTYVDYKIN LLDDNQFTRD
360
AGINTDNIVA LGLVYQF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K00541 Genomic DNA Translation: AAA24243.1 U00096 Genomic DNA Translation: AAC75275.1 AP009048 Genomic DNA Translation: BAA15998.1 U00008 Genomic DNA Translation: AAA16412.1 |
PIRi | A20867, MMECPC |
RefSeqi | NP_416719.1, NC_000913.3 WP_000865568.1, NZ_SSZK01000030.1 |
Genome annotation databases
EnsemblBacteriai | AAC75275; AAC75275; b2215 BAA15998; BAA15998; BAA15998 |
GeneIDi | 946716 |
KEGGi | ecj:JW2203 eco:b2215 |
PATRICi | fig|1411691.4.peg.20 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K00541 Genomic DNA Translation: AAA24243.1 U00096 Genomic DNA Translation: AAC75275.1 AP009048 Genomic DNA Translation: BAA15998.1 U00008 Genomic DNA Translation: AAA16412.1 |
PIRi | A20867, MMECPC |
RefSeqi | NP_416719.1, NC_000913.3 WP_000865568.1, NZ_SSZK01000030.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2J1N | X-ray | 2.00 | A/B/C | 22-367 | [»] | |
2J4U | X-ray | 2.99 | P/Q/R/U/V/W | 22-367 | [»] | |
2ZLE | electron microscopy | 28.00 | D | 22-367 | [»] | |
4A8D | electron microscopy | 28.00 | M | 22-366 | [»] | |
SMRi | P06996 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261917, 276 interactors |
DIPi | DIP-10397N |
IntActi | P06996, 9 interactors |
MINTi | P06996 |
STRINGi | 511145.b2215 |
Chemistry databases
DrugBanki | DB01017, Minocycline |
Protein family/group databases
TCDBi | 1.B.1.1.3, the general bacterial porin (gbp) family |
Proteomic databases
jPOSTi | P06996 |
PaxDbi | P06996 |
PRIDEi | P06996 |
Genome annotation databases
EnsemblBacteriai | AAC75275; AAC75275; b2215 BAA15998; BAA15998; BAA15998 |
GeneIDi | 946716 |
KEGGi | ecj:JW2203 eco:b2215 |
PATRICi | fig|1411691.4.peg.20 |
Organism-specific databases
EchoBASEi | EB0664 |
Phylogenomic databases
eggNOGi | COG3203, Bacteria |
HOGENOMi | CLU_058202_0_0_6 |
InParanoidi | P06996 |
PhylomeDBi | P06996 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10670-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P06996 |
PHI-basei | PHI:7024 |
PROi | PR:P06996 |
Family and domain databases
Gene3Di | 2.40.160.10, 1 hit |
InterProi | View protein in InterPro IPR023614, Porin_dom_sf IPR001897, Porin_gammaproteobac IPR001702, Porin_Gram-ve IPR013793, Porin_Gram-ve_CS |
Pfami | View protein in Pfam PF00267, Porin_1, 1 hit |
PRINTSi | PR00183, ECOLIPORIN PR00182, ECOLNEIPORIN |
PROSITEi | View protein in PROSITE PS00576, GRAM_NEG_PORIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OMPC_ECOLI | |
Accessioni | P06996Primary (citable) accession number: P06996 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | April 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families