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Protein

Outer membrane protein C

Gene

ompC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms pores that allow passive diffusion of small molecules across the outer membrane.

Miscellaneous

Binds 1 Mg2+ per subunit; could be Ca2+ in vivo.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi340Magnesium; via carbonyl oxygen1
Metal bindingi342Magnesium; via carbonyl oxygen1
Metal bindingi355Magnesium; via carbonyl oxygen1

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • phospholipid transport Source: EcoCyc

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10670-MONOMER
MetaCyc:EG10670-MONOMER

Protein family/group databases

TCDBi1.B.1.1.3 the general bacterial porin (gbp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein C
Alternative name(s):
Outer membrane protein 1B
Porin OmpC
Gene namesi
Name:ompC
Synonyms:meoA, par
Ordered Locus Names:b2215, JW2203
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10670 ompC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 33Periplasmic1 PublicationAdd BLAST12
Transmembranei34 – 42Beta stranded9
Topological domaini43 – 53Extracellular1 PublicationAdd BLAST11
Transmembranei54 – 63Beta stranded10
Topological domaini64 – 73Periplasmic1 Publication10
Transmembranei74 – 84Beta strandedAdd BLAST11
Topological domaini85 – 91Extracellular1 Publication7
Transmembranei92 – 101Beta stranded10
Topological domaini102 – 106Periplasmic1 Publication5
Transmembranei107 – 115Beta stranded9
Topological domaini116 – 141Extracellular1 PublicationAdd BLAST26
Transmembranei142 – 154Beta strandedAdd BLAST13
Topological domaini155 – 163Periplasmic1 Publication9
Transmembranei164 – 171Beta stranded8
Topological domaini172 – 200Extracellular1 PublicationAdd BLAST29
Transmembranei201 – 207Beta stranded7
Topological domaini208 – 211Periplasmic1 Publication4
Transmembranei212 – 219Beta stranded8
Topological domaini220 – 241Extracellular1 PublicationAdd BLAST22
Transmembranei242 – 248Beta stranded7
Topological domaini249 – 252Periplasmic1 Publication4
Transmembranei253 – 260Beta stranded8
Topological domaini261 – 269Extracellular1 Publication9
Transmembranei270 – 286Beta strandedAdd BLAST17
Topological domaini287 – 291Periplasmic1 Publication5
Transmembranei292 – 299Beta stranded8
Topological domaini300 – 318Extracellular1 PublicationAdd BLAST19
Transmembranei319 – 326Beta stranded8
Topological domaini327 – 330Periplasmic1 Publication4
Transmembranei331 – 338Beta stranded8
Topological domaini339 – 358Extracellular1 PublicationAdd BLAST20
Transmembranei359 – 366Beta stranded8
Topological domaini367Periplasmic1 Publication1

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 213 PublicationsAdd BLAST21
ChainiPRO_000002523022 – 367Outer membrane protein CAdd BLAST346

Proteomic databases

PaxDbiP06996
PRIDEiP06996

Interactioni

Subunit structurei

Homotrimer.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi4261917, 276 interactors
DIPiDIP-10397N
IntActiP06996, 9 interactors
MINTiP06996
STRINGi316385.ECDH10B_2372

Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06996
SMRiP06996
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06996

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 133Loop L3; may constrict the poreAdd BLAST18

Domaini

Loop L3 (residues 116-133) extends along the inner side of the beta barrel wall and may constrict the pore mid-length.1 Publication

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105FCK Bacteria
COG3203 LUCA
HOGENOMiHOG000272406
InParanoidiP06996
KOiK09475
OMAiYTQSYNA
PhylomeDBiP06996

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001897 Porin_gammaproteobac
IPR001702 Porin_Gram-ve
IPR013793 Porin_Gram-ve_CS
PfamiView protein in Pfam
PF00267 Porin_1, 1 hit
PRINTSiPR00183 ECOLIPORIN
PR00182 ECOLNEIPORIN
PROSITEiView protein in PROSITE
PS00576 GRAM_NEG_PORIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06996-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVKVLSLLV PALLVAGAAN AAEVYNKDGN KLDLYGKVDG LHYFSDNKDV
60 70 80 90 100
DGDQTYMRLG FKGETQVTDQ LTGYGQWEYQ IQGNSAENEN NSWTRVAFAG
110 120 130 140 150
LKFQDVGSFD YGRNYGVVYD VTSWTDVLPE FGGDTYGSDN FMQQRGNGFA
160 170 180 190 200
TYRNTDFFGL VDGLNFAVQY QGKNGNPSGE GFTSGVTNNG RDALRQNGDG
210 220 230 240 250
VGGSITYDYE GFGIGGAISS SKRTDAQNTA AYIGNGDRAE TYTGGLKYDA
260 270 280 290 300
NNIYLAAQYT QTYNATRVGS LGWANKAQNF EAVAQYQFDF GLRPSLAYLQ
310 320 330 340 350
SKGKNLGRGY DDEDILKYVD VGATYYFNKN MSTYVDYKIN LLDDNQFTRD
360
AGINTDNIVA LGLVYQF
Length:367
Mass (Da):40,368
Last modified:April 1, 1988 - v1
Checksum:i6A49370CC8A1A225
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00541 Genomic DNA Translation: AAA24243.1
U00096 Genomic DNA Translation: AAC75275.1
AP009048 Genomic DNA Translation: BAA15998.1
U00008 Genomic DNA Translation: AAA16412.1
PIRiA20867 MMECPC
RefSeqiNP_416719.1, NC_000913.3
WP_000865568.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75275; AAC75275; b2215
BAA15998; BAA15998; BAA15998
GeneIDi946716
KEGGiecj:JW2203
eco:b2215
PATRICifig|1411691.4.peg.20

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00541 Genomic DNA Translation: AAA24243.1
U00096 Genomic DNA Translation: AAC75275.1
AP009048 Genomic DNA Translation: BAA15998.1
U00008 Genomic DNA Translation: AAA16412.1
PIRiA20867 MMECPC
RefSeqiNP_416719.1, NC_000913.3
WP_000865568.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J1NX-ray2.00A/B/C22-367[»]
2J4UX-ray2.99P/Q/R/U/V/W22-367[»]
2ZLEelectron microscopy28.00D22-367[»]
3NB3electron microscopy-D22-367[»]
4A8Delectron microscopy28.00M22-366[»]
ProteinModelPortaliP06996
SMRiP06996
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261917, 276 interactors
DIPiDIP-10397N
IntActiP06996, 9 interactors
MINTiP06996
STRINGi316385.ECDH10B_2372

Protein family/group databases

TCDBi1.B.1.1.3 the general bacterial porin (gbp) family

Proteomic databases

PaxDbiP06996
PRIDEiP06996

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75275; AAC75275; b2215
BAA15998; BAA15998; BAA15998
GeneIDi946716
KEGGiecj:JW2203
eco:b2215
PATRICifig|1411691.4.peg.20

Organism-specific databases

EchoBASEiEB0664
EcoGeneiEG10670 ompC

Phylogenomic databases

eggNOGiENOG4105FCK Bacteria
COG3203 LUCA
HOGENOMiHOG000272406
InParanoidiP06996
KOiK09475
OMAiYTQSYNA
PhylomeDBiP06996

Enzyme and pathway databases

BioCyciEcoCyc:EG10670-MONOMER
MetaCyc:EG10670-MONOMER

Miscellaneous databases

EvolutionaryTraceiP06996
PROiPR:P06996

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001897 Porin_gammaproteobac
IPR001702 Porin_Gram-ve
IPR013793 Porin_Gram-ve_CS
PfamiView protein in Pfam
PF00267 Porin_1, 1 hit
PRINTSiPR00183 ECOLIPORIN
PR00182 ECOLNEIPORIN
PROSITEiView protein in PROSITE
PS00576 GRAM_NEG_PORIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOMPC_ECOLI
AccessioniPrimary (citable) accession number: P06996
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 10, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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