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UniProtKB - P06944 (NS1_INCCA)
Protein
Non-structural protein 1
Gene
NS
Organism
Influenza C virus (strain C/California/1978)
Status
Functioni
Prevents the establishment of the cellular antiviral state initiated by host DDX58, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Participates also in the up-regulation of the splicing of viral mRNAs.
UniRule annotationGO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Non-structural protein 1UniRule annotationShort name: NS1UniRule annotation Alternative name(s): NS1AUniRule annotation |
Gene namesi | Name:NSUniRule annotation |
Organismi | Influenza C virus (strain C/California/1978) |
Taxonomic identifieri | 203224 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Polyploviricotina › Insthoviricetes › Articulavirales › Orthomyxoviridae › Gammainfluenzavirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] Sus scrofa (Pig) [TaxID: 9823] |
Subcellular locationi
- Host cytoplasm UniRule annotation
- Host nucleus UniRule annotation
Keywords - Cellular componenti
Host cytoplasm, Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000044586 | 1 – 246 | Non-structural protein 1Add BLAST | 246 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the influenza C viruses NS1 family.UniRule annotation
Family and domain databases
HAMAPi | MF_04066, INFV_NS1, 1 hit |
InterProi | View protein in InterPro IPR005187, Flu_C_NS1 IPR005188, Flu_C_NS2 IPR004208, NS1 |
Pfami | View protein in Pfam PF03506, Flu_C_NS1, 1 hit PF03555, Flu_C_NS2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform NS1 (identifier: P06944-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDKTVKSTN LMAFVATKML ERQEDLDTCT EMQVEKMKTS TKARLRTESS
60 70 80 90 100
FAPRTWEDAI KDGELLFNGT ILQAESTTMT PASVEMKGKK FPIDFVPSNI
110 120 130 140 150
APIGQNPIYL SPCIPNFDGN VWEATMYHHR GATLTKTMNC NCFQRTIWCH
160 170 180 190 200
PNPSRMRLSY AFVLYCRNTK KICGYLIAKQ VAGIETGIRK CFRCIKSGFV
210 220 230 240
MATDEISLII LQSIKSGAQL DPYWGNETPD IDKTEAYMLS LREAGP
Isoform NEP (identifier: P33493-1) [UniParc]FASTAAdd to basket
Also known as: NS2
The sequence of this isoform can be found in the external entry P33493.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence cautioni
The sequence AAA43780 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M10087 Genomic RNA Translation: AAA43780.1 Frameshift. AB099625 Genomic RNA Translation: BAD37133.1 |
PIRi | A25320, MNIVC7 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M10087 Genomic RNA Translation: AAA43780.1 Frameshift. AB099625 Genomic RNA Translation: BAD37133.1 |
PIRi | A25320, MNIVC7 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
HAMAPi | MF_04066, INFV_NS1, 1 hit |
InterProi | View protein in InterPro IPR005187, Flu_C_NS1 IPR005188, Flu_C_NS2 IPR004208, NS1 |
Pfami | View protein in Pfam PF03506, Flu_C_NS1, 1 hit PF03555, Flu_C_NS2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NS1_INCCA | |
Accessioni | P06944Primary (citable) accession number: P06944 Secondary accession number(s): Q68BV4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | February 21, 2006 | |
Last modified: | February 23, 2022 | |
This is version 68 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |