Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 157 (16 Oct 2019)
Sequence version 2 (03 Oct 2012)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Complement factor H

Gene

Cfh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement alternate pathway, Immunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-977606 Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement factor H
Alternative name(s):
Protein beta-1-H
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cfh
Synonyms:Hf1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88385 Cfh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

The lack of CFH alters the microarchitecture of bone and affects osteoblast and osteoclast dynamics.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18By similarityAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000589519 – 1234Complement factor HAdd BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi21 ↔ 66PROSITE-ProRule annotation
Disulfide bondi52 ↔ 80PROSITE-ProRule annotation
Disulfide bondi85 ↔ 129PROSITE-ProRule annotation
Disulfide bondi114 ↔ 141PROSITE-ProRule annotation
Disulfide bondi146 ↔ 192PROSITE-ProRule annotation
Disulfide bondi178 ↔ 205PROSITE-ProRule annotation
Disulfide bondi210 ↔ 251PROSITE-ProRule annotation
Disulfide bondi237 ↔ 262PROSITE-ProRule annotation
Disulfide bondi267 ↔ 309PROSITE-ProRule annotation
Disulfide bondi294 ↔ 320PROSITE-ProRule annotation
Disulfide bondi325 ↔ 374PROSITE-ProRule annotation
Disulfide bondi357 ↔ 385PROSITE-ProRule annotation
Disulfide bondi389 ↔ 431PROSITE-ProRule annotation
Disulfide bondi416 ↔ 442PROSITE-ProRule annotation
Disulfide bondi448 ↔ 494PROSITE-ProRule annotation
Disulfide bondi477 ↔ 505PROSITE-ProRule annotation
Disulfide bondi509 ↔ 553PROSITE-ProRule annotation
Disulfide bondi536 ↔ 564PROSITE-ProRule annotation
Disulfide bondi569 ↔ 610PROSITE-ProRule annotation
Disulfide bondi597 ↔ 622PROSITE-ProRule annotation
Disulfide bondi629 ↔ 672PROSITE-ProRule annotation
Disulfide bondi658 ↔ 683PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi690 ↔ 732PROSITE-ProRule annotation
Disulfide bondi718 ↔ 743PROSITE-ProRule annotation
Glycosylationi721N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi752 ↔ 791PROSITE-ProRule annotation
Glycosylationi773N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi780 ↔ 802PROSITE-ProRule annotation
Glycosylationi801N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi808 ↔ 850PROSITE-ProRule annotation
Disulfide bondi836 ↔ 861PROSITE-ProRule annotation
Disulfide bondi867 ↔ 920PROSITE-ProRule annotation
Disulfide bondi906 ↔ 931PROSITE-ProRule annotation
Disulfide bondi936 ↔ 978PROSITE-ProRule annotation
Disulfide bondi964 ↔ 989PROSITE-ProRule annotation
Disulfide bondi994 ↔ 1037PROSITE-ProRule annotation
Disulfide bondi1023 ↔ 1048PROSITE-ProRule annotation
Glycosylationi1030N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1053 ↔ 1096PROSITE-ProRule annotation
Glycosylationi1061N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi1082 ↔ 1107PROSITE-ProRule annotation
Disulfide bondi1114 ↔ 1157PROSITE-ProRule annotation
Disulfide bondi1143 ↔ 1168PROSITE-ProRule annotation
Disulfide bondi1172 ↔ 1223PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1198PhosphoserineCombined sources1
Disulfide bondi1206 ↔ 1233PROSITE-ProRule annotation
Glycosylationi1225N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3900

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P06909

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06909

PRoteomics IDEntifications database

More...
PRIDEi
P06909

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
817

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P06909

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P06909

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P06909

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

CFH is one of the most abundant complement components in blood where the liver is the major source of CFH protein in vivo. in addition, CFH is secreted by additional cell types including monocytes, fibroblasts, or endothelial cells.By similarity

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026365 Expressed in 297 organ(s), highest expression level in aorta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P06909 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P06909 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Forms also homooligomers.

Interacts with complement protein C3b; this interaction inhibits complement activation.

Interacts with complement protein C3d.

Interacts with CR3/ITGAM; this interaction mediates adhesion of neutrophils to pathogens leading to pathogen clearance.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P06909, 2 interactors

Molecular INTeraction database

More...
MINTi
P06909

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000107607

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06909

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 82Sushi 1PROSITE-ProRule annotationAdd BLAST64
Domaini83 – 143Sushi 2PROSITE-ProRule annotationAdd BLAST61
Domaini144 – 207Sushi 3PROSITE-ProRule annotationAdd BLAST64
Domaini208 – 264Sushi 4PROSITE-ProRule annotationAdd BLAST57
Domaini265 – 322Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini324 – 386Sushi 6PROSITE-ProRule annotationAdd BLAST63
Domaini387 – 444Sushi 7PROSITE-ProRule annotationAdd BLAST58
Domaini446 – 507Sushi 8PROSITE-ProRule annotationAdd BLAST62
Domaini508 – 566Sushi 9PROSITE-ProRule annotationAdd BLAST59
Domaini567 – 624Sushi 10PROSITE-ProRule annotationAdd BLAST58
Domaini627 – 685Sushi 11PROSITE-ProRule annotationAdd BLAST59
Domaini688 – 745Sushi 12PROSITE-ProRule annotationAdd BLAST58
Domaini750 – 804Sushi 13PROSITE-ProRule annotationAdd BLAST55
Domaini806 – 863Sushi 14PROSITE-ProRule annotationAdd BLAST58
Domaini865 – 933Sushi 15PROSITE-ProRule annotationAdd BLAST69
Domaini934 – 991Sushi 16PROSITE-ProRule annotationAdd BLAST58
Domaini992 – 1050Sushi 17PROSITE-ProRule annotationAdd BLAST59
Domaini1051 – 1109Sushi 18PROSITE-ProRule annotationAdd BLAST59
Domaini1112 – 1170Sushi 19PROSITE-ProRule annotationAdd BLAST59
Domaini1171 – 1234Sushi 20PROSITE-ProRule annotationAdd BLAST64

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Sushi 1-3 domain represents the minimal unit capable of cofactor activity. The property to discriminate self surfaces from non-self surfaces depends on the C-terminal region made of Sushis 19-20.By similarity

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVQ9 Eukaryota
ENOG410YBAR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164315

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049040

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06909

KEGG Orthology (KO)

More...
KOi
K04004

Database of Orthologous Groups

More...
OrthoDBi
296899at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 16 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084 Sushi, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535 SSF57535, 18 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923 SUSHI, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P06909-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSARIIWL ILWTVCAAED CKGPPPRENS EILSGSWSEQ LYPEGTQATY
60 70 80 90 100
KCRPGYRTLG TIVKVCKNGK WVASNPSRIC RKKPCGHPGD TPFGSFRLAV
110 120 130 140 150
GSQFEFGAKV VYTCDDGYQL LGEIDYRECG ADGWINDIPL CEVVKCLPVT
160 170 180 190 200
ELENGRIVSG AAETDQEYYF GQVVRFECNS GFKIEGHKEI HCSENGLWSN
210 220 230 240 250
EKPRCVEILC TPPRVENGDG INVKPVYKEN ERYHYKCKHG YVPKERGDAV
260 270 280 290 300
CTGSGWSSQP FCEEKRCSPP YILNGIYTPH RIIHRSDDEI RYECNYGFYP
310 320 330 340 350
VTGSTVSKCT PTGWIPVPRC TLKPCEFPQF KYGRLYYEES LRPNFPVSIG
360 370 380 390 400
NKYSYKCDNG FSPPSGYSWD YLRCTAQGWE PEVPCVRKCV FHYVENGDSA
410 420 430 440 450
YWEKVYVQGQ SLKVQCYNGY SLQNGQDTMT CTENGWSPPP KCIRIKTCSA
460 470 480 490 500
SDIHIDNGFL SESSSIYALN RETSYRCKQG YVTNTGEISG SITCLQNGWS
510 520 530 540 550
PQPSCIKSCD MPVFENSITK NTRTWFKLND KLDYECLVGF ENEYKHTKGS
560 570 580 590 600
ITCTYYGWSD TPSCYERECS VPTLDRKLVV SPRKEKYRVG DLLEFSCHSG
610 620 630 640 650
HRVGPDSVQC YHFGWSPGFP TCKGQVASCA PPLEILNGEI NGAKKVEYSH
660 670 680 690 700
GEVVKYDCKP RFLLKGPNKI QCVDGNWTTL PVCIEEERTC GDIPELEHGS
710 720 730 740 750
AKCSVPPYHH GDSVEFICEE NFTMIGHGSV SCISGKWTQL PKCVATDQLE
760 770 780 790 800
KCRVLKSTGI EAIKPKLTEF THNSTMDYKC RDKQEYERSI CINGKWDPEP
810 820 830 840 850
NCTSKTSCPP PPQIPNTQVI ETTVKYLDGE KLSVLCQDNY LTQDSEEMVC
860 870 880 890 900
KDGRWQSLPR CIEKIPCSQP PTIEHGSINL PRSSEERRDS IESSSHEHGT
910 920 930 940 950
TFSYVCDDGF RIPEENRITC YMGKWSTPPR CVGLPCGPPP SIPLGTVSLE
960 970 980 990 1000
LESYQHGEEV TYHCSTGFGI DGPAFIICEG GKWSDPPKCI KTDCDVLPTV
1010 1020 1030 1040 1050
KNAIIRGKSK KSYRTGEQVT FRCQSPYQMN GSDTVTCVNS RWIGQPVCKD
1060 1070 1080 1090 1100
NSCVDPPHVP NATIVTRTKN KYLHGDRVRY ECNKPLELFG QVEVMCENGI
1110 1120 1130 1140 1150
WTEKPKCRDS TGKCGPPPPI DNGDITSLSL PVYEPLSSVE YQCQKYYLLK
1160 1170 1180 1190 1200
GKKTITCRNG KWSEPPTCLH ACVIPENIME SHNIILKWRH TEKIYSHSGE
1210 1220 1230
DIEFGCKYGY YKARDSPPFR TKCINGTINY PTCV
Length:1,234
Mass (Da):139,138
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A5722F34620C9F0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q8I0E9Q8I0_MOUSE
Complement factor H
Cfh
1,252Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGQ0D6RGQ0_MOUSE
Complement factor H
Cfh
1,110Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q8H9E9Q8H9_MOUSE
Complement factor H
Cfh
1,195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YVP8A0A0A6YVP8_MOUSE
Complement factor H
Cfh
707Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWP4A0A0A6YWP4_MOUSE
Complement factor H
Cfh
837Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1158R → T in AAA37759 (PubMed:2940596).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Two codominant alleles of factor H are present in mice.

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M12660 mRNA Translation: AAA37759.1
AC161408 Genomic DNA No translation available.
BC066092 mRNA Translation: AAH66092.1
J02891 mRNA Translation: AAA37795.1
AH001909 mRNA Translation: AAA37762.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A26154 NBMSH

NCBI Reference Sequences

More...
RefSeqi
NP_034018.2, NM_009888.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000066859; ENSMUSP00000066677; ENSMUSG00000026365

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12628

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12628

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12660 mRNA Translation: AAA37759.1
AC161408 Genomic DNA No translation available.
BC066092 mRNA Translation: AAH66092.1
J02891 mRNA Translation: AAA37795.1
AH001909 mRNA Translation: AAA37762.1
PIRiA26154 NBMSH
RefSeqiNP_034018.2, NM_009888.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YBYX-ray1.58A321-444[»]
SMRiP06909
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP06909, 2 interactors
MINTiP06909
STRINGi10090.ENSMUSP00000107607

PTM databases

GlyConnecti817
iPTMnetiP06909
PhosphoSitePlusiP06909
SwissPalmiP06909

Proteomic databases

CPTACinon-CPTAC-3900
jPOSTiP06909
PaxDbiP06909
PRIDEiP06909

Genome annotation databases

EnsembliENSMUST00000066859; ENSMUSP00000066677; ENSMUSG00000026365
GeneIDi12628
KEGGimmu:12628

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3075
MGIiMGI:88385 Cfh

Phylogenomic databases

eggNOGiENOG410IVQ9 Eukaryota
ENOG410YBAR LUCA
GeneTreeiENSGT00940000164315
HOGENOMiHOG000049040
InParanoidiP06909
KOiK04004
OrthoDBi296899at2759

Enzyme and pathway databases

ReactomeiR-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cfh mouse

Protein Ontology

More...
PROi
PR:P06909

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026365 Expressed in 297 organ(s), highest expression level in aorta
ExpressionAtlasiP06909 baseline and differential
GenevisibleiP06909 MM

Family and domain databases

CDDicd00033 CCP, 16 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 16 hits
SMARTiView protein in SMART
SM00032 CCP, 20 hits
SUPFAMiSSF57535 SSF57535, 18 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCFAH_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06909
Secondary accession number(s): Q6NZK3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 3, 2012
Last modified: October 16, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again