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Entry version 159 (08 May 2019)
Sequence version 4 (11 Jan 2001)
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Protein

Thyroglobulin

Gene

Tg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

Miscellaneous

It is not certain whether this thyroglobulin plays any role in the formation of triiodothyronine.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone, Thyroid hormone
Biological processThyroid hormones biosynthesis

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
ratno-thyro Thyroglobulin

MEROPS protease database

More...
MEROPSi
I31.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroglobulin
Short name:
Tg
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tg
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3848 Tg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Tg are a cause of a form of hypothyroidism in rdw rat.

Keywords - Diseasei

Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000863821 – 2768ThyroglobulinAdd BLAST2748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25Iodotyrosine; alternateBy similarity1
Modified residuei25Sulfotyrosine; alternateBy similarity1
Modified residuei25Thyroxine; alternateBy similarity1
Modified residuei25Triiodothyronine; alternateBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 53PROSITE-ProRule annotation
Disulfide bondi64 ↔ 71PROSITE-ProRule annotation
Disulfide bondi73 ↔ 93PROSITE-ProRule annotation
Disulfide bondi97 ↔ 121PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 139PROSITE-ProRule annotation
Disulfide bondi141 ↔ 161PROSITE-ProRule annotation
Modified residuei150Diiodotyrosine; alternateBy similarity1
Modified residuei150Iodotyrosine; alternateBy similarity1
Disulfide bondi165 ↔ 184PROSITE-ProRule annotation
Disulfide bondi195 ↔ 236PROSITE-ProRule annotation
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei259IodotyrosineBy similarity1
Disulfide bondi302 ↔ 320PROSITE-ProRule annotation
Disulfide bondi331 ↔ 337PROSITE-ProRule annotation
Disulfide bondi339 ↔ 365PROSITE-ProRule annotation
Glycosylationi484N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi496N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi608 ↔ 620PROSITE-ProRule annotation
Disulfide bondi631 ↔ 636PROSITE-ProRule annotation
Disulfide bondi638 ↔ 658PROSITE-ProRule annotation
Disulfide bondi662 ↔ 687PROSITE-ProRule annotation
Disulfide bondi698 ↔ 703PROSITE-ProRule annotation
Modified residuei704Diiodotyrosine; alternateBy similarity1
Modified residuei704Iodotyrosine; alternateBy similarity1
Modified residuei704Thyroxine; alternateBy similarity1
Modified residuei704Triiodothyronine; alternateBy similarity1
Disulfide bondi705 ↔ 726PROSITE-ProRule annotation
Disulfide bondi730 ↔ 763PROSITE-ProRule annotation
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi774 ↔ 899PROSITE-ProRule annotation
Modified residuei785IodotyrosineBy similarity1
Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei867Diiodotyrosine; alternateBy similarity1
Modified residuei867Iodotyrosine; alternateBy similarity1
Modified residuei884DiiodotyrosineBy similarity1
Disulfide bondi901 ↔ 922PROSITE-ProRule annotation
Glycosylationi948N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei993Diiodotyrosine; alternateBy similarity1
Modified residuei993Iodotyrosine; alternateBy similarity1
Glycosylationi1017N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1043 ↔ 1050PROSITE-ProRule annotation
Disulfide bondi1052 ↔ 1074PROSITE-ProRule annotation
Disulfide bondi1078 ↔ 1109PROSITE-ProRule annotation
Disulfide bondi1127 ↔ 1146PROSITE-ProRule annotation
Glycosylationi1141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1150 ↔ 1170PROSITE-ProRule annotation
Disulfide bondi1182 ↔ 1189PROSITE-ProRule annotation
Disulfide bondi1191 ↔ 1211PROSITE-ProRule annotation
Modified residuei1310IodotyrosineBy similarity1
Glycosylationi1349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1365N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1513 ↔ 1522PROSITE-ProRule annotation
Disulfide bondi1542 ↔ 1564PROSITE-ProRule annotation
Glycosylationi1715N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1773N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1866N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1937N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2012N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2122N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2184IodotyrosineBy similarity1
Glycosylationi2251N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2265 ↔ 2282PROSITE-ProRule annotation
Glycosylationi2296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2445N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2574Diiodotyrosine; alternateBy similarity1
Modified residuei2574Iodotyrosine; alternateBy similarity1
Modified residuei2574Thyroxine; alternateBy similarity1
Modified residuei2574Triiodothyronine; alternateBy similarity1
Glycosylationi2583N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei2588IodotyrosineBy similarity1
Modified residuei2618IodotyrosineBy similarity1
Modified residuei2698DiiodotyrosineBy similarity1
Modified residuei2766Diiodotyrosine; alternateBy similarity1
Modified residuei2766Iodotyrosine; alternateBy similarity1
Modified residuei2766Thyroxine; alternateBy similarity1
Modified residuei2766Triiodothyronine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated tyrosines are desulfated during iodination.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Iodination, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06882

PRoteomics IDEntifications database

More...
PRIDEi
P06882

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Thyroid gland specific.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P06882

Protein interaction database and analysis system

More...
IntActi
P06882, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000009241

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 93Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST62
Domaini94 – 161Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST68
Domaini162 – 298Thyroglobulin type-1 3PROSITE-ProRule annotationAdd BLAST137
Domaini299 – 359Thyroglobulin type-1 4PROSITE-ProRule annotationAdd BLAST61
Domaini605 – 658Thyroglobulin type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini659 – 726Thyroglobulin type-1 6PROSITE-ProRule annotationAdd BLAST68
Domaini727 – 922Thyroglobulin type-1 7PROSITE-ProRule annotationAdd BLAST196
Domaini923 – 1074Thyroglobulin type-1 8PROSITE-ProRule annotationAdd BLAST152
Domaini1075 – 1146Thyroglobulin type-1 9PROSITE-ProRule annotationAdd BLAST72
Domaini1147 – 1211Thyroglobulin type-1 10PROSITE-ProRule annotationAdd BLAST65
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1455 – 1468Type IIAdd BLAST14
Repeati1469 – 1485Type IIAdd BLAST17
Repeati1486 – 1502Type IIAdd BLAST17
Domaini1510 – 1564Thyroglobulin type-1 11PROSITE-ProRule annotationAdd BLAST55
Repeati1602 – 1722Type IIIAAdd BLAST121
Repeati1723 – 1891Type IIIBAdd BLAST169
Repeati1892 – 1994Type IIIAAdd BLAST103
Repeati1995 – 2127Type IIIBAdd BLAST133
Repeati2128 – 2185Type IIIAAdd BLAST58

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG6K Eukaryota
COG2272 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000128427

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06882

Database for complete collections of gene phylogenies

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PhylomeDBi
P06882

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00191 TY, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit
4.10.800.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR016324 Thyroglobulin
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00135 COesterase, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00086 Thyroglobulin_1, 11 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001831 Thyroglobulin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01411 Ephrin_rec_like, 1 hit
SM00211 TY, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit
SSF57610 SSF57610, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 9 hits
PS51162 THYROGLOBULIN_1_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P06882-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTLVLWVST LLSSVCLVAA NIFEYQVDAQ PLRPCELQRE KAFLKQDEYV
60 70 80 90 100
PQCSEDGSFQ TVQCQNDGQS CWCVDSDGTE VPGSRQLGRP TACLSFCQLH
110 120 130 140 150
KQRILLSSYI NSTDALYLPQ CQDSGNYAPV QCDLQQVQCW CVDTEGMEVY
160 170 180 190 200
GTRQQGRPTR CPRSCEIRSR RLLHGVGDKS PPQCDADGEF MPVQCKFVNT
210 220 230 240 250
TDMMIFDLIH NYNRFPDAFV TFSAFRNRFP EVSGYCYCAD SQGRELAETG
260 270 280 290 300
LELLLDEIYD TIFAGLDQAS TFTQSTMYRI LQRRFLAIQL VISGRFRCPT
310 320 330 340 350
KCEVEQFTAT SFGHPYIPSC HRDGHYQTVQ CQMERMCWCV DAQGIEIPGT
360 370 380 390 400
RQQGQPLFCA KDQSCASERQ QALSRLYFET PGYFSPQDLL SSEDRLVPVS
410 420 430 440 450
GARLDISCPP RIKELFVDSG LLRSIAVERY QQLSESRSLL REAIRAIFPS
460 470 480 490 500
RELAGLALQF TTNPKRLQQN LFGGTFLVNA AQLNLSGALG TRSTFNFSQF
510 520 530 540 550
FQQFGLPGFL VRDRATDLAK LLPVSLDSSP TPVPLRVPEK RVAMNKSVVG
560 570 580 590 600
TFGFKVNLQE NQDALKFLVS LMELPEFLVF LQRAVSVPED RARDLGDVME
610 620 630 640 650
MVFSAQACKQ TSGRFFVPSC TAEGSYEDIQ CYAGECWCVN SQGKEVEGSR
660 670 680 690 700
VSGGHPRCPT KCEKQRAQMQ NLAGAQPAGS SFFVPTCTSE GYFLPVQCFN
710 720 730 740 750
SECYCVDAEG QVIPGTQSTI GEPKLCPSVC QLQAEQAFLG VVGVLLSNSS
760 770 780 790 800
MVPPISSVYI PQCSTSGQWM PVQCDGPHEQ VFEWYERWNT QNSDGQELTT
810 820 830 840 850
ATLLMKLMSY REVASTNFSL FLQSLYDAGQ QSIFPVLAQY PSLQDVPQVV
860 870 880 890 900
LEGATIQPGE NIFLDPYIFW QILNGQLSQY PGPYSDFSMP LEHFNLRSCW
910 920 930 940 950
CVDEAGQELD GTRTRAGEIP ACPGPCEEVK FRVLKFIKET EEIVSASNAS
960 970 980 990 1000
SFPLGESFLV AKGIQLTSEE LGLPPLYPSR EAFSEKFLRG SEYAIRLAAQ
1010 1020 1030 1040 1050
STLTFYQKLR ASLGESNGTA SLLWSGPYMP QCNTIGGWEP VQCHPGTGQC
1060 1070 1080 1090 1100
WCVDGWGELI PGSLMARSSQ MPQCPTSCEL SRANGLISAW KQAGHQRNPG
1110 1120 1130 1140 1150
PGDLFTPVCL QTGEYVRQQT SGTGAWCVDP SSGEGVPTNT NSSAQCPGLC
1160 1170 1180 1190 1200
DALKSRVLSR KVGLGYTPVC EALDGGFSPV QCDLAQGSCW CVLASGEEVP
1210 1220 1230 1240 1250
GTRVVGTQPA CESPQCPLPF SGSDVTDGVV FCETASSSGV TTVQQCQLFC
1260 1270 1280 1290 1300
RQGLRNVFSP GPLICNLESQ RWVTLPLPRA CQRPQLWQTM QTQAHFQLLL
1310 1320 1330 1340 1350
PPGKMCSIDY SGLLQAFQVF ILDELITRGF CQIQVKTFGT LVSRTVCDNS
1360 1370 1380 1390 1400
SIQVGCLTAE RLGVNATWKL QLEDISVGSL PNLHSIERAL MGQDLLGRFA
1410 1420 1430 1440 1450
NLIQSGKFQL HLDSKTFSAD TILYFLNGDR FVTSPMTQLG CLEGFYRVST
1460 1470 1480 1490 1500
TSQDPLGCVK CPEGSFSQDG KCTPCPAGTY QGQAGSSACI PCPRGRTTTI
1510 1520 1530 1540 1550
TGAFSKTHCV TDCQRDEAGL QCDQNGQYQA NQKDMDSGEV FCVDSEGQRL
1560 1570 1580 1590 1600
QWLQTEAGLS ESQCLMMRKF EKAPESKVIF DASSPVIVKS RVPSANSPLV
1610 1620 1630 1640 1650
QCLADCADDE ACSFVTVSSM SSEVSCDLYS WTRDNFACVT SDQEEDAVDS
1660 1670 1680 1690 1700
LKETSFGSLR CQVKVRNSGK DSLAVYVKKG HEFTASGQKS FEPTGFQNVL
1710 1720 1730 1740 1750
SGLYSSVVFS ALGTNLTDTH LFCLLACDQD SCCDGFIVTQ VKEGPTICGL
1760 1770 1780 1790 1800
LSAPDILVCH INDWRDASDT QANGTCAGVT YDQGSRQMTM SLGGQEFLQG
1810 1820 1830 1840 1850
LTLLEGTQDS FISFQQVYLW KDSDIGSRPE SMGCGRGMVP KSEAPEGADM
1860 1870 1880 1890 1900
ATELFSPVDI TQVIVNTSHS LPSQQYWLST HLFSAEQANL WCLSRCAQEP
1910 1920 1930 1940 1950
VFCQLADIME SSSLYFTCSL YPEAQVCDND VESNAKNCSQ ILPRQPTALF
1960 1970 1980 1990 2000
QRKVVLNDRV KNFYTRLPFQ KLSGISIRDR IPMSEKLISN GFFECERLCD
2010 2020 2030 2040 2050
RDPCCTGFGF LNVSQMQGGE MTCLTLNSMG IQTCSEENGA TWRILDCGSE
2060 2070 2080 2090 2100
DTEVHTYPFG WYQKPAVWSD APSFCPSAAL QSLTEEKVAL DSWQTLALSS
2110 2120 2130 2140 2150
VIIDPSIKHF DVAHISISAT RNFSLAQDFC LQECSRHQDC LVTTLQIQQG
2160 2170 2180 2190 2200
VVRCVFYPDI QSCEHSLRSK TCWLLLHEEA AYIYRKSGAP LHQSDGISTP
2210 2220 2230 2240 2250
SVHIDSFGQL QGGSQVVKVG TAWKQVYQFL GVPYAAPPLA ENRFQAPEVL
2260 2270 2280 2290 2300
NWTGSWDATK LRSSCWQPGT RTPTPPQISE DCLYLNVFVP ENLVSNASVL
2310 2320 2330 2340 2350
VFFHNTVEME GSGGQLNIDG SILAAVGNLI VVTANYRLGV FGFLSSGSDE
2360 2370 2380 2390 2400
VAGNWGLLDQ VAALTWVQTH IGAFGGDPQR VTLAADRGGA DVASIHLLIT
2410 2420 2430 2440 2450
RPTRLQLFRK ALLMGGSALS PAAIISPDRA QQQAAALAKE VGCPNSSVQE
2460 2470 2480 2490 2500
VVSCFRQKPA NILNEAQTKL LAVSGPFHYW GPVVDGQYLR ELPSRRLKRP
2510 2520 2530 2540 2550
LPVKVDLLIG GSQDDGLINR AKAVKQFEES QGRTNSKTAF YQALQNSLGG
2560 2570 2580 2590 2600
EDSDARILAA AIWYYSLEHS TDDYASFSRA LENATRDYFI ICPIVNMASL
2610 2620 2630 2640 2650
WARRTRGNVF MYHVPESYGH GSLELLADVQ YAFGLPFYSA YQGYFSTEEQ
2660 2670 2680 2690 2700
SLSLKVMQYF SNFIRSGNPN YPHEFSQKAA EFATPWPDFV PGAGGESYKE
2710 2720 2730 2740 2750
LSAQLPNRQG LKKADCSFWS KYIQTLKDAD GAKDAQLTKS GEEDLEVGPG
2760
SEEDFSGSLE PVPKSYSK
Length:2,768
Mass (Da):304,645
Last modified:January 11, 2001 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i290DD6943FF23F3D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V6V3G3V6V3_RAT
Thyroglobulin
Tg rCG_59403
2,768Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JXY8A0A0G2JXY8_RAT
Thyroglobulin
Tg
2,720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2Q6Q9A0A1W2Q6Q9_RAT
Thyroglobulin
Tg
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44L → V in AAA50379 (PubMed:3455768).Curated1
Sequence conflicti678A → V in AAF34909 (Ref. 2) Curated1
Sequence conflicti1492C → F in AAF34909 (Ref. 2) Curated1
Sequence conflicti1732 – 1733CC → KS in AAF34909 (Ref. 2) Curated2
Sequence conflicti1914L → F in CAA26183 (PubMed:3838512).Curated1
Sequence conflicti2043R → A in CAA26183 (PubMed:3838512).Curated1
Sequence conflicti2081Q → K in CAA26183 (PubMed:3838512).Curated1
Sequence conflicti2126A → V in CAA26183 (PubMed:3838512).Curated1
Sequence conflicti2153R → K in CAA26183 (PubMed:3838512).Curated1
Sequence conflicti2169S → N in CAA26183 (PubMed:3838512).Curated1
Sequence conflicti2611M → I in CAA26183 (PubMed:3838512).Curated1
Sequence conflicti2658Q → H in CAA26183 (PubMed:3838512).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti2320G → R in hypothyroidism; suppress secretion of Tg. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB035201 mRNA Translation: BAA96132.1
AF221622 mRNA Translation: AAF34909.1
M35965 mRNA Translation: AAA42089.1 Different termination.
M12559, M12558 Genomic DNA Translation: AAA50379.1
X02318 mRNA Translation: CAA26183.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A22016 UIRT

Genome annotation databases

UCSC genome browser

More...
UCSCi
RGD:3848 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035201 mRNA Translation: BAA96132.1
AF221622 mRNA Translation: AAF34909.1
M35965 mRNA Translation: AAA42089.1 Different termination.
M12559, M12558 Genomic DNA Translation: AAA50379.1
X02318 mRNA Translation: CAA26183.1
PIRiA22016 UIRT

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

CORUMiP06882
IntActiP06882, 3 interactors
STRINGi10116.ENSRNOP00000009241

Protein family/group databases

ESTHERiratno-thyro Thyroglobulin
MEROPSiI31.950

Proteomic databases

PaxDbiP06882
PRIDEiP06882

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3848 rat

Organism-specific databases

RGDi3848 Tg

Phylogenomic databases

eggNOGiENOG410IG6K Eukaryota
COG2272 LUCA
HOGENOMiHOG000128427
InParanoidiP06882
PhylomeDBiP06882

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P06882

Family and domain databases

CDDicd00191 TY, 8 hits
Gene3Di3.40.50.1820, 1 hit
4.10.800.10, 7 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019819 Carboxylesterase_B_CS
IPR016324 Thyroglobulin
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00086 Thyroglobulin_1, 11 hits
PIRSFiPIRSF001831 Thyroglobulin, 1 hit
SMARTiView protein in SMART
SM01411 Ephrin_rec_like, 1 hit
SM00211 TY, 10 hits
SUPFAMiSSF53474 SSF53474, 1 hit
SSF57610 SSF57610, 11 hits
PROSITEiView protein in PROSITE
PS00941 CARBOXYLESTERASE_B_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 9 hits
PS51162 THYROGLOBULIN_1_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHYG_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06882
Secondary accession number(s): Q9JKY6, Q9JM94
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 11, 2001
Last modified: May 8, 2019
This is version 159 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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