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Protein

Calcitonin gene-related peptide 1

Gene

CALCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.1 Publication

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • protein-containing complex binding Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

  • activation of adenylate cyclase activity Source: UniProtKB
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • amylin receptor signaling pathway Source: ARUK-UCL
  • antibacterial humoral response Source: UniProtKB
  • antifungal humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • calcitonin gene-related peptide receptor signaling pathway Source: UniProtKB
  • cell-cell signaling Source: ProtInc
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • endothelial cell migration Source: UniProtKB
  • endothelial cell proliferation Source: UniProtKB
  • G-protein coupled receptor internalization Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: Reactome
  • innate immune response Source: UniProtKB
  • leukocyte cell-cell adhesion Source: UniProtKB
  • negative regulation of blood pressure Source: MGI
  • negative regulation of bone resorption Source: UniProtKB
  • negative regulation of calcium ion transport into cytosol Source: UniProtKB
  • negative regulation of osteoclast differentiation Source: UniProtKB
  • neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
  • positive regulation of blood vessel diameter Source: UniProtKB
  • positive regulation of cAMP metabolic process Source: ARUK-UCL
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
  • positive regulation of interleukin-1 alpha production Source: UniProtKB
  • positive regulation of interleukin-8 production Source: UniProtKB
  • positive regulation of macrophage differentiation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • receptor internalization Source: UniProtKB
  • regulation of blood pressure Source: UniProtKB
  • regulation of cytosolic calcium ion concentration Source: UniProtKB
  • response to yeast Source: UniProtKB
  • vasculature development Source: UniProtKB

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors

Protein family/group databases

TCDBi1.C.49.1.2 the cytotoxic amylin (amylin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide 1
Alternative name(s):
Alpha-type CGRP
Calcitonin gene-related peptide I
Short name:
CGRP-I
Gene namesi
Name:CALCA
Synonyms:CALC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110680.12
HGNCiHGNC:1437 CALCA
MIMi114130 gene
neXtProtiNX_P06881

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi796
PharmGKBiPA26029

Chemistry databases

ChEMBLiCHEMBL5293
DrugBankiDB05760 MK-0974
DB04869 Olcegepant

Polymorphism and mutation databases

BioMutaiCYP2R1
DMDMi308153625

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000405326 – 80Add BLAST55
PeptideiPRO_000000405483 – 119Calcitonin gene-related peptide 1Add BLAST37
PropeptideiPRO_0000004055125 – 1284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 891 Publication
Modified residuei119Phenylalanine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PeptideAtlasiP06881
PRIDEiP06881
ProteomicsDBi51940

PTM databases

iPTMnetiP06881

Expressioni

Gene expression databases

BgeeiENSG00000110680
CleanExiHS_CALCA
ExpressionAtlasiP06881 baseline and differential
GenevisibleiP06881 HS

Organism-specific databases

HPAiHPA059886

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCRLQ166022EBI-962928,EBI-962878

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107247, 11 interactors
IntActiP06881, 3 interactors

Chemistry databases

BindingDBiP06881

Structurei

3D structure databases

ProteinModelPortaliP06881
SMRiP06881
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000038203
HOVERGENiHBG031362

Family and domain databases

InterProiView protein in InterPro
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR015476 Calcitonin_gene-rel_peptide
IPR001693 Calcitonin_peptide-like
PANTHERiPTHR10505 PTHR10505, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00817 CALCITONINB
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: P06881-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL
60 70 80 90 100
LAALVQNYVQ MKASELEQEQ EREGSRIIAQ KRACDTATCV THRLAGLLSR
110 120
SGGVVKNNFV PTNVGSKAFG RRRRDLQA
Length:128
Mass (Da):13,898
Last modified:October 5, 2010 - v3
Checksum:i2AA1A9AC3060D9B6
GO
Isoform 1 (identifier: P01258-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01258.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:141
Mass (Da):15,466
GO
Isoform 2 (identifier: P01258-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01258.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:141
Mass (Da):15,534
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04858457N → D3 PublicationsCorresponds to variant dbSNP:rs5239Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12667, M12664, M12665 Genomic DNA Translation: AAA51914.1
X15943 Genomic DNA Translation: CAA34070.1
AC090835 Genomic DNA No translation available.
K03512 mRNA Translation: AAA52011.1
X02330 mRNA Translation: CAA26190.1
M28637 Genomic DNA Translation: AAA52012.1
M26094 Genomic DNA Translation: AAA51912.1
CCDSiCCDS31432.1 [P06881-1]
PIRiS07644 TCHUR
RefSeqiNP_001029125.1, NM_001033953.2
UniGeneiHs.37058

Genome annotation databases

EnsembliENST00000361010; ENSP00000354286; ENSG00000110680
ENST00000486207; ENSP00000417833; ENSG00000110680
GeneIDi796
UCSCiuc001mlt.2 human [P06881-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCALCA_HUMAN
AccessioniPrimary (citable) accession number: P06881
Secondary accession number(s): Q93048, Q9UCP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 5, 2010
Last modified: June 20, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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