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Protein

Prolactin

Gene

Prl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Molecular functioni

  • hormone activity Source: MGI
  • prolactin receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processLactation

Enzyme and pathway databases

ReactomeiR-MMU-1170546 Prolactin receptor signaling
R-MMU-982772 Growth hormone receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:Prl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:97762 Prl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000003292130 – 226ProlactinAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 38By similarity
Modified residuei53PhosphoserineBy similarity1
Disulfide bondi85 ↔ 201By similarity
Modified residuei117PhosphoserineBy similarity1
Disulfide bondi218 ↔ 226By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP06879
PeptideAtlasiP06879
PRIDEiP06879

PTM databases

iPTMnetiP06879
PhosphoSitePlusiP06879

Expressioni

Gene expression databases

CleanExiMM_PRL
ExpressionAtlasiP06879 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998

Structurei

3D structure databases

ProteinModelPortaliP06879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74 Eukaryota
ENOG410XU1S LUCA
GeneTreeiENSGT00730000110805
HOVERGENiHBG104895
InParanoidiP06879

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00338 SOMATOTROPIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P06879-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSQGSAQKA GTLLLLLISN LLFCQNVQPL PICSAGDCQT SLRELFDRVV
60 70 80 90 100
ILSHYIHTLY TDMFIEFDKQ YVQDREFMVK VINDCPTSSL ATPEDKEQAL
110 120 130 140 150
KVPPEVLLNL ILSLVQSSSD PLFQLITGVG GIQEAPEYIL SRAKEIEEQN
160 170 180 190 200
KQLLEGVEKI ISQAYPEAKG NGIYFVWSQL PSLQGVDEES KILSLRNTIR
210 220
CLRRDSHKVD NFLKVLRCQI AHQNNC
Length:226
Mass (Da):25,496
Last modified:January 1, 1988 - v1
Checksum:i40B734C1FD610E6E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9CPQ2Q9CPQ2_MOUSE
Growth hormone a1
Prl Gha1, mCG_15525
228Annotation score:
Q9CPQ0Q9CPQ0_MOUSE
Prolactin
Prl
225Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205D → H in CAA28018 (PubMed:3756168).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02892 mRNA Translation: CAA26651.1
X04418 mRNA Translation: CAA28018.1
AK017521 mRNA Translation: BAB30787.2
AK017579 mRNA Translation: BAB30816.2
UniGeneiMm.1270

Genome annotation databases

EnsembliENSMUST00000224228; ENSMUSP00000153245; ENSMUSG00000021342

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02892 mRNA Translation: CAA26651.1
X04418 mRNA Translation: CAA28018.1
AK017521 mRNA Translation: BAB30787.2
AK017579 mRNA Translation: BAB30816.2
UniGeneiMm.1270

3D structure databases

ProteinModelPortaliP06879
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998

PTM databases

iPTMnetiP06879
PhosphoSitePlusiP06879

Proteomic databases

PaxDbiP06879
PeptideAtlasiP06879
PRIDEiP06879

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000224228; ENSMUSP00000153245; ENSMUSG00000021342

Organism-specific databases

MGIiMGI:97762 Prl

Phylogenomic databases

eggNOGiENOG410II74 Eukaryota
ENOG410XU1S LUCA
GeneTreeiENSGT00730000110805
HOVERGENiHBG104895
InParanoidiP06879

Enzyme and pathway databases

ReactomeiR-MMU-1170546 Prolactin receptor signaling
R-MMU-982772 Growth hormone receptor signaling

Miscellaneous databases

ChiTaRSiPrl mouse
PROiPR:P06879
SOURCEiSearch...

Gene expression databases

CleanExiMM_PRL
ExpressionAtlasiP06879 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00338 SOMATOTROPIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRL_MOUSE
AccessioniPrimary (citable) accession number: P06879
Secondary accession number(s): Q544X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 20, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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