Transcriptional activator Myb

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb."
    Matre V., Hovring P.I., Fjeldheim A.K., Helgeland L., Orvain C., Andersson K.B., Gautvik K.M., Gabrielsen O.S.
    Biochem. J. 372:851-859(2003) [PubMed] [Europe PMC] [Abstract]
  • "A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice."
    Kurima K., Hertzano R., Gavrilova O., Monahan K., Shpargel K.B., Nadaraja G., Kawashima Y., Lee K.Y., Ito T., Higashi Y., Eisenman D.J., Strome S.E., Griffith A.J.
    PLoS Genet. 7:e1002307-e1002307(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • "Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells."
    Jin Z.X., Kishi H., Wei X.C., Matsuda T., Saito S., Muraguchi A.
    J. Immunol. 169:3783-3792(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb."
    Matre V., Hovring P.I., Fjeldheim A.K., Helgeland L., Orvain C., Andersson K.B., Gautvik K.M., Gabrielsen O.S.
    Biochem. J. 372:851-859(2003) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells."
    Jin Z.X., Kishi H., Wei X.C., Matsuda T., Saito S., Muraguchi A.
    J. Immunol. 169:3783-3792(2002) [PubMed] [Europe PMC] [Abstract]
• WD40-repeat domain binding Source: MGIInferred from direct assayⁱ
  • "TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation."
    Morita Y., Kanei-Ishii C., Nomura T., Ishii S.
    Mol. Biol. Cell 16:5433-5444(2005) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• B cell differentiation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene."
    Park E.S., Choi S., Kim J.M., Jeong Y., Choe J., Park C.S., Choi Y., Rho J.
    Biochem. Biophys. Res. Commun. 363:971-977(2007) [PubMed] [Europe PMC] [Abstract]
• calcium ion transport Source: MGIInferred from mutant phenotypeⁱ
  • "Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle."
    Afroze T., Yang L.L., Wang C., Gros R., Kalair W., Hoque A.N., Mungrue I.N., Zhu Z., Husain M.
    Am. J. Physiol., Cell Physiol. 285:C88-95(2003) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-6 Source: MGIInferred from direct assayⁱ
  • "TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation."
    Morita Y., Kanei-Ishii C., Nomura T., Ishii S.
    Mol. Biol. Cell 16:5433-5444(2005) [PubMed] [Europe PMC] [Abstract]
• cellular response to leukemia inhibitory factor Source: MGI <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells."
    Tarantino C., Paolella G., Cozzuto L., Minopoli G., Pastore L., Parisi S., Russo T.
    FASEB J. 24:3255-3263(2010) [PubMed] [Europe PMC] [Abstract]
• chromatin remodeling Source: MGI
• embryonic digestive tract development Source: MGIInferred from mutant phenotypeⁱ
  • "c-Myb is critical for murine colon development."
    Zorbas M., Sicurella C., Bertoncello I., Venter D., Ellis S., Mucenski M.L., Ramsay R.G.
    Oncogene 18:5821-5830(1999) [PubMed] [Europe PMC] [Abstract]
• G1/S transition of mitotic cell cycle Source: MGIInferred from mutant phenotypeⁱ
  • "Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle."
    Afroze T., Yang L.L., Wang C., Gros R., Kalair W., Hoque A.N., Mungrue I.N., Zhu Z., Husain M.
    Am. J. Physiol., Cell Physiol. 285:C88-95(2003) [PubMed] [Europe PMC] [Abstract]
• homeostasis of number of cells Source: MGIInferred from mutant phenotypeⁱ
  • "Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene."
    Park E.S., Choi S., Kim J.M., Jeong Y., Choe J., Park C.S., Choi Y., Rho J.
    Biochem. Biophys. Res. Commun. 363:971-977(2007) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "c-Myb is critical for murine colon development."
    Zorbas M., Sicurella C., Bertoncello I., Venter D., Ellis S., Mucenski M.L., Ramsay R.G.
    Oncogene 18:5821-5830(1999) [PubMed] [Europe PMC] [Abstract]
  • "Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene."
    Park E.S., Choi S., Kim J.M., Jeong Y., Choe J., Park C.S., Choi Y., Rho J.
    Biochem. Biophys. Res. Commun. 363:971-977(2007) [PubMed] [Europe PMC] [Abstract]
• mitotic cell cycle Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• myeloid cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis."
    Garcia P., Clarke M., Vegiopoulos A., Berlanga O., Camelo A., Lorvellec M., Frampton J.
    EMBO J. 28:1492-1504(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: MGI
• negative regulation of transcription by RNA polymerase II Source: MGI
• positive regulation of histone H3-K4 methylation Source: MGI
• positive regulation of histone H3-K9 methylation Source: MGI
• positive regulation of T-helper cell differentiation Source: MGI
• positive regulation of transcription, DNA-templated Source: MGI
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • "Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells."
    Jin Z.X., Kishi H., Wei X.C., Matsuda T., Saito S., Muraguchi A.
    J. Immunol. 169:3783-3792(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "c-Myb is critical for murine colon development."
    Zorbas M., Sicurella C., Bertoncello I., Venter D., Ellis S., Mucenski M.L., Ramsay R.G.
    Oncogene 18:5821-5830(1999) [PubMed] [Europe PMC] [Abstract]
  • "Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis."
    Garcia P., Clarke M., Vegiopoulos A., Berlanga O., Camelo A., Lorvellec M., Frampton J.
    EMBO J. 28:1492-1504(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb."
    Matre V., Hovring P.I., Fjeldheim A.K., Helgeland L., Orvain C., Andersson K.B., Gautvik K.M., Gabrielsen O.S.
    Biochem. J. 372:851-859(2003) [PubMed] [Europe PMC] [Abstract]
• spleen development Source: MGIInferred from mutant phenotypeⁱ
  • "Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis."
    Garcia P., Clarke M., Vegiopoulos A., Berlanga O., Camelo A., Lorvellec M., Frampton J.
    EMBO J. 28:1492-1504(2009) [PubMed] [Europe PMC] [Abstract]
• stem cell division Source: MGIInferred from mutant phenotypeⁱ
  • "Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis."
    Garcia P., Clarke M., Vegiopoulos A., Berlanga O., Camelo A., Lorvellec M., Frampton J.
    EMBO J. 28:1492-1504(2009) [PubMed] [Europe PMC] [Abstract]
• thymus development Source: MGIInferred from mutant phenotypeⁱ
  • "Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene."
    Park E.S., Choi S., Kim J.M., Jeong Y., Choe J., Park C.S., Choi Y., Rho J.
    Biochem. Biophys. Res. Commun. 363:971-977(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• WD40-repeat domain binding Source: MGIInferred from direct assayⁱ
  • "TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation."
    Morita Y., Kanei-Ishii C., Nomura T., Ishii S.
    Mol. Biol. Cell 16:5433-5444(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MARRPRHSIY SSDEDDEDIE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK 
        60         70         80         90        100
LKKLVEQNGT DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED 
       110        120        130        140        150
QRVIELVQKY GPKRWSVIAK HLKGRIGKQC RERWHNHLNP EVKKTSWTEE 
       160        170        180        190        200
EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA IKNHWNSTMR RKVEQEGYLQ 
       210        220        230        240        250
EPSKASQTPV ATSFQKNNHL MGFGHASPPS QLSPSGQSSV NSEYPYYHIA 
       260        270        280        290        300
EAQNISSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL 
       310        320        330        340        350
LLMSTENELK GQQALPTQNH TCSYPGWHST SIVDQTRPHG DSAPVSCLGE 
       360        370        380        390        400
HHATPSLPAD PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID 
       410        420        430        440        450
SFLNTSSNHE SSGLDAPTLP STPLIGHKLT PCRDQTVKTQ KENSIFRTPA 
       460        470        480        490        500
IKRSILESSP RTPTPFKHAL AAQEIKYGPL KMLPQTPSHA VEDLQDVIKQ 
       510        520        530        540        550
ESDESGIVAE FQESGPPLLK KIKQEVESPT EKSGNFFCSN HWAENSLSTQ 
       560        570        580        590        600
LFSQASPVAD APNILTSSVL MTPVSEDEDN VLKAFTVPKN RPLVGPLQPC 
       610        620        630 
SGAWEPASCG KTEDQMTASG PARKYVNAFS ARTLVM                

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references