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UniProtKB - P06876 (MYB_MOUSE)
Protein
Transcriptional activator Myb
Gene
Myb
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 63 – 86 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 | |
DNA bindingi | 115 – 138 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 | |
DNA bindingi | 166 – 189 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- WD40-repeat domain binding Source: MGI
GO - Biological processi
- B cell differentiation Source: MGI
- calcium ion transport Source: MGI
- cellular response to interleukin-6 Source: MGI
- cellular response to leukemia inhibitory factor Source: MGI
- chromatin remodeling Source: MGI
- embryonic digestive tract development Source: MGI
- G1/S transition of mitotic cell cycle Source: MGI
- homeostasis of number of cells Source: MGI
- in utero embryonic development Source: MGI
- mitotic cell cycle Source: GO_Central
- myeloid cell differentiation Source: MGI
- negative regulation of hematopoietic progenitor cell differentiation Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of histone H3-K4 methylation Source: MGI
- positive regulation of histone H3-K9 methylation Source: MGI
- positive regulation of T-helper cell differentiation Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of gene expression Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- spleen development Source: MGI
- stem cell division Source: MGI
- thymus development Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional activator MybAlternative name(s): Proto-oncogene c-Myb |
Gene namesi | Name:Myb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97249, Myb |
VEuPathDBi | HostDB:ENSMUSG00000019982 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000197049 | 1 – 636 | Transcriptional activator MybAdd BLAST | 636 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 467 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 476 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 476 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 528 | PhosphoserineBy similarity | 1 | |
Modified residuei | 530 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity
Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels (By similarity).By similarity
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P06876 |
jPOSTi | P06876 |
PaxDbi | P06876 |
PRIDEi | P06876 |
ProteomicsDBi | 293592 |
PTM databases
iPTMneti | P06876 |
PhosphoSitePlusi | P06876 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000019982, Expressed in thymus and 266 other tissues |
Genevisiblei | P06876, MM |
Interactioni
Subunit structurei
Binds to HIPK1 (By similarity).
Interacts with HIPK2, MAF, MYBBP1A and NLK.
By similarity5 PublicationsBinary interactionsi
P06876
With | #Exp. | IntAct |
---|---|---|
Hipk2 [Q9QZR5] | 2 | EBI-366934,EBI-366905 |
HSF3 [P38531] from Gallus gallus. | 2 | EBI-366934,EBI-16212976 |
GO - Molecular functioni
- WD40-repeat domain binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201631, 12 interactors |
ComplexPortali | CPX-685, c-Myb-C/EBPbeta complex |
DIPi | DIP-31713N |
ELMi | P06876 |
IntActi | P06876, 4 interactors |
STRINGi | 10090.ENSMUSP00000020158 |
Miscellaneous databases
RNActi | P06876, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P06876 |
SMRi | P06876 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06876 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 86 | HTH myb-type 1PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 87 – 142 | HTH myb-type 2PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 143 – 193 | HTH myb-type 3PROSITE-ProRule annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 90 – 193 | Interaction with HIPK2 and NLK1 PublicationAdd BLAST | 104 | |
Regioni | 275 – 327 | Transcriptional activation domainBy similarityAdd BLAST | 53 | |
Regioni | 328 – 460 | Negative regulatory domainAdd BLAST | 133 | |
Regioni | 337 – 368 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 375 – 396 | Leucine-zipperAdd BLAST | 22 |
Domaini
Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
C-terminal truncated mutants display increased transactivation.
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0048, Eukaryota |
GeneTreei | ENSGT01040000241306 |
HOGENOMi | CLU_015440_2_2_1 |
InParanoidi | P06876 |
OrthoDBi | 219341at2759 |
TreeFami | TF326257 |
Family and domain databases
CDDi | cd00167, SANT, 3 hits |
InterProi | View protein in InterPro IPR015395, C-myb_C IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR012642, Tscrpt_reg_Wos2-domain |
Pfami | View protein in Pfam PF09316, Cmyb_C, 1 hit PF07988, LMSTEN, 1 hit PF00249, Myb_DNA-binding, 3 hits |
SMARTi | View protein in SMART SM00717, SANT, 3 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P06876-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARRPRHSIY SSDEDDEDIE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK
60 70 80 90 100
LKKLVEQNGT DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED
110 120 130 140 150
QRVIELVQKY GPKRWSVIAK HLKGRIGKQC RERWHNHLNP EVKKTSWTEE
160 170 180 190 200
EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA IKNHWNSTMR RKVEQEGYLQ
210 220 230 240 250
EPSKASQTPV ATSFQKNNHL MGFGHASPPS QLSPSGQSSV NSEYPYYHIA
260 270 280 290 300
EAQNISSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL
310 320 330 340 350
LLMSTENELK GQQALPTQNH TCSYPGWHST SIVDQTRPHG DSAPVSCLGE
360 370 380 390 400
HHATPSLPAD PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID
410 420 430 440 450
SFLNTSSNHE SSGLDAPTLP STPLIGHKLT PCRDQTVKTQ KENSIFRTPA
460 470 480 490 500
IKRSILESSP RTPTPFKHAL AAQEIKYGPL KMLPQTPSHA VEDLQDVIKQ
510 520 530 540 550
ESDESGIVAE FQESGPPLLK KIKQEVESPT EKSGNFFCSN HWAENSLSTQ
560 570 580 590 600
LFSQASPVAD APNILTSSVL MTPVSEDEDN VLKAFTVPKN RPLVGPLQPC
610 620 630
SGAWEPASCG KTEDQMTASG PARKYVNAFS ARTLVM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WPA7 | A0A087WPA7_MOUSE | Transcriptional activator Myb | Myb | 755 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 105 | E → K in CAA26552 (PubMed:2998780).Curated | 1 | |
Sequence conflicti | 201 | E → K in CAA26552 (PubMed:2998780).Curated | 1 | |
Sequence conflicti | 267 | V → A in AAB59713 (PubMed:3010282).Curated | 1 | |
Sequence conflicti | 402 | F → V in AAA39786 (PubMed:3014527).Curated | 1 | |
Sequence conflicti | 411 | S → N in CAA26552 (PubMed:2998780).Curated | 1 | |
Sequence conflicti | 500 | Q → R in CAA26552 (PubMed:2998780).Curated | 1 | |
Sequence conflicti | 500 | Q → R in AAH11513 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 525 | E → A in CAA26552 (PubMed:2998780).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21169 Genomic DNA Translation: AAA39782.1 M12848 mRNA Translation: AAB59713.1 X02774 mRNA Translation: CAA26552.1 M20210 Genomic DNA Translation: AAA39783.1 AC153556 Genomic DNA No translation available. BC011513 mRNA Translation: AAH11513.1 X04099 , X04100, X04101, X04102, X04103, X04104 Genomic DNA Translation: CAA27724.1 X16389 Genomic DNA Translation: CAA34425.1 X16390 Genomic DNA Translation: CAA34426.1 M13989 Genomic DNA Translation: AAA39787.1 K03547 Genomic DNA Translation: AAA39786.1 |
CCDSi | CCDS35861.1 |
PIRi | A25285, TVMSMB |
RefSeqi | NP_001185843.1, NM_001198914.1 NP_034978.3, NM_010848.3 |
Genome annotation databases
Ensembli | ENSMUST00000020158; ENSMUSP00000020158; ENSMUSG00000019982 |
GeneIDi | 17863 |
KEGGi | mmu:17863 |
UCSCi | uc007eog.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21169 Genomic DNA Translation: AAA39782.1 M12848 mRNA Translation: AAB59713.1 X02774 mRNA Translation: CAA26552.1 M20210 Genomic DNA Translation: AAA39783.1 AC153556 Genomic DNA No translation available. BC011513 mRNA Translation: AAH11513.1 X04099 , X04100, X04101, X04102, X04103, X04104 Genomic DNA Translation: CAA27724.1 X16389 Genomic DNA Translation: CAA34425.1 X16390 Genomic DNA Translation: CAA34426.1 M13989 Genomic DNA Translation: AAA39787.1 K03547 Genomic DNA Translation: AAA39786.1 |
CCDSi | CCDS35861.1 |
PIRi | A25285, TVMSMB |
RefSeqi | NP_001185843.1, NM_001198914.1 NP_034978.3, NM_010848.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GUU | X-ray | 1.60 | A | 38-89 | [»] | |
1GV2 | X-ray | 1.68 | A | 89-193 | [»] | |
1GV5 | X-ray | 1.58 | A | 90-141 | [»] | |
1GVD | X-ray | 1.45 | A | 90-141 | [»] | |
1H88 | X-ray | 2.80 | C | 37-193 | [»] | |
1H89 | X-ray | 2.45 | C | 37-193 | [»] | |
1IDY | NMR | - | A | 141-193 | [»] | |
1IDZ | NMR | - | A | 141-193 | [»] | |
1MBE | NMR | - | A | 38-89 | [»] | |
1MBF | NMR | - | A | 38-89 | [»] | |
1MBG | NMR | - | A | 90-141 | [»] | |
1MBH | NMR | - | A | 90-141 | [»] | |
1MBJ | NMR | - | A | 142-193 | [»] | |
1MBK | NMR | - | A | 142-193 | [»] | |
1MSE | NMR | - | C | 90-193 | [»] | |
1MSF | NMR | - | C | 90-193 | [»] | |
1SB0 | NMR | - | B | 291-315 | [»] | |
2AGH | NMR | - | A | 291-315 | [»] | |
6DMX | X-ray | 2.80 | A/C/F/H | 284-315 | [»] | |
6DNQ | X-ray | 2.35 | A/C | 284-315 | [»] | |
BMRBi | P06876 | |||||
SMRi | P06876 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 201631, 12 interactors |
ComplexPortali | CPX-685, c-Myb-C/EBPbeta complex |
DIPi | DIP-31713N |
ELMi | P06876 |
IntActi | P06876, 4 interactors |
STRINGi | 10090.ENSMUSP00000020158 |
PTM databases
iPTMneti | P06876 |
PhosphoSitePlusi | P06876 |
Proteomic databases
EPDi | P06876 |
jPOSTi | P06876 |
PaxDbi | P06876 |
PRIDEi | P06876 |
ProteomicsDBi | 293592 |
Protocols and materials databases
Antibodypediai | 4486, 935 antibodies from 43 providers |
DNASUi | 17863 |
Genome annotation databases
Ensembli | ENSMUST00000020158; ENSMUSP00000020158; ENSMUSG00000019982 |
GeneIDi | 17863 |
KEGGi | mmu:17863 |
UCSCi | uc007eog.1, mouse |
Organism-specific databases
CTDi | 4602 |
MGIi | MGI:97249, Myb |
VEuPathDBi | HostDB:ENSMUSG00000019982 |
Phylogenomic databases
eggNOGi | KOG0048, Eukaryota |
GeneTreei | ENSGT01040000241306 |
HOGENOMi | CLU_015440_2_2_1 |
InParanoidi | P06876 |
OrthoDBi | 219341at2759 |
TreeFami | TF326257 |
Miscellaneous databases
BioGRID-ORCSi | 17863, 9 hits in 69 CRISPR screens |
EvolutionaryTracei | P06876 |
PROi | PR:P06876 |
RNActi | P06876, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019982, Expressed in thymus and 266 other tissues |
Genevisiblei | P06876, MM |
Family and domain databases
CDDi | cd00167, SANT, 3 hits |
InterProi | View protein in InterPro IPR015395, C-myb_C IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR012642, Tscrpt_reg_Wos2-domain |
Pfami | View protein in Pfam PF09316, Cmyb_C, 1 hit PF07988, LMSTEN, 1 hit PF00249, Myb_DNA-binding, 3 hits |
SMARTi | View protein in SMART SM00717, SANT, 3 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51294, HTH_MYB, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MYB_MOUSE | |
Accessioni | P06876Primary (citable) accession number: P06876 Secondary accession number(s): E9QMG8, Q61929 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references