UniProtKB - P06876 (MYB_MOUSE)

BLAST

>sp|P06876|MYB_MOUSE Transcriptional activator Myb OS=Mus musculus OX=10090 GN=Myb PE=1 SV=2
MARRPRHSIYSSDEDDEDIEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT
DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK
HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA
IKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNNHLMGFGHASPPSQLSPSGQSSV
NSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL
LLMSTENELKGQQALPTQNHTCSYPGWHSTSIVDQTRPHGDSAPVSCLGEHHATPSLPAD
PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHESSGLDAPTLP
STPLIGHKLTPCRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPL
KMLPQTPSHAVEDLQDVIKQESDESGIVAEFQESGPPLLKKIKQEVESPTEKSGNFFCSN
HWAENSLSTQLFSQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVPKNRPLVGPLQPC
SGAWEPASCGKTEDQMTASGPARKYVNAFSARTLVM

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History
Entry version 184 (10 Oct 2018)
Sequence version 2 (27 Jul 2011)
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Protein

Transcriptional activator Myb

Gene

Myb

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	63 – 86	H-T-H motifPROSITE-ProRule annotationAdd BLAST	24
DNA bindingⁱ	115 – 138	H-T-H motifPROSITE-ProRule annotationAdd BLAST	24
DNA bindingⁱ	166 – 189	H-T-H motifPROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 12628004
- 21980308
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 12628004
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12244173
RNA polymerase II transcription factor recruiting activity Source: GO_Central
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12244173
WD40-repeat domain binding
Source: MGI
Inferred from direct assayⁱ
- 16162816

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17927961
calcium ion transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 12660151
cellular response to interleukin-6
Source: MGI
Inferred from direct assayⁱ
- 16162816
cellular response to leukemia inhibitory factor
Source: MGI
Inferred from expression patternⁱ
- 20439489
chromatin remodeling Source: MGI
embryonic digestive tract development
Source: MGI
Inferred from mutant phenotypeⁱ
- 10523863
G1/S transition of mitotic cell cycle
Source: MGI
Inferred from mutant phenotypeⁱ
- 12660151
homeostasis of number of cells
Source: MGI
Inferred from mutant phenotypeⁱ
- 17927961
in utero embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
- 10523863
- 17927961
myeloid cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 19360001
negative regulation of transcription, DNA-templated Source: MGI
negative regulation of transcription by RNA polymerase II Source: MGI
positive regulation of histone H3-K4 methylation Source: MGI
positive regulation of histone H3-K9 methylation Source: MGI
positive regulation of T-helper cell differentiation Source: MGI
positive regulation of transcription, DNA-templated Source: MGI
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 12244173
regulation of gene expression
Source: MGI
Inferred from mutant phenotypeⁱ
- 10523863
- 19360001
regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 12628004
spleen development
Source: MGI
Inferred from mutant phenotypeⁱ
- 19360001
stem cell division
Source: MGI
Inferred from mutant phenotypeⁱ
- 19360001
thymus development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17927961

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcriptional activator Myb Alternative name(s): Proto-oncogene c-Myb
Gene namesⁱ	Name:Myb
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:97249 Myb

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000197049	1 – 636	Transcriptional activator MybAdd BLAST		636

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	467	N6-acetyllysineBy similarity	1
Modified residueⁱ	476	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	476	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	528	PhosphoserineBy similarity	1
Modified residueⁱ	530	PhosphothreonineBy similarity	1

Post-translational modificationⁱ

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.

Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels (By similarity).By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P06876
PaxDbⁱ	P06876
PRIDEⁱ	P06876

PTM databases

iPTMnetⁱ	P06876
PhosphoSitePlusⁱ	P06876

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000019982 Expressed in 243 organ(s), highest expression level in thymus
CleanExⁱ	MM_MYB
ExpressionAtlasⁱ	P06876 baseline and differential
Genevisibleⁱ	P06876 MM

Interactionⁱ

Subunit structureⁱ

Binds to HIPK1 (By similarity). Interacts with HIPK2, MAF, MYBBP1A and NLK.By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Hipk2	Q9QZR5	2	EBI-366934,EBI-366905
HSF3	P38531	2	EBI-366934,EBI-16212976	From Gallus gallus.

GO - Molecular functionⁱ

RNA polymerase II transcription factor recruiting activity Source: GO_Central
WD40-repeat domain binding
Source: MGI
Inferred from direct assayⁱ
- 16162816

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	201631, 12 interactors
ComplexPortalⁱ	CPX-685 c-Myb-C/EBPbeta complex
Database of interacting proteins More...DIPⁱ	DIP-31713N
ELMⁱ	P06876
IntActⁱ	P06876, 3 interactors
STRINGⁱ	10090.ENSMUSP00000020158

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	45 – 58	Combined sources	14
Helixⁱ	63 – 68	Combined sources	6
Helixⁱ	75 – 86	Combined sources	12
Beta strandⁱ	92 – 94	Combined sources	3
Helixⁱ	97 – 110	Combined sources	14
Helixⁱ	115 – 119	Combined sources	5
Helixⁱ	127 – 136	Combined sources	10
Beta strandⁱ	140 – 142	Combined sources	3
Beta strandⁱ	144 – 146	Combined sources	3
Helixⁱ	149 – 162	Combined sources	14
Helixⁱ	163 – 165	Combined sources	3
Helixⁱ	166 – 170	Combined sources	5
Beta strandⁱ	173 – 175	Combined sources	3
Helixⁱ	178 – 188	Combined sources	11
Helixⁱ	189 – 191	Combined sources	3
Helixⁱ	292 – 311	Combined sources	20

Show more details

3D structure databases

ProteinModelPortalⁱ	P06876
SMRⁱ	P06876
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P06876

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	35 – 86	HTH myb-type 1PROSITE-ProRule annotationAdd BLAST	52
Domainⁱ	87 – 142	HTH myb-type 2PROSITE-ProRule annotationAdd BLAST	56
Domainⁱ	143 – 193	HTH myb-type 3PROSITE-ProRule annotationAdd BLAST	51

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	90 – 193	Interaction with HIPK2 and NLK1 PublicationAdd BLAST	104
Regionⁱ	275 – 327	Transcriptional activation domainBy similarityAdd BLAST	53
Regionⁱ	328 – 460	Negative regulatory domainAdd BLAST	133
Regionⁱ	375 – 396	Leucine-zipperAdd BLAST	22

Domainⁱ

Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.

C-terminal truncated mutants display increased transactivation.

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0048 Eukaryota COG5147 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001038
HOVERGENⁱ	HBG007964
InParanoidⁱ	P06876
KEGG Orthology (KO) More...KOⁱ	K09420
TreeFamⁱ	TF326257

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00167 SANT, 3 hits
InterProⁱ	View protein in InterPro IPR015395 C-myb_C IPR009057 Homeobox-like_sf IPR017930 Myb_dom IPR001005 SANT/Myb IPR012642 Tscrpt_reg_Wos2-domain
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09316 Cmyb_C, 1 hit PF07988 LMSTEN, 1 hit PF00249 Myb_DNA-binding, 3 hits
SMARTⁱ	View protein in SMART SM00717 SANT, 3 hits
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS51294 HTH_MYB, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P06876-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MARRPRHSIY SSDEDDEDIE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK 
        60         70         80         90        100
LKKLVEQNGT DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED 
       110        120        130        140        150
QRVIELVQKY GPKRWSVIAK HLKGRIGKQC RERWHNHLNP EVKKTSWTEE 
       160        170        180        190        200
EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA IKNHWNSTMR RKVEQEGYLQ 
       210        220        230        240        250
EPSKASQTPV ATSFQKNNHL MGFGHASPPS QLSPSGQSSV NSEYPYYHIA 
       260        270        280        290        300
EAQNISSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL 
       310        320        330        340        350
LLMSTENELK GQQALPTQNH TCSYPGWHST SIVDQTRPHG DSAPVSCLGE 
       360        370        380        390        400
HHATPSLPAD PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID 
       410        420        430        440        450
SFLNTSSNHE SSGLDAPTLP STPLIGHKLT PCRDQTVKTQ KENSIFRTPA 
       460        470        480        490        500
IKRSILESSP RTPTPFKHAL AAQEIKYGPL KMLPQTPSHA VEDLQDVIKQ 
       510        520        530        540        550
ESDESGIVAE FQESGPPLLK KIKQEVESPT EKSGNFFCSN HWAENSLSTQ 
       560        570        580        590        600
LFSQASPVAD APNILTSSVL MTPVSEDEDN VLKAFTVPKN RPLVGPLQPC 
       610        620        630 
SGAWEPASCG KTEDQMTASG PARKYVNAFS ARTLVM

Length:636

Mass (Da):71,422

Last modified:July 27, 2011 - v2

Checksum:ⁱ0C6308E584726D01

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WPA7	A0A087WPA7_MOUSE		Transcriptional activator Myb Transcriptional activator Myb	Myb	755	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	105	E → K in CAA26552 (PubMed:2998780).Curated	1
Sequence conflictⁱ	201	E → K in CAA26552 (PubMed:2998780).Curated	1
Sequence conflictⁱ	267	V → A in AAB59713 (PubMed:3010282).Curated	1
Sequence conflictⁱ	402	F → V in AAA39786 (PubMed:3014527).Curated	1
Sequence conflictⁱ	411	S → N in CAA26552 (PubMed:2998780).Curated	1
Sequence conflictⁱ	500	Q → R in CAA26552 (PubMed:2998780).Curated	1
Sequence conflictⁱ	500	Q → R in AAH11513 (PubMed:15489334).Curated	1
Sequence conflictⁱ	525	E → A in CAA26552 (PubMed:2998780).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M21169 Genomic DNA Translation: AAA39782.1 M12848 mRNA Translation: AAB59713.1 X02774 mRNA Translation: CAA26552.1 M20210 Genomic DNA Translation: AAA39783.1 AC153556 Genomic DNA No translation available. BC011513 mRNA Translation: AAH11513.1 X04099 X04104 Genomic DNA Translation: CAA27724.1 X16389 Genomic DNA Translation: CAA34425.1 X16390 Genomic DNA Translation: CAA34426.1 M13989 Genomic DNA Translation: AAA39787.1 K03547 Genomic DNA Translation: AAA39786.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35861.1
PIRⁱ	A25285 TVMSMB
NCBI Reference Sequences More...RefSeqⁱ	NP_001185843.1, NM_001198914.1 NP_034978.3, NM_010848.3
UniGeneⁱ	Mm.473872 Mm.52109

Genome annotation databases

Ensemblⁱ	ENSMUST00000020158; ENSMUSP00000020158; ENSMUSG00000019982
GeneIDⁱ	17863
KEGGⁱ	mmu:17863
UCSC genome browser More...UCSCⁱ	uc007eog.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P06876	Uncharacterized protein		MOUSE		334	UniRef100_P06876
Uncharacterized protein (Fragment)		MOUSE		439

Protein	Similar proteins		Species	Score	Length	Source
P06876	Transcriptional activator Myb		BOVIN		640	UniRef90_P06876
Uncharacterized protein		MOUSE		334
transcriptional activator Myb isoform X1		Florida manatee		670
MYB proto-oncogene, transcription factor		MUSPF		649
MYB proto-oncogene, transcription factor		SAIBB		645
+116

Protein	Similar proteins		Species	Score	Length	Source
P06876	Isoform 6 of Transcriptional activator Myb		HUMAN		666	UniRef50_P10242-6
Transcriptional activator Myb	)	CHICK		641
Transcriptional activator Myb		BOVIN		640
Uncharacterized protein		PANPA		729
MYB proto-oncogene, transcription factor		GORGO		726
+440

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M21169 Genomic DNA Translation: AAA39782.1 M12848 mRNA Translation: AAB59713.1 X02774 mRNA Translation: CAA26552.1 M20210 Genomic DNA Translation: AAA39783.1 AC153556 Genomic DNA No translation available. BC011513 mRNA Translation: AAH11513.1 X04099 X04104 Genomic DNA Translation: CAA27724.1 X16389 Genomic DNA Translation: CAA34425.1 X16390 Genomic DNA Translation: CAA34426.1 M13989 Genomic DNA Translation: AAA39787.1 K03547 Genomic DNA Translation: AAA39786.1
CCDSⁱ	CCDS35861.1
PIRⁱ	A25285 TVMSMB
RefSeqⁱ	NP_001185843.1, NM_001198914.1 NP_034978.3, NM_010848.3
UniGeneⁱ	Mm.473872 Mm.52109

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GUU	X-ray	1.60	A	38-89	[»]
	1GV2	X-ray	1.68	A	89-193	[»]
	1GV5	X-ray	1.58	A	90-141	[»]
	1GVD	X-ray	1.45	A	90-141	[»]
	1H88	X-ray	2.80	C	37-193	[»]
	1H89	X-ray	2.45	C	37-193	[»]
	1IDY	NMR	-	A	141-193	[»]
	1IDZ	NMR	-	A	141-193	[»]
	1MBE	NMR	-	A	38-89	[»]
	1MBF	NMR	-	A	38-89	[»]
	1MBG	NMR	-	A	90-141	[»]
	1MBH	NMR	-	A	90-141	[»]
	1MBJ	NMR	-	A	142-193	[»]
	1MBK	NMR	-	A	142-193	[»]
	1MSE	NMR	-	C	90-193	[»]
	1MSF	NMR	-	C	90-193	[»]
	1SB0	NMR	-	B	291-315	[»]
	2AGH	NMR	-	A	291-315	[»]
ProteinModelPortalⁱ	P06876
SMRⁱ	P06876
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201631, 12 interactors
ComplexPortalⁱ	CPX-685 c-Myb-C/EBPbeta complex
DIPⁱ	DIP-31713N
ELMⁱ	P06876
IntActⁱ	P06876, 3 interactors
STRINGⁱ	10090.ENSMUSP00000020158

PTM databases

iPTMnetⁱ	P06876
PhosphoSitePlusⁱ	P06876

Proteomic databases

EPDⁱ	P06876
PaxDbⁱ	P06876
PRIDEⁱ	P06876

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000020158; ENSMUSP00000020158; ENSMUSG00000019982
GeneIDⁱ	17863
KEGGⁱ	mmu:17863
UCSCⁱ	uc007eog.1 mouse

Organism-specific databases

CTDⁱ	4602
MGIⁱ	MGI:97249 Myb

Phylogenomic databases

eggNOGⁱ	KOG0048 Eukaryota COG5147 LUCA
GeneTreeⁱ	ENSGT00390000001038
HOVERGENⁱ	HBG007964
InParanoidⁱ	P06876
KOⁱ	K09420
TreeFamⁱ	TF326257

Miscellaneous databases

EvolutionaryTraceⁱ	P06876
Protein Ontology More...PROⁱ	PR:P06876
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000019982 Expressed in 243 organ(s), highest expression level in thymus
CleanExⁱ	MM_MYB
ExpressionAtlasⁱ	P06876 baseline and differential
Genevisibleⁱ	P06876 MM

Family and domain databases

CDDⁱ	cd00167 SANT, 3 hits
InterProⁱ	View protein in InterPro IPR015395 C-myb_C IPR009057 Homeobox-like_sf IPR017930 Myb_dom IPR001005 SANT/Myb IPR012642 Tscrpt_reg_Wos2-domain
Pfamⁱ	View protein in Pfam PF09316 Cmyb_C, 1 hit PF07988 LMSTEN, 1 hit PF00249 Myb_DNA-binding, 3 hits
SMARTⁱ	View protein in SMART SM00717 SANT, 3 hits
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS51294 HTH_MYB, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYB_MOUSE
Accessionⁱ	P06876Primary (citable) accession number: P06876 Secondary accession number(s): E9QMG8, Q61929
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	July 27, 2011
	Last modified:	October 10, 2018
	This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P06876 (MYB_MOUSE)

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Transcriptional activator Myb

Myb

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ